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The map label for this gene is purC [H]

Identifier: 220903596

GI number: 220903596

Start: 386669

End: 387373

Strand: Direct

Name: purC [H]

Synonym: Ddes_0315

Alternate gene names: 220903596

Gene position: 386669-387373 (Clockwise)

Preceding gene: 220903595

Following gene: 220903599

Centisome position: 13.46

GC content: 55.6

Gene sequence:

>705_bases
ATGAACCTGGTGTACCGTGGCAAAACCAAAGACGTGTATGACAACGGCGAAGACGGTTTGCGTTTGATTTTTTCAGACCG
GGTGACAAAAAATGCTGCGGGAGAAATCGATCCCGGCGGAAATACGGTGGCGGAAAACACCGAGCCTGGTCAGGGAGAGG
CCTGTCTGCTCATGGCTTCGGCCATATTTGAAGAGCTGGCTGAAAAAAACGGCGTCTCCACGCACATGATCGCATACGAT
CTGCCTTCACTGTCGATGGATGTGCGCAGAGGAACCATGTTCAATCCCGGTATCGAGTGGATTGCCCGCTGGGTTTGCAC
CGGGAGTTTTTTGCGCCGGTACGGCATGGTGCCGGGCGTGTATGACGGAATGCGTTTTGCCGATCCCGTGTTTGAGATAA
CCCTCAAGGATGATGCCGCCGGCGACCCGCTTGTTGTCCCTTCCGCCCTCGTGGCCCTGGGGGTTGTGGATGCCCGGACC
ATGACTGCCCTTCTGGACAGCAACGCAAAAGCCATGCAGGCCATACAAGCCATGTTTGCGGCGCGGGATCTGGATCTCTG
GGATATCAAGATCGAGTGGGCACTTGATGCAAAGGGCGCGCCCATGCTGATTGACGAGGTTTCGCCCGGTTGCTGCAGGG
CCTTTGACATGAAGACCAAAAAACGTGTTTCAGGTATAGCACTGGCAGAGCGCTTTCGTCGTTAA

Upstream 100 bases:

>100_bases
GCGCAAACCGGCCCACCGGGATTTCCGGTGGGGGGAGCGCCGCCTTTGCGCCTGCGAAGTTTACATAAAGAAACCACGCC
ATAAAAATGGAGAGTAGAGC

Downstream 100 bases:

>100_bases
GCAGGCTTGCGTAAGGTAAGGGATGCTTTCCGGCAAGCCTGCCGGATGCGTTTTTGATGTTCCAGCCGCCTGAAATCCGG
AATGCGAAAACCGGGCTTCA

Product: phosphoribosylaminoimidazolesuccinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MNLVYRGKTKDVYDNGEDGLRLIFSDRVTKNAAGEIDPGGNTVAENTEPGQGEACLLMASAIFEELAEKNGVSTHMIAYD
LPSLSMDVRRGTMFNPGIEWIARWVCTGSFLRRYGMVPGVYDGMRFADPVFEITLKDDAAGDPLVVPSALVALGVVDART
MTALLDSNAKAMQAIQAMFAARDLDLWDIKIEWALDAKGAPMLIDEVSPGCCRAFDMKTKKRVSGIALAERFRR

Sequences:

>Translated_234_residues
MNLVYRGKTKDVYDNGEDGLRLIFSDRVTKNAAGEIDPGGNTVAENTEPGQGEACLLMASAIFEELAEKNGVSTHMIAYD
LPSLSMDVRRGTMFNPGIEWIARWVCTGSFLRRYGMVPGVYDGMRFADPVFEITLKDDAAGDPLVVPSALVALGVVDART
MTALLDSNAKAMQAIQAMFAARDLDLWDIKIEWALDAKGAPMLIDEVSPGCCRAFDMKTKKRVSGIALAERFRR
>Mature_234_residues
MNLVYRGKTKDVYDNGEDGLRLIFSDRVTKNAAGEIDPGGNTVAENTEPGQGEACLLMASAIFEELAEKNGVSTHMIAYD
LPSLSMDVRRGTMFNPGIEWIARWVCTGSFLRRYGMVPGVYDGMRFADPVFEITLKDDAAGDPLVVPSALVALGVVDART
MTALLDSNAKAMQAIQAMFAARDLDLWDIKIEWALDAKGAPMLIDEVSPGCCRAFDMKTKKRVSGIALAERFRR

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=218, Percent_Identity=27.0642201834862, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI5453539, Length=218, Percent_Identity=27.0642201834862, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17531275, Length=223, Percent_Identity=31.390134529148, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 25606; Mature: 25606

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVYRGKTKDVYDNGEDGLRLIFSDRVTKNAAGEIDPGGNTVAENTEPGQGEACLLMAS
CCCEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
AIFEELAEKNGVSTHMIAYDLPSLSMDVRRGTMFNPGIEWIARWVCTGSFLRRYGMVPGV
HHHHHHHHHCCCCEEEEEEECCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
YDGMRFADPVFEITLKDDAAGDPLVVPSALVALGVVDARTMTALLDSNAKAMQAIQAMFA
CCCCHHCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ARDLDLWDIKIEWALDAKGAPMLIDEVSPGCCRAFDMKTKKRVSGIALAERFRR
HCCCCEEEEEEEEEECCCCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLVYRGKTKDVYDNGEDGLRLIFSDRVTKNAAGEIDPGGNTVAENTEPGQGEACLLMAS
CCCEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
AIFEELAEKNGVSTHMIAYDLPSLSMDVRRGTMFNPGIEWIARWVCTGSFLRRYGMVPGV
HHHHHHHHHCCCCEEEEEEECCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
YDGMRFADPVFEITLKDDAAGDPLVVPSALVALGVVDARTMTALLDSNAKAMQAIQAMFA
CCCCHHCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ARDLDLWDIKIEWALDAKGAPMLIDEVSPGCCRAFDMKTKKRVSGIALAERFRR
HCCCCEEEEEEEEEECCCCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]