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The map label for this gene is lepB [H]

Identifier: 220903563

GI number: 220903563

Start: 334741

End: 335361

Strand: Direct

Name: lepB [H]

Synonym: Ddes_0282

Alternate gene names: 220903563

Gene position: 334741-335361 (Clockwise)

Preceding gene: 220903562

Following gene: 220903564

Centisome position: 11.65

GC content: 55.39

Gene sequence:

>621_bases
ATGACCACGCTTTTGAGATCGTCGCGCCCCAAGAAGCCCCTTTGGCGCGAATATGGCGAGGCCCTGCTTGTGGCCCTGCT
GCTTGCCCTGGTTATCCGTACCTTTGTAGTACAGGCTTTTAAAATACCGTCTGAATCCATGCTGCAAACCCTGCTGGTGG
GCGATCACCTGCTGGCAAGCAAGTTCGCCTATGGCATCAAGGTTCCCTTTACCAATCACTATATTTACAGGGGTGACGAC
CCGCAGCGCGGCGAAATCATCATCTTTGAATATCCCAATGATCCCAGTGTGGACTATATCAAGCGCATTGTGGGTGTTCC
CGGCGATATCATCGAAGTGCGCGGCAAGCAGCTGTACCGCAATGGCGAAGCTGTCAAGGAAAGCTACACGCGTTTTACGC
AGCCTGATCGTGTGGAGCCTGTACGCGACAATTTCGGACCGGTGACGGTTCCTGAAGGCAAGTACTTCGTCATGGGCGAC
AACCGCGACAACTCGCTGGATTCGCGCTTCTGGGGTTTTGTGGACCGCAGCGCCATACGGGCCAAGGCATGGCGCATCTA
CTGGTCCTGGGGCGGGCTTGACGACATGCGCTGGAACCGCATGGGCAAAAAAGTGGAATAG

Upstream 100 bases:

>100_bases
CAGCGTCCAGGAAAATGGCGCGCGGGCTGAAAACAGCAGTAATACGCTGCCCCCGGCAGGCGTTTCAAGGTAAAATGCCC
TCAACAAGGAACAGCACCTC

Downstream 100 bases:

>100_bases
CCGCCCTGCGGCTCAAGCGTGGCAAGGAGGCCCTGTGGTGGTCCGGCTGAACAGCGGCGGCGTTGAAGGCGTTGATGCCT
ATCCCGTAGAACTGGAAGTG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTTLLRSSRPKKPLWREYGEALLVALLLALVIRTFVVQAFKIPSESMLQTLLVGDHLLASKFAYGIKVPFTNHYIYRGDD
PQRGEIIIFEYPNDPSVDYIKRIVGVPGDIIEVRGKQLYRNGEAVKESYTRFTQPDRVEPVRDNFGPVTVPEGKYFVMGD
NRDNSLDSRFWGFVDRSAIRAKAWRIYWSWGGLDDMRWNRMGKKVE

Sequences:

>Translated_206_residues
MTTLLRSSRPKKPLWREYGEALLVALLLALVIRTFVVQAFKIPSESMLQTLLVGDHLLASKFAYGIKVPFTNHYIYRGDD
PQRGEIIIFEYPNDPSVDYIKRIVGVPGDIIEVRGKQLYRNGEAVKESYTRFTQPDRVEPVRDNFGPVTVPEGKYFVMGD
NRDNSLDSRFWGFVDRSAIRAKAWRIYWSWGGLDDMRWNRMGKKVE
>Mature_205_residues
TTLLRSSRPKKPLWREYGEALLVALLLALVIRTFVVQAFKIPSESMLQTLLVGDHLLASKFAYGIKVPFTNHYIYRGDDP
QRGEIIIFEYPNDPSVDYIKRIVGVPGDIIEVRGKQLYRNGEAVKESYTRFTQPDRVEPVRDNFGPVTVPEGKYFVMGDN
RDNSLDSRFWGFVDRSAIRAKAWRIYWSWGGLDDMRWNRMGKKVE

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=98, Percent_Identity=48.9795918367347, Blast_Score=109, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 23881; Mature: 23750

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLLRSSRPKKPLWREYGEALLVALLLALVIRTFVVQAFKIPSESMLQTLLVGDHLLAS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KFAYGIKVPFTNHYIYRGDDPQRGEIIIFEYPNDPSVDYIKRIVGVPGDIIEVRGKQLYR
HHHCEEECCCCCCEEECCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHCCHHHHH
NGEAVKESYTRFTQPDRVEPVRDNFGPVTVPEGKYFVMGDNRDNSLDSRFWGFVDRSAIR
CCHHHHHHHHHCCCCCCCCCHHCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHH
AKAWRIYWSWGGLDDMRWNRMGKKVE
HEEEEEEEECCCCCCHHHHHCCCCCC
>Mature Secondary Structure 
TTLLRSSRPKKPLWREYGEALLVALLLALVIRTFVVQAFKIPSESMLQTLLVGDHLLAS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KFAYGIKVPFTNHYIYRGDDPQRGEIIIFEYPNDPSVDYIKRIVGVPGDIIEVRGKQLYR
HHHCEEECCCCCCEEECCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHCCHHHHH
NGEAVKESYTRFTQPDRVEPVRDNFGPVTVPEGKYFVMGDNRDNSLDSRFWGFVDRSAIR
CCHHHHHHHHHCCCCCCCCCHHCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHH
AKAWRIYWSWGGLDDMRWNRMGKKVE
HEEEEEEEECCCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]