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The map label for this gene is zraR [H]

Identifier: 220903471

GI number: 220903471

Start: 236171

End: 237544

Strand: Direct

Name: zraR [H]

Synonym: Ddes_0187

Alternate gene names: 220903471

Gene position: 236171-237544 (Clockwise)

Preceding gene: 220903470

Following gene: 220903472

Centisome position: 8.22

GC content: 61.21

Gene sequence:

>1374_bases
GTGAAGAACAGCATTCTTGTAGTGGACGATGACGACGCGCACCGCGGTATGCTGCGAACCATGCTTCGTTCCTGGGACTA
TGTGGTGGAGGAGGCTGCCGACGGCGATGAGGCGGTGGCTCTTGTACGGGAAAAGGCCTTTGACGCCGTGCTGACCGACG
TGCGCATGGCGCGCATGAACGGCATACACGCGCTCAAGGGGATTCTTGCATATAATCCCGCGCTGCCTGTCATTCTCATG
ACGGCGTATTCCTCGGTGGAAACAGCCGTGGAGGCTTTGCGCCTGGGGGCGTATGACTATCTGGTCAAGCCTCTGGACTT
TGAAAGCCTGAAGCATTCCTTGCAGCAAGGCATTGAGCGTTCGCGCCTGAGTGTCGAAAATCGCGAACTGCGCCGTCAGT
TGAGTCACGCGGCGGCCATGCCCGGCATTATCGGCCGCAGTCCGGCCATTCGCGCCATGCAGGAAATCATGGATACCGTG
GCCCCCACCGAAGCCACGGTGCTCATTACCGGCGAGTCGGGAACCGGCAAGGAGCTGGTGGCCCGCGCCCTGCACGGCAA
AAGCCTGCGCGCCGATAAACCCCTTGTTACCGTCAACTGTGCGGCTCTGGCGGAAAACCTGCTGGAATCAGAATTGTTCG
GGCATGAAAAAGGCTCGTTCACCGGTGCGGAGCGCCGTCGCGAGGGGCGCTTTGCCCAGGCGCACGGCGGCACGCTCTTT
CTGGACGAAGTGGGTGAGATGCCCCTTTCGCTTCAGGCCAAGCTGCTGCGTGCCCTGCAGCAGGGTGAGGTGCAGCGCGT
AGGCTCTGACACGCAGCTCACTGTGGATGTGCGCGTACTGGCCGCCACCAACCGTGACCTGCGGCATGAGGTGGCGCACA
GGCGTTTTCGCGAAGACCTGTTTTTCCGCCTGAATGTCATCAGTGTTGAAGTGCCGCCCCTGCGTGAAAGGGCAGAAGAC
ATTCCTGTGCTGGCGGCATATTTTCTGGAAAATTTTGCCAGTCGTAACCGCAAGGCCGTGCGCGGGTTTTCCGCGCAGGC
GCTTGACATCATGCTGCGGCATTCCTGGCCGGGCAATGTGCGCGAACTGGAAAATGCCGTGGAGCGGGCTGTTATTCTCT
GCACCGGCGACCTTATCACCGCGCGCGAACTGCCCTCTGTGCTGTCTGAAACCGTTGCGGCGGCAGAAGCTCCGGCGGAA
GCTCCGGCAGAAGCGGATCTTTCTCTGGCGGGTCTGCCCCTGGATGAGGTGGAGCGCCGGGTCATTGAGGAAACCCTGCG
CCAGACCGGCGATAACAAGAGTGAGGCCGCGCGCCGCCTGGGCATTACCCGCGCCACCCTGCACAACAAGCTGCGCAAGT
ACGAGCTTGAATAA

Upstream 100 bases:

>100_bases
ACACCGCCTTTTGTGGAACGCAGAAAGAGAAAGCGTCTGTGATTCACCGGGCTGCGCGCGGCAAATGGCTGCGACCCGGC
TGGTCAGGAGGATTATCAGG

Downstream 100 bases:

>100_bases
CGCGGTGTTGCCGTGAACCAGCGCTGACGCCGTCCTTGTTGCTGCCCGCACTGCGCTGATCTGGCCTTTGCGAGAGCTTT
TTTCGCATTGGTGCTGCGGT

Product: Fis family two component sigma-54 specific transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKNSILVVDDDDAHRGMLRTMLRSWDYVVEEAADGDEAVALVREKAFDAVLTDVRMARMNGIHALKGILAYNPALPVILM
TAYSSVETAVEALRLGAYDYLVKPLDFESLKHSLQQGIERSRLSVENRELRRQLSHAAAMPGIIGRSPAIRAMQEIMDTV
APTEATVLITGESGTGKELVARALHGKSLRADKPLVTVNCAALAENLLESELFGHEKGSFTGAERRREGRFAQAHGGTLF
LDEVGEMPLSLQAKLLRALQQGEVQRVGSDTQLTVDVRVLAATNRDLRHEVAHRRFREDLFFRLNVISVEVPPLRERAED
IPVLAAYFLENFASRNRKAVRGFSAQALDIMLRHSWPGNVRELENAVERAVILCTGDLITARELPSVLSETVAAAEAPAE
APAEADLSLAGLPLDEVERRVIEETLRQTGDNKSEAARRLGITRATLHNKLRKYELE

Sequences:

>Translated_457_residues
MKNSILVVDDDDAHRGMLRTMLRSWDYVVEEAADGDEAVALVREKAFDAVLTDVRMARMNGIHALKGILAYNPALPVILM
TAYSSVETAVEALRLGAYDYLVKPLDFESLKHSLQQGIERSRLSVENRELRRQLSHAAAMPGIIGRSPAIRAMQEIMDTV
APTEATVLITGESGTGKELVARALHGKSLRADKPLVTVNCAALAENLLESELFGHEKGSFTGAERRREGRFAQAHGGTLF
LDEVGEMPLSLQAKLLRALQQGEVQRVGSDTQLTVDVRVLAATNRDLRHEVAHRRFREDLFFRLNVISVEVPPLRERAED
IPVLAAYFLENFASRNRKAVRGFSAQALDIMLRHSWPGNVRELENAVERAVILCTGDLITARELPSVLSETVAAAEAPAE
APAEADLSLAGLPLDEVERRVIEETLRQTGDNKSEAARRLGITRATLHNKLRKYELE
>Mature_457_residues
MKNSILVVDDDDAHRGMLRTMLRSWDYVVEEAADGDEAVALVREKAFDAVLTDVRMARMNGIHALKGILAYNPALPVILM
TAYSSVETAVEALRLGAYDYLVKPLDFESLKHSLQQGIERSRLSVENRELRRQLSHAAAMPGIIGRSPAIRAMQEIMDTV
APTEATVLITGESGTGKELVARALHGKSLRADKPLVTVNCAALAENLLESELFGHEKGSFTGAERRREGRFAQAHGGTLF
LDEVGEMPLSLQAKLLRALQQGEVQRVGSDTQLTVDVRVLAATNRDLRHEVAHRRFREDLFFRLNVISVEVPPLRERAED
IPVLAAYFLENFASRNRKAVRGFSAQALDIMLRHSWPGNVRELENAVERAVILCTGDLITARELPSVLSETVAAAEAPAE
APAEADLSLAGLPLDEVERRVIEETLRQTGDNKSEAARRLGITRATLHNKLRKYELE

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=450, Percent_Identity=56.4444444444444, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=46.4912280701754, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=41.025641025641, Blast_Score=325, Evalue=4e-90,
Organism=Escherichia coli, GI1788905, Length=453, Percent_Identity=38.6313465783664, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI87082117, Length=354, Percent_Identity=46.045197740113, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1789087, Length=335, Percent_Identity=46.2686567164179, Blast_Score=275, Evalue=7e-75,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=43.8871473354232, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI87082152, Length=320, Percent_Identity=47.5, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI87081872, Length=324, Percent_Identity=41.0493827160494, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1786524, Length=364, Percent_Identity=37.0879120879121, Blast_Score=218, Evalue=9e-58,
Organism=Escherichia coli, GI1787583, Length=335, Percent_Identity=38.8059701492537, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1789828, Length=249, Percent_Identity=39.7590361445783, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI87081858, Length=310, Percent_Identity=30.6451612903226, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1787487, Length=203, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788191, Length=119, Percent_Identity=34.453781512605, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50544; Mature: 50544

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSILVVDDDDAHRGMLRTMLRSWDYVVEEAADGDEAVALVREKAFDAVLTDVRMARMN
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIHALKGILAYNPALPVILMTAYSSVETAVEALRLGAYDYLVKPLDFESLKHSLQQGIER
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHH
SRLSVENRELRRQLSHAAAMPGIIGRSPAIRAMQEIMDTVAPTEATVLITGESGTGKELV
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH
ARALHGKSLRADKPLVTVNCAALAENLLESELFGHEKGSFTGAERRREGRFAQAHGGTLF
HHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCEEE
LDEVGEMPLSLQAKLLRALQQGEVQRVGSDTQLTVDVRVLAATNRDLRHEVAHRRFREDL
EHHHCCCCHHHHHHHHHHHHHCHHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHH
FFRLNVISVEVPPLRERAEDIPVLAAYFLENFASRNRKAVRGFSAQALDIMLRHSWPGNV
HEEEEEEEEECCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHCCCCCCH
RELENAVERAVILCTGDLITARELPSVLSETVAAAEAPAEAPAEADLSLAGLPLDEVERR
HHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHH
VIEETLRQTGDNKSEAARRLGITRATLHNKLRKYELE
HHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNSILVVDDDDAHRGMLRTMLRSWDYVVEEAADGDEAVALVREKAFDAVLTDVRMARMN
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIHALKGILAYNPALPVILMTAYSSVETAVEALRLGAYDYLVKPLDFESLKHSLQQGIER
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHH
SRLSVENRELRRQLSHAAAMPGIIGRSPAIRAMQEIMDTVAPTEATVLITGESGTGKELV
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH
ARALHGKSLRADKPLVTVNCAALAENLLESELFGHEKGSFTGAERRREGRFAQAHGGTLF
HHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCEEE
LDEVGEMPLSLQAKLLRALQQGEVQRVGSDTQLTVDVRVLAATNRDLRHEVAHRRFREDL
EHHHCCCCHHHHHHHHHHHHHCHHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHH
FFRLNVISVEVPPLRERAEDIPVLAAYFLENFASRNRKAVRGFSAQALDIMLRHSWPGNV
HEEEEEEEEECCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHCCCCCCH
RELENAVERAVILCTGDLITARELPSVLSETVAAAEAPAEAPAEADLSLAGLPLDEVERR
HHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHH
VIEETLRQTGDNKSEAARRLGITRATLHNKLRKYELE
HHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]