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The map label for this gene is mrdA [H]

Identifier: 220903447

GI number: 220903447

Start: 199816

End: 201738

Strand: Reverse

Name: mrdA [H]

Synonym: Ddes_0161

Alternate gene names: 220903447

Gene position: 201738-199816 (Counterclockwise)

Preceding gene: 220903448

Following gene: 220903446

Centisome position: 7.02

GC content: 62.09

Gene sequence:

>1923_bases
ATGCTGCGGAAAATTAAAAAGAACAGTCTGCTGGGCGCGAAAGATAAAAACGCCCGCAAAGGCATACGCTCCTGGCTCAA
AATCCAGGTAGAGGGCGAGCGCTACCAGCCTCCTCGGGGCGGGATCATCCTGCTTCAGATTCTGGTAGGCCTGCTGTTCT
TCGTGCTCGTGGTGCGCTTCTGGTACCTGCAGATGCACCGCGGCGCGGAATTTGCCCAGCAGGCGCAGAACAACCGTCTG
CGCATCGAGCGCATCTTCGCCCCGCGCGGGCGCATCATGGACGATCAGGGCAAGGTGCTGGCCGACAACCGCACGGCCTA
CGGCCTTTCCCTCGTACGCGAAGACTGCCCCGACATACCGGCCACCCTGGCCCAGATCAGCGCATGGTCGGGCATTCCCC
TGCCCCAGATATGGGAAAAATTCCGGCAGGACAGGTTCAAGGTCAAATCATTTGAACCCCTGCTCATGATCACTGACATT
GACTTTGATCTTGTGGCCCGCATCGAGTCCGAAATCCACGCCTGGCCCGGCCTGGAAATCGTTGTGCGCACCAAGCGCAG
CTATCCCGAAAAAGACCTGTTCGCGCACGTGCTCGGCTATGTGGCCGAAGCCAACGAGCAGGAGATGGCCGCAGACAGTG
CCCTGGCCATGGGCGACCTTGTGGGCAAGCAGGGGCTGGAGCTGGAGCTGGAAAAGCAGCTGCGCGGGCGCAAGGGCCTG
TACGACGTGGAAGTGGACGCCCATTCCCGCGTACTGGGCAAATTTTTGCGCGAAGAGCCGCGCGGCGGCAAGGAAATACG
CCTTTCACTGGACAGGGACCTCCAGGAGGCCGCTTGGAACGCCCTGGGTGGCGAAGCGGGCTGTGTGGTGGTGATGGAAC
CGGATACCGGCAAGCTGCGTGCGCTGGTCACCTCCCCGGCCTACGACAACAACCTGTTCGCGGCGGGCATTTCACAGCGC
GACTGGGACGCCCTGCGCACCAACAGCCGCTTTCCCCTGCAAAACCGCGTCATTCAAAGCGTGTACCCGCCCGGTTCCGT
CTGGAAGCTGGTCATAGCGGCCATGCTGCTCGAACGCGGCGTCAACCCGCGCGAAAGCGTGTTCTGTCCGGGGCAGGTCA
AGCTGGGCAACCAGATATTCCGCTGCTGGAAGCGCGGCGGGCACGGCTCGCAAGACATGCAGAGCGCGCTGGTCAATTCA
TGCGACGTGTATTTTTACCAGATGGGCGAACGCATGGGCATTGACAAGATAGAGGAATTTGCCAAGGCTAGCGGCTTCGG
ACGCCCCACCGGCATTGACCTGCCGCACGAAAAATCCGGTCTCGTGCCTTCCAAGGAATGGAAAAAGCGCCGCTTCGGAC
GGCCCTGGGTGCGCGGTGAAACGTACAACGTATCCATCGGCCAGGGCTACACCCTTGTCACCCCTGTGCAGATGGCTGTT
TTTGTGTCGGCCCTGCTCAACGGCGGCAACCTGCTCAAGCCGCAGTTGCTGGACGATGCCCAGCGTGAGATCAAGGGCAA
TATTCCCGCCAAGGCAGCAACCCTCAATTTTGTGGTTGAGGCCATGCGCAAGACGGCCACAGGCGGCACCGCAAGGATCG
TGAACCGCAAGGACGCCGACATGGGCGGCAAAACCGGCACGGCCCAGGTGGTCAAGCTCAAGATGGCCGCCGGAGACCGC
CGCCTGCGCACACATGAAATGGAATACGCCCAGCGCGACCACGCCTGGATAACGACCTGGGGCGTCAAGGACGGCAAGGC
TTACGTGGTGGTAGTTATGGTGGAGCACGGCGGCGGCGGCTCCAGCGTTGCAGGCCCGGTAGCCAAAAAGGTATACGAGC
ACCTCTTTGGCCCTGACCCCGGATCGCCTGCGGCGCCCGCGCCTGTGCCAGCGCCGGCCAGCCCCGGCGAACGGACAGAC
TAG

Upstream 100 bases:

>100_bases
CCCTTCAACTTTCAGGACACACTGGACAAAAGTCTTATCCAGGCCATATTTATTCCTTTTGCCTGGAAACTTCTGGTGGC
TACCCGACACGGAAAGGCCC

Downstream 100 bases:

>100_bases
GCATTGTACGGCATAACCGTTGCGGCCGGACTGCCCCGCACGGACAGCACGAAAACACCGTAACTGGGCACGTACCATCT
TTGCATCGCTGAACGTTCCC

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 640; Mature: 640

Protein sequence:

>640_residues
MLRKIKKNSLLGAKDKNARKGIRSWLKIQVEGERYQPPRGGIILLQILVGLLFFVLVVRFWYLQMHRGAEFAQQAQNNRL
RIERIFAPRGRIMDDQGKVLADNRTAYGLSLVREDCPDIPATLAQISAWSGIPLPQIWEKFRQDRFKVKSFEPLLMITDI
DFDLVARIESEIHAWPGLEIVVRTKRSYPEKDLFAHVLGYVAEANEQEMAADSALAMGDLVGKQGLELELEKQLRGRKGL
YDVEVDAHSRVLGKFLREEPRGGKEIRLSLDRDLQEAAWNALGGEAGCVVVMEPDTGKLRALVTSPAYDNNLFAAGISQR
DWDALRTNSRFPLQNRVIQSVYPPGSVWKLVIAAMLLERGVNPRESVFCPGQVKLGNQIFRCWKRGGHGSQDMQSALVNS
CDVYFYQMGERMGIDKIEEFAKASGFGRPTGIDLPHEKSGLVPSKEWKKRRFGRPWVRGETYNVSIGQGYTLVTPVQMAV
FVSALLNGGNLLKPQLLDDAQREIKGNIPAKAATLNFVVEAMRKTATGGTARIVNRKDADMGGKTGTAQVVKLKMAAGDR
RLRTHEMEYAQRDHAWITTWGVKDGKAYVVVVMVEHGGGGSSVAGPVAKKVYEHLFGPDPGSPAAPAPVPAPASPGERTD

Sequences:

>Translated_640_residues
MLRKIKKNSLLGAKDKNARKGIRSWLKIQVEGERYQPPRGGIILLQILVGLLFFVLVVRFWYLQMHRGAEFAQQAQNNRL
RIERIFAPRGRIMDDQGKVLADNRTAYGLSLVREDCPDIPATLAQISAWSGIPLPQIWEKFRQDRFKVKSFEPLLMITDI
DFDLVARIESEIHAWPGLEIVVRTKRSYPEKDLFAHVLGYVAEANEQEMAADSALAMGDLVGKQGLELELEKQLRGRKGL
YDVEVDAHSRVLGKFLREEPRGGKEIRLSLDRDLQEAAWNALGGEAGCVVVMEPDTGKLRALVTSPAYDNNLFAAGISQR
DWDALRTNSRFPLQNRVIQSVYPPGSVWKLVIAAMLLERGVNPRESVFCPGQVKLGNQIFRCWKRGGHGSQDMQSALVNS
CDVYFYQMGERMGIDKIEEFAKASGFGRPTGIDLPHEKSGLVPSKEWKKRRFGRPWVRGETYNVSIGQGYTLVTPVQMAV
FVSALLNGGNLLKPQLLDDAQREIKGNIPAKAATLNFVVEAMRKTATGGTARIVNRKDADMGGKTGTAQVVKLKMAAGDR
RLRTHEMEYAQRDHAWITTWGVKDGKAYVVVVMVEHGGGGSSVAGPVAKKVYEHLFGPDPGSPAAPAPVPAPASPGERTD
>Mature_640_residues
MLRKIKKNSLLGAKDKNARKGIRSWLKIQVEGERYQPPRGGIILLQILVGLLFFVLVVRFWYLQMHRGAEFAQQAQNNRL
RIERIFAPRGRIMDDQGKVLADNRTAYGLSLVREDCPDIPATLAQISAWSGIPLPQIWEKFRQDRFKVKSFEPLLMITDI
DFDLVARIESEIHAWPGLEIVVRTKRSYPEKDLFAHVLGYVAEANEQEMAADSALAMGDLVGKQGLELELEKQLRGRKGL
YDVEVDAHSRVLGKFLREEPRGGKEIRLSLDRDLQEAAWNALGGEAGCVVVMEPDTGKLRALVTSPAYDNNLFAAGISQR
DWDALRTNSRFPLQNRVIQSVYPPGSVWKLVIAAMLLERGVNPRESVFCPGQVKLGNQIFRCWKRGGHGSQDMQSALVNS
CDVYFYQMGERMGIDKIEEFAKASGFGRPTGIDLPHEKSGLVPSKEWKKRRFGRPWVRGETYNVSIGQGYTLVTPVQMAV
FVSALLNGGNLLKPQLLDDAQREIKGNIPAKAATLNFVVEAMRKTATGGTARIVNRKDADMGGKTGTAQVVKLKMAAGDR
RLRTHEMEYAQRDHAWITTWGVKDGKAYVVVVMVEHGGGGSSVAGPVAKKVYEHLFGPDPGSPAAPAPVPAPASPGERTD

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=619, Percent_Identity=32.6332794830372, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1786272, Length=522, Percent_Identity=23.3716475095785, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71075; Mature: 71075

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRKIKKNSLLGAKDKNARKGIRSWLKIQVEGERYQPPRGGIILLQILVGLLFFVLVVRF
CCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHH
WYLQMHRGAEFAQQAQNNRLRIERIFAPRGRIMDDQGKVLADNRTAYGLSLVREDCPDIP
HHHHHHCCHHHHHHHCCCCEEEEEEECCCCCEECCCCCEEECCCCHHHHHHHHHCCCCHH
ATLAQISAWSGIPLPQIWEKFRQDRFKVKSFEPLLMITDIDFDLVARIESEIHAWPGLEI
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEE
VVRTKRSYPEKDLFAHVLGYVAEANEQEMAADSALAMGDLVGKQGLELELEKQLRGRKGL
EEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCC
YDVEVDAHSRVLGKFLREEPRGGKEIRLSLDRDLQEAAWNALGGEAGCVVVMEPDTGKLR
EEEEECHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCEE
ALVTSPAYDNNLFAAGISQRDWDALRTNSRFPLQNRVIQSVYPPGSVWKLVIAAMLLERG
EEEECCCCCCCEEEECCCCCCHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCC
VNPRESVFCPGQVKLGNQIFRCWKRGGHGSQDMQSALVNSCDVYFYQMGERMGIDKIEEF
CCCHHCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AKASGFGRPTGIDLPHEKSGLVPSKEWKKRRFGRPWVRGETYNVSIGQGYTLVTPVQMAV
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCCCEEEEHHHHHHH
FVSALLNGGNLLKPQLLDDAQREIKGNIPAKAATLNFVVEAMRKTATGGTARIVNRKDAD
HHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
MGGKTGTAQVVKLKMAAGDRRLRTHEMEYAQRDHAWITTWGVKDGKAYVVVVMVEHGGGG
CCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEEECCCC
SSVAGPVAKKVYEHLFGPDPGSPAAPAPVPAPASPGERTD
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLRKIKKNSLLGAKDKNARKGIRSWLKIQVEGERYQPPRGGIILLQILVGLLFFVLVVRF
CCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHH
WYLQMHRGAEFAQQAQNNRLRIERIFAPRGRIMDDQGKVLADNRTAYGLSLVREDCPDIP
HHHHHHCCHHHHHHHCCCCEEEEEEECCCCCEECCCCCEEECCCCHHHHHHHHHCCCCHH
ATLAQISAWSGIPLPQIWEKFRQDRFKVKSFEPLLMITDIDFDLVARIESEIHAWPGLEI
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEE
VVRTKRSYPEKDLFAHVLGYVAEANEQEMAADSALAMGDLVGKQGLELELEKQLRGRKGL
EEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCC
YDVEVDAHSRVLGKFLREEPRGGKEIRLSLDRDLQEAAWNALGGEAGCVVVMEPDTGKLR
EEEEECHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCEE
ALVTSPAYDNNLFAAGISQRDWDALRTNSRFPLQNRVIQSVYPPGSVWKLVIAAMLLERG
EEEECCCCCCCEEEECCCCCCHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCC
VNPRESVFCPGQVKLGNQIFRCWKRGGHGSQDMQSALVNSCDVYFYQMGERMGIDKIEEF
CCCHHCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AKASGFGRPTGIDLPHEKSGLVPSKEWKKRRFGRPWVRGETYNVSIGQGYTLVTPVQMAV
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCCCEEEEHHHHHHH
FVSALLNGGNLLKPQLLDDAQREIKGNIPAKAATLNFVVEAMRKTATGGTARIVNRKDAD
HHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
MGGKTGTAQVVKLKMAAGDRRLRTHEMEYAQRDHAWITTWGVKDGKAYVVVVMVEHGGGG
CCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEEECCCC
SSVAGPVAKKVYEHLFGPDPGSPAAPAPVPAPASPGERTD
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]