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The map label for this gene is atoC [H]

Identifier: 220903441

GI number: 220903441

Start: 193883

End: 195607

Strand: Reverse

Name: atoC [H]

Synonym: Ddes_0155

Alternate gene names: 220903441

Gene position: 195607-193883 (Counterclockwise)

Preceding gene: 220903442

Following gene: 220903440

Centisome position: 6.81

GC content: 58.49

Gene sequence:

>1725_bases
ATGCCCGCACTGCCCGAAGAAAGTATGCTTGTTGAACAAGTCATGCACGACAATCCCGAAACCCTGACGCCCGGGCACCT
GCTCAAGGACGCACTGCCCGTTTACGAGCGCCACGGGGTCAATTGCGTACCCATTCTGGACGAAAACAAAAAAGTGCGCG
GCATTCTGACCATATTCCGCCTTGTGCAGGCCATACGCTCGGGCAAATCTTTTGAAACGCCCATCAGTGAAGTTATGGAT
GTGGACCTTGTGAGCATACGCAACGACGCCACGTTCGGCATGGCCTGCAGTATGCCCATCGACAGAATGCTGGTGCTCGA
CCACGACGACAGGCTCGTGGGCGTGCTGACCAAAAAAGAACTCATCCATAAAATTTACAAGGCATTCTGCAGCGCCGACT
GCCATAACCGGGAGCTGAGCGCGGTCATCAACTGCGCCACGGACGGCATCATCATTTTCGACACCAACGGCAACGCCCTG
TATACCAACGATAAAATTCGCTTTCTCCTGCCGGATTGCGACACCATCAACCAGCCGGCCAGCCCGGCCATGAAGGCTGT
AGCCGAACTGCTCAAAAAAACCCTGCACTCACGCAAAAGCGCCAGCACCCTGCTGGAGGACTGCAACGGCAAGCAGGTGA
TTTTTTCAACCACACCCATCTTTGACGCAGACCAGCGCCTCTTCCGCTGCGTATTGTCTGCCCAGGATATGACGGAAGTT
ACCCGCCTTCAGGAAGAAGCCGAAAACAGCCGCCGCAAGCTGGCGGCCTTTCAGGAAGCCAGCCTCAAAGGAACCAGAAC
CATCGCCCACAACCCTGCCATGCTGCGCTTGCTGGATGAGGCCGCCCGCCTTGGAAGCGTGGACTCCACCGTGCTCATCA
CCGGCGAAACAGGGGCGGGCAAAGAGGTTGTGGCCATGCACATCCACAACCACAGCAAGCGGCGCAACGGCCCGCTGGTG
CAGATAAACTGCGGCACCATCCCCCAGCACCTGCAGGAAGCGGAGCTGTTCGGCTACGAAAAAGGCAGCTTCACCGGGGC
CAATGCCACCCGTGCGGGCATGCTGGAGGTGGCCCACGAAGGCACGCTCATGCTGGACGAAGTGGGCGAAATGGATCTTA
CCCTGCAGGTCAAACTGCTGCGCGCCCTTCAGGAGGGCGTCATTTACCGCATTGGCGGGCGCAAGCCCGTCAGGCTGGAT
GTGCGCATCATTGCCATGACCAACAGGGACCTGCTCAAAATGGTGCGCGAAAACACCTTTCGCGAGGACCTTTATTACCG
CCTCAACGTCATCCCCCTGGCCGTGCCGCCCCTGCGCGAACGATGCGAGGATATCCTGCCCCTGGCCCAGCATTTTCTTT
CCTGCTTCAGCAAAAAATATTCCTGCGCCTGCAGCCTCAGCCCGGCGGAAGAAGAAATGCTGCAAGCCTATTCCTGGCCC
GGCAACGTGCGCGAACTTGCCAACTTTATGGAACGGCTGACCATCGCCAGCCTGTCGTCAGGCAACCGCGCCCCGGTGTG
GGAAAGCATCGTTCGGCCCAATGGTTCCGTAGCGCCGCCCGTCAACGCCCCCATGCGGGAGCAGATGCGCCATTTTGAAA
AACAATGTGTTGAAAACGCCCTGCGCAACACGGTGAGCATACGGGCCGCAGCCCGGGCGCTGGGCATCTCGCACGCAACC
CTCTTGCGCAAGATGCGGGAACATGACTTGGTGGTTCAAAATTAA

Upstream 100 bases:

>100_bases
ACTCTGCATCAAATCCGGCCCAACTGTTCCACACGCCCGGCAATGCCGGCACAGCGTCGTTGAAGAAACCGCGCCGGTCA
TCAAAACCCCGAGACATTCC

Downstream 100 bases:

>100_bases
ACCACTCTGAAAGGCAAACTCCCGTCCGTATCCCCCCCTTCTGTGCCATATCTGCTTCTGAACGCCCGCAGGTTGTGAAA
AAGAGCCTGTGGTTCACAAA

Product: Fis family sigma-54 specific transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MPALPEESMLVEQVMHDNPETLTPGHLLKDALPVYERHGVNCVPILDENKKVRGILTIFRLVQAIRSGKSFETPISEVMD
VDLVSIRNDATFGMACSMPIDRMLVLDHDDRLVGVLTKKELIHKIYKAFCSADCHNRELSAVINCATDGIIIFDTNGNAL
YTNDKIRFLLPDCDTINQPASPAMKAVAELLKKTLHSRKSASTLLEDCNGKQVIFSTTPIFDADQRLFRCVLSAQDMTEV
TRLQEEAENSRRKLAAFQEASLKGTRTIAHNPAMLRLLDEAARLGSVDSTVLITGETGAGKEVVAMHIHNHSKRRNGPLV
QINCGTIPQHLQEAELFGYEKGSFTGANATRAGMLEVAHEGTLMLDEVGEMDLTLQVKLLRALQEGVIYRIGGRKPVRLD
VRIIAMTNRDLLKMVRENTFREDLYYRLNVIPLAVPPLRERCEDILPLAQHFLSCFSKKYSCACSLSPAEEEMLQAYSWP
GNVRELANFMERLTIASLSSGNRAPVWESIVRPNGSVAPPVNAPMREQMRHFEKQCVENALRNTVSIRAAARALGISHAT
LLRKMREHDLVVQN

Sequences:

>Translated_574_residues
MPALPEESMLVEQVMHDNPETLTPGHLLKDALPVYERHGVNCVPILDENKKVRGILTIFRLVQAIRSGKSFETPISEVMD
VDLVSIRNDATFGMACSMPIDRMLVLDHDDRLVGVLTKKELIHKIYKAFCSADCHNRELSAVINCATDGIIIFDTNGNAL
YTNDKIRFLLPDCDTINQPASPAMKAVAELLKKTLHSRKSASTLLEDCNGKQVIFSTTPIFDADQRLFRCVLSAQDMTEV
TRLQEEAENSRRKLAAFQEASLKGTRTIAHNPAMLRLLDEAARLGSVDSTVLITGETGAGKEVVAMHIHNHSKRRNGPLV
QINCGTIPQHLQEAELFGYEKGSFTGANATRAGMLEVAHEGTLMLDEVGEMDLTLQVKLLRALQEGVIYRIGGRKPVRLD
VRIIAMTNRDLLKMVRENTFREDLYYRLNVIPLAVPPLRERCEDILPLAQHFLSCFSKKYSCACSLSPAEEEMLQAYSWP
GNVRELANFMERLTIASLSSGNRAPVWESIVRPNGSVAPPVNAPMREQMRHFEKQCVENALRNTVSIRAAARALGISHAT
LLRKMREHDLVVQN
>Mature_573_residues
PALPEESMLVEQVMHDNPETLTPGHLLKDALPVYERHGVNCVPILDENKKVRGILTIFRLVQAIRSGKSFETPISEVMDV
DLVSIRNDATFGMACSMPIDRMLVLDHDDRLVGVLTKKELIHKIYKAFCSADCHNRELSAVINCATDGIIIFDTNGNALY
TNDKIRFLLPDCDTINQPASPAMKAVAELLKKTLHSRKSASTLLEDCNGKQVIFSTTPIFDADQRLFRCVLSAQDMTEVT
RLQEEAENSRRKLAAFQEASLKGTRTIAHNPAMLRLLDEAARLGSVDSTVLITGETGAGKEVVAMHIHNHSKRRNGPLVQ
INCGTIPQHLQEAELFGYEKGSFTGANATRAGMLEVAHEGTLMLDEVGEMDLTLQVKLLRALQEGVIYRIGGRKPVRLDV
RIIAMTNRDLLKMVRENTFREDLYYRLNVIPLAVPPLRERCEDILPLAQHFLSCFSKKYSCACSLSPAEEEMLQAYSWPG
NVRELANFMERLTIASLSSGNRAPVWESIVRPNGSVAPPVNAPMREQMRHFEKQCVENALRNTVSIRAAARALGISHATL
LRKMREHDLVVQN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG3604

COG function: function code KT; Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=357, Percent_Identity=40.8963585434174, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI87082117, Length=359, Percent_Identity=41.7827298050139, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1789233, Length=314, Percent_Identity=42.0382165605096, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1789087, Length=305, Percent_Identity=44.2622950819672, Blast_Score=229, Evalue=5e-61,
Organism=Escherichia coli, GI1790299, Length=361, Percent_Identity=39.3351800554017, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI87082152, Length=315, Percent_Identity=41.9047619047619, Blast_Score=224, Evalue=2e-59,
Organism=Escherichia coli, GI1790437, Length=300, Percent_Identity=42.3333333333333, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1788905, Length=226, Percent_Identity=46.4601769911504, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1786524, Length=300, Percent_Identity=41.6666666666667, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1787583, Length=371, Percent_Identity=32.8840970350404, Blast_Score=202, Evalue=6e-53,
Organism=Escherichia coli, GI87081872, Length=312, Percent_Identity=34.2948717948718, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87081858, Length=455, Percent_Identity=27.9120879120879, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1789828, Length=239, Percent_Identity=33.4728033472803, Blast_Score=135, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 64082; Mature: 63951

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALPEESMLVEQVMHDNPETLTPGHLLKDALPVYERHGVNCVPILDENKKVRGILTIFR
CCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
LVQAIRSGKSFETPISEVMDVDLVSIRNDATFGMACSMPIDRMLVLDHDDRLVGVLTKKE
HHHHHHCCCCCCCCHHHHHCCHHEEECCCCCCCEEECCCCCEEEEEECCCCEEEHHHHHH
LIHKIYKAFCSADCHNRELSAVINCATDGIIIFDTNGNALYTNDKIRFLLPDCDTINQPA
HHHHHHHHHHCCCCCCCHHHHHEEECCCCEEEEECCCCEEEECCEEEEECCCCCCCCCCC
SPAMKAVAELLKKTLHSRKSASTLLEDCNGKQVIFSTTPIFDADQRLFRCVLSAQDMTEV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
TRLQEEAENSRRKLAAFQEASLKGTRTIAHNPAMLRLLDEAARLGSVDSTVLITGETGAG
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC
KEVVAMHIHNHSKRRNGPLVQINCGTIPQHLQEAELFGYEKGSFTGANATRAGMLEVAHE
CCEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCC
GTLMLDEVGEMDLTLQVKLLRALQEGVIYRIGGRKPVRLDVRIIAMTNRDLLKMVRENTF
CCEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEECCHHHHHHHHHHHH
REDLYYRLNVIPLAVPPLRERCEDILPLAQHFLSCFSKKYSCACSLSPAEEEMLQAYSWP
HHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCC
GNVRELANFMERLTIASLSSGNRAPVWESIVRPNGSVAPPVNAPMREQMRHFEKQCVENA
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LRNTVSIRAAARALGISHATLLRKMREHDLVVQN
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEECC
>Mature Secondary Structure 
PALPEESMLVEQVMHDNPETLTPGHLLKDALPVYERHGVNCVPILDENKKVRGILTIFR
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
LVQAIRSGKSFETPISEVMDVDLVSIRNDATFGMACSMPIDRMLVLDHDDRLVGVLTKKE
HHHHHHCCCCCCCCHHHHHCCHHEEECCCCCCCEEECCCCCEEEEEECCCCEEEHHHHHH
LIHKIYKAFCSADCHNRELSAVINCATDGIIIFDTNGNALYTNDKIRFLLPDCDTINQPA
HHHHHHHHHHCCCCCCCHHHHHEEECCCCEEEEECCCCEEEECCEEEEECCCCCCCCCCC
SPAMKAVAELLKKTLHSRKSASTLLEDCNGKQVIFSTTPIFDADQRLFRCVLSAQDMTEV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
TRLQEEAENSRRKLAAFQEASLKGTRTIAHNPAMLRLLDEAARLGSVDSTVLITGETGAG
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC
KEVVAMHIHNHSKRRNGPLVQINCGTIPQHLQEAELFGYEKGSFTGANATRAGMLEVAHE
CCEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCC
GTLMLDEVGEMDLTLQVKLLRALQEGVIYRIGGRKPVRLDVRIIAMTNRDLLKMVRENTF
CCEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEECCHHHHHHHHHHHH
REDLYYRLNVIPLAVPPLRERCEDILPLAQHFLSCFSKKYSCACSLSPAEEEMLQAYSWP
HHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCC
GNVRELANFMERLTIASLSSGNRAPVWESIVRPNGSVAPPVNAPMREQMRHFEKQCVENA
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LRNTVSIRAAARALGISHATLLRKMREHDLVVQN
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]