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The map label for this gene is fba [H]

Identifier: 220903417

GI number: 220903417

Start: 167914

End: 168840

Strand: Direct

Name: fba [H]

Synonym: Ddes_0131

Alternate gene names: 220903417

Gene position: 167914-168840 (Clockwise)

Preceding gene: 220903416

Following gene: 220903418

Centisome position: 5.84

GC content: 59.44

Gene sequence:

>927_bases
ATGCCTCTTATCAGTCCCAAAGAAATGTTTGCCGCCGCCTATGCCGGCGGTTATGCCATTGGCGCTTTCAACGTCAACAA
TATGGAAATCATCCAGGGCATCATGGGCGCGGCTTCCGAGGAAAAATCGCCTGTCATTCTTCAGGTGTCGGCGGGCGCGC
GCAAATACGCGGGGCAGCCCTACATCATGAAGCTGGTGGAAGCCGCCCTGGCCGTTGACGCCAGCGTACCCGTGGCGGTG
CACCTTGACCACGGCCCCAGTTTTGAAATGTGCCGCGAATGTATCGACGGCGGATTTACTTCCGTCATGATCGACGGCTC
GCATCTGCCCTACGAAGAAAATATCGCCCTCACCAAACAGGTGGTGGACTACGCCCGCCCCCGCGGCGTGTGGGTCGAAG
CTGAACTGGGCAAACTGGCGGGCATTGAAGAGCATGTGCAGTCGGACGAGCACGTTTATACCGACCCTGACGAAGCTGTG
GACTTTGTGGAGCGCACCGGCTGCGATTCGCTCGCCATAGCCATCGGCACAAGCCACGGCGCGTACAAGTTCAAGGGCGA
GCCCAAGCTGGACTTTGAACGCCTTGAGGCCATCTGCAGGAAGCTGCCGGACTATCCGCTGGTGCTGCACGGTGCTTCCA
GCGTACCGCAGGAGTTTGTGGACCTGTGCAACCAGTACGGCGGCAATGTGGGCGGCGCCAGAGGCGTACCCGAAGACATG
CTGCGCAGGGCCGCCGGTATGGGCGTGTGCAAGATCAACGTGGATACGGATATCCGCCTGGCGGTTACGGCCTGCATCCG
CCAGTATCTGGCTGAACATCCCGAAGAATTTGACCCCCGGTCCTATCTCAAGCCGGCCCGGGAAGCTGTAAGGCAAATGG
TGGCGCACAAGATCCGCACTGTTATGGGATCTTCAGGCAAAGCCTAA

Upstream 100 bases:

>100_bases
GCGCGTGCTGCGTCACGGTTTTTACCGGCGGCAGGGTATGAAAGGTTTTTTGAAGCGTACTTGTTTGCAACAGTTCCCAG
AAAAAAACAGGGAGGAAGTC

Downstream 100 bases:

>100_bases
ACAACATACGTTTTCGTCAAGGAGCGCAACATGCCCGTCAAACTGGGATTGAACGGCTTTGGCCGTATCGGCCGCTACCT
GCTGCGGCTGCTGGCCGATG

Product: fructose-1,6-bisphosphate aldolase, class II

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MPLISPKEMFAAAYAGGYAIGAFNVNNMEIIQGIMGAASEEKSPVILQVSAGARKYAGQPYIMKLVEAALAVDASVPVAV
HLDHGPSFEMCRECIDGGFTSVMIDGSHLPYEENIALTKQVVDYARPRGVWVEAELGKLAGIEEHVQSDEHVYTDPDEAV
DFVERTGCDSLAIAIGTSHGAYKFKGEPKLDFERLEAICRKLPDYPLVLHGASSVPQEFVDLCNQYGGNVGGARGVPEDM
LRRAAGMGVCKINVDTDIRLAVTACIRQYLAEHPEEFDPRSYLKPAREAVRQMVAHKIRTVMGSSGKA

Sequences:

>Translated_308_residues
MPLISPKEMFAAAYAGGYAIGAFNVNNMEIIQGIMGAASEEKSPVILQVSAGARKYAGQPYIMKLVEAALAVDASVPVAV
HLDHGPSFEMCRECIDGGFTSVMIDGSHLPYEENIALTKQVVDYARPRGVWVEAELGKLAGIEEHVQSDEHVYTDPDEAV
DFVERTGCDSLAIAIGTSHGAYKFKGEPKLDFERLEAICRKLPDYPLVLHGASSVPQEFVDLCNQYGGNVGGARGVPEDM
LRRAAGMGVCKINVDTDIRLAVTACIRQYLAEHPEEFDPRSYLKPAREAVRQMVAHKIRTVMGSSGKA
>Mature_307_residues
PLISPKEMFAAAYAGGYAIGAFNVNNMEIIQGIMGAASEEKSPVILQVSAGARKYAGQPYIMKLVEAALAVDASVPVAVH
LDHGPSFEMCRECIDGGFTSVMIDGSHLPYEENIALTKQVVDYARPRGVWVEAELGKLAGIEEHVQSDEHVYTDPDEAVD
FVERTGCDSLAIAIGTSHGAYKFKGEPKLDFERLEAICRKLPDYPLVLHGASSVPQEFVDLCNQYGGNVGGARGVPEDML
RRAAGMGVCKINVDTDIRLAVTACIRQYLAEHPEEFDPRSYLKPAREAVRQMVAHKIRTVMGSSGKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=309, Percent_Identity=41.747572815534, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI87082041, Length=310, Percent_Identity=40.6451612903226, Blast_Score=221, Evalue=4e-59,
Organism=Escherichia coli, GI1788072, Length=296, Percent_Identity=37.5, Blast_Score=172, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322790, Length=353, Percent_Identity=25.4957507082153, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 33402; Mature: 33270

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00602 ALDOLASE_CLASS_II_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLISPKEMFAAAYAGGYAIGAFNVNNMEIIQGIMGAASEEKSPVILQVSAGARKYAGQP
CCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEECCCCHHHCCCH
YIMKLVEAALAVDASVPVAVHLDHGPSFEMCRECIDGGFTSVMIDGSHLPYEENIALTKQ
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHH
VVDYARPRGVWVEAELGKLAGIEEHVQSDEHVYTDPDEAVDFVERTGCDSLAIAIGTSHG
HHHHHCCCCEEEEECHHHHCCHHHHHCCCCCEECCHHHHHHHHHHCCCCEEEEEEECCCC
AYKFKGEPKLDFERLEAICRKLPDYPLVLHGASSVPQEFVDLCNQYGGNVGGARGVPEDM
CEEECCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHH
LRRAAGMGVCKINVDTDIRLAVTACIRQYLAEHPEEFDPRSYLKPAREAVRQMVAHKIRT
HHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VMGSSGKA
HHCCCCCC
>Mature Secondary Structure 
PLISPKEMFAAAYAGGYAIGAFNVNNMEIIQGIMGAASEEKSPVILQVSAGARKYAGQP
CCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEECCCCHHHCCCH
YIMKLVEAALAVDASVPVAVHLDHGPSFEMCRECIDGGFTSVMIDGSHLPYEENIALTKQ
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHH
VVDYARPRGVWVEAELGKLAGIEEHVQSDEHVYTDPDEAVDFVERTGCDSLAIAIGTSHG
HHHHHCCCCEEEEECHHHHCCHHHHHCCCCCEECCHHHHHHHHHHCCCCEEEEEEECCCC
AYKFKGEPKLDFERLEAICRKLPDYPLVLHGASSVPQEFVDLCNQYGGNVGGARGVPEDM
CEEECCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHH
LRRAAGMGVCKINVDTDIRLAVTACIRQYLAEHPEEFDPRSYLKPAREAVRQMVAHKIRT
HHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VMGSSGKA
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]