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The map label for this gene is rnr [C]

Identifier: 220903389

GI number: 220903389

Start: 133985

End: 136192

Strand: Direct

Name: rnr [C]

Synonym: Ddes_0103

Alternate gene names: 220903389

Gene position: 133985-136192 (Clockwise)

Preceding gene: 220903384

Following gene: 220903390

Centisome position: 4.66

GC content: 64.31

Gene sequence:

>2208_bases
ATGTCGGATTGTGTGCGCTACCCAGCGCCGGGTTGCGTGGTGGAGTATCTGGAGGGCAATGCCGTTCAGATTGCCCTTAT
TACTGAAGAGGCCGGGGGCCGTTTACGCCTTTTGCTGCCCAACCGGCGGGAAACGCGGCTCAATGCGCCGCGCCTGCTGC
CGTGGCTTGGTCCCATGTATAGCGCGGACCTGGGCAAGGAAGACGCGGTACGCCTGCTTGAGCAGCACCGGAAAAGCCGT
GAGGAACTGGCGGCTGACGTGCCTGTGATGGACGCGTGGGAACTGGCGCAGGGCGAGGTGGCTATTGCCCCTGCGCAATG
GTTTGCCGAGCTTTTCGCCACTGATCCAGACTCTGATCAGGTGGCGGCCTACGGGCGCGCCCTGCTGGCCTGCAAAAGCC
ATTTCCGTTTCCAGCCGCCGGATTTTCAGGTTTTTCCTGCAGAAACGGTCGAAAAGCGGCTGACGGAAGAAAAAACCCGT
CTGGAGCGCGAAGCCCTTATCGCGGGCGGCGCGGCCTTTTTGCGTCTTTTGTGGGATGTGGCCTGCCGCAAGCGCGACCT
GCCGCCTCCCCCTGCCGCAGGTTCCGGCAGTGGCGAATGGCCCGCCCCCGAGGTTGCCGGGCGCCTTGAAGAGGTGCTGC
GTGTCCGCATGACAGACCCCGAAGGGCAGGAGCATGAGACCCTGTGGCGAACGCTTGCCAAGGGCCTGCCCGATGTGCCC
CATTTGCCTGTGCAGTTGCTGATGGCCTGGGGCAAACTGCCTGCCCATTACAATTTTTGGCTTGATCGCGCGGGCTATAC
CCCCGGCGACAGCTGGTGGATGCCACACCGCGAAGAGGTGGAGGCGCTTGCCGCCGCCGCTGCCGTTGGGGCCATGCCCT
TCGTGCAGCCCGCACCGGAAACAGTGTCGGCGGAAACTCCGCTGCCGGAAAACAGCAAATGCCCGGTCCCCGGCCTTTTG
CCCGAAAGCCCGCTGCCCTTTATCAGCATCGACAGCGCCAGCACCCGCGACGTGGACGATGCCTTTTATGTGGAAACCAC
GGCAGACGGGCGCACGCTCACCCTGGCGCTGGCCTGCCCTGCCCTGTACTGGCCTTTTGGCGGTCCGCTGGACAAGGCCG
TGCTGCACCGGGGAACCAGCATTTACCTGCCCGAGGGCGACTGCCATATGCTGCCCGAAGAGCTGGGAACCTCATCGTAT
TCCCTGCTGGCCGGCCAGCCGCGTCCCGCCCTGTGTGTGCGGGTTCCGGTGGACGGCAACGGGCATTTTGGCCCGTGCGA
GGTATATCTAGCCCGTGTGAATCTGGCCGCCAACCTGACCTACAGTGACAGTCAGGCCGTGCTGGACGCGCTGGCCGCCG
GTGAGTCCGCCGCTCTGCCCGACAATCCGGCCGCTACCCATGCCGATTTGCTCGGCCTGGGGCTTGCCCTGGCGCGGCAG
CGGCAGCAGGCTCGCATTGAAGGCGGGGCCGTTATTATGGACAGGCCCGACCCTGCCATCCGGCTGGAGGGTGAAGGGAC
CGAGGTGCGCGTGCACGTGGGGCCGGACTATCATGCCCCGGATGCACAGATGCTGGTGGCGGAAATGATGATTCTTGCCA
GCGCGGCCGTGGCCCATTGGGCGCTGGAACGGGACGTCGCCATGCTGCACAGGGTGCAGGATGTGGTGCTGCCCCGCGAA
TACGCCGGTATATGGCATACCCCGCAGGACATGACGCGCATCATGCGCGCCCTGACGCCTTCGGGCCTTGAGGTGCAGGC
CAGACCGCACGCGGCTTTGGGGCTTGACCGCTATACGCCCGTGACTTCGCCCCTGCGCCGCTATCCCGACCTTGTCAACG
AGGCGCAGGTGGTGCATTTCTTGTGTTCCGGGCAGCCTCGCTGGAGTGAAAGCGCCCTGACAGAGCTTTTGCAGACGCTC
TCGCCCGTACTGGATGCCGTGGGGCAGGTGCAGCGCTTCCGCCCGCGCTACTGGAAGCTGCTGTATTTCCGTCAGCAGGG
GGACAAGGTATGGTGGCCCGGCGTGATCACGGAAGAAAACGATGCCTTTGTGAGCGTGAGCCTGCAGGACCAGGGTATGT
TTGTGCGCGGCAGGCGGAAGCTCTTTGACGACAGGGCGCATCCCGGCCTGCGGGTGGATGTGCGCATCGGCAAAGTACAC
CCGCTGTATAATGAGATCATGATTCTGGAAGCAGCCACGGTGGACTAG

Upstream 100 bases:

>100_bases
AGGCGTACCGGCACTTGCCAGAAGAGAAAAAATAAAGGATTGTCCCTGTCGAAGGCGTGTGGAAGCATGGGTATGCGGCG
CGTCTTCTGAAGGAGCAGGC

Downstream 100 bases:

>100_bases
CGCGGCGTGCTCCTGAAGCTTGCGCCCCGGGCACTTCAGGACACATGCGTGACCGCCCGGCGGCTATAGACGCAAAAATG
CAGTCCGACAGCGTGTTGTG

Product: ribonuclease II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 735; Mature: 734

Protein sequence:

>735_residues
MSDCVRYPAPGCVVEYLEGNAVQIALITEEAGGRLRLLLPNRRETRLNAPRLLPWLGPMYSADLGKEDAVRLLEQHRKSR
EELAADVPVMDAWELAQGEVAIAPAQWFAELFATDPDSDQVAAYGRALLACKSHFRFQPPDFQVFPAETVEKRLTEEKTR
LEREALIAGGAAFLRLLWDVACRKRDLPPPPAAGSGSGEWPAPEVAGRLEEVLRVRMTDPEGQEHETLWRTLAKGLPDVP
HLPVQLLMAWGKLPAHYNFWLDRAGYTPGDSWWMPHREEVEALAAAAAVGAMPFVQPAPETVSAETPLPENSKCPVPGLL
PESPLPFISIDSASTRDVDDAFYVETTADGRTLTLALACPALYWPFGGPLDKAVLHRGTSIYLPEGDCHMLPEELGTSSY
SLLAGQPRPALCVRVPVDGNGHFGPCEVYLARVNLAANLTYSDSQAVLDALAAGESAALPDNPAATHADLLGLGLALARQ
RQQARIEGGAVIMDRPDPAIRLEGEGTEVRVHVGPDYHAPDAQMLVAEMMILASAAVAHWALERDVAMLHRVQDVVLPRE
YAGIWHTPQDMTRIMRALTPSGLEVQARPHAALGLDRYTPVTSPLRRYPDLVNEAQVVHFLCSGQPRWSESALTELLQTL
SPVLDAVGQVQRFRPRYWKLLYFRQQGDKVWWPGVITEENDAFVSVSLQDQGMFVRGRRKLFDDRAHPGLRVDVRIGKVH
PLYNEIMILEAATVD

Sequences:

>Translated_735_residues
MSDCVRYPAPGCVVEYLEGNAVQIALITEEAGGRLRLLLPNRRETRLNAPRLLPWLGPMYSADLGKEDAVRLLEQHRKSR
EELAADVPVMDAWELAQGEVAIAPAQWFAELFATDPDSDQVAAYGRALLACKSHFRFQPPDFQVFPAETVEKRLTEEKTR
LEREALIAGGAAFLRLLWDVACRKRDLPPPPAAGSGSGEWPAPEVAGRLEEVLRVRMTDPEGQEHETLWRTLAKGLPDVP
HLPVQLLMAWGKLPAHYNFWLDRAGYTPGDSWWMPHREEVEALAAAAAVGAMPFVQPAPETVSAETPLPENSKCPVPGLL
PESPLPFISIDSASTRDVDDAFYVETTADGRTLTLALACPALYWPFGGPLDKAVLHRGTSIYLPEGDCHMLPEELGTSSY
SLLAGQPRPALCVRVPVDGNGHFGPCEVYLARVNLAANLTYSDSQAVLDALAAGESAALPDNPAATHADLLGLGLALARQ
RQQARIEGGAVIMDRPDPAIRLEGEGTEVRVHVGPDYHAPDAQMLVAEMMILASAAVAHWALERDVAMLHRVQDVVLPRE
YAGIWHTPQDMTRIMRALTPSGLEVQARPHAALGLDRYTPVTSPLRRYPDLVNEAQVVHFLCSGQPRWSESALTELLQTL
SPVLDAVGQVQRFRPRYWKLLYFRQQGDKVWWPGVITEENDAFVSVSLQDQGMFVRGRRKLFDDRAHPGLRVDVRIGKVH
PLYNEIMILEAATVD
>Mature_734_residues
SDCVRYPAPGCVVEYLEGNAVQIALITEEAGGRLRLLLPNRRETRLNAPRLLPWLGPMYSADLGKEDAVRLLEQHRKSRE
ELAADVPVMDAWELAQGEVAIAPAQWFAELFATDPDSDQVAAYGRALLACKSHFRFQPPDFQVFPAETVEKRLTEEKTRL
EREALIAGGAAFLRLLWDVACRKRDLPPPPAAGSGSGEWPAPEVAGRLEEVLRVRMTDPEGQEHETLWRTLAKGLPDVPH
LPVQLLMAWGKLPAHYNFWLDRAGYTPGDSWWMPHREEVEALAAAAAVGAMPFVQPAPETVSAETPLPENSKCPVPGLLP
ESPLPFISIDSASTRDVDDAFYVETTADGRTLTLALACPALYWPFGGPLDKAVLHRGTSIYLPEGDCHMLPEELGTSSYS
LLAGQPRPALCVRVPVDGNGHFGPCEVYLARVNLAANLTYSDSQAVLDALAAGESAALPDNPAATHADLLGLGLALARQR
QQARIEGGAVIMDRPDPAIRLEGEGTEVRVHVGPDYHAPDAQMLVAEMMILASAAVAHWALERDVAMLHRVQDVVLPREY
AGIWHTPQDMTRIMRALTPSGLEVQARPHAALGLDRYTPVTSPLRRYPDLVNEAQVVHFLCSGQPRWSESALTELLQTLS
PVLDAVGQVQRFRPRYWKLLYFRQQGDKVWWPGVITEENDAFVSVSLQDQGMFVRGRRKLFDDRAHPGLRVDVRIGKVHP
LYNEIMILEAATVD

Specific function: 3'-5'Exoribonuclease That Participates In An Essential Cell Function. Acts Nonspecifically On Poly(A), Poly(U) And Ribosomal RNAs. Required For The Expression Of VIrulence Genes In Enteroinvasive Strains Of E.Coli. [C]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonuclease II (RNB) family [H]

Homologues:

Organism=Escherichia coli, GI87082383, Length=389, Percent_Identity=25.4498714652956, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1787542, Length=333, Percent_Identity=27.6276276276276, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323943, Length=442, Percent_Identity=23.0769230769231, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001900
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00773 RNB [H]

EC number: 3.1.13.1

Molecular weight: Translated: 81099; Mature: 80968

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDCVRYPAPGCVVEYLEGNAVQIALITEEAGGRLRLLLPNRRETRLNAPRLLPWLGPMY
CCCCCCCCCCCHHHHEECCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCHHHCCHH
SADLGKEDAVRLLEQHRKSREELAADVPVMDAWELAQGEVAIAPAQWFAELFATDPDSDQ
HCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEHHHHHHHHHCCCCCCCH
VAAYGRALLACKSHFRFQPPDFQVFPAETVEKRLTEEKTRLEREALIAGGAAFLRLLWDV
HHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
ACRKRDLPPPPAAGSGSGEWPAPEVAGRLEEVLRVRMTDPEGQEHETLWRTLAKGLPDVP
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHCCCCCC
HLPVQLLMAWGKLPAHYNFWLDRAGYTPGDSWWMPHREEVEALAAAAAVGAMPFVQPAPE
CHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
TVSAETPLPENSKCPVPGLLPESPLPFISIDSASTRDVDDAFYVETTADGRTLTLALACP
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCEEEEEEECC
ALYWPFGGPLDKAVLHRGTSIYLPEGDCHMLPEELGTSSYSLLAGQPRPALCVRVPVDGN
HHCCCCCCCHHHHHHHCCCEEEECCCCCCCCHHHHCCCCEEEEECCCCCCEEEEEEECCC
GHFGPCEVYLARVNLAANLTYSDSQAVLDALAAGESAALPDNPAATHADLLGLGLALARQ
CCCCHHHEEEEEEEEEEEEEECCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RQQARIEGGAVIMDRPDPAIRLEGEGTEVRVHVGPDYHAPDAQMLVAEMMILASAAVAHW
HHHHHCCCCEEEEECCCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
ALERDVAMLHRVQDVVLPREYAGIWHTPQDMTRIMRALTPSGLEVQARPHAALGLDRYTP
HHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHCCCCCCC
VTSPLRRYPDLVNEAQVVHFLCSGQPRWSESALTELLQTLSPVLDAVGQVQRFRPRYWKL
CCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LYFRQQGDKVWWPGVITEENDAFVSVSLQDQGMFVRGRRKLFDDRAHPGLRVDVRIGKVH
EEEEECCCEEECCCEEECCCCCEEEEEEECCCEEEECHHHHHHCCCCCCEEEEEEECCCC
PLYNEIMILEAATVD
CCCCCEEEEEEECCC
>Mature Secondary Structure 
SDCVRYPAPGCVVEYLEGNAVQIALITEEAGGRLRLLLPNRRETRLNAPRLLPWLGPMY
CCCCCCCCCCHHHHEECCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCHHHCCHH
SADLGKEDAVRLLEQHRKSREELAADVPVMDAWELAQGEVAIAPAQWFAELFATDPDSDQ
HCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEHHHHHHHHHCCCCCCCH
VAAYGRALLACKSHFRFQPPDFQVFPAETVEKRLTEEKTRLEREALIAGGAAFLRLLWDV
HHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
ACRKRDLPPPPAAGSGSGEWPAPEVAGRLEEVLRVRMTDPEGQEHETLWRTLAKGLPDVP
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHCCCCCC
HLPVQLLMAWGKLPAHYNFWLDRAGYTPGDSWWMPHREEVEALAAAAAVGAMPFVQPAPE
CHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
TVSAETPLPENSKCPVPGLLPESPLPFISIDSASTRDVDDAFYVETTADGRTLTLALACP
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCEEEEEEECC
ALYWPFGGPLDKAVLHRGTSIYLPEGDCHMLPEELGTSSYSLLAGQPRPALCVRVPVDGN
HHCCCCCCCHHHHHHHCCCEEEECCCCCCCCHHHHCCCCEEEEECCCCCCEEEEEEECCC
GHFGPCEVYLARVNLAANLTYSDSQAVLDALAAGESAALPDNPAATHADLLGLGLALARQ
CCCCHHHEEEEEEEEEEEEEECCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RQQARIEGGAVIMDRPDPAIRLEGEGTEVRVHVGPDYHAPDAQMLVAEMMILASAAVAHW
HHHHHCCCCEEEEECCCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
ALERDVAMLHRVQDVVLPREYAGIWHTPQDMTRIMRALTPSGLEVQARPHAALGLDRYTP
HHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHCCCCCCC
VTSPLRRYPDLVNEAQVVHFLCSGQPRWSESALTELLQTLSPVLDAVGQVQRFRPRYWKL
CCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LYFRQQGDKVWWPGVITEENDAFVSVSLQDQGMFVRGRRKLFDDRAHPGLRVDVRIGKVH
EEEEECCCEEECCCEEECCCCCEEEEEEECCCEEEECHHHHHHCCCCCCEEEEEEECCCC
PLYNEIMILEAATVD
CCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]