Click here to switch to the map view.

The map label for this gene is fmt

Identifier: 220903298

GI number: 220903298

Start: 16823

End: 17836

Strand: Direct

Name: fmt

Synonym: Ddes_0012

Alternate gene names: 220903298

Gene position: 16823-17836 (Clockwise)

Preceding gene: 220903297

Following gene: 220903299

Centisome position: 0.59

GC content: 63.02

Gene sequence:

>1014_bases
ATGGCTCAAGAGAAAGACTGCCGTATAGTGTTTATGGGTACTCCCGGTTTTGCGGCCGCCAGTCTGAGGAGACTGGCGGC
CTGGCCGCGTGCCCATATTGTCGCTGTATATACGCAGCCTGACCGTCCGGCGGGGCGCGGCCAAAAGCTCGCCATGTCCG
CCGTGAAAAAACTTGCGCTGGAACTGGGCATTCCCGTCTGTCAGCCCGCCAGCCTTAAAGGCGCCGAAGCCCAGGCAGAG
CTGGCGGCTTTCAGGCCCGATGTGCTGGCTGTGGCCGCGTACGGGCTTATTCTGCCTGATGCCGTGCTGGACATGCCTCG
CCTTGCGCCGGTCAACGTGCATGCCTCCATCCTGCCGGGCCTGCGCGGCGCGGCTCCCATACAGCGCGCAGTTATGGAAG
GCTGGCAGCCTGGAGCCAGGGCGGGTATATCCATAATGCGTATAGGCAGCCGGCTTGATGCAGGGCCTGTATATGCCATG
GGCGATACTCCTATCGGCGAGCACACTTCGGGCAGCCTGCATGACGCTCTGGCGGAGCTGGGCGCGGAGCTGCTTGTTAC
CGTTCTGGACGACCTGATGGAGGGCAGGGCGGTGGCTGTGGAACAGGATGAAAGCCTTGCCACCCATGCGGCCAAGCTGG
GCAAGCGCGACGGCTATATAAACTGGACGCGCAGCGCGGCCGAGGCCCATGCGCAGATACGCGGGGTTACCCCCAGGCCC
GGCGCGCGCACGGTACTGCATCTGGATGCAGGAACAGACTTTGAAGCCCGGAGCATGCCGCTTATTGTTTCACCTGGAAC
AATCGGAGAAACCGCCGCAGGTACCGCGCCGGGAAGTGTACGGCATGATGGGCAGGACATCAGCATTGCCTGCGGCGACT
GCTGGTATACCCTGGGCATGGTGCGGCCTGAAGGCCGCAAGGACATGCCGGTGCGTGACCTGCTCAACGGCAGTTTGAAA
AATCTGCCGCAGGGTGTGTGCGGGGAGGCCCGATCGCCGGAAGAGTCGTTGTAG

Upstream 100 bases:

>100_bases
CCATTGTCATGCAGCACGAATACGATCATCTTGACGGCATACTCTTTATTGACAAGGTCAGCCGCCTGCGGCGCAGCCTG
TACGACAGCAAGGTAAAAAA

Downstream 100 bases:

>100_bases
CGGGTGTCGTCAGCATATTTTATTATTGAAATTTCTTGTGGGAAAGACTCTCTTGCCAAAGGGCCTCCCCCTTCCACGTC
ACAGTCTCAAAAATCTTTTT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAQEKDCRIVFMGTPGFAAASLRRLAAWPRAHIVAVYTQPDRPAGRGQKLAMSAVKKLALELGIPVCQPASLKGAEAQAE
LAAFRPDVLAVAAYGLILPDAVLDMPRLAPVNVHASILPGLRGAAPIQRAVMEGWQPGARAGISIMRIGSRLDAGPVYAM
GDTPIGEHTSGSLHDALAELGAELLVTVLDDLMEGRAVAVEQDESLATHAAKLGKRDGYINWTRSAAEAHAQIRGVTPRP
GARTVLHLDAGTDFEARSMPLIVSPGTIGETAAGTAPGSVRHDGQDISIACGDCWYTLGMVRPEGRKDMPVRDLLNGSLK
NLPQGVCGEARSPEESL

Sequences:

>Translated_337_residues
MAQEKDCRIVFMGTPGFAAASLRRLAAWPRAHIVAVYTQPDRPAGRGQKLAMSAVKKLALELGIPVCQPASLKGAEAQAE
LAAFRPDVLAVAAYGLILPDAVLDMPRLAPVNVHASILPGLRGAAPIQRAVMEGWQPGARAGISIMRIGSRLDAGPVYAM
GDTPIGEHTSGSLHDALAELGAELLVTVLDDLMEGRAVAVEQDESLATHAAKLGKRDGYINWTRSAAEAHAQIRGVTPRP
GARTVLHLDAGTDFEARSMPLIVSPGTIGETAAGTAPGSVRHDGQDISIACGDCWYTLGMVRPEGRKDMPVRDLLNGSLK
NLPQGVCGEARSPEESL
>Mature_336_residues
AQEKDCRIVFMGTPGFAAASLRRLAAWPRAHIVAVYTQPDRPAGRGQKLAMSAVKKLALELGIPVCQPASLKGAEAQAEL
AAFRPDVLAVAAYGLILPDAVLDMPRLAPVNVHASILPGLRGAAPIQRAVMEGWQPGARAGISIMRIGSRLDAGPVYAMG
DTPIGEHTSGSLHDALAELGAELLVTVLDDLMEGRAVAVEQDESLATHAAKLGKRDGYINWTRSAAEAHAQIRGVTPRPG
ARTVLHLDAGTDFEARSMPLIVSPGTIGETAAGTAPGSVRHDGQDISIACGDCWYTLGMVRPEGRKDMPVRDLLNGSLKN
LPQGVCGEARSPEESL

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI164663775, Length=330, Percent_Identity=28.1818181818182, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI238814322, Length=261, Percent_Identity=27.5862068965517, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789683, Length=314, Percent_Identity=44.2675159235669, Blast_Score=230, Evalue=8e-62,
Organism=Escherichia coli, GI1788589, Length=263, Percent_Identity=28.5171102661597, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45550868, Length=240, Percent_Identity=30.8333333333333, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI28571984, Length=240, Percent_Identity=30.8333333333333, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_DESDA (B8J1H5)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002478610.1
- GeneID:   7283663
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_0012
- HOGENOM:   HBG571560
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 35445; Mature: 35314

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQEKDCRIVFMGTPGFAAASLRRLAAWPRAHIVAVYTQPDRPAGRGQKLAMSAVKKLAL
CCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHH
ELGIPVCQPASLKGAEAQAELAAFRPDVLAVAAYGLILPDAVLDMPRLAPVNVHASILPG
HHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCC
LRGAAPIQRAVMEGWQPGARAGISIMRIGSRLDAGPVYAMGDTPIGEHTSGSLHDALAEL
CCCCHHHHHHHHHCCCCCHHHCEEEEEECCCCCCCCEEEECCCCCCCCCCCHHHHHHHHH
GAELLVTVLDDLMEGRAVAVEQDESLATHAAKLGKRDGYINWTRSAAEAHAQIRGVTPRP
HHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCCC
GARTVLHLDAGTDFEARSMPLIVSPGTIGETAAGTAPGSVRHDGQDISIACGDCWYTLGM
CCCEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHCC
VRPEGRKDMPVRDLLNGSLKNLPQGVCGEARSPEESL
CCCCCCCCCCHHHHHCCHHHHCCHHHCCCCCCCCCCC
>Mature Secondary Structure 
AQEKDCRIVFMGTPGFAAASLRRLAAWPRAHIVAVYTQPDRPAGRGQKLAMSAVKKLAL
CCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHH
ELGIPVCQPASLKGAEAQAELAAFRPDVLAVAAYGLILPDAVLDMPRLAPVNVHASILPG
HHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCC
LRGAAPIQRAVMEGWQPGARAGISIMRIGSRLDAGPVYAMGDTPIGEHTSGSLHDALAEL
CCCCHHHHHHHHHCCCCCHHHCEEEEEECCCCCCCCEEEECCCCCCCCCCCHHHHHHHHH
GAELLVTVLDDLMEGRAVAVEQDESLATHAAKLGKRDGYINWTRSAAEAHAQIRGVTPRP
HHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCCC
GARTVLHLDAGTDFEARSMPLIVSPGTIGETAAGTAPGSVRHDGQDISIACGDCWYTLGM
CCCEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHCC
VRPEGRKDMPVRDLLNGSLKNLPQGVCGEARSPEESL
CCCCCCCCCCHHHHHCCHHHHCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA