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The map label for this gene is dnaA [H]

Identifier: 220903289

GI number: 220903289

Start: 2640

End: 4013

Strand: Direct

Name: dnaA [H]

Synonym: Ddes_0003

Alternate gene names: 220903289

Gene position: 2640-4013 (Clockwise)

Preceding gene: NA

Following gene: 220903290

Centisome position: 0.09

GC content: 56.91

Gene sequence:

>1374_bases
ATGCTGAAAAAAGAATTGCGGGAAATACTGGCGGAGAATCGGGCCACAGCGGGAGAAACCTGGCTGGAGAGCCTTACCCT
GCGCCAGGAAAAAGACACCCTGAGGGTGGTTTTTCCGCACATGTATTTTGCAGACTGGTTCAGCCTGCACCGACGCGCTG
CCTTTGAAGATGCACTGCGCAGACATTTTACACGGCTGCACGAAGATTCCGTGCCCAGGATCGTCTACGAAAGCGCCGCT
CCCGGCGCTTTTGCCGCCAGAACTCTGCCGCAGCCCGTCAGCCCGCCCCCCGGACCTGACTGCCGCAGCAACACAATGGC
TGAAGCGGAAGACCCCTTTGCAGACTTCATCTGCAATGACAAAAACGCTTTTCCTCTGGCAACGGCCAGAGATCTGGCCG
CCGACACCACATCCACGGCCTATAACCCTTTTCTGGTCTGCGGGCGTAGCGGCACAGGAAAAAGCCGCCTTCTTCAGGCC
ATGACATGCGTGATGTCCCGCACCGCCGATCCCGCCCGCATGATATGCTCCAGCGCCGCCCGTTTCTGCTCTGAACATCT
TGTGTGGGCCAGAAGGCCGGAACTGTTCTGGCTGCGCTATGACGTGCTTGTTCTGGACGACATTCAGGACCTTGCCGGGC
ATGACGCCTGGCAACGCAAGCTTGTAACCATTATAGACACCTGCCCCGGCAGACAGAAAAACTTGCCGGGTATCCCCTCC
GGGGAAGATATCCCGTCTGCGGGCGAGCAGATACACAGAGCCGCCCCACGTATGATCTTTGCCTGCTCCGGCCAGCCGCA
GGCCCTGAAAGCGCTTGACGAGCGCCTGCGTTCGCGCCTTGAAAGCGGCCTTGTGGTGGAACTTATGGAACCGGACCTGG
ATGTCCGGCTGCGCTACCTGCAGGTCATATGCAAGGAACGGCGCCTGCCGCTCACACGTGAACAGCTGCTTTTTCTAGCC
CAGCGCTGTTCGCAGTTCCGGCTTTTACAAGGCCTCATGCTCAAGGTGGGTGCGTATTGCGCTGTAAAGGGTAATAACCT
CACGCAGTCTGATATGGAAAATATCGTGCGCACCGGAGTTGCGGAAAAAATGCCCGGTTGCCGGGAAATTCTGGGCGAAG
TAGCCAGAAGGCTCAACCTGAGGCCCGAAGATGTACTGGGCGCCAAACGGCGGCCGGACCTGGTACTGGCACGGCAGGTA
TCCATGTATATATGCCGCCGGAAACTGGGGCTTTCCTACCCGGAACTTGGCCGCGCCTTTGGCGGACGTGACCATAGCAC
GGTCATATATGCCATTAATAAGATTAAGAAATTGATGGTTAGTAACAAAAGTGTACACCAACTGGTAACAGAGATTGAAA
TGAAAACACCCTGA

Upstream 100 bases:

>100_bases
TCCTGTGCGGCCGGGGCCGCGAAAATCGAGCCTCACGCCGAACCTGCGGGCAGAGCCTTTATCCACAGGGCGTGCCTGCG
AGGCCAATGAATCGTATATT

Downstream 100 bases:

>100_bases
CCCCGTAAATCAGGGTAAAGGCTTTTGGGCTGTTACCGGTGTTCTCATAAAACACGTCGGGCTGTTCCATAAAAAATTCA
ATCTTTACAAGGCGTTTAAG

Product: Chromosomal replication initiator DnaA domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MLKKELREILAENRATAGETWLESLTLRQEKDTLRVVFPHMYFADWFSLHRRAAFEDALRRHFTRLHEDSVPRIVYESAA
PGAFAARTLPQPVSPPPGPDCRSNTMAEAEDPFADFICNDKNAFPLATARDLAADTTSTAYNPFLVCGRSGTGKSRLLQA
MTCVMSRTADPARMICSSAARFCSEHLVWARRPELFWLRYDVLVLDDIQDLAGHDAWQRKLVTIIDTCPGRQKNLPGIPS
GEDIPSAGEQIHRAAPRMIFACSGQPQALKALDERLRSRLESGLVVELMEPDLDVRLRYLQVICKERRLPLTREQLLFLA
QRCSQFRLLQGLMLKVGAYCAVKGNNLTQSDMENIVRTGVAEKMPGCREILGEVARRLNLRPEDVLGAKRRPDLVLARQV
SMYICRRKLGLSYPELGRAFGGRDHSTVIYAINKIKKLMVSNKSVHQLVTEIEMKTP

Sequences:

>Translated_457_residues
MLKKELREILAENRATAGETWLESLTLRQEKDTLRVVFPHMYFADWFSLHRRAAFEDALRRHFTRLHEDSVPRIVYESAA
PGAFAARTLPQPVSPPPGPDCRSNTMAEAEDPFADFICNDKNAFPLATARDLAADTTSTAYNPFLVCGRSGTGKSRLLQA
MTCVMSRTADPARMICSSAARFCSEHLVWARRPELFWLRYDVLVLDDIQDLAGHDAWQRKLVTIIDTCPGRQKNLPGIPS
GEDIPSAGEQIHRAAPRMIFACSGQPQALKALDERLRSRLESGLVVELMEPDLDVRLRYLQVICKERRLPLTREQLLFLA
QRCSQFRLLQGLMLKVGAYCAVKGNNLTQSDMENIVRTGVAEKMPGCREILGEVARRLNLRPEDVLGAKRRPDLVLARQV
SMYICRRKLGLSYPELGRAFGGRDHSTVIYAINKIKKLMVSNKSVHQLVTEIEMKTP
>Mature_457_residues
MLKKELREILAENRATAGETWLESLTLRQEKDTLRVVFPHMYFADWFSLHRRAAFEDALRRHFTRLHEDSVPRIVYESAA
PGAFAARTLPQPVSPPPGPDCRSNTMAEAEDPFADFICNDKNAFPLATARDLAADTTSTAYNPFLVCGRSGTGKSRLLQA
MTCVMSRTADPARMICSSAARFCSEHLVWARRPELFWLRYDVLVLDDIQDLAGHDAWQRKLVTIIDTCPGRQKNLPGIPS
GEDIPSAGEQIHRAAPRMIFACSGQPQALKALDERLRSRLESGLVVELMEPDLDVRLRYLQVICKERRLPLTREQLLFLA
QRCSQFRLLQGLMLKVGAYCAVKGNNLTQSDMENIVRTGVAEKMPGCREILGEVARRLNLRPEDVLGAKRRPDLVLARQV
SMYICRRKLGLSYPELGRAFGGRDHSTVIYAINKIKKLMVSNKSVHQLVTEIEMKTP

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=461, Percent_Identity=25.1626898047722, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 51587; Mature: 51587

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKELREILAENRATAGETWLESLTLRQEKDTLRVVFPHMYFADWFSLHRRAAFEDALR
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
RHFTRLHEDSVPRIVYESAAPGAFAARTLPQPVSPPPGPDCRSNTMAEAEDPFADFICND
HHHHHHHCCCCCCEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCC
KNAFPLATARDLAADTTSTAYNPFLVCGRSGTGKSRLLQAMTCVMSRTADPARMICSSAA
CCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
RFCSEHLVWARRPELFWLRYDVLVLDDIQDLAGHDAWQRKLVTIIDTCPGRQKNLPGIPS
HHHHHHHHHHCCCCEEEEEEEEHEEHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCC
GEDIPSAGEQIHRAAPRMIFACSGQPQALKALDERLRSRLESGLVVELMEPDLDVRLRYL
CCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
QVICKERRLPLTREQLLFLAQRCSQFRLLQGLMLKVGAYCAVKGNNLTQSDMENIVRTGV
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCH
AEKMPGCREILGEVARRLNLRPEDVLGAKRRPDLVLARQVSMYICRRKLGLSYPELGRAF
HHHCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
GGRDHSTVIYAINKIKKLMVSNKSVHQLVTEIEMKTP
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLKKELREILAENRATAGETWLESLTLRQEKDTLRVVFPHMYFADWFSLHRRAAFEDALR
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
RHFTRLHEDSVPRIVYESAAPGAFAARTLPQPVSPPPGPDCRSNTMAEAEDPFADFICND
HHHHHHHCCCCCCEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCC
KNAFPLATARDLAADTTSTAYNPFLVCGRSGTGKSRLLQAMTCVMSRTADPARMICSSAA
CCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
RFCSEHLVWARRPELFWLRYDVLVLDDIQDLAGHDAWQRKLVTIIDTCPGRQKNLPGIPS
HHHHHHHHHHCCCCEEEEEEEEHEEHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCC
GEDIPSAGEQIHRAAPRMIFACSGQPQALKALDERLRSRLESGLVVELMEPDLDVRLRYL
CCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
QVICKERRLPLTREQLLFLAQRCSQFRLLQGLMLKVGAYCAVKGNNLTQSDMENIVRTGV
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCH
AEKMPGCREILGEVARRLNLRPEDVLGAKRRPDLVLARQVSMYICRRKLGLSYPELGRAF
HHHCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
GGRDHSTVIYAINKIKKLMVSNKSVHQLVTEIEMKTP
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA