Definition Streptococcus pyogenes MGAS315 chromosome, complete genome.
Accession NC_004070
Length 1,900,521

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The map label for this gene is dppE [H]

Identifier: 21911258

GI number: 21911258

Start: 1737579

End: 1738205

Strand: Direct

Name: dppE [H]

Synonym: SpyM3_1722

Alternate gene names: 21911258

Gene position: 1737579-1738205 (Clockwise)

Preceding gene: 21911257

Following gene: 21911265

Centisome position: 91.43

GC content: 38.44

Gene sequence:

>627_bases
ATGACCTTAGAGGCTAAAAAGCTTGGCTTTTATCATAAAAAAGATCAATGGCTTTTTAAGGAGATTGATTTAGAGGTAGC
ACCTGGTCAAATCTTAGGGATATTTGGACAAAGTGGGTGTGGAAAAACGAGTTTATCCAGAGTGCTTGCCGGTTTTTTGC
AGCCTAAATCTGGTGAAGTATTAGTTGATGGCAGTCATTTGCCTAACAAAGCATTTAGACCTGTGCAACTTATCCAACAA
CATCCTGAACAAACCATGAATCCTTTATGGCCTATGAAAAAAAGTTTGGAAGAAGCCTACTATCCAAGTCAAGATTTGCG
AGATGCTTTTGGCATTCAAGAAAAATGGCTAAATCGTCGCCCTAGTGAACTCTCGGGAGGGGAATTGCAACGCTTTTCGA
TTGTGCGTTCATTACATCCAGAGACGAGATACCTTATTGCAGATGAAATGACTACTATGTTGGATAGCATTACACAAGCT
AGTGTATGGAAAAGCCTGTTGGAGATTGTAAAGGATAGAAATTTAGGTCTCATCATTATTAGTCATGATTTTGATATGTT
AGAAAAACTTTGTGACGTGTGCTATATGATTGAAGAGAATCGTACTCAACTGTTCAAGCATACCTAA

Upstream 100 bases:

>100_bases
GCTAGCTTTTTTAGCGGAGGTGGGGAACAATTACAAACAGAATTTGCGAGACGTTTATGGCGCACACTCCCTCAGCAAGA
CTTTTTGAAAGGAGTTACTC

Downstream 100 bases:

>100_bases
CACCTATGGTTATTACCTATTGAGTCTTTTTCTAACAAAATCACACCATTAAAAAAACCAGTTTACAGCTGGTTTTTTTA
ATTATTTTAATTTTTCCTTA

Product: putative dipeptide ABC transporter ATP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTLEAKKLGFYHKKDQWLFKEIDLEVAPGQILGIFGQSGCGKTSLSRVLAGFLQPKSGEVLVDGSHLPNKAFRPVQLIQQ
HPEQTMNPLWPMKKSLEEAYYPSQDLRDAFGIQEKWLNRRPSELSGGELQRFSIVRSLHPETRYLIADEMTTMLDSITQA
SVWKSLLEIVKDRNLGLIIISHDFDMLEKLCDVCYMIEENRTQLFKHT

Sequences:

>Translated_208_residues
MTLEAKKLGFYHKKDQWLFKEIDLEVAPGQILGIFGQSGCGKTSLSRVLAGFLQPKSGEVLVDGSHLPNKAFRPVQLIQQ
HPEQTMNPLWPMKKSLEEAYYPSQDLRDAFGIQEKWLNRRPSELSGGELQRFSIVRSLHPETRYLIADEMTTMLDSITQA
SVWKSLLEIVKDRNLGLIIISHDFDMLEKLCDVCYMIEENRTQLFKHT
>Mature_207_residues
TLEAKKLGFYHKKDQWLFKEIDLEVAPGQILGIFGQSGCGKTSLSRVLAGFLQPKSGEVLVDGSHLPNKAFRPVQLIQQH
PEQTMNPLWPMKKSLEEAYYPSQDLRDAFGIQEKWLNRRPSELSGGELQRFSIVRSLHPETRYLIADEMTTMLDSITQAS
VWKSLLEIVKDRNLGLIIISHDFDMLEKLCDVCYMIEENRTQLFKHT

Specific function: Part of a transport system that may be involved in oligopeptide uptake. Probably responsible for energy coupling to the transport system. Important for S.aureus growth and survival during the infection process [H]

COG id: COG1124

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27436953, Length=212, Percent_Identity=28.7735849056604, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI42490749, Length=198, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI153792144, Length=205, Percent_Identity=25.8536585365854, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI116734710, Length=205, Percent_Identity=24.390243902439, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI21536378, Length=212, Percent_Identity=25.4716981132075, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787758, Length=213, Percent_Identity=31.4553990610329, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1789891, Length=213, Percent_Identity=29.1079812206573, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1786398, Length=216, Percent_Identity=32.4074074074074, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1787500, Length=191, Percent_Identity=31.413612565445, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1789890, Length=206, Percent_Identity=28.6407766990291, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788506, Length=230, Percent_Identity=29.5652173913043, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87081834, Length=190, Percent_Identity=29.4736842105263, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI87081791, Length=179, Percent_Identity=29.0502793296089, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1789962, Length=183, Percent_Identity=28.4153005464481, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI145693107, Length=192, Percent_Identity=27.0833333333333, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI48994883, Length=213, Percent_Identity=28.6384976525822, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1786698, Length=195, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787547, Length=210, Percent_Identity=23.8095238095238, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789963, Length=217, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787029, Length=207, Percent_Identity=28.0193236714976, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI48994997, Length=209, Percent_Identity=25.8373205741627, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788225, Length=208, Percent_Identity=25, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1789751, Length=197, Percent_Identity=28.9340101522843, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786703, Length=204, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787164, Length=211, Percent_Identity=24.1706161137441, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1787112, Length=205, Percent_Identity=28.2926829268293, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787759, Length=210, Percent_Identity=28.0952380952381, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1787370, Length=196, Percent_Identity=25, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786345, Length=195, Percent_Identity=27.6923076923077, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786319, Length=211, Percent_Identity=27.4881516587678, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789032, Length=196, Percent_Identity=26.530612244898, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI87081709, Length=184, Percent_Identity=23.9130434782609, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1786253, Length=203, Percent_Identity=25.615763546798, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787548, Length=216, Percent_Identity=23.6111111111111, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787105, Length=183, Percent_Identity=28.4153005464481, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1786803, Length=190, Percent_Identity=27.8947368421053, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789672, Length=197, Percent_Identity=24.3654822335025, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71984940, Length=208, Percent_Identity=29.3269230769231, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17565938, Length=223, Percent_Identity=24.6636771300448, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17543740, Length=203, Percent_Identity=26.6009852216749, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71992290, Length=212, Percent_Identity=26.8867924528302, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17541710, Length=212, Percent_Identity=27.3584905660377, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115534520, Length=214, Percent_Identity=25.2336448598131, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71996550, Length=218, Percent_Identity=25.6880733944954, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17558664, Length=204, Percent_Identity=26.9607843137255, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193208177, Length=209, Percent_Identity=25.3588516746411, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17511077, Length=226, Percent_Identity=25.6637168141593, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193202349, Length=197, Percent_Identity=25.8883248730964, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357907, Length=204, Percent_Identity=25.4901960784314, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666092, Length=196, Percent_Identity=27.5510204081633, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 23923; Mature: 23792

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MTLEAKKLGFYHKKDQWLFKEIDLEVAPGQILGIFGQSGCGKTSLSRVLAGFLQPKSGEV
CCCCCHHCCCCCCCCCHHHHHHCCEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCE
LVDGSHLPNKAFRPVQLIQQHPEQTMNPLWPMKKSLEEAYYPSQDLRDAFGIQEKWLNRR
EEECCCCCCCCCHHHHHHHHCHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCHHHHHHCCC
PSELSGGELQRFSIVRSLHPETRYLIADEMTTMLDSITQASVWKSLLEIVKDRNLGLIII
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SHDFDMLEKLCDVCYMIEENRTQLFKHT
ECCHHHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure 
TLEAKKLGFYHKKDQWLFKEIDLEVAPGQILGIFGQSGCGKTSLSRVLAGFLQPKSGEV
CCCCHHCCCCCCCCCHHHHHHCCEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCE
LVDGSHLPNKAFRPVQLIQQHPEQTMNPLWPMKKSLEEAYYPSQDLRDAFGIQEKWLNRR
EEECCCCCCCCCHHHHHHHHCHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCHHHHHHCCC
PSELSGGELQRFSIVRSLHPETRYLIADEMTTMLDSITQASVWKSLLEIVKDRNLGLIII
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SHDFDMLEKLCDVCYMIEENRTQLFKHT
ECCHHHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA