| Definition | Streptococcus pyogenes MGAS315 chromosome, complete genome. |
|---|---|
| Accession | NC_004070 |
| Length | 1,900,521 |
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The map label for this gene is hsdM [H]
Identifier: 21911180
GI number: 21911180
Start: 1652761
End: 1654341
Strand: Direct
Name: hsdM [H]
Synonym: SpyM3_1644
Alternate gene names: 21911180
Gene position: 1652761-1654341 (Clockwise)
Preceding gene: 21911179
Following gene: 21911196
Centisome position: 86.96
GC content: 36.75
Gene sequence:
>1581_bases ATGGCAGAGAAAACAACTTCACTCCGGCAAGCACTATGGCATTCGGCCGACCAATTACGTGGCCAAATGGATGCCAATGA CTATAAAAACTATCTTCTTGGACTTATTTTTTACAAACACTTATCTGATAAATTACTCTTGGCTGTTTGTGATAATCTAG AAAAACACTTCAATACCTTTACAGAGGCTCAAAAAATCTTTGAAGATGCTTATCAAGATGAAGACCTAAAAGATGACCTC ATTTCTGTTGTTACTGGTGATTTAGGTTACTTTATCGAACCGACACTGACCTTTGAAAAACTCATCCAAGATGTTTATCA CAATACTTTCCAATTAGAATCATTAGCTCAAGGTTTTCACGATATTGAACAAAATGGTGAAGACTTTGAAAACTTATTTG AAGATATTGACCTCTACTCTAAAAAATTAGGCTCTACTCCTCAAAAACAAAATCAAACCATTGCCAATGTCATGAAAACA TTAAATGAAATTGACTTTGAGGCAGTAGATGGGGATACTTTAGGCGATGCTTATGAGTACTTGATTGGTGAATTTGCCAG TGAGTCAGGAAAAAAAGCAGGTGAGTTCTATACACCACAAGCTGTCTCTCACTTGATGACTCAGATTGTCTTTTTAGGTT GTGAAGATCAAAAAGGAATGACCCTCTATGACCCTGCTATGGGATCTGGATCACTCCTTTTAAACGCTAAGAAATATAGT AACCAATCCGATACCGTTTCTTACTATGGTCAAGAAATCAATACTTCTACTTATAACTTGGCTCGTATGAACATGATGCT TCATGGCGTTGCCATCGAAAACCAACACTTAAGTAACGCTGATACCTTGGATGCAGACTGGCCAACAGATGAACCAACCA ACTTTGATGGGGTGTTGATGAACCCACCTTATTCTTTAAAATGGTCAGCGACTGCTGGTTTCTTAACGGATCCACGTTTT TCAAGTTATGGTGTATTAGCACCAAAATCAAAAGCTGACTTTGCCTTTTTACTTCATGGTTTCTATCATTTAAAAAATAC AGGAACTATGGCAATTGTCTTACCACATGGTGTTCTTTTCCGTGGAGCTGCAGAAGGCAAGATTCGCCAAAAACTACTCG AACAAGGGGCTATCGATACCATTATCGGACTCCCATCAAATATCTTTTATAATACAAGCATCCCTACGACTATTATCATA TTAAAGAAGAACAGAACCAACAAAGATGTCTTCTTTATCGATGCTTCAAAAGAGTTTGATAAAGGCAAAAATCAAAACAC AATGACAGATAGCCATATCAAAAAGATCCTTGATGCTTATAAGAGTCGTGATAATTCTGATAAGTTTTCATATTTAGCCT CATTTGATGAAATCATTGAAAATGACTATAACTTAAATATCCCACGCTATGTTGATACCTTTGAGGAAGTTCCAGTTAAA CCACTGCCAGAATTAGCTAAACAGCTCAGTGACATTGATCAAGAAATTGCCAAAACAAATGCCAAACTAGATCAACTCAT GAAACAACTAGTCGGAACAACCAAAGAAGCACAAGACGAATTGGATACTTTTAGAAACTAA
Upstream 100 bases:
>100_bases CCTAGACCAACAAATGAGTCAAATCGAAGATAAATTAACAGAACTTAAAGCACTCAAACAAACATTACTCAATCGTTTAT TCGTATAAGAAAGGACTCAC
Downstream 100 bases:
>100_bases AAGACAAAAAAACACCACAGTAGATGATTACTACTGTGGCGTTTTATTTAAAATTGAGTAGTGAACCTTTATTGAGTACT TATCAAACAAGATTCTCCTT
Product: putative type I site-specific deoxyribonuclease hsdM modification subunit
Products: NA
Alternate protein names: M.EcoR124II [H]
Number of amino acids: Translated: 526; Mature: 525
Protein sequence:
>526_residues MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTFTEAQKIFEDAYQDEDLKDDL ISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFHDIEQNGEDFENLFEDIDLYSKKLGSTPQKQNQTIANVMKT LNEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGCEDQKGMTLYDPAMGSGSLLLNAKKYS NQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRF SSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIII LKKNRTNKDVFFIDASKEFDKGKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVK PLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN
Sequences:
>Translated_526_residues MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTFTEAQKIFEDAYQDEDLKDDL ISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFHDIEQNGEDFENLFEDIDLYSKKLGSTPQKQNQTIANVMKT LNEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGCEDQKGMTLYDPAMGSGSLLLNAKKYS NQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRF SSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIII LKKNRTNKDVFFIDASKEFDKGKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVK PLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN >Mature_525_residues AEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTFTEAQKIFEDAYQDEDLKDDLI SVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFHDIEQNGEDFENLFEDIDLYSKKLGSTPQKQNQTIANVMKTL NEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGCEDQKGMTLYDPAMGSGSLLLNAKKYSN QSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRFS SYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIIIL KKNRTNKDVFFIDASKEFDKGKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVKP LPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN
Specific function: Methylation of specific adenine residues; required for both restriction and modification activities. The EcoR124/3 I enzyme recognizes 5'-GAAN(7)RTCG-3' [H]
COG id: COG0286
COG function: function code V; Type I restriction-modification system methyltransferase subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the N(4)/N(6)-methyltransferase family [H]
Homologues:
Organism=Escherichia coli, GI1790808, Length=505, Percent_Identity=23.3663366336634, Blast_Score=92, Evalue=6e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR022749 - InterPro: IPR003356 - InterPro: IPR002052 - InterPro: IPR002296 - InterPro: IPR004546 [H]
Pfam domain/function: PF12161 HsdM_N; PF02384 N6_Mtase [H]
EC number: =2.1.1.72 [H]
Molecular weight: Translated: 59457; Mature: 59326
Theoretical pI: Translated: 4.52; Mature: 4.52
Prosite motif: PS00092 N6_MTASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTF CCCHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH TEAQKIFEDAYQDEDLKDDLISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFH HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHCHHHHHHHHHHHH DIEQNGEDFENLFEDIDLYSKKLGSTPQKQNQTIANVMKTLNEIDFEAVDGDTLGDAYEY HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHH LIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGCEDQKGMTLYDPAMGSGSLLLNAKKYS HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEEEHHHC NQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPTNFDGVLM CCCCHHHHCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEE NPPYSLKWSATAGFLTDPRFSSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLF CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEE RGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIIILKKNRTNKDVFFIDASKEFD CCCCCHHHHHHHHHCCCHHHHHCCCCCCEECCCCCEEEEEEECCCCCCCEEEEECCCHHC KGKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVK CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCC PLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC >Mature Secondary Structure AEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTF CCHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH TEAQKIFEDAYQDEDLKDDLISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFH HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHCHHHHHHHHHHHH DIEQNGEDFENLFEDIDLYSKKLGSTPQKQNQTIANVMKTLNEIDFEAVDGDTLGDAYEY HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHH LIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGCEDQKGMTLYDPAMGSGSLLLNAKKYS HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEEEHHHC NQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPTNFDGVLM CCCCHHHHCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEE NPPYSLKWSATAGFLTDPRFSSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLF CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEE RGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIIILKKNRTNKDVFFIDASKEFD CCCCCHHHHHHHHHCCCHHHHHCCCCCCEECCCCCEEEEEEECCCCCCCEEEEECCCHHC KGKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVK CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCC PLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2784505 [H]