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The map label for this gene is nagB

Identifier: 21910601

GI number: 21910601

Start: 1108882

End: 1109586

Strand: Reverse

Name: nagB

Synonym: SpyM3_1065

Alternate gene names: 21910601

Gene position: 1109586-1108882 (Counterclockwise)

Preceding gene: 21910604

Following gene: 21910600

Centisome position: 58.38

GC content: 38.87

Gene sequence:

>705_bases
ATGAAAATTATTCGGGTCCAAGATCAGATTGAAGGTGGGAAAATCGCTTTTACCTTATTGAAAGATAGCTTAGCTAAGGG
AGCTAAGACGTTAGGATTAGCAACAGGAAGTTCACCAATTAGTTTTTACCAAGAAATGGTCAAAAGTCCTTTGGATTTTT
CGGACTTAACAAGTATTAACTTGGATGAATATGTCGGTCTTTCAGTAGAGAGCGATCAGAGTTATGATTATTTTATGCGT
CAAAACCTTTTTAATGCGAAGCCTTTTAAAAAGAATTACTTGCCCAATGGTTTAGCAACTGATATCGAAGCTGAAGCTAA
ACGATATGACCAAATCATTGCAGAGCATCCGATTGATTTTCAAGTGCTTGGGATTGGGCGTAATGGGCACATTGGTTTTA
ACGAACCTGGGACCTCTTTTGAAGAAGAAACGCATGTGGTGGATCTTCAAGAATCAACCATTGAAGCTAATAGTCGTTTC
TTTACAAGTATTGAGGATGTGCCAAAACAAGCTATCTCTATGGGAATTGCCTCCATCATGAAGTCCAAAATGATTGTTCT
TCTTGCCTTTGGACAAGAAAAAGCTGATGCGATCAAGGGAATGGTTTTTGGACCAATCACAGAAGACCTCCCAGCAAGTA
TTCTCCAAAAACATGATCATGTTATCGTCATTGTGGATGAAGCTGCTGCGTCACAATTAGACTAA

Upstream 100 bases:

>100_bases
AATCTTTCATCAGAAAGTAAAGGATAGGCTTGACAAAAATTGGTATATACCATATAATAAAAACACGAAAGGTCTATACC
AATTAGAAAAGGAGAATGAC

Downstream 100 bases:

>100_bases
CCTAACCAGTCGTTAAACCTTGTAAGAACAAAAATGAGGAGATAGTCAGCCTCATTTAAGAAGAAGTCTTGTAACTTCTA
TTTCTTTTGCAAGGGTAAAT

Product: putative N-acetylglucosamine-6-phosphate isomerase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKIIRVQDQIEGGKIAFTLLKDSLAKGAKTLGLATGSSPISFYQEMVKSPLDFSDLTSINLDEYVGLSVESDQSYDYFMR
QNLFNAKPFKKNYLPNGLATDIEAEAKRYDQIIAEHPIDFQVLGIGRNGHIGFNEPGTSFEEETHVVDLQESTIEANSRF
FTSIEDVPKQAISMGIASIMKSKMIVLLAFGQEKADAIKGMVFGPITEDLPASILQKHDHVIVIVDEAAASQLD

Sequences:

>Translated_234_residues
MKIIRVQDQIEGGKIAFTLLKDSLAKGAKTLGLATGSSPISFYQEMVKSPLDFSDLTSINLDEYVGLSVESDQSYDYFMR
QNLFNAKPFKKNYLPNGLATDIEAEAKRYDQIIAEHPIDFQVLGIGRNGHIGFNEPGTSFEEETHVVDLQESTIEANSRF
FTSIEDVPKQAISMGIASIMKSKMIVLLAFGQEKADAIKGMVFGPITEDLPASILQKHDHVIVIVDEAAASQLD
>Mature_234_residues
MKIIRVQDQIEGGKIAFTLLKDSLAKGAKTLGLATGSSPISFYQEMVKSPLDFSDLTSINLDEYVGLSVESDQSYDYFMR
QNLFNAKPFKKNYLPNGLATDIEAEAKRYDQIIAEHPIDFQVLGIGRNGHIGFNEPGTSFEEETHVVDLQESTIEANSRF
FTSIEDVPKQAISMGIASIMKSKMIVLLAFGQEKADAIKGMVFGPITEDLPASILQKHDHVIVIVDEAAASQLD

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily

Homologues:

Organism=Homo sapiens, GI13027378, Length=213, Percent_Identity=34.2723004694836, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI19923881, Length=212, Percent_Identity=33.4905660377358, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1786893, Length=211, Percent_Identity=35.0710900473934, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1789530, Length=208, Percent_Identity=28.8461538461538, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI48994958, Length=232, Percent_Identity=29.7413793103448, Blast_Score=84, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17554876, Length=212, Percent_Identity=35.8490566037736, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24581960, Length=212, Percent_Identity=36.7924528301887, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI19920764, Length=212, Percent_Identity=36.7924528301887, Blast_Score=139, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NAGB_STRPG (A2RDX6)

Other databases:

- EMBL:   AM295007
- RefSeq:   YP_001128286.1
- ProteinModelPortal:   A2RDX6
- SMR:   A2RDX6
- STRING:   A2RDX6
- EnsemblBacteria:   EBSTRT00000047994
- GeneID:   4963232
- GenomeReviews:   AM295007_GR
- KEGG:   spf:SpyM50718
- eggNOG:   COG0363
- GeneTree:   EBGT00050000027970
- HOGENOM:   HBG725991
- OMA:   IIAEHPI
- ProtClustDB:   CLSK698703
- HAMAP:   MF_01241
- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321
- PANTHER:   PTHR11280
- TIGRFAMs:   TIGR00502

Pfam domain/function: PF01182 Glucosamine_iso

EC number: =3.5.99.6

Molecular weight: Translated: 25793; Mature: 25793

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: ACT_SITE 62-62 ACT_SITE 128-128 ACT_SITE 130-130 ACT_SITE 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIRVQDQIEGGKIAFTLLKDSLAKGAKTLGLATGSSPISFYQEMVKSPLDFSDLTSIN
CEEEEECCCCCCCEEEEHHHHHHHHCCHHHEEECCCCCHHHHHHHHHHCCCCHHHCCCCC
LDEYVGLSVESDQSYDYFMRQNLFNAKPFKKNYLPNGLATDIEAEAKRYDQIIAEHPIDF
HHHHCCCEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
QVLGIGRNGHIGFNEPGTSFEEETHVVDLQESTIEANSRFFTSIEDVPKQAISMGIASIM
EEEEECCCCCCCCCCCCCCCCCCCEEEECHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
KSKMIVLLAFGQEKADAIKGMVFGPITEDLPASILQKHDHVIVIVDEAAASQLD
HCCEEEEEEECCHHHHHHCCCEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MKIIRVQDQIEGGKIAFTLLKDSLAKGAKTLGLATGSSPISFYQEMVKSPLDFSDLTSIN
CEEEEECCCCCCCEEEEHHHHHHHHCCHHHEEECCCCCHHHHHHHHHHCCCCHHHCCCCC
LDEYVGLSVESDQSYDYFMRQNLFNAKPFKKNYLPNGLATDIEAEAKRYDQIIAEHPIDF
HHHHCCCEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
QVLGIGRNGHIGFNEPGTSFEEETHVVDLQESTIEANSRFFTSIEDVPKQAISMGIASIM
EEEEECCCCCCCCCCCCCCCCCCCEEEECHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
KSKMIVLLAFGQEKADAIKGMVFGPITEDLPASILQKHDHVIVIVDEAAASQLD
HCCEEEEEEECCHHHHHHCCCEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA