| Definition | Streptococcus pyogenes MGAS315 chromosome, complete genome. |
|---|---|
| Accession | NC_004070 |
| Length | 1,900,521 |
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The map label for this gene is glmU [H]
Identifier: 21909848
GI number: 21909848
Start: 354516
End: 355898
Strand: Direct
Name: glmU [H]
Synonym: SpyM3_0312
Alternate gene names: 21909848
Gene position: 354516-355898 (Clockwise)
Preceding gene: 21909847
Following gene: 21909849
Centisome position: 18.65
GC content: 43.17
Gene sequence:
>1383_bases ATGACAAATTATGCCATTATTTTAGCAGCGGGCAAAGGGACTCGCATGACTTCTGATCTCCCAAAAGTTCTTCATAAAGT ATCTGGACTAACCATGCTTGAGCATGTTTTTCGTAGTGTAAAAGCGATTAATCCTGAAAAAGCCGTGACGGTTATTGGTC ACAAATCAGAAATGGTACGTGCTGTCTTAGCAGATCAATCAGCCTTTGTCCATCAAACAGAGCAGTTAGGAACTGGCCAT GCCGTGATGATGGCAGAAACACAACTAGAAGGACTAGAAGGGCATACCTTGGTGATTGCAGGAGATACTCCCTTGATCAC TGGAGAAAGCCTGAAAAGTCTGATTGATTTTCATGTGAATCATAAAAATGTCGCCACTATTTTAACAGCTACGGCTCCAG ATCCATTTGGTTATGGTCGTATTGTTCGCAACAAAGATGGCGAAGTGATCAAGATTGTTGAGCAAAAAGACGCCAATGAG TATGAGCAACAATTAAAAGAAATCAATACAGGAACCTATGTGTTTGATAACAAGCGTCTCTTTGAAGCGCTCAAATGCAT CACTACCAACAATGCTCAAGGAGAGTATTACCTGACTGACGTTGTGGCTATTTTTAGAGCAAACAAAGAAAAGGTAGGAG CCTATATCCTGAGAGACTTCAATGAAAGTCTGGGAGTAAATGATCGTGTGGCCTTAGCAACAGCTGAAACAGTGATGCGT CAGCGCATTACCCAAAAACATATGGTCAATGGGGTGACCTTTCACAATCCTGAAACTGTTTATATTGAAAGCGATGTAAC GATTGCTCCAGACGTCCTTATCGAAGGAAATGTGACCTTGAAAGGGCGTACACATATCGGCTCAGGAACTGTCTTAACGA ATGGTACTTATATTGTGGATTCTGAAATTGGTGATAACTGTGTTGTTACCAATTCGATGATCGAATCATCTGTTTTAGCT GCAGGAGTTACGGTTGGCCCTTACGCCCACCTTCGACCAGGAACGACCTTAGATAGAGAAGTCCATATCGGTAACTTTGT TGAGGTCAAGGGTTCTCACATTGGTGAAAAAACAAAGGCTGGGCATCTGACTTATATTGGAAACGCTCAGGTTGGGTCTT CAGTCAATGTTGGGGCTGGAACCATCACTGTCAACTACGACGGCCAAAACAAATATGAAACAGTCGTTGGAGATCACGCT TTTATTGGGAGCAACTCGACTCTTATCGCACCACTAGAAATCGGGGATAACGCTTTAACAGCAGCTGGCTCAACGATTTC TAAGACAGTACCAGCTGATAGCATTGTTATTGGTCGTAGCCGCCAAGTCACAAAAGAAGGTTATGCCAAGCGCCTAGCGC ATCACCCAAGTCGAAGCAAATAA
Upstream 100 bases:
>100_bases GACACTATAAAAGACAAGAAAATGCTAGGATGTTTCAGGAAAAAAAGAGAAAATATGCTATAATGAGAAGGTATTTAAAT TATATAGTAAGGAAAAACAA
Downstream 100 bases:
>100_bases TTCAAGATCTATTTAGTAAGGAGGCCAGGCATGAAATTTGAAGAAAAAACGCTTAAGAGACAAACAGTTTTTGATGGTCA TATTTTTAAAGTTGTTGTGG
Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase
Products: NA
Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]
Number of amino acids: Translated: 460; Mature: 459
Protein sequence:
>460_residues MTNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAINPEKAVTVIGHKSEMVRAVLADQSAFVHQTEQLGTGH AVMMAETQLEGLEGHTLVIAGDTPLITGESLKSLIDFHVNHKNVATILTATAPDPFGYGRIVRNKDGEVIKIVEQKDANE YEQQLKEINTGTYVFDNKRLFEALKCITTNNAQGEYYLTDVVAIFRANKEKVGAYILRDFNESLGVNDRVALATAETVMR QRITQKHMVNGVTFHNPETVYIESDVTIAPDVLIEGNVTLKGRTHIGSGTVLTNGTYIVDSEIGDNCVVTNSMIESSVLA AGVTVGPYAHLRPGTTLDREVHIGNFVEVKGSHIGEKTKAGHLTYIGNAQVGSSVNVGAGTITVNYDGQNKYETVVGDHA FIGSNSTLIAPLEIGDNALTAAGSTISKTVPADSIVIGRSRQVTKEGYAKRLAHHPSRSK
Sequences:
>Translated_460_residues MTNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAINPEKAVTVIGHKSEMVRAVLADQSAFVHQTEQLGTGH AVMMAETQLEGLEGHTLVIAGDTPLITGESLKSLIDFHVNHKNVATILTATAPDPFGYGRIVRNKDGEVIKIVEQKDANE YEQQLKEINTGTYVFDNKRLFEALKCITTNNAQGEYYLTDVVAIFRANKEKVGAYILRDFNESLGVNDRVALATAETVMR QRITQKHMVNGVTFHNPETVYIESDVTIAPDVLIEGNVTLKGRTHIGSGTVLTNGTYIVDSEIGDNCVVTNSMIESSVLA AGVTVGPYAHLRPGTTLDREVHIGNFVEVKGSHIGEKTKAGHLTYIGNAQVGSSVNVGAGTITVNYDGQNKYETVVGDHA FIGSNSTLIAPLEIGDNALTAAGSTISKTVPADSIVIGRSRQVTKEGYAKRLAHHPSRSK >Mature_459_residues TNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAINPEKAVTVIGHKSEMVRAVLADQSAFVHQTEQLGTGHA VMMAETQLEGLEGHTLVIAGDTPLITGESLKSLIDFHVNHKNVATILTATAPDPFGYGRIVRNKDGEVIKIVEQKDANEY EQQLKEINTGTYVFDNKRLFEALKCITTNNAQGEYYLTDVVAIFRANKEKVGAYILRDFNESLGVNDRVALATAETVMRQ RITQKHMVNGVTFHNPETVYIESDVTIAPDVLIEGNVTLKGRTHIGSGTVLTNGTYIVDSEIGDNCVVTNSMIESSVLAA GVTVGPYAHLRPGTTLDREVHIGNFVEVKGSHIGEKTKAGHLTYIGNAQVGSSVNVGAGTITVNYDGQNKYETVVGDHAF IGSNSTLIAPLEIGDNALTAAGSTISKTVPADSIVIGRSRQVTKEGYAKRLAHHPSRSK
Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]
COG id: COG1207
COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]
Homologues:
Organism=Escherichia coli, GI1790168, Length=454, Percent_Identity=41.8502202643172, Blast_Score=344, Evalue=6e-96, Organism=Drosophila melanogaster, GI21355443, Length=350, Percent_Identity=24, Blast_Score=77, Evalue=3e-14, Organism=Drosophila melanogaster, GI24644084, Length=350, Percent_Identity=24, Blast_Score=77, Evalue=3e-14,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005882 - InterPro: IPR005835 - InterPro: IPR011004 [H]
Pfam domain/function: PF00483 NTP_transferase [H]
EC number: =2.7.7.23; =2.3.1.157 [H]
Molecular weight: Translated: 49602; Mature: 49471
Theoretical pI: Translated: 6.91; Mature: 6.91
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAINPEKAVTVIGHKSEMVR CCCEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECHHHHHH AVLADQSAFVHQTEQLGTGHAVMMAETQLEGLEGHTLVIAGDTPLITGESLKSLIDFHVN HHHHCCHHHHHHHHHCCCCCEEEEEECHHCCCCCCEEEEECCCCEECHHHHHHHHHHHCC HKNVATILTATAPDPFGYGRIVRNKDGEVIKIVEQKDANEYEQQLKEINTGTYVFDNKRL CCCEEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCEEEECCHHH FEALKCITTNNAQGEYYLTDVVAIFRANKEKVGAYILRDFNESLGVNDRVALATAETVMR HHHHHHHCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHH QRITQKHMVNGVTFHNPETVYIESDVTIAPDVLIEGNVTLKGRTHIGSGTVLTNGTYIVD HHHHHHHHHCCEEECCCEEEEEECCCEECCCEEEECCEEEEECEECCCCEEEECCEEEEE SEIGDNCVVTNSMIESSVLAAGVTVGPYAHLRPGTTLDREVHIGNFVEVKGSHIGEKTKA CCCCCCEEEEHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEECCCEEEECCCCCCCCCCC GHLTYIGNAQVGSSVNVGAGTITVNYDGQNKYETVVGDHAFIGSNSTLIAPLEIGDNALT CEEEEEECCCCCCCEECCCEEEEEEECCCCCEEEEECCEEEECCCCCEEEEEECCCCCEE AAGSTISKTVPADSIVIGRSRQVTKEGYAKRLAHHPSRSK CCCCCHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCC >Mature Secondary Structure TNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAINPEKAVTVIGHKSEMVR CCEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECHHHHHH AVLADQSAFVHQTEQLGTGHAVMMAETQLEGLEGHTLVIAGDTPLITGESLKSLIDFHVN HHHHCCHHHHHHHHHCCCCCEEEEEECHHCCCCCCEEEEECCCCEECHHHHHHHHHHHCC HKNVATILTATAPDPFGYGRIVRNKDGEVIKIVEQKDANEYEQQLKEINTGTYVFDNKRL CCCEEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCEEEECCHHH FEALKCITTNNAQGEYYLTDVVAIFRANKEKVGAYILRDFNESLGVNDRVALATAETVMR HHHHHHHCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHH QRITQKHMVNGVTFHNPETVYIESDVTIAPDVLIEGNVTLKGRTHIGSGTVLTNGTYIVD HHHHHHHHHCCEEECCCEEEEEECCCEECCCEEEECCEEEEECEECCCCEEEECCEEEEE SEIGDNCVVTNSMIESSVLAAGVTVGPYAHLRPGTTLDREVHIGNFVEVKGSHIGEKTKA CCCCCCEEEEHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEECCCEEEECCCCCCCCCCC GHLTYIGNAQVGSSVNVGAGTITVNYDGQNKYETVVGDHAFIGSNSTLIAPLEIGDNALT CEEEEEECCCCCCCEECCCEEEEEEECCCCCEEEEECCEEEECCCCCEEEEEECCCCCEE AAGSTISKTVPADSIVIGRSRQVTKEGYAKRLAHHPSRSK CCCCCHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11296296 [H]