| Definition | Streptococcus pyogenes MGAS315 chromosome, complete genome. |
|---|---|
| Accession | NC_004070 |
| Length | 1,900,521 |
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The map label for this gene is ackA [H]
Identifier: 21909622
GI number: 21909622
Start: 106969
End: 108165
Strand: Direct
Name: ackA [H]
Synonym: SpyM3_0086
Alternate gene names: 21909622
Gene position: 106969-108165 (Clockwise)
Preceding gene: 21909621
Following gene: 21909623
Centisome position: 5.63
GC content: 39.1
Gene sequence:
>1197_bases ATGTCAAAGACAATTGCAATTAATGCAGGTAGTTCTAGTTTAAAATGGCAACTTTATCAGATGCCAGAAGAAGCAGTGTT AGCACAAGGAATTATTGAGCGTATCGGTCTCAAGGATTCTATTTCAACAGTTAAGTACGATGGCAAAAAAGAAGAGCAAA TTCTTGATATTCACGATCATACAGAAGCTGTTAAAATCTTATTGAACGATTTGATTCACTTTGGAATCATTGCAGCTTAT GATGAAATTACAGGAGTTGGACACCGTGTTGTTGCTGGTGGTGAACTTTTCAAAGAATCCGTTGTGGTTAATGATAAAGT TCTTGAGCAGATTGAAGAATTATCCGTTTTAGCTCCACTTCACAATCCTGGAGCGGCGGCAGGGATTCGTGCCTTCCGTG ATATTTTGCCAGATATTACCAGTGTTTGTGTGTTTGACACGTCATTTCACACCAGCATGGCAAAGCATACTTACCTTTAC CCAATTCCTCAAAAATATTATACGGACTACAAGGTTCGTAAATATGGAGCTCATGGGACAAGTCATAAATATGTAGCGCA AGAAGCTGCTAAAATGCTTGGTCGTCCATTAGAAGAATTAAAACTAATTACTGCTCATATTGGAAATGGTGTCTCAATTA CAGCTAATTACCACGGTAAATCAGTTGATACCTCAATGGGATTCACTCCATTAGCTGGTCCTATGATGGGAACACGTTCT GGTGACATTGACCCAGCTATCATTCCTTATTTAATTGAGCAAGACCCAGAGTTAAAAGACGCTGCTGATGTTGTGAATAT GTTAAATAAGAAATCAGGTCTTAGTGGGGTGTCAGGCATTTCTAGTGATATGCGTGATATCGAGGCTGGTTTACAAGAAG ATAATCCAGATGCTGTTTTAGCTTACAATATCTTTATTGATCGCATTAAAAAATGCATCGGTCAATATTTTGCTGTTTTG AATGGAGCAGATGCTTTGGTCTTTACAGCTGGTATGGGTGAAAATGCACCATTGATGCGTCAAGACGTTATTGGTGGCTT AACATGGTTCGGCATGGACATTGATCCTGAGAAAAATGTTTTTGGATACCGTGGTGACATTTCAACTCCTGAGTCAAAAG TGAAGGTGCTTGTTATCTCAACAGACGAAGAATTGTGCATCGCGCGTGACGTTGAGCGTTTGAAAAATACAAAATAA
Upstream 100 bases:
>100_bases ATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAATTGATTTTTTGTTATAATAAAAAAGCATCACAGAAAAC GATTTCAAGAGAGGTTAAAA
Downstream 100 bases:
>100_bases AAGAGACTAAGTCTCAATAGATTAACCAAGTAAGGCAACACTTTACTTGGTTTTTTATGAGGTTTATCTGTTAGTTATGG TGCCTAGGTATTAGTTCTGA
Product: acetate kinase
Products: NA
Alternate protein names: Acetokinase [H]
Number of amino acids: Translated: 398; Mature: 397
Protein sequence:
>398_residues MSKTIAINAGSSSLKWQLYQMPEEAVLAQGIIERIGLKDSISTVKYDGKKEEQILDIHDHTEAVKILLNDLIHFGIIAAY DEITGVGHRVVAGGELFKESVVVNDKVLEQIEELSVLAPLHNPGAAAGIRAFRDILPDITSVCVFDTSFHTSMAKHTYLY PIPQKYYTDYKVRKYGAHGTSHKYVAQEAAKMLGRPLEELKLITAHIGNGVSITANYHGKSVDTSMGFTPLAGPMMGTRS GDIDPAIIPYLIEQDPELKDAADVVNMLNKKSGLSGVSGISSDMRDIEAGLQEDNPDAVLAYNIFIDRIKKCIGQYFAVL NGADALVFTAGMGENAPLMRQDVIGGLTWFGMDIDPEKNVFGYRGDISTPESKVKVLVISTDEELCIARDVERLKNTK
Sequences:
>Translated_398_residues MSKTIAINAGSSSLKWQLYQMPEEAVLAQGIIERIGLKDSISTVKYDGKKEEQILDIHDHTEAVKILLNDLIHFGIIAAY DEITGVGHRVVAGGELFKESVVVNDKVLEQIEELSVLAPLHNPGAAAGIRAFRDILPDITSVCVFDTSFHTSMAKHTYLY PIPQKYYTDYKVRKYGAHGTSHKYVAQEAAKMLGRPLEELKLITAHIGNGVSITANYHGKSVDTSMGFTPLAGPMMGTRS GDIDPAIIPYLIEQDPELKDAADVVNMLNKKSGLSGVSGISSDMRDIEAGLQEDNPDAVLAYNIFIDRIKKCIGQYFAVL NGADALVFTAGMGENAPLMRQDVIGGLTWFGMDIDPEKNVFGYRGDISTPESKVKVLVISTDEELCIARDVERLKNTK >Mature_397_residues SKTIAINAGSSSLKWQLYQMPEEAVLAQGIIERIGLKDSISTVKYDGKKEEQILDIHDHTEAVKILLNDLIHFGIIAAYD EITGVGHRVVAGGELFKESVVVNDKVLEQIEELSVLAPLHNPGAAAGIRAFRDILPDITSVCVFDTSFHTSMAKHTYLYP IPQKYYTDYKVRKYGAHGTSHKYVAQEAAKMLGRPLEELKLITAHIGNGVSITANYHGKSVDTSMGFTPLAGPMMGTRSG DIDPAIIPYLIEQDPELKDAADVVNMLNKKSGLSGVSGISSDMRDIEAGLQEDNPDAVLAYNIFIDRIKKCIGQYFAVLN GADALVFTAGMGENAPLMRQDVIGGLTWFGMDIDPEKNVFGYRGDISTPESKVKVLVISTDEELCIARDVERLKNTK
Specific function: Involved In The Activation Of Acetate To Acetyl CoA And The Secretion Of Acetate. During Anaerobic Growth Of The Organism, This Enzyme Is Also Involved In The Synthesis Of Most Of The ATP Formed Catabolically. [C]
COG id: COG0282
COG function: function code C; Acetate kinase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the acetokinase family [H]
Homologues:
Organism=Escherichia coli, GI1788633, Length=402, Percent_Identity=42.2885572139304, Blast_Score=289, Evalue=3e-79, Organism=Escherichia coli, GI145693184, Length=394, Percent_Identity=39.8477157360406, Blast_Score=275, Evalue=4e-75,
Paralogues:
None
Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000890 - InterPro: IPR004372 [H]
Pfam domain/function: PF00871 Acetate_kinase [H]
EC number: =2.7.2.1 [H]
Molecular weight: Translated: 43547; Mature: 43416
Theoretical pI: Translated: 5.17; Mature: 5.17
Prosite motif: PS01075 ACETATE_KINASE_1 ; PS01076 ACETATE_KINASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 3.8 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSKTIAINAGSSSLKWQLYQMPEEAVLAQGIIERIGLKDSISTVKYDGKKEEQILDIHDH CCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHEEECCCCCCEEEEHHHH TEAVKILLNDLIHFGIIAAYDEITGVGHRVVAGGELFKESVVVNDKVLEQIEELSVLAPL HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCHHHHHHHHHHHHHCCC HNPGAAAGIRAFRDILPDITSVCVFDTSFHTSMAKHTYLYPIPQKYYTDYKVRKYGAHGT CCCCHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHCCEEEECCHHHCCCCCEEEECCCCC SHKYVAQEAAKMLGRPLEELKLITAHIGNGVSITANYHGKSVDTSMGFTPLAGPMMGTRS CHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC GDIDPAIIPYLIEQDPELKDAADVVNMLNKKSGLSGVSGISSDMRDIEAGLQEDNPDAVL CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEE AYNIFIDRIKKCIGQYFAVLNGADALVFTAGMGENAPLMRQDVIGGLTWFGMDIDPEKNV EHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCCEEECCCCCCCCCC FGYRGDISTPESKVKVLVISTDEELCIARDVERLKNTK CEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCC >Mature Secondary Structure SKTIAINAGSSSLKWQLYQMPEEAVLAQGIIERIGLKDSISTVKYDGKKEEQILDIHDH CCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHEEECCCCCCEEEEHHHH TEAVKILLNDLIHFGIIAAYDEITGVGHRVVAGGELFKESVVVNDKVLEQIEELSVLAPL HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCHHHHHHHHHHHHHCCC HNPGAAAGIRAFRDILPDITSVCVFDTSFHTSMAKHTYLYPIPQKYYTDYKVRKYGAHGT CCCCHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHCCEEEECCHHHCCCCCEEEECCCCC SHKYVAQEAAKMLGRPLEELKLITAHIGNGVSITANYHGKSVDTSMGFTPLAGPMMGTRS CHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC GDIDPAIIPYLIEQDPELKDAADVVNMLNKKSGLSGVSGISSDMRDIEAGLQEDNPDAVL CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEE AYNIFIDRIKKCIGQYFAVLNGADALVFTAGMGENAPLMRQDVIGGLTWFGMDIDPEKNV EHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCCEEECCCCCCCCCC FGYRGDISTPESKVKVLVISTDEELCIARDVERLKNTK CEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA