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The map label for this gene is hemL [H]

Identifier: 218930406

GI number: 218930406

Start: 3782549

End: 3783829

Strand: Direct

Name: hemL [H]

Synonym: YPO3389

Alternate gene names: 218930406

Gene position: 3782549-3783829 (Clockwise)

Preceding gene: 218930403

Following gene: 218930412

Centisome position: 81.28

GC content: 50.9

Gene sequence:

>1281_bases
ATGAGTAAATCCGAAAATCTGTATGCCCAAGCACAACAGTTGATCCCGGGCGGGGTTAACTCTCCGGTGCGTGCATTCAC
AGGTGTTGGGGGCATCCCACTCTTTATTGAACGTGCTGATGGTGCTTACCTCTTTGACGTAGATGGCAAAGCCTATATTG
ACTATGTCGGCTCTTGGGGGCCAATGATCTTGGGCCATAATCACCCTGCTATTCGTCAGGCGGTCATTGAGGCCGTTGAA
CGTGGCCTAAGTTTTGGTGCACCGACAGAGATGGAAGTGAAAATGGCTCAGTTGGTTACAGATTTGGTGCCAACCATGGA
TATGGTACGGATGGTCAATTCCGGCACCGAAGCCACCATGAGTGCCATCCGTCTGGCCCGAGGCTATACCGGTCGCGATA
AGATAATTAAATTCGAAGGCTGCTATCACGGCCATGCCGATTGTTTGTTGGTAAAAGCAGGCTCAGGCGCACTGACACTG
GGTCAGCCCAATTCACCTGGTGTTCCTACGGATTTTGCCAAACACACCCTGACCTGTACCTATAACGATCTGGCTTCTGT
ACGGCAGGCCTTTGAGCAATATCCGCAAGAAGTGGCGTGTATTATCGTTGAGCCAGTAGCCGGTAATATGAATTGCATTC
CCCCGTTGCCAGAGTTCCTGCCTGGTCTGCGCGCTTTGTGTGATGAGTTTGGTGCTCTGCTTATCATCGATGAAGTCATG
ACCGGTTTTCGCGTAGCCTTAGCTGGCGCGCAGGATTATTACCATGTCATCCCTGATTTAACCTGTCTGGGTAAAATCAT
TGGTGGCGGTATGCCAGTAGGCGCTTTTGGTGGCCGCCGTGAGGTAATGAATGCGCTGGCACCGACTGGCCCGGTTTACC
AAGCCGGTACGCTATCCGGTAACCCTATCGCTATGGCTGCCGGTTTTGCCTGCCTGACAGAAATCTCTCAGGTCGGTGTT
TATGAAACACTGACCGAATTAACCGACTCACTGGCTACAGGCCTGCGACATGCCGCTAAAGAGGAGAACATCCCACTGGT
GGTTAACCACGTCGGTGGGATGTTTGGCCTATTCTTTACCAATGCTGATACCGTCACCTGCTATCAGGATGTGATGAATT
GTGATGTTGAGCGCTTTAAACGTTTCTTCCATTTGATGCTGGAAGAAGGGGTCTATCTGGCACCGTCAGCCTTTGAAGCG
GGCTTTATGTCTCTGGCTCACAGCAACGAAGATATTCAGAAAACCGTCAATGCCGCTCGTCGATGCTTTGCTAAACTTTA
A

Upstream 100 bases:

>100_bases
CCTAGATGAATAATGTTGCCAAGGTAAATAATAAGGTTGCCAAGGTAAATAATGTTGCCAAAGTGAATAACGTTGCCAAG
CCCAATTCAGGAGCCAATTT

Downstream 100 bases:

>100_bases
TTCAATATTTGTTTGAATTTTAGTCAAAACAATATCTATTTGAGTTTTAGCCCAAAATAGAAGGTAATCAGACTGCTGAC
AACCCCCGAACACTCGATCT

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSKSENLYAQAQQLIPGGVNSPVRAFTGVGGIPLFIERADGAYLFDVDGKAYIDYVGSWGPMILGHNHPAIRQAVIEAVE
RGLSFGAPTEMEVKMAQLVTDLVPTMDMVRMVNSGTEATMSAIRLARGYTGRDKIIKFEGCYHGHADCLLVKAGSGALTL
GQPNSPGVPTDFAKHTLTCTYNDLASVRQAFEQYPQEVACIIVEPVAGNMNCIPPLPEFLPGLRALCDEFGALLIIDEVM
TGFRVALAGAQDYYHVIPDLTCLGKIIGGGMPVGAFGGRREVMNALAPTGPVYQAGTLSGNPIAMAAGFACLTEISQVGV
YETLTELTDSLATGLRHAAKEENIPLVVNHVGGMFGLFFTNADTVTCYQDVMNCDVERFKRFFHLMLEEGVYLAPSAFEA
GFMSLAHSNEDIQKTVNAARRCFAKL

Sequences:

>Translated_426_residues
MSKSENLYAQAQQLIPGGVNSPVRAFTGVGGIPLFIERADGAYLFDVDGKAYIDYVGSWGPMILGHNHPAIRQAVIEAVE
RGLSFGAPTEMEVKMAQLVTDLVPTMDMVRMVNSGTEATMSAIRLARGYTGRDKIIKFEGCYHGHADCLLVKAGSGALTL
GQPNSPGVPTDFAKHTLTCTYNDLASVRQAFEQYPQEVACIIVEPVAGNMNCIPPLPEFLPGLRALCDEFGALLIIDEVM
TGFRVALAGAQDYYHVIPDLTCLGKIIGGGMPVGAFGGRREVMNALAPTGPVYQAGTLSGNPIAMAAGFACLTEISQVGV
YETLTELTDSLATGLRHAAKEENIPLVVNHVGGMFGLFFTNADTVTCYQDVMNCDVERFKRFFHLMLEEGVYLAPSAFEA
GFMSLAHSNEDIQKTVNAARRCFAKL
>Mature_425_residues
SKSENLYAQAQQLIPGGVNSPVRAFTGVGGIPLFIERADGAYLFDVDGKAYIDYVGSWGPMILGHNHPAIRQAVIEAVER
GLSFGAPTEMEVKMAQLVTDLVPTMDMVRMVNSGTEATMSAIRLARGYTGRDKIIKFEGCYHGHADCLLVKAGSGALTLG
QPNSPGVPTDFAKHTLTCTYNDLASVRQAFEQYPQEVACIIVEPVAGNMNCIPPLPEFLPGLRALCDEFGALLIIDEVMT
GFRVALAGAQDYYHVIPDLTCLGKIIGGGMPVGAFGGRREVMNALAPTGPVYQAGTLSGNPIAMAAGFACLTEISQVGVY
ETLTELTDSLATGLRHAAKEENIPLVVNHVGGMFGLFFTNADTVTCYQDVMNCDVERFKRFFHLMLEEGVYLAPSAFEAG
FMSLAHSNEDIQKTVNAARRCFAKL

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=318, Percent_Identity=30.188679245283, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI13994255, Length=373, Percent_Identity=26.0053619302949, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI284507298, Length=236, Percent_Identity=30.9322033898305, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=88.4976525821596, Blast_Score=790, Evalue=0.0,
Organism=Escherichia coli, GI1789016, Length=384, Percent_Identity=31.7708333333333, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1787560, Length=348, Percent_Identity=31.8965517241379, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI145693181, Length=313, Percent_Identity=31.3099041533546, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788044, Length=332, Percent_Identity=30.421686746988, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1789759, Length=332, Percent_Identity=29.5180722891566, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786991, Length=298, Percent_Identity=26.8456375838926, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=341, Percent_Identity=27.5659824046921, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71992977, Length=363, Percent_Identity=28.099173553719, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=335, Percent_Identity=25.6716417910448, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25144274, Length=183, Percent_Identity=31.6939890710383, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=341, Percent_Identity=28.7390029325513, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=351, Percent_Identity=26.7806267806268, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357415, Length=320, Percent_Identity=26.5625, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356575, Length=329, Percent_Identity=29.7872340425532, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 45794; Mature: 45663

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSENLYAQAQQLIPGGVNSPVRAFTGVGGIPLFIERADGAYLFDVDGKAYIDYVGSWG
CCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEEECCCEEEEECCCCEEEEECCCCC
PMILGHNHPAIRQAVIEAVERGLSFGAPTEMEVKMAQLVTDLVPTMDMVRMVNSGTEATM
CEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SAIRLARGYTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPTDFAKHTLTCT
HHHHHHCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCCHHHHCEEEEE
YNDLASVRQAFEQYPQEVACIIVEPVAGNMNCIPPLPEFLPGLRALCDEFGALLIIDEVM
HHHHHHHHHHHHHCCHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEHHHHH
TGFRVALAGAQDYYHVIPDLTCLGKIIGGGMPVGAFGGRREVMNALAPTGPVYQAGTLSG
HHHHHHHCCCCHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPIAMAAGFACLTEISQVGVYETLTELTDSLATGLRHAAKEENIPLVVNHVGGMFGLFFT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHCC
NADTVTCYQDVMNCDVERFKRFFHLMLEEGVYLAPSAFEAGFMSLAHSNEDIQKTVNAAR
CCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHCCCHHHHHHHHHHH
RCFAKL
HHHHCC
>Mature Secondary Structure 
SKSENLYAQAQQLIPGGVNSPVRAFTGVGGIPLFIERADGAYLFDVDGKAYIDYVGSWG
CCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEEECCCEEEEECCCCEEEEECCCCC
PMILGHNHPAIRQAVIEAVERGLSFGAPTEMEVKMAQLVTDLVPTMDMVRMVNSGTEATM
CEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SAIRLARGYTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPTDFAKHTLTCT
HHHHHHCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCCHHHHCEEEEE
YNDLASVRQAFEQYPQEVACIIVEPVAGNMNCIPPLPEFLPGLRALCDEFGALLIIDEVM
HHHHHHHHHHHHHCCHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEHHHHH
TGFRVALAGAQDYYHVIPDLTCLGKIIGGGMPVGAFGGRREVMNALAPTGPVYQAGTLSG
HHHHHHHCCCCHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPIAMAAGFACLTEISQVGVYETLTELTDSLATGLRHAAKEENIPLVVNHVGGMFGLFFT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHCC
NADTVTCYQDVMNCDVERFKRFFHLMLEEGVYLAPSAFEAGFMSLAHSNEDIQKTVNAAR
CCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHCCCHHHHHHHHHHH
RCFAKL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA