Click here to switch to the map view.

The map label for this gene is rpiA

Identifier: 218928443

GI number: 218928443

Start: 1451517

End: 1452227

Strand: Direct

Name: rpiA

Synonym: YPO1292

Alternate gene names: 218928443

Gene position: 1451517-1452227 (Clockwise)

Preceding gene: 218928442

Following gene: 218928444

Centisome position: 31.19

GC content: 54.57

Gene sequence:

>711_bases
ATGAGCAATCAACAAAATGACGCCAAGAGGGCTGCCGCCCGTCGGGTGATTCAGGATTTCGTGTTCGATGGCATGACGTT
GGGGCTGGGTTCCGGGACCACCTCGCATTTCTTTGTGCGCGAACTGGGCCAGCATGTTGCCAAGGGCTTGCAGTTAACCT
GCACCACAACTTCTCGTGCGACGAGCGAGGTGGCGCGTGACGTGGGCATTGAGCTCTCGGATCCGAATGAGATGAATGAG
ATTGATCTGACCATCGACGGCCCAGATGAGATTGACCGGCGGTTCAATATGATCAAGGGCGGTGGAGCCTGCCTTCTGTG
GGAGAAAATTATCGCCCATGCCTCGAAGCGGATGATTTGTATTTGTGATGAGACAAAAATCGTCAATTGCTTGGGGCAAT
TTCCGCTGCCAGTCGAAATCGTCCCCTTTGCCTGGAAACAGACCGAACGCAGGGTCGAGCGGGTACTCGCGGAACAGGGT
CTCCATCATGTGCCGATTATTCGGCGTATGGGGGGCGGGCACCCGGTGATCACTGACAGTGGAAACTTTATTCTGGATTG
CCATTGCGGGGCGATTATCACGGCCCCTGAACCGCTGGAAATAGAGCTTAATCGCATTCCGGGGGTGGTTGAAAACGGTC
TTTTCACCCGTGAGGCTACCGGTATGGTGGTGGGCTATTTTGACGGTTCCTCCTACGTTCAACTGCGATAA

Upstream 100 bases:

>100_bases
GAGGCCCAACGCATTTACCGTACTCTTTACCCGGCGCTGAGAGAAACCTTCGCAGAACTTGGCGACCCCACCTTTATGTA
GTCATGATCAGGAGTCACGA

Downstream 100 bases:

>100_bases
TCACGGCCTTTTTCGACGCTGTCGCGAGTCGCGTCACCTTGGCACCAAGAGAGCAAAAGAGCAAAAGAGCAAAAGAGCAA
AAGAGCAAAAGAGAGTATCA

Product: putative ribose 5-phosphate isomerase

Products: NA

Alternate protein names: Phosphoriboisomerase A 2; PRI 2

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSNQQNDAKRAAARRVIQDFVFDGMTLGLGSGTTSHFFVRELGQHVAKGLQLTCTTTSRATSEVARDVGIELSDPNEMNE
IDLTIDGPDEIDRRFNMIKGGGACLLWEKIIAHASKRMICICDETKIVNCLGQFPLPVEIVPFAWKQTERRVERVLAEQG
LHHVPIIRRMGGGHPVITDSGNFILDCHCGAIITAPEPLEIELNRIPGVVENGLFTREATGMVVGYFDGSSYVQLR

Sequences:

>Translated_236_residues
MSNQQNDAKRAAARRVIQDFVFDGMTLGLGSGTTSHFFVRELGQHVAKGLQLTCTTTSRATSEVARDVGIELSDPNEMNE
IDLTIDGPDEIDRRFNMIKGGGACLLWEKIIAHASKRMICICDETKIVNCLGQFPLPVEIVPFAWKQTERRVERVLAEQG
LHHVPIIRRMGGGHPVITDSGNFILDCHCGAIITAPEPLEIELNRIPGVVENGLFTREATGMVVGYFDGSSYVQLR
>Mature_235_residues
SNQQNDAKRAAARRVIQDFVFDGMTLGLGSGTTSHFFVRELGQHVAKGLQLTCTTTSRATSEVARDVGIELSDPNEMNEI
DLTIDGPDEIDRRFNMIKGGGACLLWEKIIAHASKRMICICDETKIVNCLGQFPLPVEIVPFAWKQTERRVERVLAEQGL
HHVPIIRRMGGGHPVITDSGNFILDCHCGAIITAPEPLEIELNRIPGVVENGLFTREATGMVVGYFDGSSYVQLR

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family

Homologues:

Organism=Homo sapiens, GI94536842, Length=232, Percent_Identity=35.7758620689655, Blast_Score=127, Evalue=9e-30,
Organism=Escherichia coli, GI1789280, Length=231, Percent_Identity=38.0952380952381, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17551758, Length=230, Percent_Identity=35.2173913043478, Blast_Score=120, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6324669, Length=245, Percent_Identity=34.6938775510204, Blast_Score=121, Evalue=8e-29,
Organism=Drosophila melanogaster, GI281364072, Length=222, Percent_Identity=34.2342342342342, Blast_Score=114, Evalue=8e-26,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): RPIA2_YERPE (Q8ZGJ9)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AH0157
- RefSeq:   NP_670192.1
- RefSeq:   NP_992665.1
- RefSeq:   YP_002346318.1
- ProteinModelPortal:   Q8ZGJ9
- SMR:   Q8ZGJ9
- IntAct:   Q8ZGJ9
- GeneID:   1147839
- GeneID:   1174135
- GeneID:   2763250
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO1292
- KEGG:   ypk:y2892
- KEGG:   ypm:YP_1299
- HOGENOM:   HBG515603
- OMA:   MVVIADA
- ProtClustDB:   CLSK888796
- BioCyc:   YPES187410:Y2892-MONOMER
- BioCyc:   YPES214092:YPO1292-MONOMER
- BRENDA:   5.3.1.6
- HAMAP:   MF_00170
- InterPro:   IPR004788
- InterPro:   IPR020672
- PANTHER:   PTHR11934
- TIGRFAMs:   TIGR00021

Pfam domain/function: PF06026 Rib_5-P_isom_A

EC number: =5.3.1.6

Molecular weight: Translated: 26034; Mature: 25903

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQQNDAKRAAARRVIQDFVFDGMTLGLGSGTTSHFFVRELGQHVAKGLQLTCTTTSRA
CCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCEEEEEECCHHH
TSEVARDVGIELSDPNEMNEIDLTIDGPDEIDRRFNMIKGGGACLLWEKIIAHASKRMIC
HHHHHHHCCCEECCCCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEE
ICDETKIVNCLGQFPLPVEIVPFAWKQTERRVERVLAEQGLHHVPIIRRMGGGHPVITDS
EECCCHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEECC
GNFILDCHCGAIITAPEPLEIELNRIPGVVENGLFTREATGMVVGYFDGSSYVQLR
CCEEEEECCCEEEECCCCCEEEECCCCCHHHCCCEEEECCCEEEEEECCCCEEEEC
>Mature Secondary Structure 
SNQQNDAKRAAARRVIQDFVFDGMTLGLGSGTTSHFFVRELGQHVAKGLQLTCTTTSRA
CCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCEEEEEECCHHH
TSEVARDVGIELSDPNEMNEIDLTIDGPDEIDRRFNMIKGGGACLLWEKIIAHASKRMIC
HHHHHHHCCCEECCCCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEE
ICDETKIVNCLGQFPLPVEIVPFAWKQTERRVERVLAEQGLHHVPIIRRMGGGHPVITDS
EECCCHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEECC
GNFILDCHCGAIITAPEPLEIELNRIPGVVENGLFTREATGMVVGYFDGSSYVQLR
CCEEEEECCCEEEECCCCCEEEECCCCCHHHCCCEEEECCCEEEEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430