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The map label for this gene is acs [H]

Identifier: 218927458

GI number: 218927458

Start: 250732

End: 252690

Strand: Reverse

Name: acs [H]

Synonym: YPO0253

Alternate gene names: 218927458

Gene position: 252690-250732 (Counterclockwise)

Preceding gene: 218927460

Following gene: 218927457

Centisome position: 5.43

GC content: 47.78

Gene sequence:

>1959_bases
ATGAGCCAAATACATAAACATCCTATTCCAGCTGCAATTGCAGAGCATGCTCTAATTACCCCAGAAAAATACCAACATTA
TTACCAACAATCCGTGCAGAACCCTGATGAATTCTGGGGCGAACAAGGCAAAATCATTGATTGGATTAAACCCTATAAAA
CGGTAAAAAATACCTCCTTTGACCCCGGTCATGTGAGTATCCGCTGGTTTGAGGACGGTACATTGAACCTCGCGGCGAAT
TGCCTTGATCGCCATTTGGCAGAGCGTGGTGATCAAACAGCCATCATTTGGGAAGGTGATGACCCTAATCAATCAAAAAC
CGTCACTTATAAGCAACTGCACCATGATGTGTGCCAGTTTGCTAATGTCCTAAAAAGTTTAGGCGTCAAAAAAGGCGATG
TGGTTGCCATCTATATGCCAATGGTGCCTGAAGCTGCCGTGGCGATGTTGGCTTGCGCGCGCATCGGCGCTGTTCATTCC
GTTATCTTTGGTGGATTTTCTCCAGATGCCGTTGCCGGGCGTATCATCGATTCTCACTCTAAACTGGTGATTACTGCCGA
TGAAGGTATCCGTGCAGGCCGTGCTATTCCACTGAAAAAAAATGTCGATGAAGCACTGAAAAACCCCGCTATCACCAGTA
TTAAAAATGTTGTGGTCTTCCAACGTACTGGTAACGCCAGCTATTGGGAAGATGGGCGCGATGTATGGTGGCATGACCTG
ATAAAAGAGGCATCCGCTGACTGCCCGCCAGAAGAGATGAATGCAGAAGACCCGCTGTTCATCCTTTATACCTCTGGCTC
TACCGGTAAACCTAAAGGGGTTGTACATACGACGGGCGGTTATCTGGTTTATGCTGCACTGACATTCAAATATGTCTTTG
ATTATCACCCTGGCGATATCTACTGGTGTACTGCAGACGTTGGCTGGGTAACCGGACACAGCTATCTGTTATATGGACCA
CTGGCTTGTGGGGCCATCACTCTAATGTTTGAAGGCGTGCCTAACTACCCTGGCGTCAATCGCTTAAGCCAAGTTGTTGA
TAAACATAAAGTCAATATTCTATACACCGCGCCTACAGCGATTCGGGCCTTAATGGCCGAAGGTGACAAAGCCATCGAAG
GAACCAAACGCGACTCACTGCGTATTATGGGATCGGTCGGCGAGCCGATTAATCCAGAAGCCTGGGAATGGTATTACAAC
AAGATCGGTAACAGTAAATGCCCGATTGTCGATACTTGGTGGCAGACTGAAACCGGTGGTTTCATGATAACCCCTCTGCC
GGGTGCCACCGAGTTGAAAGCCGGTTCCGCAACGCGTCCATTCTTTGGGGTACAACCTGCGTTGGTAGATAACCTGGGCA
ATCCTCAGGAAGGGGTGGCAGAAGGTAATCTGGTCATAACCGACTCATGGCCGGGGCAAGCCAGAACATTATTTGGCGAT
CATGAACGTTTCGAACAAACCTACTTCTCAACCTTTAAAGGCATGTATTTCAGTGGCGACGGCGCACGTCGTGACGAAGA
CGGTTACTACTGGATAACCGGTCGAGTTGATGACGTACTAAACGTTTCAGGCCATCGCTTAGGAACGGCTGAAATTGAAT
CTGCATTGGTTGCACACCCGAAAATTGCCGAAGCGGCTGTTGTCGGTGTTCCACATAATATTAAAGGACAGGCTATTTAT
GCCTATATCACGCTAAATCACGGTGAAGAACCAACGCCAGAGTTATATACCGAAGTACGCAACTGGGTACGTAAAGAGAT
TGGCCCACTCGCAACACCCGATATTTTGCATTGGACGGACTCATTACCCAAAACCCGTTCAGGCAAGATCATGCGCCGTA
TTTTACGCAAAATTGCGACAGGAGATACCAGCAACTTGGGCGATACCTCAACACTTGCCGATCCAAGCGTGGTAGAAAAA
TTACTAGAAGAAAAACAATCAATGCAGACACCGTCGTAA

Upstream 100 bases:

>100_bases
TTTATACGTGATCTGCCGCCCAAAAAAGAAACAAAACACTCTCTCATACTATAATTAACCTTTATTTGACATATTATTAA
CAACCTCAAGGAGAATGACG

Downstream 100 bases:

>100_bases
ATTGTGCCGCCTATATAGGCGGCAAACTTAATTGATGCCTCAAAGGAGAGACTCTGATGAATGACAGCATTTATCAAGAG
ATTGAAGATAATCCACGTTT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MSQIHKHPIPAAIAEHALITPEKYQHYYQQSVQNPDEFWGEQGKIIDWIKPYKTVKNTSFDPGHVSIRWFEDGTLNLAAN
CLDRHLAERGDQTAIIWEGDDPNQSKTVTYKQLHHDVCQFANVLKSLGVKKGDVVAIYMPMVPEAAVAMLACARIGAVHS
VIFGGFSPDAVAGRIIDSHSKLVITADEGIRAGRAIPLKKNVDEALKNPAITSIKNVVVFQRTGNASYWEDGRDVWWHDL
IKEASADCPPEEMNAEDPLFILYTSGSTGKPKGVVHTTGGYLVYAALTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGP
LACGAITLMFEGVPNYPGVNRLSQVVDKHKVNILYTAPTAIRALMAEGDKAIEGTKRDSLRIMGSVGEPINPEAWEWYYN
KIGNSKCPIVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNLGNPQEGVAEGNLVITDSWPGQARTLFGD
HERFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGVPHNIKGQAIY
AYITLNHGEEPTPELYTEVRNWVRKEIGPLATPDILHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVEK
LLEEKQSMQTPS

Sequences:

>Translated_652_residues
MSQIHKHPIPAAIAEHALITPEKYQHYYQQSVQNPDEFWGEQGKIIDWIKPYKTVKNTSFDPGHVSIRWFEDGTLNLAAN
CLDRHLAERGDQTAIIWEGDDPNQSKTVTYKQLHHDVCQFANVLKSLGVKKGDVVAIYMPMVPEAAVAMLACARIGAVHS
VIFGGFSPDAVAGRIIDSHSKLVITADEGIRAGRAIPLKKNVDEALKNPAITSIKNVVVFQRTGNASYWEDGRDVWWHDL
IKEASADCPPEEMNAEDPLFILYTSGSTGKPKGVVHTTGGYLVYAALTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGP
LACGAITLMFEGVPNYPGVNRLSQVVDKHKVNILYTAPTAIRALMAEGDKAIEGTKRDSLRIMGSVGEPINPEAWEWYYN
KIGNSKCPIVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNLGNPQEGVAEGNLVITDSWPGQARTLFGD
HERFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGVPHNIKGQAIY
AYITLNHGEEPTPELYTEVRNWVRKEIGPLATPDILHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVEK
LLEEKQSMQTPS
>Mature_651_residues
SQIHKHPIPAAIAEHALITPEKYQHYYQQSVQNPDEFWGEQGKIIDWIKPYKTVKNTSFDPGHVSIRWFEDGTLNLAANC
LDRHLAERGDQTAIIWEGDDPNQSKTVTYKQLHHDVCQFANVLKSLGVKKGDVVAIYMPMVPEAAVAMLACARIGAVHSV
IFGGFSPDAVAGRIIDSHSKLVITADEGIRAGRAIPLKKNVDEALKNPAITSIKNVVVFQRTGNASYWEDGRDVWWHDLI
KEASADCPPEEMNAEDPLFILYTSGSTGKPKGVVHTTGGYLVYAALTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGPL
ACGAITLMFEGVPNYPGVNRLSQVVDKHKVNILYTAPTAIRALMAEGDKAIEGTKRDSLRIMGSVGEPINPEAWEWYYNK
IGNSKCPIVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNLGNPQEGVAEGNLVITDSWPGQARTLFGDH
ERFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGVPHNIKGQAIYA
YITLNHGEEPTPELYTEVRNWVRKEIGPLATPDILHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVEKL
LEEKQSMQTPS

Specific function: Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=653, Percent_Identity=52.833078101072, Blast_Score=704, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=666, Percent_Identity=51.8018018018018, Blast_Score=699, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=633, Percent_Identity=49.13112164297, Blast_Score=634, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=635, Percent_Identity=37.7952755905512, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI42544132, Length=556, Percent_Identity=28.9568345323741, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI122937307, Length=559, Percent_Identity=28.0858676207513, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI31982927, Length=646, Percent_Identity=25.6965944272446, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI38505220, Length=607, Percent_Identity=28.995057660626, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI115511026, Length=570, Percent_Identity=28.4210526315789, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI58082049, Length=573, Percent_Identity=26.1780104712042, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI157311624, Length=573, Percent_Identity=25.6544502617801, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI157311622, Length=573, Percent_Identity=25.6544502617801, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI187761345, Length=404, Percent_Identity=28.2178217821782, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI187761343, Length=404, Percent_Identity=28.2178217821782, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI195947378, Length=464, Percent_Identity=25.8620689655172, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI42544134, Length=373, Percent_Identity=25.7372654155496, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI156151445, Length=385, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1790505, Length=652, Percent_Identity=84.8159509202454, Blast_Score=1174, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=643, Percent_Identity=36.3919129082426, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI221142682, Length=530, Percent_Identity=23.3962264150943, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1788107, Length=581, Percent_Identity=24.6127366609294, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1786810, Length=551, Percent_Identity=22.5045372050817, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI145693145, Length=127, Percent_Identity=37.007874015748, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71983001, Length=668, Percent_Identity=49.1017964071856, Blast_Score=632, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982997, Length=649, Percent_Identity=49.768875192604, Blast_Score=630, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=644, Percent_Identity=21.7391304347826, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17559526, Length=585, Percent_Identity=23.7606837606838, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17557194, Length=565, Percent_Identity=23.716814159292, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=579, Percent_Identity=24.1796200345423, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17558820, Length=550, Percent_Identity=22.7272727272727, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=546, Percent_Identity=22.7106227106227, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=543, Percent_Identity=22.4677716390424, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994703, Length=543, Percent_Identity=22.4677716390424, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994690, Length=543, Percent_Identity=22.4677716390424, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560140, Length=537, Percent_Identity=20.2979515828678, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115534440, Length=554, Percent_Identity=20.9386281588448, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323182, Length=637, Percent_Identity=48.9795918367347, Blast_Score=627, Evalue=1e-180,
Organism=Saccharomyces cerevisiae, GI6319264, Length=638, Percent_Identity=47.1786833855799, Blast_Score=598, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319699, Length=377, Percent_Identity=25.9946949602122, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667955, Length=654, Percent_Identity=53.822629969419, Blast_Score=707, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=56.2277580071174, Blast_Score=647, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=56.5384615384615, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI21355225, Length=631, Percent_Identity=35.4992076069731, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI18859661, Length=531, Percent_Identity=25.0470809792844, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24656500, Length=525, Percent_Identity=21.1428571428571, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581924, Length=555, Percent_Identity=20.9009009009009, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72072; Mature: 71941

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQIHKHPIPAAIAEHALITPEKYQHYYQQSVQNPDEFWGEQGKIIDWIKPYKTVKNTSF
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHCCCCCEEHHHHHHHHHCCCCC
DPGHVSIRWFEDGTLNLAANCLDRHLAERGDQTAIIWEGDDPNQSKTVTYKQLHHDVCQF
CCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHH
ANVLKSLGVKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPDAVAGRIIDSHS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEECCC
KLVITADEGIRAGRAIPLKKNVDEALKNPAITSIKNVVVFQRTGNASYWEDGRDVWWHDL
EEEEECCCCCCCCCCCCCCCCHHHHHCCCCHHCCCEEEEEEECCCCCCCCCCCCHHHHHH
IKEASADCPPEEMNAEDPLFILYTSGSTGKPKGVVHTTGGYLVYAALTFKYVFDYHPGDI
HHHHCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEHHHHHHHHEEECCCCE
YWCTADVGWVTGHSYLLYGPLACGAITLMFEGVPNYPGVNRLSQVVDKHKVNILYTAPTA
EEEECCCCEECCCCEEEECCHHHHHHHHEECCCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAEGDKAIEGTKRDSLRIMGSVGEPINPEAWEWYYNKIGNSKCPIVDTWWQTETGG
HHHHHHCCCHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCC
FMITPLPGATELKAGSATRPFFGVQPALVDNLGNPQEGVAEGNLVITDSWPGQARTLFGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHCCC
HERFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHP
HHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCC
KIAEAAVVGVPHNIKGQAIYAYITLNHGEEPTPELYTEVRNWVRKEIGPLATPDILHWTD
CHHCEEEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCC
SLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVEKLLEEKQSMQTPS
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQIHKHPIPAAIAEHALITPEKYQHYYQQSVQNPDEFWGEQGKIIDWIKPYKTVKNTSF
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHCCCCCEEHHHHHHHHHCCCCC
DPGHVSIRWFEDGTLNLAANCLDRHLAERGDQTAIIWEGDDPNQSKTVTYKQLHHDVCQF
CCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHH
ANVLKSLGVKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPDAVAGRIIDSHS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEECCC
KLVITADEGIRAGRAIPLKKNVDEALKNPAITSIKNVVVFQRTGNASYWEDGRDVWWHDL
EEEEECCCCCCCCCCCCCCCCHHHHHCCCCHHCCCEEEEEEECCCCCCCCCCCCHHHHHH
IKEASADCPPEEMNAEDPLFILYTSGSTGKPKGVVHTTGGYLVYAALTFKYVFDYHPGDI
HHHHCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEHHHHHHHHEEECCCCE
YWCTADVGWVTGHSYLLYGPLACGAITLMFEGVPNYPGVNRLSQVVDKHKVNILYTAPTA
EEEECCCCEECCCCEEEECCHHHHHHHHEECCCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAEGDKAIEGTKRDSLRIMGSVGEPINPEAWEWYYNKIGNSKCPIVDTWWQTETGG
HHHHHHCCCHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCC
FMITPLPGATELKAGSATRPFFGVQPALVDNLGNPQEGVAEGNLVITDSWPGQARTLFGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHCCC
HERFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHP
HHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCC
KIAEAAVVGVPHNIKGQAIYAYITLNHGEEPTPELYTEVRNWVRKEIGPLATPDILHWTD
CHHCEEEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCC
SLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVEKLLEEKQSMQTPS
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA