Click here to switch to the map view.

The map label for this gene is xanP [H]

Identifier: 218927255

GI number: 218927255

Start: 44322

End: 45707

Strand: Reverse

Name: xanP [H]

Synonym: YPO0034

Alternate gene names: 218927255

Gene position: 45707-44322 (Counterclockwise)

Preceding gene: 218927257

Following gene: 218927254

Centisome position: 0.98

GC content: 50.51

Gene sequence:

>1386_bases
ATGTCTACGCAATCTGCCGAACTTGATACTGCACCGCCATCACCGGCTCACCCCAGCGAATTGATCTACCACCTAGAAGA
CCGACCGCCACTCCCACAAACACTGTTTGCCGCTTGCCAGCATCTCTTGGCGATGTTTGTTGCGGTAATCACCCCCGGTT
TATTGATTTGTCAGGCTTTGGGGTTACCCGCAGAAGATACTCAACGCATTATTAGTATGTCGTTATTTGCTTCGGGCCTA
GCGTCTTTACTGCAGATTAAAACTTGGGGCCCCGTGGGTTCAGGCCTGTTATCCATTCAAGGCACCAGTTTTAACTTTGT
TTCTCCGTTGATTATGGGGGGGCTGGCGCTAAAAAACGGTGGGGCAGATATCCCAACGATGATGGCGGCGCTGTTCGGTA
CGTTAATGGTTGCGTCCTGCACCGAGATCTTACTCTCACATGTGCTGCATCTGGCACGCCGTATTATCACCCCGCTGGTA
TCCGGTATTGTGGTGATGATTATCGGCCTGTCATTGATTCAAGTTGGGCTGACATCTATTGGTGGTGGTTATGGTGCGAT
GAGCGATAACACCTTTGGTGCACCGAAAAACTTATTATTAGCCGGTGCCGTATTGGGGGTGATCATTCTGCTTAACCGCC
AGCGTAACCCGTATTTACGTGTTGCCTCTTTGGTGATCGCTATGGCCGTGGGTTATCTGCTCGCCTGGGCATTGGGGATG
TTGCCTGAGAGCCGCCCAGTTGTAGATACCGCGCTGATTACTATTCCAACGCCGTTGTACTATGGGCTGTCCTTCGACTG
GAACTTACTGATTCCTCTGATGCTGATCTTTATGGTGACCTCACTGGAAACCATAGGCGATATTACCGCAACATCTGATG
TATCAGAGCAACCGGTTCGCGGCCCGTTATATATGAAACGCCTAAAAGGCGGTGTACTGGCCAATGGTTTGAACTCGATG
CTGTCCGCTATATTCAATACCTTCCCCAACTCCTGCTTCGGTCAGAATAATGGCGTGATCCAATTGACTGGCGTTGCCAG
CCGTTATGTCGGTTTTGTTGTGGCAATAATGCTCATCATTTTGGGCCTGTTCCCTGCTGTCGCTGGGTTTGTGCAGCATA
TTCCTGAGCCGGTACTGGGTGGAGCAACTCTCGTGATGTTCGGGACTATCGCAGCGTCTGGTGTGCGTATTGTGTCACGC
GAGACCCTGAATCGCCGGGCGATTATGATAATGGCCTTATCATTAGCGGTTGGTATGGGTGTCGCACAGCAGCCATTGAT
TTTGCAATTTGCGCCTGACTGGATCAAAACGCTGTTCTCTTCTGGGATTGCCGCTGGCGGTATTACTGCCATCGTACTTA
ACTTACTCTTCCCACAAGAAAAATAG

Upstream 100 bases:

>100_bases
AGCAAAAAAATAGAAATAATATAAAAACCCAGCGCAAACGATTGCTTTTGTGAGCCGGATCATTAAAATGCCCCCTTTGC
CGATCTGGAAATACCACGCC

Downstream 100 bases:

>100_bases
TCTTTACACTAACACATCACTGAAATGGTCGGTCATTAATGATGCCGGCCATTTTTTTTATGGTCCGATAGCTGATTATC
TATTGAGCTAATGGAAAAAT

Product: putative membrane permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSTQSAELDTAPPSPAHPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQALGLPAEDTQRIISMSLFASGL
ASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSHVLHLARRIITPLV
SGIVVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMAVGYLLAWALGM
LPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVRGPLYMKRLKGGVLANGLNSM
LSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSR
ETLNRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK

Sequences:

>Translated_461_residues
MSTQSAELDTAPPSPAHPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQALGLPAEDTQRIISMSLFASGL
ASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSHVLHLARRIITPLV
SGIVVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMAVGYLLAWALGM
LPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVRGPLYMKRLKGGVLANGLNSM
LSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSR
ETLNRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK
>Mature_460_residues
STQSAELDTAPPSPAHPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQALGLPAEDTQRIISMSLFASGLA
SLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSHVLHLARRIITPLVS
GIVVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMAVGYLLAWALGML
PESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVRGPLYMKRLKGGVLANGLNSML
SAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRE
TLNRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=511, Percent_Identity=22.3091976516634, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI40316845, Length=511, Percent_Identity=22.3091976516634, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790087, Length=462, Percent_Identity=83.982683982684, Blast_Score=763, Evalue=0.0,
Organism=Escherichia coli, GI87082178, Length=440, Percent_Identity=46.5909090909091, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI87082181, Length=460, Percent_Identity=30.8695652173913, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1788843, Length=399, Percent_Identity=27.0676691729323, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87081818, Length=414, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558856, Length=452, Percent_Identity=24.1150442477876, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=269, Percent_Identity=26.7657992565056, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 48642; Mature: 48511

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQSAELDTAPPSPAHPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQAL
CCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
GLPAEDTQRIISMSLFASGLASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHCCHHCCCC
GADIPTMMAALFGTLMVASCTEILLSHVLHLARRIITPLVSGIVVMIIGLSLIQVGLTSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMAVGYLLAWALGM
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
LPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVR
CCCCCCCHHHHHEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GPLYMKRLKGGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLII
CHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHH
LGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRETLNRRAIMIMALSLAVGMG
HHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK
CCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STQSAELDTAPPSPAHPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQAL
CCCCCCCCCCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
GLPAEDTQRIISMSLFASGLASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHCCHHCCCC
GADIPTMMAALFGTLMVASCTEILLSHVLHLARRIITPLVSGIVVMIIGLSLIQVGLTSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASLVIAMAVGYLLAWALGM
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
LPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVR
CCCCCCCHHHHHEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GPLYMKRLKGGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLII
CHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHH
LGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRETLNRRAIMIMALSLAVGMG
HHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK
CCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]