BacMap

Definition	Bacillus cereus AH820, complete genome.
Accession	NC_011773
Length	5,302,683

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The map label for this gene is fabG [H]

Identifier: 218905854

GI number: 218905854

Start: 4492190

End: 4492948

Strand: Reverse

Name: fabG [H]

Synonym: BCAH820_4742

Alternate gene names: 218905854

Gene position: 4492948-4492190 (Counterclockwise)

Preceding gene: 218905856

Following gene: 218905853

Centisome position: 84.73

GC content: 37.29

Gene sequence:

>759_bases
GTGAGACACGCGCTCATTACAGCCGGTACGAAAGGTTTAGGAAAGCAAGTAACAGAGAAGTTATTGGCTAAAGGGTATTC
AGTAACAGTAACGTATCATAGCGATATCACGGCTATGAAAAAGATGAAAGAAACATATAAAAATATGGAAGAGCGTCTAC
AATTCGTGCAAGCGGATGTCACGAAAAAGGAAGATTTACATAAAATAGTAGAAGAAGCGATAAGCTGTTTTGGCAAAATT
GATTTCTTAATTAATAATGCTGGTCCATATGTATTTGAACGAAAAAAGTTAGTCGATTATGAAGAAGATGAATGGAATGA
AATGATTCAGGGTAATTTAACAGCTGTATTTCATTTGTTGAAGCTTGTCGTTCCGATTATGAGAAAACAGAACTTTGGCC
GTATTATTAATTACGGATTCCAAGGGGCAGATAGTGCACCGGGATGGATTTATCGTTCAGCTTTTGCAGCAGCGAAAGTA
GGACTTGTTTCATTAACGAAAACTGTTGCTTACGAAGAAGCAGAATATGGAATTACTGCAAATATGGTATGTCCTGGTGA
TATTATTGGTGAAATGAAAGAAGCGACAATTCAAGAAGCACGTCAGTTGAAAGAACGTAACACACCAATTGGTAGATCTG
GAACAGGTGAAGATATCGCAAGAACGATTTCGTTTTTATGCGAGGAAGATTCCGATATGATTACCGGTACAATTATTGAA
GTAACTGGTGCAGTAGATGTTATTCATAGACATCGATAG

Upstream 100 bases:

>100_bases
GTTACAGAATTTCGAAAACTCTGTTTTGATTCATTTTAGTTGTAATTGGTGCGAGAACTTGTTACATATGAACTATAGCA
ATTTAAAAGGGGGCCGTTTT

Downstream 100 bases:

>100_bases
AGAAAAATAAAGTGAAGTTTCGAATGATTGGACAGTTTATCCTTTATGCTGATAGGTGCGGATAATACTGTCCTTTAATA
TAAAATTAAATCTATCGGAA

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDITAMKKMKETYKNMEERLQFVQADVTKKEDLHKIVEEAISCFGKI
DFLINNAGPYVFERKKLVDYEEDEWNEMIQGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGWIYRSAFAAAKV
GLVSLTKTVAYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERNTPIGRSGTGEDIARTISFLCEEDSDMITGTIIE
VTGAVDVIHRHR

Sequences:

>Translated_252_residues
MRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDITAMKKMKETYKNMEERLQFVQADVTKKEDLHKIVEEAISCFGKI
DFLINNAGPYVFERKKLVDYEEDEWNEMIQGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGWIYRSAFAAAKV
GLVSLTKTVAYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERNTPIGRSGTGEDIARTISFLCEEDSDMITGTIIE
VTGAVDVIHRHR
>Mature_252_residues
MRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDITAMKKMKETYKNMEERLQFVQADVTKKEDLHKIVEEAISCFGKI
DFLINNAGPYVFERKKLVDYEEDEWNEMIQGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGWIYRSAFAAAKV
GLVSLTKTVAYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERNTPIGRSGTGEDIARTISFLCEEDSDMITGTIIE
VTGAVDVIHRHR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=250, Percent_Identity=28.4, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI19923817, Length=249, Percent_Identity=26.1044176706827, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=29.2307692307692, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI66933014, Length=206, Percent_Identity=29.126213592233, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI59889578, Length=203, Percent_Identity=28.0788177339901, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI126723750, Length=268, Percent_Identity=27.6119402985075, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI5031737, Length=253, Percent_Identity=24.901185770751, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI31542939, Length=194, Percent_Identity=27.8350515463918, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4758504, Length=193, Percent_Identity=27.4611398963731, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=24.4897959183673, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI4504505, Length=245, Percent_Identity=24.8979591836735, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=32.2314049586777, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1788459, Length=241, Percent_Identity=29.8755186721992, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87082160, Length=248, Percent_Identity=28.2258064516129, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=26.6932270916335, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=29.0322580645161, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=29.8804780876494, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082100, Length=247, Percent_Identity=27.5303643724696, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI2367175, Length=255, Percent_Identity=26.2745098039216, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=25, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=24.7058823529412, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=22.9838709677419, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=28.8, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17562910, Length=259, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=26.3779527559055, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=254, Percent_Identity=27.9527559055118, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=260, Percent_Identity=25.3846153846154, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=271, Percent_Identity=26.9372693726937, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=258, Percent_Identity=25.968992248062, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=261, Percent_Identity=23.7547892720307, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=30.5343511450382, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=25.6916996047431, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=270, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=196, Percent_Identity=29.0816326530612, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=24.904214559387, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=259, Percent_Identity=25.4826254826255, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=25.2830188679245, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=25.9398496240602, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=244, Percent_Identity=25.4098360655738, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=25.2873563218391, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=265, Percent_Identity=25.6603773584906, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=274, Percent_Identity=27.3722627737226, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508651, Length=258, Percent_Identity=27.1317829457364, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=196, Percent_Identity=24.4897959183673, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=126, Percent_Identity=36.5079365079365, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324126, Length=249, Percent_Identity=24.0963855421687, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=28.3400809716599, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=27.2357723577236, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=26.5873015873016, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI18859837, Length=239, Percent_Identity=28.0334728033473, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=28.4584980237154, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=26.2096774193548, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=25.296442687747, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=25.8964143426295, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 28246; Mature: 28246

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDITAMKKMKETYKNMEERLQFVQADV
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
TKKEDLHKIVEEAISCFGKIDFLINNAGPYVFERKKLVDYEEDEWNEMIQGNLTAVFHLL
CCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEHHHHCCCCCHHHHHHHHCCHHHHHHHH
KLVVPIMRKQNFGRIINYGFQGADSAPGWIYRSAFAAAKVGLVSLTKTVAYEEAEYGITA
HHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
NMVCPGDIIGEMKEATIQEARQLKERNTPIGRSGTGEDIARTISFLCEEDSDMITGTIIE
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHEE
VTGAVDVIHRHR
HHHHHHHHHCCC
>Mature Secondary Structure
MRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDITAMKKMKETYKNMEERLQFVQADV
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
TKKEDLHKIVEEAISCFGKIDFLINNAGPYVFERKKLVDYEEDEWNEMIQGNLTAVFHLL
CCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEHHHHCCCCCHHHHHHHHCCHHHHHHHH
KLVVPIMRKQNFGRIINYGFQGADSAPGWIYRSAFAAAKVGLVSLTKTVAYEEAEYGITA
HHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
NMVCPGDIIGEMKEATIQEARQLKERNTPIGRSGTGEDIARTISFLCEEDSDMITGTIIE
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHEE
VTGAVDVIHRHR
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]