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The map label for this gene is hisS1 [H]

Identifier: 218904467

GI number: 218904467

Start: 3198121

End: 3199401

Strand: Direct

Name: hisS1 [H]

Synonym: BCAH820_3351

Alternate gene names: 218904467

Gene position: 3198121-3199401 (Clockwise)

Preceding gene: 218904458

Following gene: 218904468

Centisome position: 60.31

GC content: 37.55

Gene sequence:

>1281_bases
ATGATGGAAATGAGAAATGTAAAAGGAACGAAAGACTATTTACCAGAAGAACAAGTGCTGCGAAATAAAATTAAAAGAGC
GTGCGAGGATACGTTTGAACGTTATGGCTGTAAACCGTTAGAAACGCCGACATTAAATATGTATGAGCTTATGTCTTACA
AGTACGGAGGTGGCGATGAAATATTAAAAGAAATATATACGCTTCAAGATCAAGGAAAACGCGCACTTGCCTTACGTTAC
GATTTGACTATTCCATTCGCAAAAGTTGTGGCAATGAATCCGAACATCCGCCTTCCTTTTAAACGGTATGAAATTGGGAA
AGTATTTCGAGATGGCCCTATTAAACAAGGGAGATTTCGTGAATTCATACAATGTGACGTTGATATTGTCGGTGTTGAGT
CTGTCATGGCAGAAGCTGAACTTATGAGCATGGCGTTTGAACTGTTCCGAACGTTAAACTTAGAAGTAACGATCCAATAT
AATAACCGAAAATTGTTAAACGGTATTCTTCAGGCCATTAACATCCCTACTGAGTTAACGAGTGACGTCATTTTATCATT
AGACAAAATCGAAAAAATTGGGATTGATGGTGTAAGAAAAGATGTATTAGAGCGCGGAATTACTGAAGAAATGGCTGATA
CGATATGTAATACTGTTTTATCTTGTCTAAAGCTTACAATTGCTGACTTTAAAGAAGCTTTCAATAATCCACTCGTTGCC
GATGGAGTAAACGAATTACAACAATTACAGCAATATTTAATCGCTCTTGGAATAAATGAAAATGCTATATTCAACCCATT
TTTAGCACGAGGACTCACAATGTATACAGGTACCGTATATGAAATCTTTTTAAAAGATGGCTCGATTACATCTAGCATCG
GTAGCGGTGGTCGTTACGATAATATTATTGGCGCATTCCGCGGTGATAATATGAACTATCCAACAGTCGGTATTTCATTC
GGCTTAGACGTTATTTATACAGCACTATCACAGAAAGAAACGATATCATCTACAGCGGATGTATTTATCATCCCGCTTGG
GACAGAATTACAATGCTTACAACTTGCCCAGCAATTACGTTCTACCACTTCCTTAAAAGTCGAACTTGAACTAGCAGGAC
GCAAATTAAAACGCGCCCTTAATTATGCAAATAAAGAGAATATCCCTTATGTGCTTATTATTGGGGAAGAAGAACTTAGT
ACAGAAACCGCTATGCTGCGGAATATGAAGGAAGGTAGTGAGGTGAAGGTTCCGCTTTCTTCTTTAAGTAATTATTTGTA
A

Upstream 100 bases:

>100_bases
GTGGGTACAGGGCTTTTCCTGTTGACCCACGAAGCGTTCATAAAGCTATGTGGGTATTTTTATACCTGCATAGCTTTTTT
TAATTTAAAAAGGAGTGATT

Downstream 100 bases:

>100_bases
TACGAACCACCCTCGTTTGGGTGGTTTTTCTATTTTATAGATATCCCACAATTAGTTAACATAAAAAAATTACATTCTAC
TAAATTCTACAAATATATAA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase 1; HisRS 1 [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MMEMRNVKGTKDYLPEEQVLRNKIKRACEDTFERYGCKPLETPTLNMYELMSYKYGGGDEILKEIYTLQDQGKRALALRY
DLTIPFAKVVAMNPNIRLPFKRYEIGKVFRDGPIKQGRFREFIQCDVDIVGVESVMAEAELMSMAFELFRTLNLEVTIQY
NNRKLLNGILQAINIPTELTSDVILSLDKIEKIGIDGVRKDVLERGITEEMADTICNTVLSCLKLTIADFKEAFNNPLVA
DGVNELQQLQQYLIALGINENAIFNPFLARGLTMYTGTVYEIFLKDGSITSSIGSGGRYDNIIGAFRGDNMNYPTVGISF
GLDVIYTALSQKETISSTADVFIIPLGTELQCLQLAQQLRSTTSLKVELELAGRKLKRALNYANKENIPYVLIIGEEELS
TETAMLRNMKEGSEVKVPLSSLSNYL

Sequences:

>Translated_426_residues
MMEMRNVKGTKDYLPEEQVLRNKIKRACEDTFERYGCKPLETPTLNMYELMSYKYGGGDEILKEIYTLQDQGKRALALRY
DLTIPFAKVVAMNPNIRLPFKRYEIGKVFRDGPIKQGRFREFIQCDVDIVGVESVMAEAELMSMAFELFRTLNLEVTIQY
NNRKLLNGILQAINIPTELTSDVILSLDKIEKIGIDGVRKDVLERGITEEMADTICNTVLSCLKLTIADFKEAFNNPLVA
DGVNELQQLQQYLIALGINENAIFNPFLARGLTMYTGTVYEIFLKDGSITSSIGSGGRYDNIIGAFRGDNMNYPTVGISF
GLDVIYTALSQKETISSTADVFIIPLGTELQCLQLAQQLRSTTSLKVELELAGRKLKRALNYANKENIPYVLIIGEEELS
TETAMLRNMKEGSEVKVPLSSLSNYL
>Mature_426_residues
MMEMRNVKGTKDYLPEEQVLRNKIKRACEDTFERYGCKPLETPTLNMYELMSYKYGGGDEILKEIYTLQDQGKRALALRY
DLTIPFAKVVAMNPNIRLPFKRYEIGKVFRDGPIKQGRFREFIQCDVDIVGVESVMAEAELMSMAFELFRTLNLEVTIQY
NNRKLLNGILQAINIPTELTSDVILSLDKIEKIGIDGVRKDVLERGITEEMADTICNTVLSCLKLTIADFKEAFNNPLVA
DGVNELQQLQQYLIALGINENAIFNPFLARGLTMYTGTVYEIFLKDGSITSSIGSGGRYDNIIGAFRGDNMNYPTVGISF
GLDVIYTALSQKETISSTADVFIIPLGTELQCLQLAQQLRSTTSLKVELELAGRKLKRALNYANKENIPYVLIIGEEELS
TETAMLRNMKEGSEVKVPLSSLSNYL

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI15029520, Length=441, Percent_Identity=33.1065759637188, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI6996014, Length=443, Percent_Identity=32.2799097065463, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI65287717, Length=428, Percent_Identity=27.1028037383178, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788861, Length=456, Percent_Identity=22.5877192982456, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71993693, Length=456, Percent_Identity=32.0175438596491, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71993686, Length=456, Percent_Identity=32.0175438596491, Blast_Score=202, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6325290, Length=445, Percent_Identity=32.1348314606742, Blast_Score=192, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24643061, Length=460, Percent_Identity=31.7391304347826, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24643059, Length=479, Percent_Identity=30.4801670146138, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 47947; Mature: 47947

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEMRNVKGTKDYLPEEQVLRNKIKRACEDTFERYGCKPLETPTLNMYELMSYKYGGGDE
CCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCHHH
ILKEIYTLQDQGKRALALRYDLTIPFAKVVAMNPNIRLPFKRYEIGKVFRDGPIKQGRFR
HHHHHHHHHHCCCEEEEEEEECCCCHHHEEEECCCEECCHHHHHHHHHHCCCCCCCHHHH
EFIQCDVDIVGVESVMAEAELMSMAFELFRTLNLEVTIQYNNRKLLNGILQAINIPTELT
HHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHCCCHHHH
SDVILSLDKIEKIGIDGVRKDVLERGITEEMADTICNTVLSCLKLTIADFKEAFNNPLVA
HHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DGVNELQQLQQYLIALGINENAIFNPFLARGLTMYTGTVYEIFLKDGSITSSIGSGGRYD
CCHHHHHHHHHHHHHHCCCCCCEECHHHHCCHHHHCCEEEEEEEECCCEECCCCCCCCCC
NIIGAFRGDNMNYPTVGISFGLDVIYTALSQKETISSTADVFIIPLGTELQCLQLAQQLR
CCEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
STTSLKVELELAGRKLKRALNYANKENIPYVLIIGEEELSTETAMLRNMKEGSEVKVPLS
CCCCEEEEEEHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEHH
SLSNYL
HHCCCC
>Mature Secondary Structure
MMEMRNVKGTKDYLPEEQVLRNKIKRACEDTFERYGCKPLETPTLNMYELMSYKYGGGDE
CCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCHHH
ILKEIYTLQDQGKRALALRYDLTIPFAKVVAMNPNIRLPFKRYEIGKVFRDGPIKQGRFR
HHHHHHHHHHCCCEEEEEEEECCCCHHHEEEECCCEECCHHHHHHHHHHCCCCCCCHHHH
EFIQCDVDIVGVESVMAEAELMSMAFELFRTLNLEVTIQYNNRKLLNGILQAINIPTELT
HHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHCCCHHHH
SDVILSLDKIEKIGIDGVRKDVLERGITEEMADTICNTVLSCLKLTIADFKEAFNNPLVA
HHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DGVNELQQLQQYLIALGINENAIFNPFLARGLTMYTGTVYEIFLKDGSITSSIGSGGRYD
CCHHHHHHHHHHHHHHCCCCCCEECHHHHCCHHHHCCEEEEEEEECCCEECCCCCCCCCC
NIIGAFRGDNMNYPTVGISFGLDVIYTALSQKETISSTADVFIIPLGTELQCLQLAQQLR
CCEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
STTSLKVELELAGRKLKRALNYANKENIPYVLIIGEEELSTETAMLRNMKEGSEVKVPLS
CCCCEEEEEEHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEHH
SLSNYL
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA