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The map label for this gene is yvaE [H]

Identifier: 218904441

GI number: 218904441

Start: 3173250

End: 3173612

Strand: Reverse

Name: yvaE [H]

Synonym: BCAH820_3325

Alternate gene names: 218904441

Gene position: 3173612-3173250 (Counterclockwise)

Preceding gene: 218904442

Following gene: 218904440

Centisome position: 59.85

GC content: 31.4

Gene sequence:

>363_bases
GTGCAGTGGATTTATTTAAGTTTAGCAATTTTATTTGAAGTAGCAGGTACAACTGCGATGAAACTATCTGATGGATTAAC
GAAACTTGTACCAAGCATTCTTATTTTTGTATTTTATGTAGTAAGTTTTGCATTTCTGTCATTTGCATTAAAAGGGATGG
AAATGTCCGTTGCATATGCGGTTTGGTCAGGTATGGGAATTGTAACGATTACAACAATTGGTTTTATCTATTTTGGAGAA
AGTATCAATATAATTAAGATAGTAGCAATTCTTTTTATTTTAATTGGAGTCGTAATTTTAAATTTTAATAGTACGGCACA
TGAAGCGAAGAAAAAAGAAATGGTGGAGGAACGTATACATTGA

Upstream 100 bases:

>100_bases
TTATTGAAAAAAGTGATTATACGTTGGGAAGTATGCTTGAATCGATTATGGACATGTTACTATATGGCATTTCTAATTCG
AAATAAAAGGTGGGAAAATA

Downstream 100 bases:

>100_bases
ATCGATTAAAGTATTTTTTCCTTATTACTGATGTTGGGTTTGTTATATATTGGCTCATAACAATTTTTCATATGATTCCG
CAAGAATATTTGTTTAAAGA

Product: multidrug resistance protein, Smr family

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 120; Mature: 120

Protein sequence:

>120_residues
MQWIYLSLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFAFLSFALKGMEMSVAYAVWSGMGIVTITTIGFIYFGE
SINIIKIVAILFILIGVVILNFNSTAHEAKKKEMVEERIH

Sequences:

>Translated_120_residues
MQWIYLSLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFAFLSFALKGMEMSVAYAVWSGMGIVTITTIGFIYFGE
SINIIKIVAILFILIGVVILNFNSTAHEAKKKEMVEERIH
>Mature_120_residues
MQWIYLSLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFAFLSFALKGMEMSVAYAVWSGMGIVTITTIGFIYFGE
SINIIKIVAILFILIGVVILNFNSTAHEAKKKEMVEERIH

Specific function: Multidrug Transporter. Confers Resistance To A Wide Range Of Toxic Compounds By Removing Them For The Cells. The Efflux Is Coupled To An Influx Of Protons. Probably Prevents The Incorporation Of Methyl VIologen Into Cells. Involved In Ethidium Bromide Ef

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=108, Percent_Identity=41.6666666666667, Blast_Score=84, Evalue=2e-18,
Organism=Escherichia coli, GI87082378, Length=104, Percent_Identity=33.6538461538462, Blast_Score=74, Evalue=3e-15,
Organism=Escherichia coli, GI1787884, Length=112, Percent_Identity=37.5, Blast_Score=69, Evalue=1e-13,
Organism=Escherichia coli, GI1787883, Length=97, Percent_Identity=32.9896907216495, Blast_Score=62, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 13346; Mature: 13346

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQWIYLSLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFAFLSFALKGMEMSVAYA
CCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWSGMGIVTITTIGFIYFGESINIIKIVAILFILIGVVILNFNSTAHEAKKKEMVEERIH
HHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQWIYLSLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFAFLSFALKGMEMSVAYA
CCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWSGMGIVTITTIGFIYFGESINIIKIVAILFILIGVVILNFNSTAHEAKKKEMVEERIH
HHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]