Click here to switch to the map view.

The map label for this gene is hblA [H]

Identifier: 218904262

GI number: 218904262

Start: 2980320

End: 2981540

Strand: Reverse

Name: hblA [H]

Synonym: BCAH820_3146

Alternate gene names: 218904262

Gene position: 2981540-2980320 (Counterclockwise)

Preceding gene: 218904263

Following gene: 218904261

Centisome position: 56.23

GC content: 36.12

Gene sequence:

>1221_bases
ATGAAAAAATTTCCATTCAAAGTACTAACTTTAGCTACATTAGCAACTGTTATAACTGCTACTACCGGTAACACTATTCA
TGCATTTGCACAAGAAACGACTGCTCAAGAACAAAAAGTAGGCAATTATGCATTAGGCCCCGAAGGACTGAAGAAAGCAT
TGGCTGAAACAGGGTCTCATATTCTAGTAATGGATTTATACGCAAAAACAATGATTAAGCAACCAAATGTAAATTTATCT
AATATCGATTTAGGCTCAGAGGGGGGAGAGTTGCTCAAAAATATTCACCTTAATCAAGAGCTGTCACGAATCAATGCGAA
TTACTGGTTAGATACAGCGAAGCCACAGATTCAAAAAACTGCTCGTAATATTGTAAATTACGATGAACAATTTCAAAATT
ATTACGACACATTAGTAGAAACTGTACAAAAGAAAGATAAGGCAGGTCTAAAAGAGGGTATAAATGATTTAATTACTACA
ATCAATACAAATTCAAAAGAAGTTACAGATGTGATTAAGATGCTACAAGACTTCAAAGGGAAACTATATCAAAATTCTAC
AGATTTTAAAAATAATGTTGGTGGTCCAGATGGGAAAGGTGGATTAACTGCAATATTAGCAGGTCAACAGGCAACGATTC
CACAACTTCAAGCTGAAATTGAGCAACTTCGTTCTACTCAGAAAAAACATTTTGATGATGTATTAGCATGGTCAATTGGT
GGTGGATTGGGAGCAGCTATTTTAGTTATTGCAGCTATTGGAGGAGCGGTAGTTATTGTTGTAACTGGCGGTACAGCAAC
ACCGGCTGTTGTTGGTGGACTCTCGGCTCTTGGTGCAGCTGGTATCGGTCTAGGAACTGCGGCTGGTGTCACAGCATCTA
AGCATATGGACTCCTATAATGAAATTTCTAACAAAATCGGAGAATTAAGTATGAAAGCAGATCGTGCTAATCAAGCAGTT
CTTTCGCTTACTAACGCGAAAGAAACATTGGCATATTTATATCAGACTGTAGATCAAGCGATATTGTCTCTAACAAATAT
TCAAAAGCAATGGAATACAATGGGCGCAAATTATACAGATTTATTGGATAATATCGATTCTATGCAAGACCACAAATTCT
CTTTAATACCAGATGATTTAAAAGCCGCTAAAGAAAGTTGGAATGATATTCATAAAGATGCAGAATTCATTTCAAAAGAT
ATTGCTTTTAAACAGGAGTAG

Upstream 100 bases:

>100_bases
GTAATGAGTTACCTTGAAGAACAAGTAAATAAATTTTAATATTGCGTTTTTTGGAAATATATAAAGATTATAAGCATTTA
GCGAAAGAAGGAGAATAGTG

Downstream 100 bases:

>100_bases
AACTGAAATTTAAAACCTAAATTGGAGGAAAATGAAATGATAAAAAAAATCCCTTACAAATTACTCGCTGTATCGACGCT
ATTAACTATTACAACTGCTA

Product: hemolysin BL lytic component L1

Products: NA

Alternate protein names: Enterotoxin 40 kDa subunit [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MKKFPFKVLTLATLATVITATTGNTIHAFAQETTAQEQKVGNYALGPEGLKKALAETGSHILVMDLYAKTMIKQPNVNLS
NIDLGSEGGELLKNIHLNQELSRINANYWLDTAKPQIQKTARNIVNYDEQFQNYYDTLVETVQKKDKAGLKEGINDLITT
INTNSKEVTDVIKMLQDFKGKLYQNSTDFKNNVGGPDGKGGLTAILAGQQATIPQLQAEIEQLRSTQKKHFDDVLAWSIG
GGLGAAILVIAAIGGAVVIVVTGGTATPAVVGGLSALGAAGIGLGTAAGVTASKHMDSYNEISNKIGELSMKADRANQAV
LSLTNAKETLAYLYQTVDQAILSLTNIQKQWNTMGANYTDLLDNIDSMQDHKFSLIPDDLKAAKESWNDIHKDAEFISKD
IAFKQE

Sequences:

>Translated_406_residues
MKKFPFKVLTLATLATVITATTGNTIHAFAQETTAQEQKVGNYALGPEGLKKALAETGSHILVMDLYAKTMIKQPNVNLS
NIDLGSEGGELLKNIHLNQELSRINANYWLDTAKPQIQKTARNIVNYDEQFQNYYDTLVETVQKKDKAGLKEGINDLITT
INTNSKEVTDVIKMLQDFKGKLYQNSTDFKNNVGGPDGKGGLTAILAGQQATIPQLQAEIEQLRSTQKKHFDDVLAWSIG
GGLGAAILVIAAIGGAVVIVVTGGTATPAVVGGLSALGAAGIGLGTAAGVTASKHMDSYNEISNKIGELSMKADRANQAV
LSLTNAKETLAYLYQTVDQAILSLTNIQKQWNTMGANYTDLLDNIDSMQDHKFSLIPDDLKAAKESWNDIHKDAEFISKD
IAFKQE
>Mature_406_residues
MKKFPFKVLTLATLATVITATTGNTIHAFAQETTAQEQKVGNYALGPEGLKKALAETGSHILVMDLYAKTMIKQPNVNLS
NIDLGSEGGELLKNIHLNQELSRINANYWLDTAKPQIQKTARNIVNYDEQFQNYYDTLVETVQKKDKAGLKEGINDLITT
INTNSKEVTDVIKMLQDFKGKLYQNSTDFKNNVGGPDGKGGLTAILAGQQATIPQLQAEIEQLRSTQKKHFDDVLAWSIG
GGLGAAILVIAAIGGAVVIVVTGGTATPAVVGGLSALGAAGIGLGTAAGVTASKHMDSYNEISNKIGELSMKADRANQAV
LSLTNAKETLAYLYQTVDQAILSLTNIQKQWNTMGANYTDLLDNIDSMQDHKFSLIPDDLKAAKESWNDIHKDAEFISKD
IAFKQE

Specific function: Cytotoxic protein, part of the enterotoxin complex. Responsible for binding to erythrocytes. This enterotoxin is thought to be the cause of the diarrheal form of gastroenteritis caused by food-borne strains of B.cereus [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cell membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008414
- InterPro:   IPR010356 [H]

Pfam domain/function: PF05791 Bacillus_HBL [H]

EC number: NA

Molecular weight: Translated: 43830; Mature: 43830

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFPFKVLTLATLATVITATTGNTIHAFAQETTAQEQKVGNYALGPEGLKKALAETGSH
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
ILVMDLYAKTMIKQPNVNLSNIDLGSEGGELLKNIHLNQELSRINANYWLDTAKPQIQKT
EEEHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHH
ARNIVNYDEQFQNYYDTLVETVQKKDKAGLKEGINDLITTINTNSKEVTDVIKMLQDFKG
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
KLYQNSTDFKNNVGGPDGKGGLTAILAGQQATIPQLQAEIEQLRSTQKKHFDDVLAWSIG
HHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGLGAAILVIAAIGGAVVIVVTGGTATPAVVGGLSALGAAGIGLGTAAGVTASKHMDSYN
CHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHH
EISNKIGELSMKADRANQAVLSLTNAKETLAYLYQTVDQAILSLTNIQKQWNTMGANYTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LLDNIDSMQDHKFSLIPDDLKAAKESWNDIHKDAEFISKDIAFKQE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKFPFKVLTLATLATVITATTGNTIHAFAQETTAQEQKVGNYALGPEGLKKALAETGSH
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
ILVMDLYAKTMIKQPNVNLSNIDLGSEGGELLKNIHLNQELSRINANYWLDTAKPQIQKT
EEEHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHH
ARNIVNYDEQFQNYYDTLVETVQKKDKAGLKEGINDLITTINTNSKEVTDVIKMLQDFKG
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
KLYQNSTDFKNNVGGPDGKGGLTAILAGQQATIPQLQAEIEQLRSTQKKHFDDVLAWSIG
HHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGLGAAILVIAAIGGAVVIVVTGGTATPAVVGGLSALGAAGIGLGTAAGVTASKHMDSYN
CHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHH
EISNKIGELSMKADRANQAVLSLTNAKETLAYLYQTVDQAILSLTNIQKQWNTMGANYTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LLDNIDSMQDHKFSLIPDDLKAAKESWNDIHKDAEFISKDIAFKQE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7693651; 8319899 [H]