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The map label for this gene is pcP [H]

Identifier: 218904212

GI number: 218904212

Start: 2930400

End: 2931047

Strand: Reverse

Name: pcP [H]

Synonym: BCAH820_3096

Alternate gene names: 218904212

Gene position: 2931047-2930400 (Counterclockwise)

Preceding gene: 218904213

Following gene: 218904211

Centisome position: 55.27

GC content: 38.73

Gene sequence:

>648_bases
ATGAAAACAGTATTATTAACAGGATTTGATCCGTTCGGCGGAGAAAGTATCAATCCAGCTTGGGAAGTCGCAAAAAGTTT
ACATGAAAAAACAATCGGAGAATACAAGATTATTAGTAAACAAGTACCCACTGTATTTCATAAATCAATCAGTGTATTAA
AAGAGTATATAGAAGAACTAGCACCGGAATGTATTATATGCATTGGACAAGCTGGGGGTAGACCAGATATTACGATAGAG
CGTGTCGCAATTAATATTGATGATGCAAGAATTGCTGACAATGAAGGAAACCAGCCGGTAGATGTACCAGTCGTAGAAGA
AGGACCAGCTGCTTATTGGTCTACACTTCCGATGAAAGCAATTGTAAAAAAACTTCAAGAAGAAGGTATACCGGCTTCCG
TTTCACAAACAGCAGGTACGTTCGTTTGTAATCATTTATTCTATGGTCTCATGCATGAACTAGAAAAACATGATACAAAA
ATGAAAGGCGGATTTATTCATATTCCGTTTTTACCAGAGCAAGCGAGTAATTATCCAGGGCAACCGAGTATGTCACTTTC
TACTATTCGTAAAGGGATAGAGTTGGCAGTTGAAGTAACGACGACAGTTGAGGTAGATATAGTGGAAATTGGGGGCGCGA
CGCATTAA

Upstream 100 bases:

>100_bases
GGACAGGAAAAAGGTGAGATTCCTTTTCGGTAGTTGGCATTTGACTTGGTTCGCCAACAATTTATAGGTTTTTATAAGAA
TTTTAAACCAGGAGAAAACT

Downstream 100 bases:

>100_bases
GTAGAATGAATTGTACGACACCTCCTGTAAACAACTGGTATAATAAGTATAGGAATATACATAGAGGTGATTTTTGTGCA
ATTTGAAGAAGTACGTACAA

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIGEYKIISKQVPTVFHKSISVLKEYIEELAPECIICIGQAGGRPDITIE
RVAINIDDARIADNEGNQPVDVPVVEEGPAAYWSTLPMKAIVKKLQEEGIPASVSQTAGTFVCNHLFYGLMHELEKHDTK
MKGGFIHIPFLPEQASNYPGQPSMSLSTIRKGIELAVEVTTTVEVDIVEIGGATH

Sequences:

>Translated_215_residues
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIGEYKIISKQVPTVFHKSISVLKEYIEELAPECIICIGQAGGRPDITIE
RVAINIDDARIADNEGNQPVDVPVVEEGPAAYWSTLPMKAIVKKLQEEGIPASVSQTAGTFVCNHLFYGLMHELEKHDTK
MKGGFIHIPFLPEQASNYPGQPSMSLSTIRKGIELAVEVTTTVEVDIVEIGGATH
>Mature_215_residues
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIGEYKIISKQVPTVFHKSISVLKEYIEELAPECIICIGQAGGRPDITIE
RVAINIDDARIADNEGNQPVDVPVVEEGPAAYWSTLPMKAIVKKLQEEGIPASVSQTAGTFVCNHLFYGLMHELEKHDTK
MKGGFIHIPFLPEQASNYPGQPSMSLSTIRKGIELAVEVTTTVEVDIVEIGGATH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

Organism=Homo sapiens, GI8923198, Length=178, Percent_Identity=24.7191011235955, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 23453; Mature: 23453

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS01333 PYRASE_GLU ; PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIGEYKIISKQVPTVFHKSISVLKEYIEEL
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
APECIICIGQAGGRPDITIERVAINIDDARIADNEGNQPVDVPVVEEGPAAYWSTLPMKA
CCCEEEEEECCCCCCCEEEEEEEEECCCCEECCCCCCCCCCCEEECCCCCHHHHHCCHHH
IVKKLQEEGIPASVSQTAGTFVCNHLFYGLMHELEKHDTKMKGGFIHIPFLPEQASNYPG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCCC
QPSMSLSTIRKGIELAVEVTTTVEVDIVEIGGATH
CCCCCHHHHHHCCEEEEEEEEEEEEEEEECCCCCC
>Mature Secondary Structure
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIGEYKIISKQVPTVFHKSISVLKEYIEEL
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
APECIICIGQAGGRPDITIERVAINIDDARIADNEGNQPVDVPVVEEGPAAYWSTLPMKA
CCCEEEEEECCCCCCCEEEEEEEEECCCCEECCCCCCCCCCCEEECCCCCHHHHHCCHHH
IVKKLQEEGIPASVSQTAGTFVCNHLFYGLMHELEKHDTKMKGGFIHIPFLPEQASNYPG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCCC
QPSMSLSTIRKGIELAVEVTTTVEVDIVEIGGATH
CCCCCHHHHHHCCEEEEEEEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA