Click here to switch to the map view.

The map label for this gene is cobB [H]

Identifier: 218904211

GI number: 218904211

Start: 2929599

End: 2930324

Strand: Reverse

Name: cobB [H]

Synonym: BCAH820_3095

Alternate gene names: 218904211

Gene position: 2930324-2929599 (Counterclockwise)

Preceding gene: 218904212

Following gene: 218904209

Centisome position: 55.26

GC content: 34.71

Gene sequence:

>726_bases
GTGCAATTTGAAGAAGTACGTACAATTTTAGAAAAAGCAAAGAAAATTACAGTATTAACAGGAGCTGGTGCAAGTACGGA
AAGTGGTATCCCAGATTTTCGTTCAGCAAATGGATTGTATGCTGATGCGAATGTGGAGATGTACTTATCAAGAGGGTACT
ATAACCGAAGTCCGAAAGAATTTTGGAAGCATTATAAAGAAATCTTTCAAATCAATACGTTTCATCAATATAAACCAAAT
CGTGGGCATCGTTTTTTAGCAGAGCTAGAAGAGCAAGGGAAAGATATTACGATTTTAACGCAAAATATTGACGGTTTACA
TCAATTAGGTGGTAGTAAACATGTTATTGATTTACATGGAACGCTTCAAACAGCACATTGTCCAAAGTGTAGAACGGGAT
ATGATTTGCAGTATATGATTGATCATGAAGTGCCGCGCTGTCAGAAGTGTAATTTCATTTTAAATCCAGACGTTGTTTTA
TATGGAGATACATTGCCGCAATATCAAAATGCGATAAAACGTTTATATGAAACAAATGTGCTTATCGTTATGGGAACGTC
ATTAAAAGTACAACCTGTCGCTTCATTCCCAGAAATCGCAAAGAGAGAAGTAGGAGCAACAACCGTCTTAGTAAATGAAG
AGTTAACAGGACAAGAATATAACTTTGATTATGTTTTTCAAAATAAGATTGGTGAATTTGTTGAAGGATTATCTTCAATA
AAATAA

Upstream 100 bases:

>100_bases
GGAAATTGGGGGCGCGACGCATTAAGTAGAATGAATTGTACGACACCTCCTGTAAACAACTGGTATAATAAGTATAGGAA
TATACATAGAGGTGATTTTT

Downstream 100 bases:

>100_bases
ATTATCAAAAAAACTGAGGTATCCGCCTCAGTTTTTTATTTGAGTAATCGTTATACTAAGCAACGTGAAAACATGTCGAT
AATGTAGTAACAACATCTCT

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MQFEEVRTILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKEFWKHYKEIFQINTFHQYKPN
RGHRFLAELEEQGKDITILTQNIDGLHQLGGSKHVIDLHGTLQTAHCPKCRTGYDLQYMIDHEVPRCQKCNFILNPDVVL
YGDTLPQYQNAIKRLYETNVLIVMGTSLKVQPVASFPEIAKREVGATTVLVNEELTGQEYNFDYVFQNKIGEFVEGLSSI
K

Sequences:

>Translated_241_residues
MQFEEVRTILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKEFWKHYKEIFQINTFHQYKPN
RGHRFLAELEEQGKDITILTQNIDGLHQLGGSKHVIDLHGTLQTAHCPKCRTGYDLQYMIDHEVPRCQKCNFILNPDVVL
YGDTLPQYQNAIKRLYETNVLIVMGTSLKVQPVASFPEIAKREVGATTVLVNEELTGQEYNFDYVFQNKIGEFVEGLSSI
K
>Mature_241_residues
MQFEEVRTILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKEFWKHYKEIFQINTFHQYKPN
RGHRFLAELEEQGKDITILTQNIDGLHQLGGSKHVIDLHGTLQTAHCPKCRTGYDLQYMIDHEVPRCQKCNFILNPDVVL
YGDTLPQYQNAIKRLYETNVLIVMGTSLKVQPVASFPEIAKREVGATTVLVNEELTGQEYNFDYVFQNKIGEFVEGLSSI
K

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7657575, Length=231, Percent_Identity=36.7965367965368, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI13775602, Length=231, Percent_Identity=35.4978354978355, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI13775600, Length=231, Percent_Identity=35.4978354978355, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI6912660, Length=242, Percent_Identity=33.0578512396694, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI63054862, Length=237, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI6912664, Length=257, Percent_Identity=29.9610894941634, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI300795542, Length=244, Percent_Identity=30.7377049180328, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI300797705, Length=203, Percent_Identity=34.4827586206897, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI13787215, Length=253, Percent_Identity=29.2490118577075, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI215982798, Length=173, Percent_Identity=35.8381502890173, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI6912662, Length=225, Percent_Identity=29.7777777777778, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI300797577, Length=250, Percent_Identity=26.8, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI308199517, Length=230, Percent_Identity=33.4782608695652, Blast_Score=99, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17541892, Length=230, Percent_Identity=33.4782608695652, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17567771, Length=227, Percent_Identity=27.3127753303965, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71990482, Length=222, Percent_Identity=27.027027027027, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71990487, Length=224, Percent_Identity=26.7857142857143, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324599, Length=296, Percent_Identity=28.3783783783784, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324504, Length=282, Percent_Identity=27.6595744680851, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325242, Length=234, Percent_Identity=30.3418803418803, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320163, Length=254, Percent_Identity=27.9527559055118, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320397, Length=231, Percent_Identity=25.974025974026, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137536, Length=250, Percent_Identity=33.2, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24648389, Length=222, Percent_Identity=34.6846846846847, Blast_Score=130, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28571445, Length=186, Percent_Identity=30.1075268817204, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24645650, Length=249, Percent_Identity=23.2931726907631, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27489; Mature: 27489

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFEEVRTILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKE
CCHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCHHH
FWKHYKEIFQINTFHQYKPNRGHRFLAELEEQGKDITILTQNIDGLHQLGGSKHVIDLHG
HHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHCCCCCEEEEECC
TLQTAHCPKCRTGYDLQYMIDHEVPRCQKCNFILNPDVVLYGDTLPQYQNAIKRLYETNV
CEECCCCCCCCCCCCEEEEECCCCCCCCCCCEEECCCEEEECCCCHHHHHHHHHHHHCCE
LIVMGTSLKVQPVASFPEIAKREVGATTVLVNEELTGQEYNFDYVFQNKIGEFVEGLSSI
EEEECCCEEEEECCCCHHHHHHHCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHC
K
C
>Mature Secondary Structure
MQFEEVRTILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKE
CCHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCHHH
FWKHYKEIFQINTFHQYKPNRGHRFLAELEEQGKDITILTQNIDGLHQLGGSKHVIDLHG
HHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHCCCCCEEEEECC
TLQTAHCPKCRTGYDLQYMIDHEVPRCQKCNFILNPDVVLYGDTLPQYQNAIKRLYETNV
CEECCCCCCCCCCCCEEEEECCCCCCCCCCCEEECCCEEEECCCCHHHHHHHHHHHHCCE
LIVMGTSLKVQPVASFPEIAKREVGATTVLVNEELTGQEYNFDYVFQNKIGEFVEGLSSI
EEEECCCEEEEECCCCHHHHHHHCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]