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The map label for this gene is acoC [H]

Identifier: 218903893

GI number: 218903893

Start: 2644674

End: 2645336

Strand: Reverse

Name: acoC [H]

Synonym: BCAH820_2777

Alternate gene names: 218903893

Gene position: 2645336-2644674 (Counterclockwise)

Preceding gene: 218903894

Following gene: 218903892

Centisome position: 49.89

GC content: 34.99

Gene sequence:

>663_bases
ATGCGGAAAGCAATCGCAAACCGTATGCATGCAAGCTTACAAAATAGTGCACAATTAACATTAACGATGAAAGTAGATGT
GACAGATTTAGTTGCTTTACATAAAGAAATAGCAGAAGTTGTACAAAAACGGTACGATAACAAATTAACCATTACGGATT
TCGTTTCTCGAGCTGTTGTATTAGCGCTTGGGGATCATAAAGAAATGAACAGCGCTTATATAGATGATGCAATTCATCAA
TTTGAACATGTTCATTTAGGTATGGCAGTCGCATTAGAAAAAGGATTAGTCGTTCCAGCTATTCGCTTCGCAAATAATCT
CTCACTAGTAGAGTTATCTAAAGAGATTAAGAATGTGGCACAAAAGGCACGAGCAGGCAATTTAAATAGTGATGATATGC
AAGGAACAACATTTACAATTAGTAATTTAGGAAGCTTCGGTATTGAATATTTTACACCAGTATTAAATGCACCAGAAACT
GGTATTTTAGGTGTAGGTTCAATTGAACATGTTCCTGTATATAAAGGGAAAAAATTAAGAAAAGGAAGTATGTTACCTTT
AAGTTTAACATTCGATCATCGTGTACTAGACGGTGCACCAGCAGCTGCATTTTTACGCACAATCAAACGCTATTTAGAAG
AACCTGTAACAATTCTTTTATAA

Upstream 100 bases:

>100_bases
AAGAATTACAAAGGTAGATGTATTAAAGGCGCTTGAAGAAAGAGTAGCAGTTCCAGAAGTACTTGAACAAGAAGAAAGTA
AAGTAATTCCTGTTACTGGC

Downstream 100 bases:

>100_bases
AGAGAAGGTGAGAGAATGAGTAAATTAGTCGTTATTGGAGGCGGACCTGCTGGCTATGTAGCGGCAATTACCGCGGCTCA
AAATGGAAAAGATGTCACTC

Product: acetoin dehydrogenase, E2 component, dihydrolipoyllysine-residue acetyltransferase

Products: NA

Alternate protein names: Acetoin dehydrogenase E2 component; Dihydrolipoamide acetyltransferase component of acetoin cleaving system [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MRKAIANRMHASLQNSAQLTLTMKVDVTDLVALHKEIAEVVQKRYDNKLTITDFVSRAVVLALGDHKEMNSAYIDDAIHQ
FEHVHLGMAVALEKGLVVPAIRFANNLSLVELSKEIKNVAQKARAGNLNSDDMQGTTFTISNLGSFGIEYFTPVLNAPET
GILGVGSIEHVPVYKGKKLRKGSMLPLSLTFDHRVLDGAPAAAFLRTIKRYLEEPVTILL

Sequences:

>Translated_220_residues
MRKAIANRMHASLQNSAQLTLTMKVDVTDLVALHKEIAEVVQKRYDNKLTITDFVSRAVVLALGDHKEMNSAYIDDAIHQ
FEHVHLGMAVALEKGLVVPAIRFANNLSLVELSKEIKNVAQKARAGNLNSDDMQGTTFTISNLGSFGIEYFTPVLNAPET
GILGVGSIEHVPVYKGKKLRKGSMLPLSLTFDHRVLDGAPAAAFLRTIKRYLEEPVTILL
>Mature_220_residues
MRKAIANRMHASLQNSAQLTLTMKVDVTDLVALHKEIAEVVQKRYDNKLTITDFVSRAVVLALGDHKEMNSAYIDDAIHQ
FEHVHLGMAVALEKGLVVPAIRFANNLSLVELSKEIKNVAQKARAGNLNSDDMQGTTFTISNLGSFGIEYFTPVLNAPET
GILGVGSIEHVPVYKGKKLRKGSMLPLSLTFDHRVLDGAPAAAFLRTIKRYLEEPVTILL

Specific function: The Pyruvate Dehydrogenase Complex Catalyzes The Overall Conversion Of Pyruvate To Acetyl-CoA And Co(2). It Contains Multiple Copies Of Three Enzymatic Components: Pyruvate Dehydrogenase (E1), Dihydrolipoamide Acetyltransferase (E2) And Lipoamide Dehydrog

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=222, Percent_Identity=35.1351351351351, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI19923748, Length=223, Percent_Identity=34.9775784753363, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI203098753, Length=225, Percent_Identity=29.7777777777778, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI203098816, Length=223, Percent_Identity=30.0448430493274, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI110671329, Length=224, Percent_Identity=30.3571428571429, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI260898739, Length=158, Percent_Identity=34.1772151898734, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1786305, Length=194, Percent_Identity=40.2061855670103, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786946, Length=220, Percent_Identity=34.5454545454545, Blast_Score=141, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17560088, Length=226, Percent_Identity=35.3982300884956, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI25146366, Length=222, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17537937, Length=200, Percent_Identity=30.5, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17538894, Length=216, Percent_Identity=28.7037037037037, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320352, Length=220, Percent_Identity=38.1818181818182, Blast_Score=151, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6324258, Length=226, Percent_Identity=29.2035398230088, Blast_Score=115, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24582497, Length=226, Percent_Identity=33.1858407079646, Blast_Score=133, Evalue=7e-32,
Organism=Drosophila melanogaster, GI20129315, Length=226, Percent_Identity=33.1858407079646, Blast_Score=133, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24645909, Length=219, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI18859875, Length=224, Percent_Identity=30.3571428571429, Blast_Score=107, Evalue=5e-24,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 912 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 4,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001078
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 24204; Mature: 24204

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKAIANRMHASLQNSAQLTLTMKVDVTDLVALHKEIAEVVQKRYDNKLTITDFVSRAVV
CCHHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHE
LALGDHKEMNSAYIDDAIHQFEHVHLGMAVALEKGLVVPAIRFANNLSLVELSKEIKNVA
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHH
QKARAGNLNSDDMQGTTFTISNLGSFGIEYFTPVLNAPETGILGVGSIEHVPVYKGKKLR
HHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCC
KGSMLPLSLTFDHRVLDGAPAAAFLRTIKRYLEEPVTILL
CCCCCEEEEEECCHHCCCCCHHHHHHHHHHHHHCCCEECC
>Mature Secondary Structure
MRKAIANRMHASLQNSAQLTLTMKVDVTDLVALHKEIAEVVQKRYDNKLTITDFVSRAVV
CCHHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHE
LALGDHKEMNSAYIDDAIHQFEHVHLGMAVALEKGLVVPAIRFANNLSLVELSKEIKNVA
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHH
QKARAGNLNSDDMQGTTFTISNLGSFGIEYFTPVLNAPETGILGVGSIEHVPVYKGKKLR
HHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCC
KGSMLPLSLTFDHRVLDGAPAAAFLRTIKRYLEEPVTILL
CCCCCEEEEEECCHHCCCCCHHHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377 [H]