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The map label for this gene is acoL [H]

Identifier: 218903892

GI number: 218903892

Start: 2643279

End: 2644658

Strand: Reverse

Name: acoL [H]

Synonym: BCAH820_2776

Alternate gene names: 218903892

Gene position: 2644658-2643279 (Counterclockwise)

Preceding gene: 218903893

Following gene: 218903890

Centisome position: 49.87

GC content: 36.81

Gene sequence:

>1380_bases
ATGAGTAAATTAGTCGTTATTGGAGGCGGACCTGCTGGCTATGTAGCGGCAATTACCGCGGCTCAAAATGGAAAAGATGT
CACTCTTATTGATGAAGCTGATCTTGGCGGGACTTGTTTAAATGTCGGGTGCATGCCTACAAAATCATTGTTAGAAAGTG
CAGAAGTGCATGACATTGTGAGAATGGCTAATAATTATGGAGTTACACTTAACAAAGAAAGTATATCAGTTGATTGGAAG
CAAATGCAGGCGAGGAAATCACAAATCGTAACGCAGCTTGTCCAAGGAATTCAATATTTAATGAAGAAAAATAAAATAAA
AGTTATACAAGGTAAAGCGAAATTTGAAACGGATCACCGTGTACGAGTTACATGCGGTGATAAAGAATATGTAGTAGATG
GAGAACAGTTCATTATAGCGGCAGGTTCAGAACCGACTGAATTACCTTTTGTTCCATTTGACGGAAAGTGGATTTTAAAT
AGTAGCCATGCAATGTCCATAGATAATATACCAAAATCATTATTAATTGTTGGCGGTGGTGTAATAGGGTGCGAGTTTGC
AAGTATTTATAGTCGTCTTGGAACAAAAGTTACGATTATTGAAATGGCACCGCAATTATTACCTGGTGAAGATGAAGATA
TCGCAAATATTTTAAGAGAGAAGCTAGAAAATGATGGTGTAGAAATATTTACAGGAGCAGCTTTAAAAGGATTAAATAAT
TATAAGAAGCAGGCTTCATTTGAATATGAAGGAAGTATTAGAGAAGCCAATTCAGAATTTGTTCTTATTTCTGTAGGTCG
AAAACCACGTGTACAAGAGATAGGATTAGAAAAAGCAGGAATTCAATTTTCAAATAAAGGGATTGTTGTGAATAAACATA
TGCAAACCAATGTATCACATATTTACGCAGCAGGTGATGTAATTGGTGGAATCCAGCTTGCTCATGTTGCTTTCCATGAA
GGAACGACGGCAGCATTACACGCGAGTGGAGAAGATGTAAAAGTAAACTACCATGCTGTACCTCGCTGTATTTATACAGC
ACCAGAAATTGCTAGCGTCGGTTTAAGTGAAAAATTAGCAAGAGAGCAATATGGTGATATTCTTATCGGAGAATTTCCTT
TTACAGCAAACGGAAAAGCACTTATTATTGGAGAACAAATGGGTAAAGTAAAAGTTATTGTGGAACCTAAATATCAAGAA
ATTGTTGGGATTTCTATTATTGGTCCACATGCAACTGAACTGATTGGTCAAGGAACTGTAATGATTCATACGGAAGTTAC
AGCTGATATTATGAGAGATTATATTGCAGCGCATCCAACTTTATCTGAATCGATTCATGAAGCTTTATTGCAAGCTGTAG
GGCATGCTGTACATGCTTAA

Upstream 100 bases:

>100_bases
TCGTGTACTAGACGGTGCACCAGCAGCTGCATTTTTACGCACAATCAAACGCTATTTAGAAGAACCTGTAACAATTCTTT
TATAAAGAGAAGGTGAGAGA

Downstream 100 bases:

>100_bases
ATGGAATTATAATAAACCACTATTCTCTAAACGAATAAGAGAATAGTGGTTTGGATTTTTACGGAAGAAATTGAATATCC
TATTATTTTTTTACGTCAAT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of acetoin cleaving system [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSKLVVIGGGPAGYVAAITAAQNGKDVTLIDEADLGGTCLNVGCMPTKSLLESAEVHDIVRMANNYGVTLNKESISVDWK
QMQARKSQIVTQLVQGIQYLMKKNKIKVIQGKAKFETDHRVRVTCGDKEYVVDGEQFIIAAGSEPTELPFVPFDGKWILN
SSHAMSIDNIPKSLLIVGGGVIGCEFASIYSRLGTKVTIIEMAPQLLPGEDEDIANILREKLENDGVEIFTGAALKGLNN
YKKQASFEYEGSIREANSEFVLISVGRKPRVQEIGLEKAGIQFSNKGIVVNKHMQTNVSHIYAAGDVIGGIQLAHVAFHE
GTTAALHASGEDVKVNYHAVPRCIYTAPEIASVGLSEKLAREQYGDILIGEFPFTANGKALIIGEQMGKVKVIVEPKYQE
IVGISIIGPHATELIGQGTVMIHTEVTADIMRDYIAAHPTLSESIHEALLQAVGHAVHA

Sequences:

>Translated_459_residues
MSKLVVIGGGPAGYVAAITAAQNGKDVTLIDEADLGGTCLNVGCMPTKSLLESAEVHDIVRMANNYGVTLNKESISVDWK
QMQARKSQIVTQLVQGIQYLMKKNKIKVIQGKAKFETDHRVRVTCGDKEYVVDGEQFIIAAGSEPTELPFVPFDGKWILN
SSHAMSIDNIPKSLLIVGGGVIGCEFASIYSRLGTKVTIIEMAPQLLPGEDEDIANILREKLENDGVEIFTGAALKGLNN
YKKQASFEYEGSIREANSEFVLISVGRKPRVQEIGLEKAGIQFSNKGIVVNKHMQTNVSHIYAAGDVIGGIQLAHVAFHE
GTTAALHASGEDVKVNYHAVPRCIYTAPEIASVGLSEKLAREQYGDILIGEFPFTANGKALIIGEQMGKVKVIVEPKYQE
IVGISIIGPHATELIGQGTVMIHTEVTADIMRDYIAAHPTLSESIHEALLQAVGHAVHA
>Mature_458_residues
SKLVVIGGGPAGYVAAITAAQNGKDVTLIDEADLGGTCLNVGCMPTKSLLESAEVHDIVRMANNYGVTLNKESISVDWKQ
MQARKSQIVTQLVQGIQYLMKKNKIKVIQGKAKFETDHRVRVTCGDKEYVVDGEQFIIAAGSEPTELPFVPFDGKWILNS
SHAMSIDNIPKSLLIVGGGVIGCEFASIYSRLGTKVTIIEMAPQLLPGEDEDIANILREKLENDGVEIFTGAALKGLNNY
KKQASFEYEGSIREANSEFVLISVGRKPRVQEIGLEKAGIQFSNKGIVVNKHMQTNVSHIYAAGDVIGGIQLAHVAFHEG
TTAALHASGEDVKVNYHAVPRCIYTAPEIASVGLSEKLAREQYGDILIGEFPFTANGKALIIGEQMGKVKVIVEPKYQEI
VGISIIGPHATELIGQGTVMIHTEVTADIMRDYIAAHPTLSESIHEALLQAVGHAVHA

Specific function: Lipoamide Dehydrogenase Is A Component Of The Glycine Cleavage System As Well As Of The Alpha-Ketoacid Dehydrogenase Complexes. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=460, Percent_Identity=33.9130434782609, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI50301238, Length=448, Percent_Identity=28.125, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI148277071, Length=461, Percent_Identity=28.6334056399132, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI148277065, Length=460, Percent_Identity=28.2608695652174, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI33519430, Length=461, Percent_Identity=28.6334056399132, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI33519428, Length=461, Percent_Identity=28.6334056399132, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI33519426, Length=461, Percent_Identity=28.6334056399132, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI22035672, Length=458, Percent_Identity=28.1659388646288, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI291045266, Length=458, Percent_Identity=26.4192139737991, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI291045268, Length=449, Percent_Identity=24.4988864142539, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1786307, Length=449, Percent_Identity=32.0712694877506, Blast_Score=258, Evalue=8e-70,
Organism=Escherichia coli, GI87081717, Length=451, Percent_Identity=31.0421286031042, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI87082354, Length=456, Percent_Identity=27.6315789473684, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=29.1954022988506, Blast_Score=175, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=35.8369098712446, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=25.8474576271186, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71983429, Length=444, Percent_Identity=25, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71983419, Length=444, Percent_Identity=25, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71982272, Length=465, Percent_Identity=24.0860215053763, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=36.228813559322, Blast_Score=271, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6325166, Length=449, Percent_Identity=27.3942093541203, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6325240, Length=485, Percent_Identity=27.2164948453608, Blast_Score=159, Evalue=7e-40,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=36.6013071895425, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24640549, Length=467, Percent_Identity=27.6231263383298, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24640553, Length=467, Percent_Identity=27.6231263383298, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24640551, Length=465, Percent_Identity=27.741935483871, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17737741, Length=466, Percent_Identity=27.0386266094421, Blast_Score=138, Evalue=9e-33,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49523; Mature: 49391

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLVVIGGGPAGYVAAITAAQNGKDVTLIDEADLGGTCLNVGCMPTKSLLESAEVHDIV
CCEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHH
RMANNYGVTLNKESISVDWKQMQARKSQIVTQLVQGIQYLMKKNKIKVIQGKAKFETDHR
HHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEECCCCE
VRVTCGDKEYVVDGEQFIIAAGSEPTELPFVPFDGKWILNSSHAMSIDNIPKSLLIVGGG
EEEEECCCEEEECCCEEEEECCCCCCCCCEECCCCEEEECCCCEEECCCCCCEEEEECCC
VIGCEFASIYSRLGTKVTIIEMAPQLLPGEDEDIANILREKLENDGVEIFTGAALKGLNN
EEEHHHHHHHHHHCCEEEEEEECHHHCCCCCHHHHHHHHHHHCCCCEEEEECHHHHHHHH
YKKQASFEYEGSIREANSEFVLISVGRKPRVQEIGLEKAGIQFSNKGIVVNKHMQTNVSH
HHHHCCCEECCCEECCCCCEEEEECCCCCCHHHCCCHHCCCEECCCCEEEECCCCCCCCE
IYAAGDVIGGIQLAHVAFHEGTTAALHASGEDVKVNYHAVPRCIYTAPEIASVGLSEKLA
EEECCCHHCCEEEEEEEEECCCEEEEEECCCEEEEEEEECCEEEECCCHHHHCCHHHHHH
REQYGDILIGEFPFTANGKALIIGEQMGKVKVIVEPKYQEIVGISIIGPHATELIGQGTV
HHHHCCEEEECCCCCCCCCEEEEECCCCCEEEEECCCHHHEEEEEEECCCHHHHHCCCEE
MIHTEVTADIMRDYIAAHPTLSESIHEALLQAVGHAVHA
EEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKLVVIGGGPAGYVAAITAAQNGKDVTLIDEADLGGTCLNVGCMPTKSLLESAEVHDIV
CEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHH
RMANNYGVTLNKESISVDWKQMQARKSQIVTQLVQGIQYLMKKNKIKVIQGKAKFETDHR
HHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEECCCCE
VRVTCGDKEYVVDGEQFIIAAGSEPTELPFVPFDGKWILNSSHAMSIDNIPKSLLIVGGG
EEEEECCCEEEECCCEEEEECCCCCCCCCEECCCCEEEECCCCEEECCCCCCEEEEECCC
VIGCEFASIYSRLGTKVTIIEMAPQLLPGEDEDIANILREKLENDGVEIFTGAALKGLNN
EEEHHHHHHHHHHCCEEEEEEECHHHCCCCCHHHHHHHHHHHCCCCEEEEECHHHHHHHH
YKKQASFEYEGSIREANSEFVLISVGRKPRVQEIGLEKAGIQFSNKGIVVNKHMQTNVSH
HHHHCCCEECCCEECCCCCEEEEECCCCCCHHHCCCHHCCCEECCCCEEEECCCCCCCCE
IYAAGDVIGGIQLAHVAFHEGTTAALHASGEDVKVNYHAVPRCIYTAPEIASVGLSEKLA
EEECCCHHCCEEEEEEEEECCCEEEEEECCCEEEEEEEECCEEEECCCHHHHCCHHHHHH
REQYGDILIGEFPFTANGKALIIGEQMGKVKVIVEPKYQEIVGISIIGPHATELIGQGTV
HHHHCCEEEECCCCCCCCCEEEEECCCCCEEEEECCCHHHEEEEEEECCCHHHHHCCCEE
MIHTEVTADIMRDYIAAHPTLSESIHEALLQAVGHAVHA
EEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10368162; 8969503; 9384377 [H]