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The map label for this gene is mutX [H]

Identifier: 218903816

GI number: 218903816

Start: 2568551

End: 2569063

Strand: Direct

Name: mutX [H]

Synonym: BCAH820_2700

Alternate gene names: 218903816

Gene position: 2568551-2569063 (Clockwise)

Preceding gene: 218903815

Following gene: 218903817

Centisome position: 48.44

GC content: 29.43

Gene sequence:

>513_bases
ATGTACAAACACACTTTATGTTTCATAAAAAGAAATGAAGAGATACTTATGCTAAATAGAAAATATGACCCTGTAAAAGG
GTTATGGAATGGTGTAGGAGGAAAGATAGAAAAGGGAGAAACACCTCTAGAAAATGCAATTCGTGAAATAAAAGAAGAGA
CTAATATAAAAGTTACGCATGATCAAATTCAATTTAAAGGCATTATTAAATGGGAGGATTCTTCATATTCTGGCGGAATG
TATGTTTATCTAGTAGAGTTACTTCATGAATTTACATATCACACTCCAAAAAAAGTCTCAGAAGGAATTCTAGATTGGAA
AGAGATTTCTTGGATTCTAAGTGACTATAATTACGGCGTAGGAGAGATGATACCTAAATTTTTAGTTGAAGTGCTTCACA
ATGAATTAATATTAGAGCACAATTTTGTTTTATCTAATCATAAATTAATAGATTATAGGAATAAAGAATTAGCTAAGCAG
GATAACTCTATAGATAATATAATTCCATTATAA

Upstream 100 bases:

>100_bases
TCTATGAGACCAATATTAATTGAAGCAGGGACACAATCTGCAGCAATCCATCTTATATCTCCAGTAAGAGCTTATTAAAA
ACAGAGGAAGGAATCACATT

Downstream 100 bases:

>100_bases
AAAGTAAGAATCGTAATCTATCATACACAACAAAGTAATTATCACCTAAATATAAAAGCCATAGATTATTCGAAGAGTAG
CTAAGGAGAAAATTTATATG

Product: mutT/nudix family protein

Products: dAMP; pyrophosphate [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MYKHTLCFIKRNEEILMLNRKYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTHDQIQFKGIIKWEDSSYSGGM
YVYLVELLHEFTYHTPKKVSEGILDWKEISWILSDYNYGVGEMIPKFLVEVLHNELILEHNFVLSNHKLIDYRNKELAKQ
DNSIDNIIPL

Sequences:

>Translated_170_residues
MYKHTLCFIKRNEEILMLNRKYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTHDQIQFKGIIKWEDSSYSGGM
YVYLVELLHEFTYHTPKKVSEGILDWKEISWILSDYNYGVGEMIPKFLVEVLHNELILEHNFVLSNHKLIDYRNKELAKQ
DNSIDNIIPL
>Mature_170_residues
MYKHTLCFIKRNEEILMLNRKYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTHDQIQFKGIIKWEDSSYSGGM
YVYLVELLHEFTYHTPKKVSEGILDWKEISWILSDYNYGVGEMIPKFLVEVLHNELILEHNFVLSNHKLIDYRNKELAKQ
DNSIDNIIPL

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19981; Mature: 19981

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKHTLCFIKRNEEILMLNRKYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTH
CCCCEEEEEECCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCEEEEE
DQIQFKGIIKWEDSSYSGGMYVYLVELLHEFTYHTPKKVSEGILDWKEISWILSDYNYGV
CEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCH
GEMIPKFLVEVLHNELILEHNFVLSNHKLIDYRNKELAKQDNSIDNIIPL
HHHHHHHHHHHHHHHHHHHCCEEECCCEEEECCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MYKHTLCFIKRNEEILMLNRKYDPVKGLWNGVGGKIEKGETPLENAIREIKEETNIKVTH
CCCCEEEEEECCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCEEEEE
DQIQFKGIIKWEDSSYSGGMYVYLVELLHEFTYHTPKKVSEGILDWKEISWILSDYNYGV
CEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCH
GEMIPKFLVEVLHNELILEHNFVLSNHKLIDYRNKELAKQDNSIDNIIPL
HHHHHHHHHHHHHHHHHHHCCEEECCCEEEECCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]