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The map label for this gene is hly [H]

Identifier: 218903660

GI number: 218903660

Start: 2417459

End: 2418697

Strand: Direct

Name: hly [H]

Synonym: BCAH820_2544

Alternate gene names: 218903660

Gene position: 2417459-2418697 (Clockwise)

Preceding gene: 218903659

Following gene: 218903661

Centisome position: 45.59

GC content: 33.49

Gene sequence:

>1239_bases
ATGAAAAAAGCAAAGGGAATAGCTAAAAGTGTTGCCGTAGCGTCCGTTATAATGTCTGGATCACTTGGTTTACAAGCAAC
ATCTGCATTTGCAGATTCTAAAGGAACTGTAGAAAATCTTCAAAATGGTGGGAAAGTCTATAATAGTTTTAAAACTACTT
ATGACATGAAGCAGAATATCAAAAATTCAATAAAGGTTTCTTTTATTGAGGATCCTTACGCAGATAAAAAAATTGCAATT
GTTACCACTGATGGTAGTAATATAGATGCGAAATATACAATTAATGGGGGATACTATAACGCAGGTTTAAAATGGCCATC
GGCGTATCATACGGAAGCAGAAATAACTAGTGGCGATAGCGCTCAATTCCATAAAGCTGCCCCAGTTAATACAATGACTT
CAGCAAAGGTTACTTCTGAGGTAGGGTATACACTTGGTGGGAGTGTTAAAGTTGGAGTAAACGATAAAGGGCCAAATGCC
GATGCAAGTATTACAGGTAGCTTTGCTTGGAAAGAAAGTGTATCTTATGATCAGGTAGACTATAAAACGGTATTAGAGAC
TCACACAGATAAAAAATTAAATTGGAAAGTAGGATTCCAATCGTTTAATTTCCCAGAGTGGGGAATTTATAATCGTGATT
CATTCAATACTTTCTATGGTAATCAACTATTTATGAAATCACGTAGTTATAATGAAGGAACGAATAATTTTGTTTCAAAA
GACACAGTACCAGCTTTAACAGGATATGGTTTTTCTCCTAATGTAGTAGCGGTTATCACTGCTGATAAAACAGAATCTAC
ATCAGATTTAAAAATAACAAATCGTAGAATTTCAGATCAGTACAATATTGAATGGGTAAGTTCAAAATGGTGGGGAACAA
ATAATAAGGATACATATAATGAGTTCTTTACAAACAACTATAAATTAGACTGGAAAAACCATCAAGTTACTCTTGATAAC
CAAAAAGCCCCTGAAGAACAAATGATTGGTATCAACAACGTGAATAACCAGCTTAACAAAGGAAAAGGAAAATTATCTTT
TTCAATGAATGGAAATCAGCTTAAGGCTACATCTAGCAATGCTGGTTATGGTATCAGTTACGAAGATAAAAATTGGGGTA
TCTTTGTAAATGGTGAAAAGGTCTACACGTTTAATGAAAAAACAACTGTAGGTAATATCTCAAATGACATTAACAAATTA
AACATCAAAGGACCTTATATTGAGATTAAAAAAATCTAA

Upstream 100 bases:

>100_bases
AAATTTCTACATTGTAACGTTATAAATCTATCTCTAGTATTGAGAGCTAAAAATAATACGTTTATATCTTTTAAATGTTT
AAGAAGGAGTGGCTGTCTGT

Downstream 100 bases:

>100_bases
TCAGTAAATAAGGTACAATTGATGGATAATTATTTCATCAAAATATGAGTATAAAGGTTTATTTTAAATCTGTATAACGT
AATGAAAGGACCAGATAAAC

Product: hemolysin II

Products: NA

Alternate protein names: Alpha-HL; Alpha-toxin [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKKAKGIAKSVAVASVIMSGSLGLQATSAFADSKGTVENLQNGGKVYNSFKTTYDMKQNIKNSIKVSFIEDPYADKKIAI
VTTDGSNIDAKYTINGGYYNAGLKWPSAYHTEAEITSGDSAQFHKAAPVNTMTSAKVTSEVGYTLGGSVKVGVNDKGPNA
DASITGSFAWKESVSYDQVDYKTVLETHTDKKLNWKVGFQSFNFPEWGIYNRDSFNTFYGNQLFMKSRSYNEGTNNFVSK
DTVPALTGYGFSPNVVAVITADKTESTSDLKITNRRISDQYNIEWVSSKWWGTNNKDTYNEFFTNNYKLDWKNHQVTLDN
QKAPEEQMIGINNVNNQLNKGKGKLSFSMNGNQLKATSSNAGYGISYEDKNWGIFVNGEKVYTFNEKTTVGNISNDINKL
NIKGPYIEIKKI

Sequences:

>Translated_412_residues
MKKAKGIAKSVAVASVIMSGSLGLQATSAFADSKGTVENLQNGGKVYNSFKTTYDMKQNIKNSIKVSFIEDPYADKKIAI
VTTDGSNIDAKYTINGGYYNAGLKWPSAYHTEAEITSGDSAQFHKAAPVNTMTSAKVTSEVGYTLGGSVKVGVNDKGPNA
DASITGSFAWKESVSYDQVDYKTVLETHTDKKLNWKVGFQSFNFPEWGIYNRDSFNTFYGNQLFMKSRSYNEGTNNFVSK
DTVPALTGYGFSPNVVAVITADKTESTSDLKITNRRISDQYNIEWVSSKWWGTNNKDTYNEFFTNNYKLDWKNHQVTLDN
QKAPEEQMIGINNVNNQLNKGKGKLSFSMNGNQLKATSSNAGYGISYEDKNWGIFVNGEKVYTFNEKTTVGNISNDINKL
NIKGPYIEIKKI
>Mature_412_residues
MKKAKGIAKSVAVASVIMSGSLGLQATSAFADSKGTVENLQNGGKVYNSFKTTYDMKQNIKNSIKVSFIEDPYADKKIAI
VTTDGSNIDAKYTINGGYYNAGLKWPSAYHTEAEITSGDSAQFHKAAPVNTMTSAKVTSEVGYTLGGSVKVGVNDKGPNA
DASITGSFAWKESVSYDQVDYKTVLETHTDKKLNWKVGFQSFNFPEWGIYNRDSFNTFYGNQLFMKSRSYNEGTNNFVSK
DTVPALTGYGFSPNVVAVITADKTESTSDLKITNRRISDQYNIEWVSSKWWGTNNKDTYNEFFTNNYKLDWKNHQVTLDN
QKAPEEQMIGINNVNNQLNKGKGKLSFSMNGNQLKATSSNAGYGISYEDKNWGIFVNGEKVYTFNEKTTVGNISNDINKL
NIKGPYIEIKKI

Specific function: Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Secreted as a monomer. After oligomerization and pore formation, the complex is translocated across the bilayer, probably via the Gly-rich domain of each strand [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerolysin family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005831
- InterPro:   IPR003963
- InterPro:   IPR001340
- InterPro:   IPR016183 [H]

Pfam domain/function: PF07968 Leukocidin [H]

EC number: NA

Molecular weight: Translated: 45664; Mature: 45664

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAKGIAKSVAVASVIMSGSLGLQATSAFADSKGTVENLQNGGKVYNSFKTTYDMKQNI
CCCHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCCCHHHHHCCCCEEHHHHHHHHHHHHC
KNSIKVSFIEDPYADKKIAIVTTDGSNIDAKYTINGGYYNAGLKWPSAYHTEAEITSGDS
CCCEEEEEEECCCCCCEEEEEEECCCCCEEEEEECCCEEECCCCCCCCCCCCEEECCCCC
AQFHKAAPVNTMTSAKVTSEVGYTLGGSVKVGVNDKGPNADASITGSFAWKESVSYDQVD
CCEECCCCCCCCCCCHHHHHCCEEECCEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCC
YKTVLETHTDKKLNWKVGFQSFNFPEWGIYNRDSFNTFYGNQLFMKSRSYNEGTNNFVSK
HHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEECCCEEEEECCCCCCCCCCCCCC
DTVPALTGYGFSPNVVAVITADKTESTSDLKITNRRISDQYNIEWVSSKWWGTNNKDTYN
CCCCCEECCCCCCCEEEEEEECCCCCCCCEEEECEECCCCCCEEEEECCCCCCCCCCCHH
EFFTNNYKLDWKNHQVTLDNQKAPEEQMIGINNVNNQLNKGKGKLSFSMNGNQLKATSSN
HHHCCCEEEEECCCEEEECCCCCCHHHEEECCCCCCHHCCCCCEEEEEECCCEEEEECCC
AGYGISYEDKNWGIFVNGEKVYTFNEKTTVGNISNDINKLNIKGPYIEIKKI
CCCEEEEECCCCEEEECCCEEEEECCCCEECCCCCCCEEEEECCCEEEEEEC
>Mature Secondary Structure
MKKAKGIAKSVAVASVIMSGSLGLQATSAFADSKGTVENLQNGGKVYNSFKTTYDMKQNI
CCCHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCCCHHHHHCCCCEEHHHHHHHHHHHHC
KNSIKVSFIEDPYADKKIAIVTTDGSNIDAKYTINGGYYNAGLKWPSAYHTEAEITSGDS
CCCEEEEEEECCCCCCEEEEEEECCCCCEEEEEECCCEEECCCCCCCCCCCCEEECCCCC
AQFHKAAPVNTMTSAKVTSEVGYTLGGSVKVGVNDKGPNADASITGSFAWKESVSYDQVD
CCEECCCCCCCCCCCHHHHHCCEEECCEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCC
YKTVLETHTDKKLNWKVGFQSFNFPEWGIYNRDSFNTFYGNQLFMKSRSYNEGTNNFVSK
HHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEECCCEEEEECCCCCCCCCCCCCC
DTVPALTGYGFSPNVVAVITADKTESTSDLKITNRRISDQYNIEWVSSKWWGTNNKDTYN
CCCCCEECCCCCCCEEEEEEECCCCCCCCEEEECEECCCCCCEEEEECCCCCCCCCCCHH
EFFTNNYKLDWKNHQVTLDNQKAPEEQMIGINNVNNQLNKGKGKLSFSMNGNQLKATSSN
HHHCCCEEEEECCCEEEECCCCCCHHHEEECCCCCCHHCCCCCEEEEEECCCEEEEECCC
AGYGISYEDKNWGIFVNGEKVYTFNEKTTVGNISNDINKLNIKGPYIEIKKI
CCCEEEEECCCCEEEECCCEEEEECCCCEECCCCCCCEEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6500704; 1587866; 8943190; 1400487; 8168947; 8188346; 7559447 [H]