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The map label for this gene is fumC [H]

Identifier: 218902936

GI number: 218902936

Start: 1713999

End: 1715387

Strand: Direct

Name: fumC [H]

Synonym: BCAH820_1819

Alternate gene names: 218902936

Gene position: 1713999-1715387 (Clockwise)

Preceding gene: 218902933

Following gene: 218902939

Centisome position: 32.32

GC content: 37.72

Gene sequence:

>1389_bases
ATGGAGTACAGAATTGAAAGAGATACATTAGGAGAAATAAAAGTTCCAGCTGATAAATTATGGGCAGCACAAACACAACG
TAGTAAAGAAAACTTCCCGATTGGAACAGAGCAAATGCCGCTTGAAATTGTAAAAGCATTTGCAATTTTAAAGAAGAGTG
CAGCACTTAGCAATCAAAAATTAGGAAAGTTATCAGAAGAAAAAGCAGAAGCAATTGTGGCAGCAGCTGACGAAGTGATT
GCAGGGAAATGGAATGAACATTTTCCGCTTGTCGTATGGCAAACGGGCAGTGGTACACAGTCAAACATGAATGTGAATGA
AGTAATTGCAAATCGTGGGAATCAAATTTTGAAAGAAAAGAGATCTGACGTACATATTCATCCGAATGATGACGTGAACA
TGTCTCAAAGTTCAAATGATACATTTCCAACGGCGCTTCATGTAGCATGTGTACTCGCAGTAGAAAATCACGTATTACCA
GCTATTACGAAATTAAAAGAAACGTTAGCAGAAAAAGTAACTGCATTTGAACATATTATAAAAATTGGTCGTACACATTT
ACAAGATGCGACACCGTTAACTTTAGGGCAAGAAATTAGTGGATGGCACCGTATGCTTGAAAAAACAGAGCGTATGATTG
CAGAGAGCAATACATATATGAAAGAGCTTGCGATTGGTGGTACAGCAGTTGGAACAGGTATTAACGCTCATCCTAAATTT
GGTGAGATGGTATCAGAGGAAATTAGCCAATTTACAGGTAAACAATTTATTTCTGCACCAAATAAGTTCCATGCATTAAC
GAGCCATGATGAAGTTGTATATACTCACGGTGCATTAAAAGCATTAGCTGCGGATTTAATGAAAATCGCTAACGATGTAC
GTTGGCTTGCAAGTGGTCCACGTAGTGGTCTTGGAGAAATTATTATTCCAGCAAATGAACCGGGAAGCTCTATTATGCCA
GGTAAAGTAAATCCAACGCAAAGTGAAGCATTAACGATGGTTGTAGCGCAAGTGATGGGGAATGATGCAACAATCGGATT
TGCTGCGAGTCAAGGTAATTTTGAGTTGAACGTATTTAAACCTGTTATTGCATATAACTTCTTACAATCCGCTCACTTAT
TAGCAGATGCAATTGTTTCATTTAATGATAATTGTGCAGTTGGTATTGAAGCAGATGAAGAAGTCATTAAAGAGAATGTG
AATCGTTCATTAATGCTTGTTACAGCATTAAACCCGCATATCGGATATGAAAATGCAGCGAAAATTGCGAAGCATGCTCA
TAAAGAAGGGTTAACTTTAAAAGAAGCAGCATTGCAATCTGGACTACTAACAGAAGAGCAATTTGATGAAATTGTCGATC
CGAAAAAAATGATTGCTCCGAAAGAGTAA

Upstream 100 bases:

>100_bases
ATATATAATATCTATATATAAGAGTGAGAATTCTTATCATTTAAGAGAAAGTCTGTTATTATAAGAGATGTAGGTATTAT
ATTTTCAAGGGGATGAAAAC

Downstream 100 bases:

>100_bases
TAAAAAAAGCCGAGATTCTTTGTTTAGAATCTTGGCTTTTTTAATATTTATCTTTTCTATTTGTATTACTGTAAGTACCA
AAATAAATTATTTGTTAGCA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQKLGKLSEEKAEAIVAAADEVI
AGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKRSDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLP
AITKLKETLAEKVTAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE

Sequences:

>Translated_462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQKLGKLSEEKAEAIVAAADEVI
AGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKRSDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLP
AITKLKETLAEKVTAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE
>Mature_462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQKLGKLSEEKAEAIVAAADEVI
AGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKRSDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLP
AITKLKETLAEKVTAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=59.3073593073593, Blast_Score=531, Evalue=1e-151,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=61.7067833698031, Blast_Score=567, Evalue=1e-163,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=38.8286334056399, Blast_Score=329, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=58.1344902386117, Blast_Score=533, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=57.0121951219512, Blast_Score=382, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=58.1344902386117, Blast_Score=542, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=56.6810344827586, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=56.6810344827586, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=54.9568965517241, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=53.5483870967742, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=46.2365591397849, Blast_Score=422, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50389; Mature: 50389

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQK
CCEECCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGKLSEEKAEAIVAAADEVIAGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEK
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCHHHHHHC
RSDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLPAITKLKETLAEKVTAFEHII
CCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHCCCCCCCCCHH
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGP
HHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RSGLGEIIIPANEPGSSIMPGKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFK
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENVNRSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCEEEEEEECCCCCCCHHHH
KIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQK
CCEECCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGKLSEEKAEAIVAAADEVIAGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEK
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCHHHHHHC
RSDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLPAITKLKETLAEKVTAFEHII
CCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHCCCCCCCCCHH
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGP
HHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RSGLGEIIIPANEPGSSIMPGKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFK
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENVNRSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCEEEEEEECCCCCCCHHHH
KIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]