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The map label for this gene is hisI

Identifier: 218902619

GI number: 218902619

Start: 1420005

End: 1420310

Strand: Direct

Name: hisI

Synonym: BCAH820_1502

Alternate gene names: 218902619

Gene position: 1420005-1420310 (Clockwise)

Preceding gene: 218902618

Following gene: 218902620

Centisome position: 26.78

GC content: 34.64

Gene sequence:

>306_bases
ATGAAACCTAACTTTTCAAAAGGACTATTACCGGCAGTTGTAATTGAAGAAGGTACAAAAGAAGTTTTAATGCTAGCTTA
TATGAATGAAGAAGCATATGAAAAAACGCTAAAAACGAAAAGAACATGGTTTTATTCTCGTTCAAGAAGGTCGCTATGGA
ATAAAGGAGAAACGTCAGGTCATGTCCAACATGTGCAATCTCTTTATTTAGATTGTGATCAAGATGCAATCGTCGTTTTC
GTAAAACAAGTAGGACCTGCTTGCCATACGGGAGAAAAAACGTGTTTTCATTACAAAATTATATAG

Upstream 100 bases:

>100_bases
CAGTAGATGCAGCGTTAGCGGCATCAATCTTTCATTACGGTGAAGTGACAATAGGGGACGTAAAGAGAAAGTTAAGAAAT
GCAAACGTCGAGGTGCGGTT

Downstream 100 bases:

>100_bases
GGGGATACATATGGAAAATACCTTCAAATTACTATTCGAAACAATTGAAGAACGAAAGAGAAATCCACTTCCTGAATCAT
ATACAAATTACTTGTTTTCA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 101; Mature: 101

Protein sequence:

>101_residues
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLKTKRTWFYSRSRRSLWNKGETSGHVQHVQSLYLDCDQDAIVVF
VKQVGPACHTGEKTCFHYKII

Sequences:

>Translated_101_residues
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLKTKRTWFYSRSRRSLWNKGETSGHVQHVQSLYLDCDQDAIVVF
VKQVGPACHTGEKTCFHYKII
>Mature_101_residues
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLKTKRTWFYSRSRRSLWNKGETSGHVQHVQSLYLDCDQDAIVVF
VKQVGPACHTGEKTCFHYKII

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=46.1538461538462, Blast_Score=99, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_BACAC (C3L9P6)

Other databases:

- EMBL:   CP001215
- RefSeq:   YP_002815750.1
- ProteinModelPortal:   C3L9P6
- SMR:   C3L9P6
- EnsemblBacteria:   EBBACT00000122432
- GeneID:   7783473
- GenomeReviews:   CP001215_GR
- KEGG:   bah:BAMEG_3164
- GeneTree:   EBGT00050000000892
- ProtClustDB:   PRK00051
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 11656; Mature: 11656

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLKTKRTWFYSRSRRSLWNKGETSG
CCCCCCCCCCCEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
HVQHVQSLYLDCDQDAIVVFVKQVGPACHTGEKTCFHYKII
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLKTKRTWFYSRSRRSLWNKGETSG
CCCCCCCCCCCEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
HVQHVQSLYLDCDQDAIVVFVKQVGPACHTGEKTCFHYKII
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA