Click here to switch to the map view.

The map label for this gene is hisA [H]

Identifier: 218902617

GI number: 218902617

Start: 1418537

End: 1419256

Strand: Direct

Name: hisA [H]

Synonym: BCAH820_1500

Alternate gene names: 218902617

Gene position: 1418537-1419256 (Clockwise)

Preceding gene: 218902616

Following gene: 218902618

Centisome position: 26.75

GC content: 38.47

Gene sequence:

>720_bases
ATGGAAATCTTCCCAGCTATCGATTTAAAAGAAGGGCGATGCGTTAGACTGTATCAAGGCGAGTTTAGTAAAGAAACAGT
AATGAATGAAGACCCGGTTGCGCAAGCGATTATATTTGAAAAATTTGGGGCGAAAAGGTTGCACATTGTTGATTTAGATG
GAGCAGTTGCTGGCGAGTCATTAAACTTGTCCGTCATTGAAAGGATTTGCAAGGCAGTACGTATTCCTGTGCAAGTTGGA
GGAGGAATTCGATCACTTGTAGCGGTAGAGAAGTTATTTTCAGTAGGGGTAGATAAAGTGATTTTAGGAACAGCTGCTCT
TTATGATAAGACATTTTTAGAAGAAGCAGTTCTTCTATATAAAGAAAAAATCATCGTTGGAATTGATGCGAAAAATGGTT
TCGTAGCAACGAGAGGTTGGCTTGATGTGTCTGAAATTTCTTACATTGATTTAGCAAAGCAAATGGAGAAGATAGGTGTT
CAAACGATTGTGTTTACAGACATTTCGAAAGACGGGACACTTGGAGGGCCGAATGTAGAGCAATTGGAGTTACTACAAAA
AAGCGTTGCTATTCGTCTTATTGCTTCTGGAGGAGTTGCATCTATACAAGATGTGAAAAAGTTAAATGATATGAACATAT
ACGGCGTCATAATTGGTAAGGCTCTTTACGAGAAAACGATTGATTTAGAAGAAGTGCTAGAGGTAACAAAGTTATGTTAG

Upstream 100 bases:

>100_bases
TTGTAGCAAAAGGAAATATATATGGTGCACAGTTTCACCCTGAAAAAAGTGGTGACATAGGAATGCAAATGTTGAAAAAT
TTTAAAGGAGTGGTAGAAAC

Downstream 100 bases:

>100_bases
CGAAACGCATTATTCCATGTCTAGATGTGAAAGAAGGGCGAGTCGTAAAGGGGGTAAATTTTATAGGGTTACAAGATGTC
GGTGATCCTGTTGAAATAGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MEIFPAIDLKEGRCVRLYQGEFSKETVMNEDPVAQAIIFEKFGAKRLHIVDLDGAVAGESLNLSVIERICKAVRIPVQVG
GGIRSLVAVEKLFSVGVDKVILGTAALYDKTFLEEAVLLYKEKIIVGIDAKNGFVATRGWLDVSEISYIDLAKQMEKIGV
QTIVFTDISKDGTLGGPNVEQLELLQKSVAIRLIASGGVASIQDVKKLNDMNIYGVIIGKALYEKTIDLEEVLEVTKLC

Sequences:

>Translated_239_residues
MEIFPAIDLKEGRCVRLYQGEFSKETVMNEDPVAQAIIFEKFGAKRLHIVDLDGAVAGESLNLSVIERICKAVRIPVQVG
GGIRSLVAVEKLFSVGVDKVILGTAALYDKTFLEEAVLLYKEKIIVGIDAKNGFVATRGWLDVSEISYIDLAKQMEKIGV
QTIVFTDISKDGTLGGPNVEQLELLQKSVAIRLIASGGVASIQDVKKLNDMNIYGVIIGKALYEKTIDLEEVLEVTKLC
>Mature_239_residues
MEIFPAIDLKEGRCVRLYQGEFSKETVMNEDPVAQAIIFEKFGAKRLHIVDLDGAVAGESLNLSVIERICKAVRIPVQVG
GGIRSLVAVEKLFSVGVDKVILGTAALYDKTFLEEAVLLYKEKIIVGIDAKNGFVATRGWLDVSEISYIDLAKQMEKIGV
QTIVFTDISKDGTLGGPNVEQLELLQKSVAIRLIASGGVASIQDVKKLNDMNIYGVIIGKALYEKTIDLEEVLEVTKLC

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=238, Percent_Identity=32.7731092436975, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788336, Length=242, Percent_Identity=25.6198347107438, Blast_Score=88, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26117; Mature: 26117

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFPAIDLKEGRCVRLYQGEFSKETVMNEDPVAQAIIFEKFGAKRLHIVDLDGAVAGES
CCCCCCCCCCCCCEEEEECCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
LNLSVIERICKAVRIPVQVGGGIRSLVAVEKLFSVGVDKVILGTAALYDKTFLEEAVLLY
CCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KEKIIVGIDAKNGFVATRGWLDVSEISYIDLAKQMEKIGVQTIVFTDISKDGTLGGPNVE
HCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHH
QLELLQKSVAIRLIASGGVASIQDVKKLNDMNIYGVIIGKALYEKTIDLEEVLEVTKLC
HHHHHHHHHHEEEEECCCCHHHHHHHHHCCCCEEEEEHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure
MEIFPAIDLKEGRCVRLYQGEFSKETVMNEDPVAQAIIFEKFGAKRLHIVDLDGAVAGES
CCCCCCCCCCCCCEEEEECCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
LNLSVIERICKAVRIPVQVGGGIRSLVAVEKLFSVGVDKVILGTAALYDKTFLEEAVLLY
CCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KEKIIVGIDAKNGFVATRGWLDVSEISYIDLAKQMEKIGVQTIVFTDISKDGTLGGPNVE
HCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHH
QLELLQKSVAIRLIASGGVASIQDVKKLNDMNIYGVIIGKALYEKTIDLEEVLEVTKLC
HHHHHHHHHHEEEEECCCCHHHHHHHHHCCCCEEEEEHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA