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The map label for this gene is trpA [H]

Identifier: 218902440

GI number: 218902440

Start: 1260042

End: 1260818

Strand: Direct

Name: trpA [H]

Synonym: BCAH820_1322

Alternate gene names: 218902440

Gene position: 1260042-1260818 (Clockwise)

Preceding gene: 218902439

Following gene: 218902441

Centisome position: 23.76

GC content: 40.15

Gene sequence:

>777_bases
ATGGGAGTAGAAAGAATTAAAGCAGCATTTGAAAATGGTAAGAAAGCATTTATTCCGTACGTAATGGGCGGAGATGGTGG
CCTTGAAATATTAAAAGAAAGAATGCGTTTTCTAGACGAAGCGGGAGCAAGCATCGTTGAAATTGGTATCCCGTTTTCAG
ATCCAGTCGCAGATGGCCCAACGATTCAAAGAGCAGGGAAACGAGCGCTAGATAGCGGTGTAACAGTAAAAGGCATTTTT
CAAGCATTAATAGAGGTAAGGAAAGAAGTGCAAATTCCGTTTGTACTCATGACATATTTAAATCCAGTGCTCGCTTTCGG
AAAAGAACGATTCATTGAGAGATGCTTAGAGGCAGGTGTAGACGGCATCATCGTTCCAGACTTACCGTATGAAGAACAAG
ACATTATTGCTCCGTTACTTCGAGAGGCAAACATTGCGCTCATTCCACTTGTTACTGTTACGAGCCCAATTGAGCGAATC
AAAAAAATTACGAGTGAATCAGAAGGATTTGTCTACGCCGTTACAGTAGCGGGCGTAACAGGAGTACGTCAAAATTTTAA
AGATGAGATTCATAGTTACTTAGAAAAAGTGAAATCGCATACACATTTACCGGTAGTGGCAGGGTTCGGTATTTCAACAA
AGGAACATGTGGAAGAAATGGTTACAATATGTGATGGTGTTGTCGTTGGAAGTAAAGTGATTGAGCTATTAGAAAATGAA
AAACGAGAAGAAATATGTGAATTCATACAGGCAACAAAACAAAAAGAAGAGGCGTAA

Upstream 100 bases:

>100_bases
GCCGCAAATGAAGGAAGATGAAGGACTTGTCATTTGTTTATCCGGCCGTGGTGATAAAGATGTAGAGAGTATAAAACGTT
ATATGGAAGAGGTGTAAAAA

Downstream 100 bases:

>100_bases
GTCTCTTCTTTTTGTTTTGTGTAATAAATGTTAAAATATACAGAAAATACATATAATTTAGAGGGTGAGAAAGCATGCTA
AGACGAAAACTACTATATCT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MGVERIKAAFENGKKAFIPYVMGGDGGLEILKERMRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIF
QALIEVRKEVQIPFVLMTYLNPVLAFGKERFIERCLEAGVDGIIVPDLPYEEQDIIAPLLREANIALIPLVTVTSPIERI
KKITSESEGFVYAVTVAGVTGVRQNFKDEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENE
KREEICEFIQATKQKEEA

Sequences:

>Translated_258_residues
MGVERIKAAFENGKKAFIPYVMGGDGGLEILKERMRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIF
QALIEVRKEVQIPFVLMTYLNPVLAFGKERFIERCLEAGVDGIIVPDLPYEEQDIIAPLLREANIALIPLVTVTSPIERI
KKITSESEGFVYAVTVAGVTGVRQNFKDEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENE
KREEICEFIQATKQKEEA
>Mature_257_residues
GVERIKAAFENGKKAFIPYVMGGDGGLEILKERMRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIFQ
ALIEVRKEVQIPFVLMTYLNPVLAFGKERFIERCLEAGVDGIIVPDLPYEEQDIIAPLLREANIALIPLVTVTSPIERIK
KITSESEGFVYAVTVAGVTGVRQNFKDEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENEK
REEICEFIQATKQKEEA

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=250, Percent_Identity=34.8, Blast_Score=133, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321412, Length=258, Percent_Identity=34.4961240310078, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 28397; Mature: 28266

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVERIKAAFENGKKAFIPYVMGGDGGLEILKERMRFLDEAGASIVEIGIPFSDPVADGP
CCHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
TIQRAGKRALDSGVTVKGIFQALIEVRKEVQIPFVLMTYLNPVLAFGKERFIERCLEAGV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
DGIIVPDLPYEEQDIIAPLLREANIALIPLVTVTSPIERIKKITSESEGFVYAVTVAGVT
CEEEECCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHH
GVRQNFKDEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENE
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
KREEICEFIQATKQKEEA
CHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GVERIKAAFENGKKAFIPYVMGGDGGLEILKERMRFLDEAGASIVEIGIPFSDPVADGP
CHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
TIQRAGKRALDSGVTVKGIFQALIEVRKEVQIPFVLMTYLNPVLAFGKERFIERCLEAGV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
DGIIVPDLPYEEQDIIAPLLREANIALIPLVTVTSPIERIKKITSESEGFVYAVTVAGVT
CEEEECCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHH
GVRQNFKDEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENE
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
KREEICEFIQATKQKEEA
CHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA