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The map label for this gene is glpK [H]

Identifier: 218902224

GI number: 218902224

Start: 1057712

End: 1059202

Strand: Direct

Name: glpK [H]

Synonym: BCAH820_1106

Alternate gene names: 218902224

Gene position: 1057712-1059202 (Clockwise)

Preceding gene: 218902223

Following gene: 218902225

Centisome position: 19.95

GC content: 40.17

Gene sequence:

>1491_bases
ATGAAAAAATATATTCTTTCATTAGACCAAGGAACAACTAGCTCACGCGCAATTCTTTTCAATAAAAAAGGTGAAATTGT
TCATTCAGCTCAAAAAGAATTTACACAACATTTTCCAAAGCCAGGCTGGGTAGAGCATAACGCGCAAGAAATTTGGGGAT
CTATTTTAGCGGTTATCGCAACTTGCTTAAGCGAAGCTGATGTAAAGCCAGAACAAATCGCTGGTATCGGTATTACGAAC
CAACGTGAAACAGCGGTTGTATGGGATAAAACGACTGGTAAACCAATTTATAACGCAATTGTATGGCAATCTCGCCAAAC
AGCTGAAATTTGTGATGAGTTAAAAGAAAAAGGTTATAGCGAAATGGTTCGCGAAAAAACAGGTCTTTTAATTGACGCAT
ACTTCTCTGGTACGAAAGTAAAATGGATTTTAGATAACGTTGAAGGTGCAAGAGAGAAAGCAGAAAACGGCGATCTATTA
TTCGGAACAATTGATACGTGGCTTGTATGGAAACTATCTGGTGGTAAAGCGCACGTAACGGATTACTCAAATGCGTCACG
TACATTAATGTTTAACATTCACGACTTACAGTGGGATGATGAACTTCTAGACATGTTAACAGTACCAAAGAGCATGCTTC
CAGAAGTACGTCCATCATCTGAAGTGTATGGAGAAACAATTGACTATCACTTCTTCGGTCAAAATGTACCGATTGCAGGT
GTAGCTGGTGATCAACAAGCGGCATTATTTGGACAAGCTTGTTTCGGTGAAGGTATGGCGAAAAATACTTACGGAACTGG
TTGCTTCATGTTAATGAATACTGGTGAAAAAGCAGTAGCTTCTGAGCACGGCCTATTAACAACAATTGCATGGGGAATAG
ATGGTAAAGTAAACTACGCATTAGAAGGAAGTATTTTCGTAGCGGGTTCTGCAATTCAGTGGTTACGTGACGGAATGCGC
ATGTTTAAAGATGCAAGTGAGAGTGAAGTATATGCTTCTCGTGTTGAATCAACTGACGGTGTATACGTTGTACCAGCATT
CGTAGGATTAGGTACGCCTTACTGGGATAGTGAAGTACGCGGCGCTATGTTTGGTGTAACGCGCGGTACGACGAAAGAAC
ACTTCATTCGTGCAACATTAGAATCTTTAGCTTACCAAACAAAAGACGTATTATGCGCAATGGAAGCAGATTCAGGTATT
GAACTAAAAACATTACGCGTTGATGGCGGAGCAGTTAAAAATAACTTCTTAATGAAGTTCCAAAGTGATATTTTAGACGT
TCCTGTAGAGCGTCCAGTGATCAATGAAACAACAGCTTTAGGTGCAGCGTACTTAGCTGGTCTTGCGGTTGGATATTGGA
AAAACCAAGATGAAATTAAAGAACAGTGGCATATGGACAAACGCTTTGAGCCAACGATGGAAGCGGAAACAAGCGAAGAG
CTATATGCTGGATGGAAAAAAGCAATTGAAGCAACAAAAGCTTTCAAATAA

Upstream 100 bases:

>100_bases
ATTATTGCAACTGTGATTGTACTAGCAATCTCTTATATGACAAGCAAAAAAAGTGGAAGCAATACAAATAGTAGAAAAGT
AGCATAAGGGGGAAACCATT

Downstream 100 bases:

>100_bases
TCATAAACAGTGTTATAATGGTGACAAGTTAATAATTCGGTAGGAGATTTGGAGAGACCACAACACGCTATAGAGGCGAA
ATCTATAGCGGAGTTTGTGG

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIATCLSEADVKPEQIAGIGITN
QRETAVVWDKTTGKPIYNAIVWQSRQTAEICDELKEKGYSEMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLL
FGTIDTWLVWKLSGGKAHVTDYSNASRTLMFNIHDLQWDDELLDMLTVPKSMLPEVRPSSEVYGETIDYHFFGQNVPIAG
VAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGMR
MFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVRGAMFGVTRGTTKEHFIRATLESLAYQTKDVLCAMEADSGI
ELKTLRVDGGAVKNNFLMKFQSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAETSEE
LYAGWKKAIEATKAFK

Sequences:

>Translated_496_residues
MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIATCLSEADVKPEQIAGIGITN
QRETAVVWDKTTGKPIYNAIVWQSRQTAEICDELKEKGYSEMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLL
FGTIDTWLVWKLSGGKAHVTDYSNASRTLMFNIHDLQWDDELLDMLTVPKSMLPEVRPSSEVYGETIDYHFFGQNVPIAG
VAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGMR
MFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVRGAMFGVTRGTTKEHFIRATLESLAYQTKDVLCAMEADSGI
ELKTLRVDGGAVKNNFLMKFQSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAETSEE
LYAGWKKAIEATKAFK
>Mature_496_residues
MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIATCLSEADVKPEQIAGIGITN
QRETAVVWDKTTGKPIYNAIVWQSRQTAEICDELKEKGYSEMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLL
FGTIDTWLVWKLSGGKAHVTDYSNASRTLMFNIHDLQWDDELLDMLTVPKSMLPEVRPSSEVYGETIDYHFFGQNVPIAG
VAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGMR
MFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVRGAMFGVTRGTTKEHFIRATLESLAYQTKDVLCAMEADSGI
ELKTLRVDGGAVKNNFLMKFQSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAETSEE
LYAGWKKAIEATKAFK

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393575, Length=493, Percent_Identity=47.0588235294118, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI42794763, Length=500, Percent_Identity=46.4, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI4504007, Length=496, Percent_Identity=46.7741935483871, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI189409120, Length=496, Percent_Identity=46.7741935483871, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI88196792, Length=503, Percent_Identity=33.0019880715706, Blast_Score=313, Evalue=3e-85,
Organism=Escherichia coli, GI1790361, Length=495, Percent_Identity=63.4343434343434, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1790005, Length=526, Percent_Identity=24.1444866920152, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1789168, Length=494, Percent_Identity=24.2914979757085, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1787789, Length=495, Percent_Identity=24.040404040404, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1789987, Length=486, Percent_Identity=23.2510288065844, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17535599, Length=500, Percent_Identity=41.2, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71986140, Length=520, Percent_Identity=25.9615384615385, Blast_Score=191, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI71986147, Length=272, Percent_Identity=30.8823529411765, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6321755, Length=515, Percent_Identity=36.3106796116505, Blast_Score=311, Evalue=2e-85,
Organism=Drosophila melanogaster, GI17864214, Length=501, Percent_Identity=42.7145708582834, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24654573, Length=432, Percent_Identity=44.4444444444444, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655555, Length=466, Percent_Identity=40.1287553648069, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655560, Length=466, Percent_Identity=40.1287553648069, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655570, Length=466, Percent_Identity=40.1287553648069, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655574, Length=466, Percent_Identity=40.1287553648069, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655565, Length=466, Percent_Identity=40.1287553648069, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19922058, Length=522, Percent_Identity=30.6513409961686, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24652871, Length=489, Percent_Identity=31.2883435582822, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24656367, Length=508, Percent_Identity=27.5590551181102, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21357867, Length=523, Percent_Identity=26.5774378585086, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24656372, Length=343, Percent_Identity=28.2798833819242, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45552909, Length=290, Percent_Identity=26.2068965517241, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55045; Mature: 55045

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIA
CCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
TCLSEADVKPEQIAGIGITNQRETAVVWDKTTGKPIYNAIVWQSRQTAEICDELKEKGYS
HHHHHCCCCHHHEEECCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHCCHH
EMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLLFGTIDTWLVWKLSGGKAHVT
HHHHHHCCCEEEEEECCCEEEEEEECCHHHHHHCCCCCEEEEEECEEEEEEECCCEEEEE
DYSNASRTLMFNIHDLQWDDELLDMLTVPKSMLPEVRPSSEVYGETIDYHFFGQNVPIAG
ECCCCCEEEEEEEECCCCCHHHHHHHHCCHHHCCCCCCCHHHCCCCEEEEEECCCCCEEE
VAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYA
ECCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHCCCCCEEEEEECCCCEEEEE
LEGSIFVAGSAIQWLRDGMRMFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVR
EECCEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCCCCCCC
GAMFGVTRGTTKEHFIRATLESLAYQTKDVLCAMEADSGIELKTLRVDGGAVKNNFLMKF
CEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCCCCCHHHHEE
QSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAETSEE
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHH
LYAGWKKAIEATKAFK
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIA
CCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
TCLSEADVKPEQIAGIGITNQRETAVVWDKTTGKPIYNAIVWQSRQTAEICDELKEKGYS
HHHHHCCCCHHHEEECCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHCCHH
EMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLLFGTIDTWLVWKLSGGKAHVT
HHHHHHCCCEEEEEECCCEEEEEEECCHHHHHHCCCCCEEEEEECEEEEEEECCCEEEEE
DYSNASRTLMFNIHDLQWDDELLDMLTVPKSMLPEVRPSSEVYGETIDYHFFGQNVPIAG
ECCCCCEEEEEEEECCCCCHHHHHHHHCCHHHCCCCCCCHHHCCCCEEEEEECCCCCEEE
VAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYA
ECCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHCCCCCEEEEEECCCCEEEEE
LEGSIFVAGSAIQWLRDGMRMFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVR
EECCEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCCCCCCC
GAMFGVTRGTTKEHFIRATLESLAYQTKDVLCAMEADSGIELKTLRVDGGAVKNNFLMKF
CEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCCCCCHHHHEE
QSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAETSEE
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHH
LYAGWKKAIEATKAFK
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA