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The map label for this gene is 218884636

Identifier: 218884636

GI number: 218884636

Start: 1236959

End: 1237678

Strand: Reverse

Name: 218884636

Synonym: DKAM_1325

Alternate gene names: NA

Gene position: 1237678-1236959 (Counterclockwise)

Preceding gene: 218884637

Following gene: 218884635

Centisome position: 90.66

GC content: 41.81

Gene sequence:

>720_bases
ATGAAGGTTCTAGTAGCTGATAGACAGTTAGTGAGACCGGGAGACTGCCTCGCGATACTTGAGGAAGGCATTATCTCAAA
TGAGATCAAGAGGTACCCGGATAAACACATATATGTTCTAGACAATAAGGTATACAGCGATGTACTCGGCATAGTCTACA
TTGAGGATAAAGACATCAATGTCATACCACTTGAAAGCGTTTACTACCCAAGGAAAGATGATACAGTTATAGGGATCGTA
GATAGTATAGGCGTAACCTCGTGGAGCATAGATATACGTGCACCATACAAGGCGATCCTGCCCGGTTCAGATGTTATCGA
GGGATTCAACCCTATAACTCATAACTTGAGGAACTACCTGGATACAGGTGATTTAATCCTGGCGAAAATAGCGATCTTCG
ATAGAACCAGAGACCCCATGCTAACTACGAAGGGTAAAGGATTAGGGAAAATACTTGAAGGGGTAGTTGTCGAGATTAAG
CCGAGTAAAGTAGCTAGGCTGGTGGGTAAGAAGGGTAGTATGTATAATCTACTATCGAGTAAAAGCGGCTGTGATATAAC
GATTGCACAGAACGGGTACGTATGGCTAAAATGCAAAGATGAATATGTTACCAAAGTTTTAATAGAGGCAATAAGACTCA
TTGAGTTAAAAGCACACATACGTGGTCTAACCGAGGAAGTAAGAGTATTTCTAGAATCCAAGCTTGGTGAAGGCAAATGA

Upstream 100 bases:

>100_bases
GAGATTCCGGCTGGATTGCAACAAGAGTTAATAGATAAAGTCAACGCTTTAACAAAGGGTAGCGGGGAAGTTAAGATATT
GAACGTGGGGTGAGAGATCG

Downstream 100 bases:

>100_bases
GTGGAAAACCTGTATTAATCAGGGATGGATTAAGAATAGATGGGAGAAAACCGGAGGAACTACGTCCGGTTAGAATAGCG
TTAGGAGTCTTGAAAAATGC

Product: exosome complex RNA-binding protein Rrp4

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MKVLVADRQLVRPGDCLAILEEGIISNEIKRYPDKHIYVLDNKVYSDVLGIVYIEDKDINVIPLESVYYPRKDDTVIGIV
DSIGVTSWSIDIRAPYKAILPGSDVIEGFNPITHNLRNYLDTGDLILAKIAIFDRTRDPMLTTKGKGLGKILEGVVVEIK
PSKVARLVGKKGSMYNLLSSKSGCDITIAQNGYVWLKCKDEYVTKVLIEAIRLIELKAHIRGLTEEVRVFLESKLGEGK

Sequences:

>Translated_239_residues
MKVLVADRQLVRPGDCLAILEEGIISNEIKRYPDKHIYVLDNKVYSDVLGIVYIEDKDINVIPLESVYYPRKDDTVIGIV
DSIGVTSWSIDIRAPYKAILPGSDVIEGFNPITHNLRNYLDTGDLILAKIAIFDRTRDPMLTTKGKGLGKILEGVVVEIK
PSKVARLVGKKGSMYNLLSSKSGCDITIAQNGYVWLKCKDEYVTKVLIEAIRLIELKAHIRGLTEEVRVFLESKLGEGK
>Mature_239_residues
MKVLVADRQLVRPGDCLAILEEGIISNEIKRYPDKHIYVLDNKVYSDVLGIVYIEDKDINVIPLESVYYPRKDDTVIGIV
DSIGVTSWSIDIRAPYKAILPGSDVIEGFNPITHNLRNYLDTGDLILAKIAIFDRTRDPMLTTKGKGLGKILEGVVVEIK
PSKVARLVGKKGSMYNLLSSKSGCDITIAQNGYVWLKCKDEYVTKVLIEAIRLIELKAHIRGLTEEVRVFLESKLGEGK

Specific function: Probably involved in degradation of a variety of RNA species; could act a RNA-binding component of the exosome (Potential) [H]

COG id: COG1097

COG function: function code J; RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321860, Length=199, Percent_Identity=26.1306532663317, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24762324, Length=166, Percent_Identity=28.3132530120482, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004087
- InterPro:   IPR018111
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967 [H]

Pfam domain/function: PF00013 KH_1; PF00575 S1 [H]

EC number: NA

Molecular weight: Translated: 26703; Mature: 26703

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVADRQLVRPGDCLAILEEGIISNEIKRYPDKHIYVLDNKVYSDVLGIVYIEDKDIN
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHCEEEEEEEECCCCE
VIPLESVYYPRKDDTVIGIVDSIGVTSWSIDIRAPYKAILPGSDVIEGFNPITHNLRNYL
EEECHHEECCCCCCEEEEEECCCCCEEEEEEEECCEEEECCCHHHHHCCCHHHHHHHHHC
DTGDLILAKIAIFDRTRDPMLTTKGKGLGKILEGVVVEIKPSKVARLVGKKGSMYNLLSS
CCCHHHHHHHHHHCCCCCCCEEECCCCHHHHHCCEEEEECHHHHHHHHCCCCCEEHHHCC
KSGCDITIAQNGYVWLKCKDEYVTKVLIEAIRLIELKAHIRGLTEEVRVFLESKLGEGK
CCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKVLVADRQLVRPGDCLAILEEGIISNEIKRYPDKHIYVLDNKVYSDVLGIVYIEDKDIN
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHCEEEEEEEECCCCE
VIPLESVYYPRKDDTVIGIVDSIGVTSWSIDIRAPYKAILPGSDVIEGFNPITHNLRNYL
EEECHHEECCCCCCEEEEEECCCCCEEEEEEEECCEEEECCCHHHHHCCCHHHHHHHHHC
DTGDLILAKIAIFDRTRDPMLTTKGKGLGKILEGVVVEIKPSKVARLVGKKGSMYNLLSS
CCCHHHHHHHHHHCCCCCCCEEECCCCHHHHHCCEEEEECHHHHHHHHCCCCCEEHHHCC
KSGCDITIAQNGYVWLKCKDEYVTKVLIEAIRLIELKAHIRGLTEEVRVFLESKLGEGK
CCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]