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The map label for this gene is top6A [H]

Identifier: 218884529

GI number: 218884529

Start: 1140303

End: 1141604

Strand: Reverse

Name: top6A [H]

Synonym: DKAM_1218

Alternate gene names: 218884529

Gene position: 1141604-1140303 (Counterclockwise)

Preceding gene: 218884530

Following gene: 218884528

Centisome position: 83.62

GC content: 45.85

Gene sequence:

>1302_bases
ATGGTGTCCGCAATCGATCTTGAGGCGAGGAAGAAGGCGGCTGAGTTAATGAGGAAAATATTTATGAATATAGTAAGTGA
GATAGAAAGGGAAGGGCGTCCAGTACTCGTGTTACCTAAGAGAACCCTCTCCAACACCATATACGATTATAAAAATAAGC
TTCTCTTGCTTGGTCCTGAGACGTCGAAGAGAAGCTTCATGGATGTCAATGAAGCAAGGAAGTTCATGCAAACGGTTCTC
GTGGCCTCGATAATTTATGATTCACTAGTTAACAACGAGTATCCCACTATCCGTGACCTCTACTACAGGGGGAAGCATAG
TATAAGCTATAGGAGCGGAGGGAAGGAGGTCCATGAAAACACGTGGGACGAGCAGAAGGAGTCTGATGGGGTGATAAGGG
ATCTAGAAGTATATCTCAACATCTTAAGGGAGGAGCTCCTCATACTCAGCAAGGAGAAGGGTAAGGTCGTAGGAAACCTC
GTTATAAGGAGCGGTGATGACGTGATAGATTTAAGCCGTATGGGGCATGGTGCATACTCAATTGAACCTACCCCTGACCT
AATAGAGTTCAAGGATGTTGATGCAGAATATATCCTAGTAGTTGAGAAGGATGCGGTTTTCCAGCAGTTACATAGGTATG
GCTTCTGGAAGAAGCATAAGGCTATATTGATCACTAGTGCGGGCCAGCCTGACAGGGCTACAAGACGTTTCCTGAGAAGG
CTCAGCGATGAGTATAATCTACCAGTGTATATCCTAGCCGACAGCGACCCCTATGGGTTTTACATATATAGCGTCTTCAA
GATAGGTAGTATAACACTGTCATATGAAAGCGAGAGGCTTGCAACACCTAGGGCTAAATTCATAGGGGTCATGATGACCG
ATGTCTTCGGGGACGACATCTTCAGGGAGATGCTCAGGGAAAAGGATTCCAGGAGCAGGTTAAACTCCATTGTTAAGGGA
CTAGATAAGCTGGCTAAGAAGAAGCCCTACCTCTCGGAGGCGGAGAGAAGAAACTATATAATCAAGGCTAAACAGCGAGA
TCTAGAGAGAGCAGTAGAGCTAGTGGGCTACGATATAGCGGATACATGCCTCGACAACACAGAGTTGAAGAGCAAGCTGA
AGAAGAAAGAAGGATTAACAGGCTACCCATGGTTCCAGACACCGGAATGGATCAGGGAGCTCTGCATATTCTTCAAAACA
CTGAGCAAGCTTGAAATAGAGGCGATGGCGAGCAAGGGATTGAAATTCCTAGCTGACCATTATATTCCAGAGAAAATATC
CGGCGGGGACTGGATAGATTAG

Upstream 100 bases:

>100_bases
AAAAGCTGGTCTCAATAATATCTAGGCGTACAGGTATACCTGAATCCGAGATACAGCAGGTACTTGAATCAATTAGAATA
GGGACTTAGGTGATTGTATA

Downstream 100 bases:

>100_bases
GGATGGGTTTTCATAGCGGTTTATGGTGATTGATTTCACCGCTTGACATCATGTCCCCCGTCTTCTCTCTACGCCGCCTA
CGAGGGCATGCCTCCCCTCG

Product: DNA topoisomerase VI subunit A

Products: NA

Alternate protein names: Type II DNA topoisomerase VI subunit A [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MVSAIDLEARKKAAELMRKIFMNIVSEIEREGRPVLVLPKRTLSNTIYDYKNKLLLLGPETSKRSFMDVNEARKFMQTVL
VASIIYDSLVNNEYPTIRDLYYRGKHSISYRSGGKEVHENTWDEQKESDGVIRDLEVYLNILREELLILSKEKGKVVGNL
VIRSGDDVIDLSRMGHGAYSIEPTPDLIEFKDVDAEYILVVEKDAVFQQLHRYGFWKKHKAILITSAGQPDRATRRFLRR
LSDEYNLPVYILADSDPYGFYIYSVFKIGSITLSYESERLATPRAKFIGVMMTDVFGDDIFREMLREKDSRSRLNSIVKG
LDKLAKKKPYLSEAERRNYIIKAKQRDLERAVELVGYDIADTCLDNTELKSKLKKKEGLTGYPWFQTPEWIRELCIFFKT
LSKLEIEAMASKGLKFLADHYIPEKISGGDWID

Sequences:

>Translated_433_residues
MVSAIDLEARKKAAELMRKIFMNIVSEIEREGRPVLVLPKRTLSNTIYDYKNKLLLLGPETSKRSFMDVNEARKFMQTVL
VASIIYDSLVNNEYPTIRDLYYRGKHSISYRSGGKEVHENTWDEQKESDGVIRDLEVYLNILREELLILSKEKGKVVGNL
VIRSGDDVIDLSRMGHGAYSIEPTPDLIEFKDVDAEYILVVEKDAVFQQLHRYGFWKKHKAILITSAGQPDRATRRFLRR
LSDEYNLPVYILADSDPYGFYIYSVFKIGSITLSYESERLATPRAKFIGVMMTDVFGDDIFREMLREKDSRSRLNSIVKG
LDKLAKKKPYLSEAERRNYIIKAKQRDLERAVELVGYDIADTCLDNTELKSKLKKKEGLTGYPWFQTPEWIRELCIFFKT
LSKLEIEAMASKGLKFLADHYIPEKISGGDWID
>Mature_433_residues
MVSAIDLEARKKAAELMRKIFMNIVSEIEREGRPVLVLPKRTLSNTIYDYKNKLLLLGPETSKRSFMDVNEARKFMQTVL
VASIIYDSLVNNEYPTIRDLYYRGKHSISYRSGGKEVHENTWDEQKESDGVIRDLEVYLNILREELLILSKEKGKVVGNL
VIRSGDDVIDLSRMGHGAYSIEPTPDLIEFKDVDAEYILVVEKDAVFQQLHRYGFWKKHKAILITSAGQPDRATRRFLRR
LSDEYNLPVYILADSDPYGFYIYSVFKIGSITLSYESERLATPRAKFIGVMMTDVFGDDIFREMLREKDSRSRLNSIVKG
LDKLAKKKPYLSEAERRNYIIKAKQRDLERAVELVGYDIADTCLDNTELKSKLKKKEGLTGYPWFQTPEWIRELCIFFKT
LSKLEIEAMASKGLKFLADHYIPEKISGGDWID

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity [H]

COG id: COG1697

COG function: function code L; DNA topoisomerase VI, subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6A family [H]

Homologues:

Organism=Homo sapiens, GI6912680, Length=420, Percent_Identity=25.7142857142857, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI38201680, Length=364, Percent_Identity=27.1978021978022, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17542064, Length=253, Percent_Identity=32.4110671936759, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45552753, Length=292, Percent_Identity=28.0821917808219, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002815
- InterPro:   IPR013049
- InterPro:   IPR004085
- InterPro:   IPR022904
- InterPro:   IPR011991 [H]

Pfam domain/function: PF04406 TP6A_N [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 50110; Mature: 50110

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSAIDLEARKKAAELMRKIFMNIVSEIEREGRPVLVLPKRTLSNTIYDYKNKLLLLGPE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCEEEECCC
TSKRSFMDVNEARKFMQTVLVASIIYDSLVNNEYPTIRDLYYRGKHSISYRSGGKEVHEN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEECCCCCHHHHC
TWDEQKESDGVIRDLEVYLNILREELLILSKEKGKVVGNLVIRSGDDVIDLSRMGHGAYS
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEHHHCCCCCEE
IEPTPDLIEFKDVDAEYILVVEKDAVFQQLHRYGFWKKHKAILITSAGQPDRATRRFLRR
CCCCCCCEEEECCCCEEEEEEECHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHH
LSDEYNLPVYILADSDPYGFYIYSVFKIGSITLSYESERLATPRAKFIGVMMTDVFGDDI
HCCCCCCCEEEEECCCCCCEEEEEEEHHCEEEEEECCHHHCCCHHHHHHHHHHHHHHHHH
FREMLREKDSRSRLNSIVKGLDKLAKKKPYLSEAERRNYIIKAKQRDLERAVELVGYDIA
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCEEEEHHHHHHHHHHHHHCCCHH
DTCLDNTELKSKLKKKEGLTGYPWFQTPEWIRELCIFFKTLSKLEIEAMASKGLKFLADH
HHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
YIPEKISGGDWID
CCCCCCCCCCCCC
>Mature Secondary Structure
MVSAIDLEARKKAAELMRKIFMNIVSEIEREGRPVLVLPKRTLSNTIYDYKNKLLLLGPE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCEEEECCC
TSKRSFMDVNEARKFMQTVLVASIIYDSLVNNEYPTIRDLYYRGKHSISYRSGGKEVHEN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEECCCCCHHHHC
TWDEQKESDGVIRDLEVYLNILREELLILSKEKGKVVGNLVIRSGDDVIDLSRMGHGAYS
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEHHHCCCCCEE
IEPTPDLIEFKDVDAEYILVVEKDAVFQQLHRYGFWKKHKAILITSAGQPDRATRRFLRR
CCCCCCCEEEECCCCEEEEEEECHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHH
LSDEYNLPVYILADSDPYGFYIYSVFKIGSITLSYESERLATPRAKFIGVMMTDVFGDDI
HCCCCCCCEEEEECCCCCCEEEEEEEHHCEEEEEECCHHHCCCHHHHHHHHHHHHHHHHH
FREMLREKDSRSRLNSIVKGLDKLAKKKPYLSEAERRNYIIKAKQRDLERAVELVGYDIA
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCEEEEHHHHHHHHHHHHHCCCHH
DTCLDNTELKSKLKKKEGLTGYPWFQTPEWIRELCIFFKTLSKLEIEAMASKGLKFLADH
HHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
YIPEKISGGDWID
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA