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The map label for this gene is secY [H]

Identifier: 218884463

GI number: 218884463

Start: 1080829

End: 1082268

Strand: Reverse

Name: secY [H]

Synonym: DKAM_1152

Alternate gene names: 218884463

Gene position: 1082268-1080829 (Counterclockwise)

Preceding gene: 218884464

Following gene: 218884462

Centisome position: 79.27

GC content: 47.22

Gene sequence:

>1440_bases
ATGGGGGTCTGGGGAATGGGTTTACTCAGGGTGATGGCTAAAATAGCGGATTACCTACCTACAGCGGTTAAGCCGCAGGG
CAAGCCCTCGATGTATGAGAGGCTGTTCTGGACCGGTGTGGCTTTAATAGTCTACATGATAATGGCTAATACACCGCTCT
ACGGTATATCCTATGCTGGACCTGAGCAGATATTATTAATACAGATAATATTCGCGTCCAACAGGGGTACGTTAATGGAG
CTCGGTATAGGGCCTATTGTAACGGCAGGCTTGATAATGCAGATCCTTGTGGGTGCTAAGTTGATCAACCTTGATTTAAC
GGATCCCGAGGACAGGAAGGTTTTCACTGCTTCCCAGAAAACCCTAGCCGTTATACTGGCGGCCTTCGAGGCCGGAATGT
ACGTCTTGTCATGCAGGTACTGGATGCCTCTGGGTAATCCTGTGACAGCTTGTAGTGCTGGATGGCATGTCCGCTTAATA
GTGTGGCTCCAATTATTCGTTGCATCCTACCTTGTAATAGTCCTGGATGAGACGATTCAAAAGGGCTGGGGTATAGGCTC
CGGTGTCTCACTGTTCATACTGGCTGGTGTTGCTACAACTATATTCTGGAATATCTTCAGCACTGTGACTTATCAGGGGC
AGCCAATAGGCTTCATACCATACATGATCCAGGTGATAAGCAGTGGTGGTGGCTTAGGTAATGTATTGCTCAGGCCCGGC
GGTAGAGACCTTGTTGGACTCATAGCTACTATAGTTATAATGTTTATCCTTGTATACTTGAGCAATATGAAGGTCGAAAT
ACCCGTTACATCACCGAGGTTGCAGAGCATTAAGACCAAGATACCGCTCCAGTTCCTCTATGTAACCAATATACCCGTGT
TATTTGTAGGTATACTTTACGCCAACATACTTGTCTTCGCAACATTGTTCAGGGTTTACCTTGCGTCAGTGGTGCCCCCG
AGCTTTGTTGACCTATTAGCTAGATACGATACCTCAGGTAGGCTTGTCGGTGGATTAGCATACTACCTCGCATCGCCTAA
TGGCTTATATAGTGCTCTATCCGATCCAGCTCATCTAATAGTGTATAGTTTACTGGTCTTCATACTGGCAGTCCTATTCG
GGTTGATGTGGGTCGAGGTCGCTGGATTAAACCCGGCTGCACAGGCTGAACAATTAATCAGTAGTGGATTCGAGGTTCCA
GGGTTAAGAAACAACCCGAAGATTCTTGAGAAAATACTAGCCAAGTACATTTATCCCTTGACAGTGCTTTCAAGCCTTAT
TGTTGCAGCGATAGCTGTGCTAGCGGATGCATTAGGAGCCTATGGTACTGGCACCGGGATACTGCTGGCTATAGGTATCC
TGCAGCAGTACTACGCGTTAATAGCTTACGAGAGAACTCTCGAGGCATACCCGTTGCTAAGGCGCCTTGTGGGAGAGTAG

Upstream 100 bases:

>100_bases
AGACCCGAACCCTCCATAATGAAATGAATTTAATAAGCCCCTCACGACTCATTATAGAGTCTAGTCTAGACTAAATATTG
GGCTTATACTACAGTGATGG

Downstream 100 bases:

>100_bases
TAATGATCACAACGATTGTTTTACTCGTCTCCATTTCATCAGCCATATTAATATCCCTGCTTATTAAAGCTGTTAGGAAT
CATCCATATTTCAGCGAAGC

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: Protein transport protein SEC61 subunit alpha homolog [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MGVWGMGLLRVMAKIADYLPTAVKPQGKPSMYERLFWTGVALIVYMIMANTPLYGISYAGPEQILLIQIIFASNRGTLME
LGIGPIVTAGLIMQILVGAKLINLDLTDPEDRKVFTASQKTLAVILAAFEAGMYVLSCRYWMPLGNPVTACSAGWHVRLI
VWLQLFVASYLVIVLDETIQKGWGIGSGVSLFILAGVATTIFWNIFSTVTYQGQPIGFIPYMIQVISSGGGLGNVLLRPG
GRDLVGLIATIVIMFILVYLSNMKVEIPVTSPRLQSIKTKIPLQFLYVTNIPVLFVGILYANILVFATLFRVYLASVVPP
SFVDLLARYDTSGRLVGGLAYYLASPNGLYSALSDPAHLIVYSLLVFILAVLFGLMWVEVAGLNPAAQAEQLISSGFEVP
GLRNNPKILEKILAKYIYPLTVLSSLIVAAIAVLADALGAYGTGTGILLAIGILQQYYALIAYERTLEAYPLLRRLVGE

Sequences:

>Translated_479_residues
MGVWGMGLLRVMAKIADYLPTAVKPQGKPSMYERLFWTGVALIVYMIMANTPLYGISYAGPEQILLIQIIFASNRGTLME
LGIGPIVTAGLIMQILVGAKLINLDLTDPEDRKVFTASQKTLAVILAAFEAGMYVLSCRYWMPLGNPVTACSAGWHVRLI
VWLQLFVASYLVIVLDETIQKGWGIGSGVSLFILAGVATTIFWNIFSTVTYQGQPIGFIPYMIQVISSGGGLGNVLLRPG
GRDLVGLIATIVIMFILVYLSNMKVEIPVTSPRLQSIKTKIPLQFLYVTNIPVLFVGILYANILVFATLFRVYLASVVPP
SFVDLLARYDTSGRLVGGLAYYLASPNGLYSALSDPAHLIVYSLLVFILAVLFGLMWVEVAGLNPAAQAEQLISSGFEVP
GLRNNPKILEKILAKYIYPLTVLSSLIVAAIAVLADALGAYGTGTGILLAIGILQQYYALIAYERTLEAYPLLRRLVGE
>Mature_478_residues
GVWGMGLLRVMAKIADYLPTAVKPQGKPSMYERLFWTGVALIVYMIMANTPLYGISYAGPEQILLIQIIFASNRGTLMEL
GIGPIVTAGLIMQILVGAKLINLDLTDPEDRKVFTASQKTLAVILAAFEAGMYVLSCRYWMPLGNPVTACSAGWHVRLIV
WLQLFVASYLVIVLDETIQKGWGIGSGVSLFILAGVATTIFWNIFSTVTYQGQPIGFIPYMIQVISSGGGLGNVLLRPGG
RDLVGLIATIVIMFILVYLSNMKVEIPVTSPRLQSIKTKIPLQFLYVTNIPVLFVGILYANILVFATLFRVYLASVVPPS
FVDLLARYDTSGRLVGGLAYYLASPNGLYSALSDPAHLIVYSLLVFILAVLFGLMWVEVAGLNPAAQAEQLISSGFEVPG
LRNNPKILEKILAKYIYPLTVLSSLIVAAIAVLADALGAYGTGTGILLAIGILQQYYALIAYERTLEAYPLLRRLVGE

Specific function: Involved in protein export. Interacts with secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel [H]

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family [H]

Homologues:

Organism=Homo sapiens, GI14589847, Length=477, Percent_Identity=34.1719077568134, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI7019415, Length=472, Percent_Identity=33.6864406779661, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI217330618, Length=477, Percent_Identity=33.3333333333333, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI217330616, Length=422, Percent_Identity=32.9383886255924, Blast_Score=218, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17543770, Length=474, Percent_Identity=32.4894514767932, Blast_Score=243, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6323411, Length=473, Percent_Identity=30.0211416490486, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319760, Length=467, Percent_Identity=23.5546038543897, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI19920826, Length=478, Percent_Identity=33.4728033472803, Blast_Score=252, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002208
- InterPro:   IPR023201
- InterPro:   IPR019561 [H]

Pfam domain/function: PF10559 Plug_translocon; PF00344 SecY [H]

EC number: NA

Molecular weight: Translated: 52058; Mature: 51927

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00755 SECY_1 ; PS00756 SECY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVWGMGLLRVMAKIADYLPTAVKPQGKPSMYERLFWTGVALIVYMIMANTPLYGISYAG
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PEQILLIQIIFASNRGTLMELGIGPIVTAGLIMQILVGAKLINLDLTDPEDRKVFTASQK
CCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEECCHH
TLAVILAAFEAGMYVLSCRYWMPLGNPVTACSAGWHVRLIVWLQLFVASYLVIVLDETIQ
HHHHHHHHHHHCHHEEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KGWGIGSGVSLFILAGVATTIFWNIFSTVTYQGQPIGFIPYMIQVISSGGGLGNVLLRPG
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCCEEEECCC
GRDLVGLIATIVIMFILVYLSNMKVEIPVTSPRLQSIKTKIPLQFLYVTNIPVLFVGILY
CCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCEEEEEHHCHHHHHHHHHH
ANILVFATLFRVYLASVVPPSFVDLLARYDTSGRLVGGLAYYLASPNGLYSALSDPAHLI
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHCCHHHHH
VYSLLVFILAVLFGLMWVEVAGLNPAAQAEQLISSGFEVPGLRNNPKILEKILAKYIYPL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
TVLSSLIVAAIAVLADALGAYGTGTGILLAIGILQQYYALIAYERTLEAYPLLRRLVGE
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GVWGMGLLRVMAKIADYLPTAVKPQGKPSMYERLFWTGVALIVYMIMANTPLYGISYAG
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PEQILLIQIIFASNRGTLMELGIGPIVTAGLIMQILVGAKLINLDLTDPEDRKVFTASQK
CCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEECCHH
TLAVILAAFEAGMYVLSCRYWMPLGNPVTACSAGWHVRLIVWLQLFVASYLVIVLDETIQ
HHHHHHHHHHHCHHEEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KGWGIGSGVSLFILAGVATTIFWNIFSTVTYQGQPIGFIPYMIQVISSGGGLGNVLLRPG
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCCEEEECCC
GRDLVGLIATIVIMFILVYLSNMKVEIPVTSPRLQSIKTKIPLQFLYVTNIPVLFVGILY
CCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCEEEEEHHCHHHHHHHHHH
ANILVFATLFRVYLASVVPPSFVDLLARYDTSGRLVGGLAYYLASPNGLYSALSDPAHLI
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHCCHHHHH
VYSLLVFILAVLFGLMWVEVAGLNPAAQAEQLISSGFEVPGLRNNPKILEKILAKYIYPL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
TVLSSLIVAAIAVLADALGAYGTGTGILLAIGILQQYYALIAYERTLEAYPLLRRLVGE
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]