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The map label for this gene is serA [H]

Identifier: 218884408

GI number: 218884408

Start: 1036556

End: 1037563

Strand: Reverse

Name: serA [H]

Synonym: DKAM_1097

Alternate gene names: 218884408

Gene position: 1037563-1036556 (Counterclockwise)

Preceding gene: 218884409

Following gene: 218884406

Centisome position: 76.0

GC content: 40.28

Gene sequence:

>1008_bases
ATGTCTAGGGTTAAAATAGCGATAGTAAACTCTAAATCGTTTGGTGTATATACGAATGCTGTTGAGCGATTAAAGGAGGT
AGGTGTCGTCGATAAAATAGAAGTTGAAAAAGACCTAAAGGGTAAACCACTAGCAGAGAAACTTCAGGGATATCACATAA
TTATCGCTAGTGTTACACCTAACTATGACAGAGAGTTCTTCGAGTATAATAAGACGGTCGTACTAATAGTGAGACATGGC
ATCGGGTATGATAATATAGATGTAGAGGCGGCTAGAGAACATGGCGTAATAGTTGCTAGGGTCCCTGGTTGGAGAGAAAG
AGAAGCGGTTGCCGAGCACACCATCTCATTAATGTTATCAGCGCTGAGGTATGTCCCCCAATCATATATAGCTGTAAAGG
AGGGTAAATGGAGTGAGCGAGCGAAATATGTAGGTAGGGAGATCAATCATTTAACAATAGGGATCATAGGGTTTGGAAAC
ATAGGTTCCAGGGTTGCTGAGATACTATCCAAGGGATTTAATTCAAAAATAATAGTATATGATCCATATGTTCCACGTGA
GAAAGTAGAGTCTTATGGCTACCGTTATGCAACCTCTCTAGAGGATATAGCTAGGGAATGCGATATTGTGACGCTACATA
CAGCATTAACAAATGAGACAAAGCATATGTTGAATGAGAAATTTTTCGAGAAGGCTAAGAAAGGAATAATAATAGTCAAC
ACGGCTAGAGGTGAATTGGTAGATACCAATGCACTGGTTAAATACATTGAGAAAGGGATTGTTGCAGCGTATTCTGCAGA
TGTTGTGGAAGGCGAACCGATAGGATGTGATCATGTTTTACTAAAGTATCCCAACGTCATAATAACCCCACATATAGCAG
CATATACGTTTGAGGCGCTTGCAGGGATGGATGAAGCCGTGGTAGAGGCTGTTATAAATTATCTAGATAAGAAGCCTATT
GATGGAATAGTAGTGTATCCACCTAGCCCGAGGAGTGTTAGAAATTAA

Upstream 100 bases:

>100_bases
CTGAAGCCTGGTTATCCACCGTTACAACTGGATTTCGACTACGATGAGAAAACAACAGAGGAATTAAAAGCAGCATTAAG
CAAAGTATTGGGTGTTATAA

Downstream 100 bases:

>100_bases
TTATAGCTGTCTTGGATATTATTGTTTTCAAGAATTTTTTTAACTAGTTTTTCAACGGCCTTCCTAACCATGATGCTGGC
TGTAGGTTTAGCTAGACCTA

Product: Lactate dehydrogenase-like protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSRVKIAIVNSKSFGVYTNAVERLKEVGVVDKIEVEKDLKGKPLAEKLQGYHIIIASVTPNYDREFFEYNKTVVLIVRHG
IGYDNIDVEAAREHGVIVARVPGWREREAVAEHTISLMLSALRYVPQSYIAVKEGKWSERAKYVGREINHLTIGIIGFGN
IGSRVAEILSKGFNSKIIVYDPYVPREKVESYGYRYATSLEDIARECDIVTLHTALTNETKHMLNEKFFEKAKKGIIIVN
TARGELVDTNALVKYIEKGIVAAYSADVVEGEPIGCDHVLLKYPNVIITPHIAAYTFEALAGMDEAVVEAVINYLDKKPI
DGIVVYPPSPRSVRN

Sequences:

>Translated_335_residues
MSRVKIAIVNSKSFGVYTNAVERLKEVGVVDKIEVEKDLKGKPLAEKLQGYHIIIASVTPNYDREFFEYNKTVVLIVRHG
IGYDNIDVEAAREHGVIVARVPGWREREAVAEHTISLMLSALRYVPQSYIAVKEGKWSERAKYVGREINHLTIGIIGFGN
IGSRVAEILSKGFNSKIIVYDPYVPREKVESYGYRYATSLEDIARECDIVTLHTALTNETKHMLNEKFFEKAKKGIIIVN
TARGELVDTNALVKYIEKGIVAAYSADVVEGEPIGCDHVLLKYPNVIITPHIAAYTFEALAGMDEAVVEAVINYLDKKPI
DGIVVYPPSPRSVRN
>Mature_334_residues
SRVKIAIVNSKSFGVYTNAVERLKEVGVVDKIEVEKDLKGKPLAEKLQGYHIIIASVTPNYDREFFEYNKTVVLIVRHGI
GYDNIDVEAAREHGVIVARVPGWREREAVAEHTISLMLSALRYVPQSYIAVKEGKWSERAKYVGREINHLTIGIIGFGNI
GSRVAEILSKGFNSKIIVYDPYVPREKVESYGYRYATSLEDIARECDIVTLHTALTNETKHMLNEKFFEKAKKGIIIVNT
ARGELVDTNALVKYIEKGIVAAYSADVVEGEPIGCDHVLLKYPNVIITPHIAAYTFEALAGMDEAVVEAVINYLDKKPID
GIVVYPPSPRSVRN

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=289, Percent_Identity=33.9100346020761, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI145580578, Length=342, Percent_Identity=30.9941520467836, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI4557499, Length=342, Percent_Identity=30.9941520467836, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI145580575, Length=343, Percent_Identity=31.4868804664723, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI4557497, Length=262, Percent_Identity=33.206106870229, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI61743967, Length=262, Percent_Identity=33.206106870229, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI6912396, Length=295, Percent_Identity=25.4237288135593, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI87082289, Length=240, Percent_Identity=35, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1787645, Length=257, Percent_Identity=32.6848249027237, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789279, Length=318, Percent_Identity=27.9874213836478, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081824, Length=194, Percent_Identity=29.3814432989691, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788660, Length=160, Percent_Identity=32.5, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=240, Percent_Identity=36.6666666666667, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=306, Percent_Identity=29.4117647058824, Blast_Score=114, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=263, Percent_Identity=32.319391634981, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=305, Percent_Identity=27.5409836065574, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=326, Percent_Identity=27.3006134969325, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=267, Percent_Identity=26.9662921348315, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=283, Percent_Identity=25.7950530035336, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=185, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24646446, Length=258, Percent_Identity=37.2093023255814, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646448, Length=258, Percent_Identity=37.2093023255814, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646452, Length=258, Percent_Identity=37.2093023255814, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646450, Length=258, Percent_Identity=37.2093023255814, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI62472511, Length=258, Percent_Identity=37.2093023255814, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI19921140, Length=284, Percent_Identity=32.3943661971831, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24585516, Length=243, Percent_Identity=30.4526748971193, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI28571528, Length=269, Percent_Identity=29.7397769516729, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28574286, Length=263, Percent_Identity=26.9961977186312, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28574284, Length=243, Percent_Identity=26.7489711934156, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24585514, Length=243, Percent_Identity=26.7489711934156, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28574282, Length=243, Percent_Identity=26.7489711934156, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45552429, Length=243, Percent_Identity=26.7489711934156, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45551003, Length=243, Percent_Identity=26.7489711934156, Blast_Score=91, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37453; Mature: 37321

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVKIAIVNSKSFGVYTNAVERLKEVGVVDKIEVEKDLKGKPLAEKLQGYHIIIASVTP
CCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHCCCCEEEEEECCC
NYDREFFEYNKTVVLIVRHGIGYDNIDVEAAREHGVIVARVPGWREREAVAEHTISLMLS
CCCHHHHHCCCEEEEEEECCCCCCCCCCEEHHHCCEEEEECCCCCHHHHHHHHHHHHHHH
ALRYVPQSYIAVKEGKWSERAKYVGREINHLTIGIIGFGNIGSRVAEILSKGFNSKIIVY
HHHHCCHHHEEEECCCHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCEEEEE
DPYVPREKVESYGYRYATSLEDIARECDIVTLHTALTNETKHMLNEKFFEKAKKGIIIVN
CCCCCHHHHHHCCCCCCCCHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEE
TARGELVDTNALVKYIEKGIVAAYSADVVEGEPIGCDHVLLKYPNVIITPHIAAYTFEAL
CCCCCEECHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHEEECCCEEECCCHHHHHHHHH
AGMDEAVVEAVINYLDKKPIDGIVVYPPSPRSVRN
HCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
SRVKIAIVNSKSFGVYTNAVERLKEVGVVDKIEVEKDLKGKPLAEKLQGYHIIIASVTP
CCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHCCCCEEEEEECCC
NYDREFFEYNKTVVLIVRHGIGYDNIDVEAAREHGVIVARVPGWREREAVAEHTISLMLS
CCCHHHHHCCCEEEEEEECCCCCCCCCCEEHHHCCEEEEECCCCCHHHHHHHHHHHHHHH
ALRYVPQSYIAVKEGKWSERAKYVGREINHLTIGIIGFGNIGSRVAEILSKGFNSKIIVY
HHHHCCHHHEEEECCCHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCEEEEE
DPYVPREKVESYGYRYATSLEDIARECDIVTLHTALTNETKHMLNEKFFEKAKKGIIIVN
CCCCCHHHHHHCCCCCCCCHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEE
TARGELVDTNALVKYIEKGIVAAYSADVVEGEPIGCDHVLLKYPNVIITPHIAAYTFEAL
CCCCCEECHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHEEECCCEEECCCHHHHHHHHH
AGMDEAVVEAVINYLDKKPIDGIVVYPPSPRSVRN
HCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]