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The map label for this gene is 218884294

Identifier: 218884294

GI number: 218884294

Start: 932299

End: 933333

Strand: Reverse

Name: 218884294

Synonym: DKAM_0983

Alternate gene names: NA

Gene position: 933333-932299 (Counterclockwise)

Preceding gene: 218884295

Following gene: 218884293

Centisome position: 68.36

GC content: 45.22

Gene sequence:

>1035_bases
ATGATCAAAATACTCGTCTCGAAAAACTCTATGCATATGCATGTATCGAGGGAGCATCACCCTGAAAATCCTGAGAGAAT
AGTGAGGGTAATCTCAGCGCTCAAGAGGCATGGCATCAGATATGAATTACATGATGCCGGCTGGATGGATATCGGTGAGG
CATTAAGCATTGCTAGAAGAATACATAGCAGAGGATACATCGATAAAATACTGATGTTATCGAAGAAGGCGCCATTAAAC
ATAGACCAGGATACATATCTATCTAGTGACACTTTGACTCTAGCACTGGAAACGCTTTACACATCATACCTAACGGCTCT
AAACTTGGGTAGGGATATTGTTTTCTACATAGCTAGGCCTCCTGGTCATCATGCTGGATACCGTGGGAAAACCAGGAGGG
CTTATACGCAGGGTTTCTGCATATTTAATAATGCTGTGGCTGCTGTACATGGTCTTATTGATGGGGGATTCAAGAATATA
GGGGTTCTCGACTTTGATGCCCATTATGGTAATGGATCCATGGAGCTGCTCTATACAAGTAGAATACTCCAAGTTGATCT
ACACCAGGATACCCGTTCCCTACCGGTTTTCCCCTGGAATCCCAGCGAGATAGGGGCTGGTGATGGATACGGGTATAAAA
TAGGTATTCCCCTAGAACCCGGTACAGGCGATGACTCCTTTGTCCAGGTACTAGGCATAGTGGGGAGGATTATTGAGAAA
TATAATCCTGAAGCACTTGTAGTATCAGCTGGCTTCGACGGCTTTATCGGGGATGGTTTAACTGATCTAGTGTTAACCGA
GTATAGTTATTACAGGATCGGCCATATGATCCAGAGCCTCGGTACACCGGTTATAATAGTCTTGGAGGGGGGTTATTCAA
GGGGGCTTGATAAAGGATTGGTAGCGTTTATACATGGGCTCACTAGGGCGAGGGTTACTTATACGTCGGGAAGGAGTCTT
CAGGGCGGGATTGCCAGGATCAACCTTGCAAGGGCGAATAAAATAATTAGCCGGGTTGAGAAATACATCGTGTAG

Upstream 100 bases:

>100_bases
CTAGCTATAGTGAGATTACCGAAAGACCTGGAGAAGCAAGAGCTGATTAAAATACTGTATCAAGCCGTATACTACTCCAC
ATAACCTGCAGGAACATGCC

Downstream 100 bases:

>100_bases
AAAGGGTTAAACCATGGACACTGGTAGAAAGAACGCAACAGTGGAGTCGGAGGTCAAGCTACAAGTATTAGTGGACATAG
AGGTTATTGAGAAATATCTG

Product: histone deacetylase superfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MIKILVSKNSMHMHVSREHHPENPERIVRVISALKRHGIRYELHDAGWMDIGEALSIARRIHSRGYIDKILMLSKKAPLN
IDQDTYLSSDTLTLALETLYTSYLTALNLGRDIVFYIARPPGHHAGYRGKTRRAYTQGFCIFNNAVAAVHGLIDGGFKNI
GVLDFDAHYGNGSMELLYTSRILQVDLHQDTRSLPVFPWNPSEIGAGDGYGYKIGIPLEPGTGDDSFVQVLGIVGRIIEK
YNPEALVVSAGFDGFIGDGLTDLVLTEYSYYRIGHMIQSLGTPVIIVLEGGYSRGLDKGLVAFIHGLTRARVTYTSGRSL
QGGIARINLARANKIISRVEKYIV

Sequences:

>Translated_344_residues
MIKILVSKNSMHMHVSREHHPENPERIVRVISALKRHGIRYELHDAGWMDIGEALSIARRIHSRGYIDKILMLSKKAPLN
IDQDTYLSSDTLTLALETLYTSYLTALNLGRDIVFYIARPPGHHAGYRGKTRRAYTQGFCIFNNAVAAVHGLIDGGFKNI
GVLDFDAHYGNGSMELLYTSRILQVDLHQDTRSLPVFPWNPSEIGAGDGYGYKIGIPLEPGTGDDSFVQVLGIVGRIIEK
YNPEALVVSAGFDGFIGDGLTDLVLTEYSYYRIGHMIQSLGTPVIIVLEGGYSRGLDKGLVAFIHGLTRARVTYTSGRSL
QGGIARINLARANKIISRVEKYIV
>Mature_344_residues
MIKILVSKNSMHMHVSREHHPENPERIVRVISALKRHGIRYELHDAGWMDIGEALSIARRIHSRGYIDKILMLSKKAPLN
IDQDTYLSSDTLTLALETLYTSYLTALNLGRDIVFYIARPPGHHAGYRGKTRRAYTQGFCIFNNAVAAVHGLIDGGFKNI
GVLDFDAHYGNGSMELLYTSRILQVDLHQDTRSLPVFPWNPSEIGAGDGYGYKIGIPLEPGTGDDSFVQVLGIVGRIIEK
YNPEALVVSAGFDGFIGDGLTDLVLTEYSYYRIGHMIQSLGTPVIIVLEGGYSRGLDKGLVAFIHGLTRARVTYTSGRSL
QGGIARINLARANKIISRVEKYIV

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=319, Percent_Identity=28.2131661442006, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI20070354, Length=352, Percent_Identity=26.4204545454545, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI30795202, Length=193, Percent_Identity=32.6424870466321, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI30795204, Length=193, Percent_Identity=32.6424870466321, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI17158039, Length=194, Percent_Identity=32.9896907216495, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI169234807, Length=191, Percent_Identity=31.9371727748691, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI148539870, Length=191, Percent_Identity=31.9371727748691, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI153085395, Length=192, Percent_Identity=30.2083333333333, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI13128860, Length=292, Percent_Identity=24.6575342465753, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI293336691, Length=146, Percent_Identity=31.5068493150685, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI262073088, Length=168, Percent_Identity=27.3809523809524, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI8923769, Length=173, Percent_Identity=26.0115606936416, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI62750349, Length=194, Percent_Identity=31.9587628865979, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI62750347, Length=194, Percent_Identity=31.9587628865979, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=305, Percent_Identity=27.2131147540984, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193206283, Length=305, Percent_Identity=27.2131147540984, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17540332, Length=305, Percent_Identity=27.2131147540984, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17508561, Length=173, Percent_Identity=30.0578034682081, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17537347, Length=251, Percent_Identity=28.2868525896414, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561978, Length=173, Percent_Identity=29.4797687861272, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17534739, Length=306, Percent_Identity=25.1633986928105, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193209491, Length=232, Percent_Identity=29.3103448275862, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25154020, Length=296, Percent_Identity=26.6891891891892, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324307, Length=312, Percent_Identity=26.6025641025641, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6321244, Length=289, Percent_Identity=24.2214532871972, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323999, Length=173, Percent_Identity=28.3236994219653, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24642146, Length=302, Percent_Identity=28.476821192053, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642144, Length=302, Percent_Identity=28.476821192053, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642142, Length=302, Percent_Identity=28.476821192053, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281360899, Length=302, Percent_Identity=27.4834437086093, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281360801, Length=191, Percent_Identity=30.3664921465969, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281360799, Length=191, Percent_Identity=30.3664921465969, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24641720, Length=191, Percent_Identity=30.3664921465969, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24657891, Length=173, Percent_Identity=28.9017341040462, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644244, Length=305, Percent_Identity=24.2622950819672, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 38100; Mature: 38100

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKILVSKNSMHMHVSREHHPENPERIVRVISALKRHGIRYELHDAGWMDIGEALSIARR
CEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHH
IHSRGYIDKILMLSKKAPLNIDQDTYLSSDTLTLALETLYTSYLTALNLGRDIVFYIARP
HHHCCHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
PGHHAGYRGKTRRAYTQGFCIFNNAVAAVHGLIDGGFKNIGVLDFDAHYGNGSMELLYTS
CCCCCCCCCCCCHHHHCCEEEECHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEE
RILQVDLHQDTRSLPVFPWNPSEIGAGDGYGYKIGIPLEPGTGDDSFVQVLGIVGRIIEK
EEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
YNPEALVVSAGFDGFIGDGLTDLVLTEYSYYRIGHMIQSLGTPVIIVLEGGYSRGLDKGL
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHH
VAFIHGLTRARVTYTSGRSLQGGIARINLARANKIISRVEKYIV
HHHHHHHHHEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIKILVSKNSMHMHVSREHHPENPERIVRVISALKRHGIRYELHDAGWMDIGEALSIARR
CEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHH
IHSRGYIDKILMLSKKAPLNIDQDTYLSSDTLTLALETLYTSYLTALNLGRDIVFYIARP
HHHCCHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
PGHHAGYRGKTRRAYTQGFCIFNNAVAAVHGLIDGGFKNIGVLDFDAHYGNGSMELLYTS
CCCCCCCCCCCCHHHHCCEEEECHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEE
RILQVDLHQDTRSLPVFPWNPSEIGAGDGYGYKIGIPLEPGTGDDSFVQVLGIVGRIIEK
EEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
YNPEALVVSAGFDGFIGDGLTDLVLTEYSYYRIGHMIQSLGTPVIIVLEGGYSRGLDKGL
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHH
VAFIHGLTRARVTYTSGRSLQGGIARINLARANKIISRVEKYIV
HHHHHHHHHEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]