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The map label for this gene is dys2 [H]

Identifier: 218884255

GI number: 218884255

Start: 895518

End: 896531

Strand: Direct

Name: dys2 [H]

Synonym: DKAM_0944

Alternate gene names: 218884255

Gene position: 895518-896531 (Clockwise)

Preceding gene: 218884253

Following gene: 218884269

Centisome position: 65.59

GC content: 45.56

Gene sequence:

>1014_bases
ATGGGTGAGGTTAAGAGCCTGAGTGTTAAGCGTAGGAGCATACATGAGCTTCTCCTTGAAATGGCTGATACAGCGTTCCA
GGGTAGGAGTCTAGGCGAGGCATACCGTGTCCTTATAGATATGTTTAGCGATGAAGATAACCTCGTGTTCCTAGGGCTCG
CTGGATCCATGAGTACTGCAGGTATGTGGAGGATCATTAAGTGGCTTGTAGAGGAGAGATATGTTGATGTAGTGGTCTCG
ACTGGTGCTGTAATAAGCGAAGACATCTATGAAGCCATGGGCTTCAAATACTATAAGACACATCCCTGCGTCAACGATGA
AGAACTCCTCAGATATAAGTATGATAGATTCTACGATACCGTTGCCAACGAGGAGGACTATAGGAAAATGGAGAAGCTAA
TACAGGAATTTATTGAAACCCTACCAGCTGGAAAAACCTACAGTACAGCCGAGTTCCTTCACGAATTCGGGAAATACCTG
AATGAAAAAGGAATTAACAGCATTGTAGCTGCAGCATACAGAGCCAAGGTACCCGTGTTCTCACCAGCCCTAGTTGACAG
CGGTTACGGTATGGGCGCTCTCCTAGCATATAGGAGGGGACACAGGATAATCCTGGACATGGTGAGAGACTTCTACCATA
TAGTAGAGATAGGTAGAAGGGCTAGTAAGCTCTCAGCAATATATATTGGGGGAGGAGTACCAAAGGACTATGTAAACCTT
GTAACAGTAGCTCAAACCTTGATAGGAGAGTACGAGGAAGGCAAACATGATTATTACAAGAGCCTAGAGTATGTTGTACA
GTTCACAACCGATGCACCACAGTGGGGAGGACTCAGCGGTGCAACCCTAGAGGAAGCCGTGAGCTGGGGTAAGGTGTCGC
CTAAGGCTAAAAAGAAAGTAGTCTACGTTGATGCTACAATAGCTTTACCAATAATAGCTCATGCACTAGTGGATGGTGGC
ATTAGGAGAAGAAGACCAGCAGACCTATCATGGTTTTTCAATAATCCACCATGA

Upstream 100 bases:

>100_bases
ATGGGTCTTTCAGCGGTCTGAGCTACATGTTTTATTTTTATTTTATAATTTTGTAATTCTTGTATTGGAGGCGTGGATCA
TGGGTGCCCCGTACTTTGTG

Downstream 100 bases:

>100_bases
CCACGGGTCCAGTAAAAACTCAAGTCCCCGGAAGTCTTTGTTTCACTATTAGTCATTTTCAAGGGGCTAGCGCTAAGATA
AGGGATATTATTGATAATGG

Product: putative deoxyhypusine synthase

Products: NA

Alternate protein names: DHS 2 [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MGEVKSLSVKRRSIHELLLEMADTAFQGRSLGEAYRVLIDMFSDEDNLVFLGLAGSMSTAGMWRIIKWLVEERYVDVVVS
TGAVISEDIYEAMGFKYYKTHPCVNDEELLRYKYDRFYDTVANEEDYRKMEKLIQEFIETLPAGKTYSTAEFLHEFGKYL
NEKGINSIVAAAYRAKVPVFSPALVDSGYGMGALLAYRRGHRIILDMVRDFYHIVEIGRRASKLSAIYIGGGVPKDYVNL
VTVAQTLIGEYEEGKHDYYKSLEYVVQFTTDAPQWGGLSGATLEEAVSWGKVSPKAKKKVVYVDATIALPIIAHALVDGG
IRRRRPADLSWFFNNPP

Sequences:

>Translated_337_residues
MGEVKSLSVKRRSIHELLLEMADTAFQGRSLGEAYRVLIDMFSDEDNLVFLGLAGSMSTAGMWRIIKWLVEERYVDVVVS
TGAVISEDIYEAMGFKYYKTHPCVNDEELLRYKYDRFYDTVANEEDYRKMEKLIQEFIETLPAGKTYSTAEFLHEFGKYL
NEKGINSIVAAAYRAKVPVFSPALVDSGYGMGALLAYRRGHRIILDMVRDFYHIVEIGRRASKLSAIYIGGGVPKDYVNL
VTVAQTLIGEYEEGKHDYYKSLEYVVQFTTDAPQWGGLSGATLEEAVSWGKVSPKAKKKVVYVDATIALPIIAHALVDGG
IRRRRPADLSWFFNNPP
>Mature_336_residues
GEVKSLSVKRRSIHELLLEMADTAFQGRSLGEAYRVLIDMFSDEDNLVFLGLAGSMSTAGMWRIIKWLVEERYVDVVVST
GAVISEDIYEAMGFKYYKTHPCVNDEELLRYKYDRFYDTVANEEDYRKMEKLIQEFIETLPAGKTYSTAEFLHEFGKYLN
EKGINSIVAAAYRAKVPVFSPALVDSGYGMGALLAYRRGHRIILDMVRDFYHIVEIGRRASKLSAIYIGGGVPKDYVNLV
TVAQTLIGEYEEGKHDYYKSLEYVVQFTTDAPQWGGLSGATLEEAVSWGKVSPKAKKKVVYVDATIALPIIAHALVDGGI
RRRRPADLSWFFNNPP

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503325, Length=323, Percent_Identity=25.6965944272446, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17536927, Length=328, Percent_Identity=23.780487804878, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6321859, Length=350, Percent_Identity=22.2857142857143, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI45550569, Length=317, Percent_Identity=23.6593059936909, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002773
- InterPro:   IPR022899 [H]

Pfam domain/function: PF01916 DS [H]

EC number: =2.5.1.46 [H]

Molecular weight: Translated: 38068; Mature: 37937

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEVKSLSVKRRSIHELLLEMADTAFQGRSLGEAYRVLIDMFSDEDNLVFLGLAGSMSTA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHH
GMWRIIKWLVEERYVDVVVSTGAVISEDIYEAMGFKYYKTHPCVNDEELLRYKYDRFYDT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHH
VANEEDYRKMEKLIQEFIETLPAGKTYSTAEFLHEFGKYLNEKGINSIVAAAYRAKVPVF
HCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
SPALVDSGYGMGALLAYRRGHRIILDMVRDFYHIVEIGRRASKLSAIYIGGGVPKDYVNL
CHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHH
VTVAQTLIGEYEEGKHDYYKSLEYVVQFTTDAPQWGGLSGATLEEAVSWGKVSPKAKKKV
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHCEE
VYVDATIALPIIAHALVDGGIRRRRPADLSWFFNNPP
EEEEHHHHHHHHHHHHHHCCHHCCCCCCCEECCCCCC
>Mature Secondary Structure 
GEVKSLSVKRRSIHELLLEMADTAFQGRSLGEAYRVLIDMFSDEDNLVFLGLAGSMSTA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHH
GMWRIIKWLVEERYVDVVVSTGAVISEDIYEAMGFKYYKTHPCVNDEELLRYKYDRFYDT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHH
VANEEDYRKMEKLIQEFIETLPAGKTYSTAEFLHEFGKYLNEKGINSIVAAAYRAKVPVF
HCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
SPALVDSGYGMGALLAYRRGHRIILDMVRDFYHIVEIGRRASKLSAIYIGGGVPKDYVNL
CHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHH
VTVAQTLIGEYEEGKHDYYKSLEYVVQFTTDAPQWGGLSGATLEEAVSWGKVSPKAKKKV
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHCEE
VYVDATIALPIIAHALVDGGIRRRRPADLSWFFNNPP
EEEEHHHHHHHHHHHHHHCCHHCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]