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The map label for this gene is eIF5A

Identifier: 218884134

GI number: 218884134

Start: 792083

End: 792481

Strand: Direct

Name: eIF5A

Synonym: DKAM_0823

Alternate gene names: 218884134

Gene position: 792083-792481 (Clockwise)

Preceding gene: 218884133

Following gene: 218884140

Centisome position: 58.02

GC content: 44.11

Gene sequence:

>399_bases
ATGAGTAAGGTATATGATACCCTTGGAAACCTGAAGGTCGGCAGCTTTATAGTAATAGATGGAGAACCATGCAGAATAGT
CGAGATGTCTCGTGCTAAGACGGGAAAACACGGAAGTGCTAAAGCAAATGTAGTAGCGATAGGTTTATTCTCAAAGGCTA
AAAAAACTCTCGTAGCCCCTGTCGACACCCAGGTAGAGGTCCCAGTTATAGAGAAACATGTAGGTCAAATAATAGCTGAT
ATGGGCACTATGTACCAGGTTATGGATATGGAGACGTATGAGACCTTTGAGGTGGAAAAAGACTCCATAGAGGAGGATAT
TAGAAACAAGCTGGGAGTAGGCTCAGAGGTAGAATACTGGGTCGTAATGGGTAAGAGACTTATCATCCGTCCCCGCTAG

Upstream 100 bases:

>100_bases
AGTTCCAATATTCCAGGTATTAATCAAGAGAAATTTATTTTTAGGGCTTAAATAGTGTAATAATGCTTATGTATGAGCTA
ATTCACATAGGTGGTGTTCA

Downstream 100 bases:

>100_bases
ATGTCATCCGGTAGGAAAACCGGTTTTTCAGCAAGTGATATTATAGGTATAGCTATGCCTGGCCTAGGGCTCTTGGAGAA
CTCTATTTTTTCATCACTGG

Product: translation initiation factor IF-5A

Products: NA

Alternate protein names: Hypusine-containing protein; eIF-5A

Number of amino acids: Translated: 132; Mature: 131

Protein sequence:

>132_residues
MSKVYDTLGNLKVGSFIVIDGEPCRIVEMSRAKTGKHGSAKANVVAIGLFSKAKKTLVAPVDTQVEVPVIEKHVGQIIAD
MGTMYQVMDMETYETFEVEKDSIEEDIRNKLGVGSEVEYWVVMGKRLIIRPR

Sequences:

>Translated_132_residues
MSKVYDTLGNLKVGSFIVIDGEPCRIVEMSRAKTGKHGSAKANVVAIGLFSKAKKTLVAPVDTQVEVPVIEKHVGQIIAD
MGTMYQVMDMETYETFEVEKDSIEEDIRNKLGVGSEVEYWVVMGKRLIIRPR
>Mature_131_residues
SKVYDTLGNLKVGSFIVIDGEPCRIVEMSRAKTGKHGSAKANVVAIGLFSKAKKTLVAPVDTQVEVPVIEKHVGQIIADM
GTMYQVMDMETYETFEVEKDSIEEDIRNKLGVGSEVEYWVVMGKRLIIRPR

Specific function: Functions by promoting the formation of the first peptide bond

COG id: COG0231

COG function: function code J; Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-5A family

Homologues:

Organism=Homo sapiens, GI219555707, Length=120, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI219555712, Length=120, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI219555710, Length=120, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI4503545, Length=120, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI153791632, Length=120, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI9966867, Length=114, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534327, Length=84, Percent_Identity=38.0952380952381, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71990399, Length=84, Percent_Identity=36.9047619047619, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320801, Length=81, Percent_Identity=38.2716049382716, Blast_Score=65, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322507, Length=121, Percent_Identity=29.7520661157025, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922878, Length=120, Percent_Identity=30.8333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24762531, Length=120, Percent_Identity=30.8333333333333, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF5A_DESK1 (B8D4W8)

Other databases:

- EMBL:   CP001140
- RefSeq:   YP_002428516.1
- GeneID:   7170973
- GenomeReviews:   CP001140_GR
- KEGG:   dka:DKAM_0823
- HOGENOM:   HBG497107
- OMA:   CRIVEMS
- ProtClustDB:   CLSK2805660
- GO:   GO:0005737
- HAMAP:   MF_00085
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR019769
- InterPro:   IPR001884
- InterPro:   IPR022847
- InterPro:   IPR020189
- InterPro:   IPR013185
- InterPro:   IPR014722
- InterPro:   IPR008991
- Gene3D:   G3DSA:2.40.50.140
- Gene3D:   G3DSA:2.30.30.30
- PANTHER:   PTHR11673
- PIRSF:   PIRSF003025
- TIGRFAMs:   TIGR00037

Pfam domain/function: PF08207 EFP_N; PF01287 eIF-5a; SSF50249 Nucleic_acid_OB; SSF50104 Transl_SH3_like

EC number: NA

Molecular weight: Translated: 14690; Mature: 14559

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00302 IF5A_HYPUSINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVYDTLGNLKVGSFIVIDGEPCRIVEMSRAKTGKHGSAKANVVAIGLFSKAKKTLVAP
CCCHHHHHCCEEECCEEEECCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCCEEECC
VDTQVEVPVIEKHVGQIIADMGTMYQVMDMETYETFEVEKDSIEEDIRNKLGVGSEVEYW
CCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHCCCCCCCEEE
VVMGKRLIIRPR
EEECCEEEEECC
>Mature Secondary Structure 
SKVYDTLGNLKVGSFIVIDGEPCRIVEMSRAKTGKHGSAKANVVAIGLFSKAKKTLVAP
CCHHHHHCCEEECCEEEECCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCCEEECC
VDTQVEVPVIEKHVGQIIADMGTMYQVMDMETYETFEVEKDSIEEDIRNKLGVGSEVEYW
CCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHCCCCCCCEEE
VVMGKRLIIRPR
EEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA