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The map label for this gene is ydhC [H]

Identifier: 218711020

GI number: 218711020

Start: 3284967

End: 3286178

Strand: Direct

Name: ydhC [H]

Synonym: VS_3149

Alternate gene names: 218711020

Gene position: 3284967-3286178 (Clockwise)

Preceding gene: 218711018

Following gene: NA

Centisome position: 99.57

GC content: 46.53

Gene sequence:

>1212_bases
ATGAATATTTCTAAATTTCAATTGGTCTACCTTGCAGTACTTTCAATGCTTGGCTTTATTGCGACCGATATGTACCTTCC
TGCATTTAAGGCAATGGAAGTTGATTTCGCAACCGGTCCAGAGCAGATTGCTCTGTCTCTAACTGTATTCCTTGGCGGTA
TGGCAATGGGTCAGCTTCTTTGGGGTCTGGCGAGTGACAAGTATGGTCACCGCAACACACTAGCGGTTGGTCTTGTTATC
TTTACGGCAGCGTCATTCGGCTTGGCATTCAGCACCGAGGTATGGCACCTACTAACACTACGCTTCATTCAAGCGATCGG
TGTGTGTGCGCCTGCGGTAATCTGGCAAGCAATGGTTATCAAGCGTTACTCGCAAAGCAGTAGCCAGCAAATTTTTGCTA
CTATCATGCCTCTAGTAGCGCTATCTCCAGCACTAGCACCTCAACTGGGTGTGTTGCTAGCAAACAGCTTTGGCTGGCAC
AGTATCTTCATTACATTGACTTTGATGGGCGCACTACTAATTGCAACAACAATGGCTCAACCAAAAGAAGCGCCTGAAGT
AAAGCAGACATCGATTAAGACAGACATCAAGATGTTGATAAAATCAAAGCCTTACATGGGTAATGTTTTAATGTTTGCTT
CGGCATCTGCAGCGTTCTTCGCTTACCTAACAGGTATGCCAGAGATAATGGCTCAGCTAGGTTATGAAGCAAAAGACATC
GGCTTGAGCTTTATCCCACAGACAATCGCGTTCATGGCGGGTGGTTATTTCGGTAAGCAAGCGGTGAAGAAATATGGTGA
TGGCGTTGTACTAAGAAATCTTATCGGTTTGTTCAGCGTTGCAGCGATGCTTATCTTCATTGCATCACAGTGGGAACTGA
CGTCAATCTGGCCTCTGCTTGCGCCTTTCTGTTTGATTGCAGTAGCAAACGGTGCACTTTACCCAATCGTAGTAAACCGT
GCTCTATCAAGTGCCAAGCAAAGCCCAGCAACAGCTGCTGGCCTACAAAACAGCCTGCAAATCAGTATCAGTGGCCTATC
AAGTGCATTGGTCGCGGCAATGGCTAGCCAAGCACTAAGCACAACGGGTATCGCGGTTGTGATTTGTTTAGGGACTTTGT
GGATTGGTTACATCGTTTCGAACAAAGAACTGTCTGACCACTTTGTTGCGCCAGATAACTCTCGCGTGGTTGCTGACGAT
AAGCAAGACTAG

Upstream 100 bases:

>100_bases
AATAGAATGTCAGCACAAATAAACAGGGGCTTTCACTTCTGTATATCAAACAATTTTTTTGATGATAAAAACATCACTAC
CTTTAGCTTAATGGCATCTT

Downstream 100 bases:

>100_bases
TTTCTAAGTTAAAGAAAACAAAAAAGAGCGAGATTAATCGCTCTTTTTTTATATCTAGATATCTAAGAAAAACCAATAGC
AGTGCTATTAGCTCTATCGC

Product: inner membrane transport protein YdhC

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MNISKFQLVYLAVLSMLGFIATDMYLPAFKAMEVDFATGPEQIALSLTVFLGGMAMGQLLWGLASDKYGHRNTLAVGLVI
FTAASFGLAFSTEVWHLLTLRFIQAIGVCAPAVIWQAMVIKRYSQSSSQQIFATIMPLVALSPALAPQLGVLLANSFGWH
SIFITLTLMGALLIATTMAQPKEAPEVKQTSIKTDIKMLIKSKPYMGNVLMFASASAAFFAYLTGMPEIMAQLGYEAKDI
GLSFIPQTIAFMAGGYFGKQAVKKYGDGVVLRNLIGLFSVAAMLIFIASQWELTSIWPLLAPFCLIAVANGALYPIVVNR
ALSSAKQSPATAAGLQNSLQISISGLSSALVAAMASQALSTTGIAVVICLGTLWIGYIVSNKELSDHFVAPDNSRVVADD
KQD

Sequences:

>Translated_403_residues
MNISKFQLVYLAVLSMLGFIATDMYLPAFKAMEVDFATGPEQIALSLTVFLGGMAMGQLLWGLASDKYGHRNTLAVGLVI
FTAASFGLAFSTEVWHLLTLRFIQAIGVCAPAVIWQAMVIKRYSQSSSQQIFATIMPLVALSPALAPQLGVLLANSFGWH
SIFITLTLMGALLIATTMAQPKEAPEVKQTSIKTDIKMLIKSKPYMGNVLMFASASAAFFAYLTGMPEIMAQLGYEAKDI
GLSFIPQTIAFMAGGYFGKQAVKKYGDGVVLRNLIGLFSVAAMLIFIASQWELTSIWPLLAPFCLIAVANGALYPIVVNR
ALSSAKQSPATAAGLQNSLQISISGLSSALVAAMASQALSTTGIAVVICLGTLWIGYIVSNKELSDHFVAPDNSRVVADD
KQD
>Mature_403_residues
MNISKFQLVYLAVLSMLGFIATDMYLPAFKAMEVDFATGPEQIALSLTVFLGGMAMGQLLWGLASDKYGHRNTLAVGLVI
FTAASFGLAFSTEVWHLLTLRFIQAIGVCAPAVIWQAMVIKRYSQSSSQQIFATIMPLVALSPALAPQLGVLLANSFGWH
SIFITLTLMGALLIATTMAQPKEAPEVKQTSIKTDIKMLIKSKPYMGNVLMFASASAAFFAYLTGMPEIMAQLGYEAKDI
GLSFIPQTIAFMAGGYFGKQAVKKYGDGVVLRNLIGLFSVAAMLIFIASQWELTSIWPLLAPFCLIAVANGALYPIVVNR
ALSSAKQSPATAAGLQNSLQISISGLSSALVAAMASQALSTTGIAVVICLGTLWIGYIVSNKELSDHFVAPDNSRVVADD
KQD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=367, Percent_Identity=44.141689373297, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI1788509, Length=369, Percent_Identity=23.0352303523035, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082312, Length=341, Percent_Identity=23.1671554252199, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1787065, Length=244, Percent_Identity=23.3606557377049, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1790794, Length=205, Percent_Identity=25.3658536585366, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790146, Length=222, Percent_Identity=21.6216216216216, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43078; Mature: 43078

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISKFQLVYLAVLSMLGFIATDMYLPAFKAMEVDFATGPEQIALSLTVFLGGMAMGQLL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHH
WGLASDKYGHRNTLAVGLVIFTAASFGLAFSTEVWHLLTLRFIQAIGVCAPAVIWQAMVI
HHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRYSQSSSQQIFATIMPLVALSPALAPQLGVLLANSFGWHSIFITLTLMGALLIATTMAQ
HHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
PKEAPEVKQTSIKTDIKMLIKSKPYMGNVLMFASASAAFFAYLTGMPEIMAQLGYEAKDI
CCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCHHHHHHCCCCHHHC
GLSFIPQTIAFMAGGYFGKQAVKKYGDGVVLRNLIGLFSVAAMLIFIASQWELTSIWPLL
CHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
APFCLIAVANGALYPIVVNRALSSAKQSPATAAGLQNSLQISISGLSSALVAAMASQALS
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
TTGIAVVICLGTLWIGYIVSNKELSDHFVAPDNSRVVADDKQD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCC
>Mature Secondary Structure
MNISKFQLVYLAVLSMLGFIATDMYLPAFKAMEVDFATGPEQIALSLTVFLGGMAMGQLL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHH
WGLASDKYGHRNTLAVGLVIFTAASFGLAFSTEVWHLLTLRFIQAIGVCAPAVIWQAMVI
HHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRYSQSSSQQIFATIMPLVALSPALAPQLGVLLANSFGWHSIFITLTLMGALLIATTMAQ
HHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
PKEAPEVKQTSIKTDIKMLIKSKPYMGNVLMFASASAAFFAYLTGMPEIMAQLGYEAKDI
CCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCHHHHHHCCCCHHHC
GLSFIPQTIAFMAGGYFGKQAVKKYGDGVVLRNLIGLFSVAAMLIFIASQWELTSIWPLL
CHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
APFCLIAVANGALYPIVVNRALSSAKQSPATAAGLQNSLQISISGLSSALVAAMASQALS
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
TTGIAVVICLGTLWIGYIVSNKELSDHFVAPDNSRVVADDKQD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]