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The map label for this gene is recQ [H]

Identifier: 218710963

GI number: 218710963

Start: 3220820

End: 3222658

Strand: Reverse

Name: recQ [H]

Synonym: VS_3077

Alternate gene names: 218710963

Gene position: 3222658-3220820 (Counterclockwise)

Preceding gene: 218710970

Following gene: 218710962

Centisome position: 97.68

GC content: 48.45

Gene sequence:

>1839_bases
ATGACCGCCACTCTGATTGCTGAGCAAACACCAACTCCCGCGAATGATGCGCAAGATATCTTACAAGATGTCTTTGGTTA
TCAAAGCTTTCGTGATGGTCAGCAAGAGGTCATAGACCTAGCCGTTGAAGGCAAAGACAGCTTGGTGATTATGCCAACCG
GTGGTGGTAAGTCTCTGTGTTACCAGATCCCGGCTTTAGTGCGTGATGGGCTGACTTTGGTTATCTCACCGCTCATTTCA
TTGATGAAAGACCAAGTTGACCAGTTGAAAGCTAATGGTGTGGCGGCTGAGTGCATAAACTCATCGATGCCACGCGATCA
ACTGTTGAGCGTGTTCAACCGCATGAACTCAGGCCAATTGAAGATGGTTTATGCTTCACCAGAGCGTGTGTTGATGCGTG
ACTTTATCGAGCGTCTACAAGGCTTACCGCTTTCGATGATTGCGGTCGATGAAGCGCACTGTATCTCTCAGTGGGGACAC
GATTTCCGCCCTGAATATGCATCATTAGGCCAGCTTAAACAGTATTTTCCGCATGTGCCTTATATGGCGCTAACGGCAAC
CGCTGATGATGCGACGCGCAAAGATATTATCTCGCGTTTGCAGTTGGTGGATCCGCATACGCATTTAGGTAGCTTCGATC
GCCCTAATATTCGTTACAACTTGGTTGAGAAGCATAAGCCCGTGTCACAGGTGGTTCGCTACCTAGAAACACAGAAAGGC
AATTGCGGCATCATCTACTGTGGTAGCCGTAAGAAAGTGGAGATGGTGACCGAGAAGCTGTGCAATAACGGTATTCGCGC
AGCGGGTTATCATGCTGGCATGGACACCGATGAACGTGCTTACGTTCAAGAAGCCTTCCAGCGTGATGATATTCAGATCG
TTGTCGCGACTGTAGCCTTTGGTATGGGCATCAACAAACCCAATGTACGCTTCGTGGTGCACTTTGATATTCCACGCAAT
ATCGAATCTTACTACCAAGAGACAGGCCGCGCAGGTCGTGATGGCTTGCCTGCTGAAGCTATGATGTTGTTTGACCCGGC
TGATATGGGTTGGCTGCGTCGTATGCTGGATGAGAAAGAAGAAGGCCCGCAAAAACAAGTTGAGATGCACAAGCTGAACG
CGATGAGCGCCTTTGCTGAAGCGCAAACCTGTCGTCGTCAGGTTCTGTTGAACTACTTTGGCGAATATCGCGAGAAGCAA
TGTGGCAACTGCGATATCTGCTTAGATCCACCAAAACACTTTGATGCGACCCAAGAGGCACAGAAGGCGTTGTCTTGTGT
GTACCGCGTTAATCAGTCATTTGGTATGGGCTATGTGGTGGAAGTGATGCGTGGTATGCAGAACATCCGTGTACGCGATA
ATGGTCACGATAAGCTGTCTACTTACGGTATCGGCCGCGACCATAGCCATGATTACTGGATCAGTATCTTCCGTCAGCTG
ATTCACAAAGGTTTGTTGTTCCAAAACATCACTCGTAACTCGACATTACAGTTAACAGAAGAAGCCCGCCCGTTACTGCG
TGGTGAGATGTCTTTGGAGTTGGCTGTACCTCGTTTAGATACAGCAGTGCGTAATGCTAAGTCCGATAAGTTAAGCAGCA
AGAACTACGATAAGAAGTTGTTTGCCAAACTGCGTAAGCTGCGTAAGTCGATCGCTGATGAAGATGGCTTGCCACCATAC
GTGGTATTCAGTGATGCGACGCTGATTGATATGGCCGAAATCCTACCCACATCTTATGGCGAGATGCTGGCAGTCAATGG
CGTTGGTCAGCGTAAACTCGATAAGTACGCAGACCCATTCTTAGATTTGATTCAAGAGCACATCACCACACACGGTTAA

Upstream 100 bases:

>100_bases
CCTAACAATTTGCGGTTTAATTCGCCAGCGTTCCCCTCTACAATGTGCGCCTTGCTTGCCAATGCTGCACGCTGACTTTA
TACCTTGATTAGGAACCACA

Downstream 100 bases:

>100_bases
TTGGCTGATTGCTAGTTTTCAAAAGTGTTTAGCTTATAAAAACGATTAGTTCATAAAAAAGAATAAGGTTGATAGGGACA
TGACAACACCAACAGAATTT

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MTATLIAEQTPTPANDAQDILQDVFGYQSFRDGQQEVIDLAVEGKDSLVIMPTGGGKSLCYQIPALVRDGLTLVISPLIS
LMKDQVDQLKANGVAAECINSSMPRDQLLSVFNRMNSGQLKMVYASPERVLMRDFIERLQGLPLSMIAVDEAHCISQWGH
DFRPEYASLGQLKQYFPHVPYMALTATADDATRKDIISRLQLVDPHTHLGSFDRPNIRYNLVEKHKPVSQVVRYLETQKG
NCGIIYCGSRKKVEMVTEKLCNNGIRAAGYHAGMDTDERAYVQEAFQRDDIQIVVATVAFGMGINKPNVRFVVHFDIPRN
IESYYQETGRAGRDGLPAEAMMLFDPADMGWLRRMLDEKEEGPQKQVEMHKLNAMSAFAEAQTCRRQVLLNYFGEYREKQ
CGNCDICLDPPKHFDATQEAQKALSCVYRVNQSFGMGYVVEVMRGMQNIRVRDNGHDKLSTYGIGRDHSHDYWISIFRQL
IHKGLLFQNITRNSTLQLTEEARPLLRGEMSLELAVPRLDTAVRNAKSDKLSSKNYDKKLFAKLRKLRKSIADEDGLPPY
VVFSDATLIDMAEILPTSYGEMLAVNGVGQRKLDKYADPFLDLIQEHITTHG

Sequences:

>Translated_612_residues
MTATLIAEQTPTPANDAQDILQDVFGYQSFRDGQQEVIDLAVEGKDSLVIMPTGGGKSLCYQIPALVRDGLTLVISPLIS
LMKDQVDQLKANGVAAECINSSMPRDQLLSVFNRMNSGQLKMVYASPERVLMRDFIERLQGLPLSMIAVDEAHCISQWGH
DFRPEYASLGQLKQYFPHVPYMALTATADDATRKDIISRLQLVDPHTHLGSFDRPNIRYNLVEKHKPVSQVVRYLETQKG
NCGIIYCGSRKKVEMVTEKLCNNGIRAAGYHAGMDTDERAYVQEAFQRDDIQIVVATVAFGMGINKPNVRFVVHFDIPRN
IESYYQETGRAGRDGLPAEAMMLFDPADMGWLRRMLDEKEEGPQKQVEMHKLNAMSAFAEAQTCRRQVLLNYFGEYREKQ
CGNCDICLDPPKHFDATQEAQKALSCVYRVNQSFGMGYVVEVMRGMQNIRVRDNGHDKLSTYGIGRDHSHDYWISIFRQL
IHKGLLFQNITRNSTLQLTEEARPLLRGEMSLELAVPRLDTAVRNAKSDKLSSKNYDKKLFAKLRKLRKSIADEDGLPPY
VVFSDATLIDMAEILPTSYGEMLAVNGVGQRKLDKYADPFLDLIQEHITTHG
>Mature_611_residues
TATLIAEQTPTPANDAQDILQDVFGYQSFRDGQQEVIDLAVEGKDSLVIMPTGGGKSLCYQIPALVRDGLTLVISPLISL
MKDQVDQLKANGVAAECINSSMPRDQLLSVFNRMNSGQLKMVYASPERVLMRDFIERLQGLPLSMIAVDEAHCISQWGHD
FRPEYASLGQLKQYFPHVPYMALTATADDATRKDIISRLQLVDPHTHLGSFDRPNIRYNLVEKHKPVSQVVRYLETQKGN
CGIIYCGSRKKVEMVTEKLCNNGIRAAGYHAGMDTDERAYVQEAFQRDDIQIVVATVAFGMGINKPNVRFVVHFDIPRNI
ESYYQETGRAGRDGLPAEAMMLFDPADMGWLRRMLDEKEEGPQKQVEMHKLNAMSAFAEAQTCRRQVLLNYFGEYREKQC
GNCDICLDPPKHFDATQEAQKALSCVYRVNQSFGMGYVVEVMRGMQNIRVRDNGHDKLSTYGIGRDHSHDYWISIFRQLI
HKGLLFQNITRNSTLQLTEEARPLLRGEMSLELAVPRLDTAVRNAKSDKLSSKNYDKKLFAKLRKLRKSIADEDGLPPYV
VFSDATLIDMAEILPTSYGEMLAVNGVGQRKLDKYADPFLDLIQEHITTHG

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=635, Percent_Identity=32.4409448818898, Blast_Score=328, Evalue=1e-89,
Organism=Homo sapiens, GI110735439, Length=527, Percent_Identity=36.0531309297913, Blast_Score=319, Evalue=5e-87,
Organism=Homo sapiens, GI169218196, Length=527, Percent_Identity=36.0531309297913, Blast_Score=318, Evalue=7e-87,
Organism=Homo sapiens, GI14591902, Length=559, Percent_Identity=34.8837209302326, Blast_Score=315, Evalue=7e-86,
Organism=Homo sapiens, GI14591904, Length=559, Percent_Identity=34.8837209302326, Blast_Score=315, Evalue=7e-86,
Organism=Homo sapiens, GI148612816, Length=430, Percent_Identity=37.2093023255814, Blast_Score=276, Evalue=6e-74,
Organism=Homo sapiens, GI51242947, Length=360, Percent_Identity=40.5555555555556, Blast_Score=265, Evalue=1e-70,
Organism=Homo sapiens, GI51242943, Length=360, Percent_Identity=40.5555555555556, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI284005309, Length=369, Percent_Identity=37.3983739837398, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI4758138, Length=374, Percent_Identity=24.0641711229947, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI148613856, Length=360, Percent_Identity=24.7222222222222, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI38201710, Length=360, Percent_Identity=24.7222222222222, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI7661920, Length=364, Percent_Identity=21.978021978022, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI13514831, Length=368, Percent_Identity=23.6413043478261, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI222352149, Length=336, Percent_Identity=22.3214285714286, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI20149629, Length=348, Percent_Identity=23.2758620689655, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI55749865, Length=386, Percent_Identity=22.7979274611399, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI48994977, Length=592, Percent_Identity=65.7094594594595, Blast_Score=834, Evalue=0.0,
Organism=Escherichia coli, GI87082221, Length=346, Percent_Identity=24.5664739884393, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25145561, Length=647, Percent_Identity=33.0757341576507, Blast_Score=337, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI32564293, Length=673, Percent_Identity=30.9063893016345, Blast_Score=298, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI71987997, Length=409, Percent_Identity=37.8973105134474, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71987993, Length=409, Percent_Identity=37.8973105134474, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17552866, Length=445, Percent_Identity=35.0561797752809, Blast_Score=259, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17537549, Length=382, Percent_Identity=22.7748691099476, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17552114, Length=361, Percent_Identity=23.5457063711911, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI32565321, Length=366, Percent_Identity=24.0437158469945, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71995724, Length=358, Percent_Identity=21.5083798882682, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17507121, Length=358, Percent_Identity=21.2290502793296, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533224, Length=360, Percent_Identity=24.4444444444444, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71987143, Length=380, Percent_Identity=24.7368421052632, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17555296, Length=335, Percent_Identity=24.1791044776119, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323844, Length=521, Percent_Identity=39.7312859884837, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6320224, Length=376, Percent_Identity=22.8723404255319, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324217, Length=336, Percent_Identity=24.702380952381, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320041, Length=365, Percent_Identity=24.1095890410959, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321360, Length=340, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321856, Length=353, Percent_Identity=22.9461756373938, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646066, Length=627, Percent_Identity=33.652312599681, Blast_Score=358, Evalue=7e-99,
Organism=Drosophila melanogaster, GI24664226, Length=451, Percent_Identity=36.8070953436807, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24664230, Length=452, Percent_Identity=36.7256637168142, Blast_Score=284, Evalue=2e-76,
Organism=Drosophila melanogaster, GI62472181, Length=452, Percent_Identity=36.7256637168142, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI21358123, Length=387, Percent_Identity=36.1757105943152, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI28574962, Length=378, Percent_Identity=25.9259259259259, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24585582, Length=350, Percent_Identity=24, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583281, Length=367, Percent_Identity=23.433242506812, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24583279, Length=367, Percent_Identity=23.7057220708447, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355075, Length=394, Percent_Identity=19.7969543147208, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17977678, Length=335, Percent_Identity=24.4776119402985, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 69103; Mature: 68972

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATLIAEQTPTPANDAQDILQDVFGYQSFRDGQQEVIDLAVEGKDSLVIMPTGGGKSLC
CCCEEEECCCCCCCCHHHHHHHHHHCCHHHCCCHHHHHHHHCCCCCCEEEEECCCCCHHH
YQIPALVRDGLTLVISPLISLMKDQVDQLKANGVAAECINSSMPRDQLLSVFNRMNSGQL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHCCCCCCE
KMVYASPERVLMRDFIERLQGLPLSMIAVDEAHCISQWGHDFRPEYASLGQLKQYFPHVP
EEEEECHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
YMALTATADDATRKDIISRLQLVDPHTHLGSFDRPNIRYNLVEKHKPVSQVVRYLETQKG
CEEEEECCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCEEEHHHHCCCHHHHHHHHHCCCC
NCGIIYCGSRKKVEMVTEKLCNNGIRAAGYHAGMDTDERAYVQEAFQRDDIQIVVATVAF
CEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEHHHHHHH
GMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMMLFDPADMGWLRRMLDEKE
HCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
EGPQKQVEMHKLNAMSAFAEAQTCRRQVLLNYFGEYREKQCGNCDICLDPPKHFDATQEA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHH
QKALSCVYRVNQSFGMGYVVEVMRGMQNIRVRDNGHDKLSTYGIGRDHSHDYWISIFRQL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCEECCCCCCCHHHCCCCCCCCCHHHHHHHHHH
IHKGLLFQNITRNSTLQLTEEARPLLRGEMSLELAVPRLDTAVRNAKSDKLSSKNYDKKL
HHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCEEEECCHHHHHHHCCCHHHCCCCCCCHHH
FAKLRKLRKSIADEDGLPPYVVFSDATLIDMAEILPTSYGEMLAVNGVGQRKLDKYADPF
HHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHH
LDLIQEHITTHG
HHHHHHHHHCCC
>Mature Secondary Structure 
TATLIAEQTPTPANDAQDILQDVFGYQSFRDGQQEVIDLAVEGKDSLVIMPTGGGKSLC
CCEEEECCCCCCCCHHHHHHHHHHCCHHHCCCHHHHHHHHCCCCCCEEEEECCCCCHHH
YQIPALVRDGLTLVISPLISLMKDQVDQLKANGVAAECINSSMPRDQLLSVFNRMNSGQL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHCCCCCCE
KMVYASPERVLMRDFIERLQGLPLSMIAVDEAHCISQWGHDFRPEYASLGQLKQYFPHVP
EEEEECHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
YMALTATADDATRKDIISRLQLVDPHTHLGSFDRPNIRYNLVEKHKPVSQVVRYLETQKG
CEEEEECCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCEEEHHHHCCCHHHHHHHHHCCCC
NCGIIYCGSRKKVEMVTEKLCNNGIRAAGYHAGMDTDERAYVQEAFQRDDIQIVVATVAF
CEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEHHHHHHH
GMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMMLFDPADMGWLRRMLDEKE
HCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
EGPQKQVEMHKLNAMSAFAEAQTCRRQVLLNYFGEYREKQCGNCDICLDPPKHFDATQEA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHH
QKALSCVYRVNQSFGMGYVVEVMRGMQNIRVRDNGHDKLSTYGIGRDHSHDYWISIFRQL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCEECCCCCCCHHHCCCCCCCCCHHHHHHHHHH
IHKGLLFQNITRNSTLQLTEEARPLLRGEMSLELAVPRLDTAVRNAKSDKLSSKNYDKKL
HHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCEEEECCHHHHHHHCCCHHHCCCCCCCHHH
FAKLRKLRKSIADEDGLPPYVVFSDATLIDMAEILPTSYGEMLAVNGVGQRKLDKYADPF
HHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHH
LDLIQEHITTHG
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]