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The map label for this gene is ycdW [C]

Identifier: 218710873

GI number: 218710873

Start: 3115884

End: 3116810

Strand: Direct

Name: ycdW [C]

Synonym: VS_2957

Alternate gene names: 218710873

Gene position: 3115884-3116810 (Clockwise)

Preceding gene: 218710871

Following gene: 218710874

Centisome position: 94.44

GC content: 45.31

Gene sequence:

>927_bases
ATGAACAATTTTACGAATAAGCTCTATATTCTTACCGAGCATGACGATACCTATACGCAACTGATTCTAAACCAAGGGTT
ACCTGACCTCGAAATCACTCAAAACCCCGAATTAGCTGAGATCGTACTGGCTGCTCCTCCTTTAATAGTGGAGCGACTTA
ATGAGTTTAAAAAGCTAGACTGGGTGCAAAGTACCTATGCTGGAATCAATAAACTCACTCAGCCGGATCTTCGCCAAGAT
TATACGCTGACCAACGTCAAAGGCATCTTCGGCCCTGCGATTGCTGAATACGTGTTGGGTTACACGATCAGCCACTGTAG
ACACTTTCCTCACTACCACCAGCAACAAGTACAACGAAACTGGCAGCCGCAGCTTTATACCAGCCTAACTGACAAAACCA
TGGTGATTTTAGGAACGGGGTCAATTGGCAGTCATTTAGCTAAAACCGCTGCTGCTTTTGGTATTCACACCATAGGTGTC
AACCGGACAGGTATCCCATCAAAGCAAGAAACCTTCAAAGACACTTTCCACATCAATGAGATAGAGGCTGCCCTTAAGCA
AGCGGATATTGTGGTCAACACCTTGCCATCAACAGCTGAAACCTATCAATTACTCAATCAAACGACCTTAAGTTACTGCT
CGAATGTACTGCTGTTCAATGTTGGCAGAGGAGAGAGCTTAGATAAAAAAGCCTTGCTGCTTGCGATTAAGAATAAGTGG
GTTGAGCATGCTTTCTTGGATGTGTTTGAAAGTGAGCCCCTCTCGCAGGAGCACCCTTTCTGGACATTACCGCAAGTGAC
CATCACCCCGCACATTGCAGCGCTGAGTGAGCCAAGGCAGGTGGTAAAGATCTTCGCCGAGAATTACCAACAATGGCGAG
ATGGCTTTAAACTGAACCATGTCATCGATTTTGATAAAGGTTACTGA

Upstream 100 bases:

>100_bases
AGACGAACCTGCAGTGGATTCTGAAGCATAGTCACTCAATAATTGCAGAAAAAGACAGCGAAAGTGTACTTGATAAACCC
TGGGGGGAAAAGGTAAGCCG

Downstream 100 bases:

>100_bases
TGTCCTCATCGTTACTCAAAGAGATTCGACAATGCCGAGCTTGTGAGCCTCACCTATCACACGGTGCTAACCCGGTAATT
CAAGCGCATCCAAACGCGCG

Product: phosphoglycerate dehydrogenase

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MNNFTNKLYILTEHDDTYTQLILNQGLPDLEITQNPELAEIVLAAPPLIVERLNEFKKLDWVQSTYAGINKLTQPDLRQD
YTLTNVKGIFGPAIAEYVLGYTISHCRHFPHYHQQQVQRNWQPQLYTSLTDKTMVILGTGSIGSHLAKTAAAFGIHTIGV
NRTGIPSKQETFKDTFHINEIEAALKQADIVVNTLPSTAETYQLLNQTTLSYCSNVLLFNVGRGESLDKKALLLAIKNKW
VEHAFLDVFESEPLSQEHPFWTLPQVTITPHIAALSEPRQVVKIFAENYQQWRDGFKLNHVIDFDKGY

Sequences:

>Translated_308_residues
MNNFTNKLYILTEHDDTYTQLILNQGLPDLEITQNPELAEIVLAAPPLIVERLNEFKKLDWVQSTYAGINKLTQPDLRQD
YTLTNVKGIFGPAIAEYVLGYTISHCRHFPHYHQQQVQRNWQPQLYTSLTDKTMVILGTGSIGSHLAKTAAAFGIHTIGV
NRTGIPSKQETFKDTFHINEIEAALKQADIVVNTLPSTAETYQLLNQTTLSYCSNVLLFNVGRGESLDKKALLLAIKNKW
VEHAFLDVFESEPLSQEHPFWTLPQVTITPHIAALSEPRQVVKIFAENYQQWRDGFKLNHVIDFDKGY
>Mature_308_residues
MNNFTNKLYILTEHDDTYTQLILNQGLPDLEITQNPELAEIVLAAPPLIVERLNEFKKLDWVQSTYAGINKLTQPDLRQD
YTLTNVKGIFGPAIAEYVLGYTISHCRHFPHYHQQQVQRNWQPQLYTSLTDKTMVILGTGSIGSHLAKTAAAFGIHTIGV
NRTGIPSKQETFKDTFHINEIEAALKQADIVVNTLPSTAETYQLLNQTTLSYCSNVLLFNVGRGESLDKKALLLAIKNKW
VEHAFLDVFESEPLSQEHPFWTLPQVTITPHIAALSEPRQVVKIFAENYQQWRDGFKLNHVIDFDKGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=273, Percent_Identity=25.6410256410256, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI6912396, Length=244, Percent_Identity=27.0491803278689, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87081824, Length=222, Percent_Identity=32.8828828828829, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87082289, Length=188, Percent_Identity=28.7234042553192, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787645, Length=207, Percent_Identity=25.6038647342995, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=271, Percent_Identity=26.5682656826568, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=152, Percent_Identity=34.8684210526316, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324055, Length=249, Percent_Identity=27.3092369477912, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=151, Percent_Identity=31.7880794701987, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322116, Length=203, Percent_Identity=26.6009852216749, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320925, Length=209, Percent_Identity=25.8373205741627, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574286, Length=247, Percent_Identity=27.1255060728745, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571528, Length=185, Percent_Identity=28.6486486486486, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585514, Length=241, Percent_Identity=25.7261410788382, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574282, Length=241, Percent_Identity=25.7261410788382, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574284, Length=241, Percent_Identity=25.7261410788382, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45551003, Length=241, Percent_Identity=25.7261410788382, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45552429, Length=241, Percent_Identity=25.7261410788382, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 35021; Mature: 35021

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNFTNKLYILTEHDDTYTQLILNQGLPDLEITQNPELAEIVLAAPPLIVERLNEFKKLD
CCCCCCEEEEEEECCCHHHHHHHHCCCCCCEECCCCCHHHHHHHCCHHHHHHHHHHHHHH
WVQSTYAGINKLTQPDLRQDYTLTNVKGIFGPAIAEYVLGYTISHCRHFPHYHQQQVQRN
HHHHHHHHHHHCCCCCHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
WQPQLYTSLTDKTMVILGTGSIGSHLAKTAAAFGIHTIGVNRTGIPSKQETFKDTFHINE
CCCHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHCHHH
IEAALKQADIVVNTLPSTAETYQLLNQTTLSYCSNVLLFNVGRGESLDKKALLLAIKNKW
HHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHH
VEHAFLDVFESEPLSQEHPFWTLPQVTITPHIAALSEPRQVVKIFAENYQQWRDGFKLNH
HHHHHHHHHCCCCCCCCCCEEECCCEEECCHHHHHCCHHHHHHHHHHHHHHHHCCCEECE
VIDFDKGY
EECCCCCC
>Mature Secondary Structure
MNNFTNKLYILTEHDDTYTQLILNQGLPDLEITQNPELAEIVLAAPPLIVERLNEFKKLD
CCCCCCEEEEEEECCCHHHHHHHHCCCCCCEECCCCCHHHHHHHCCHHHHHHHHHHHHHH
WVQSTYAGINKLTQPDLRQDYTLTNVKGIFGPAIAEYVLGYTISHCRHFPHYHQQQVQRN
HHHHHHHHHHHCCCCCHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
WQPQLYTSLTDKTMVILGTGSIGSHLAKTAAAFGIHTIGVNRTGIPSKQETFKDTFHINE
CCCHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHCHHH
IEAALKQADIVVNTLPSTAETYQLLNQTTLSYCSNVLLFNVGRGESLDKKALLLAIKNKW
HHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHH
VEHAFLDVFESEPLSQEHPFWTLPQVTITPHIAALSEPRQVVKIFAENYQQWRDGFKLNH
HHHHHHHHHCCCCCCCCCCEEECCCEEECCHHHHHCCHHHHHHHHHHHHHHHHCCCEECE
VIDFDKGY
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]