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The map label for this gene is cytR [H]

Identifier: 218710816

GI number: 218710816

Start: 3053866

End: 3054870

Strand: Direct

Name: cytR [H]

Synonym: VS_2899

Alternate gene names: 218710816

Gene position: 3053866-3054870 (Clockwise)

Preceding gene: 218710815

Following gene: 218710817

Centisome position: 92.56

GC content: 48.16

Gene sequence:

>1005_bases
ATGGCGACAATGAAGGATGTTGCCCAGCTAGCAGGCGTTTCAACAGCCACGGTATCACGTGCATTGATGAACCCTGAAAA
AGTCTCGGTTTCTACTCGTAAGCGAGTGGAGACAGCAGTACTTGAAGCTGGATACTCACCCAATACATTAGCTAGAAACT
TACGTCGCAACGAATCAAAAACCATCATCACTATTGTTCCTGATATCTGTGACCCGTATTTCGCAGAGATCATTCGTGGT
ATCGAAGATGCCGCAGTAGAAAATGACTACCTCGTTTTACTGGGTGATAGCGGCCAACAGAAGAAGCGTGAGTCTTCATT
TGTTAACTTAGTATTCACCAAACAAGCTGACGGCATGCTACTACTTGGCACCGACCACCCGTTTGATGTCAGTAAGCCTG
AACAAAAAAATTTACCGCCGATGGTGATGGCGTGTGAGTTTGCCCCTGAGCTTGAACTCCCTACCGTACACATCGATAAC
CTGACCTCAGCATTTGAAGCGGTGAACTACCTAGCTCAGTTAGGCCATAAACGTATCGCTCAAATCTCAGGGCCCATATC
GGCAACGCTGTGTAAATTCCGCCAACAAGGTTACCAACAAGCGCTACGTCGTGCAGGAGTATCAATGAATCCTGCCTACA
GCACTGTCGGTGACTTTACCTTTGAAGCGGGCGCTCAAGCTGTTCGTCAATTACTCGCTCTTCCTGAACAACCTACAGCG
ATCTTCTGTCATAACGATGCGATGGCCATCGGCGCGATTCAAGAAGCGAAAAAATTAGGCTTACGCGTTCCTCAAGACCT
ATCGATTGTCGGCTTTGATGACATCCAATTCGCTCAATACTGCGATCCACCGCTAACCACTATTTCTCAGCCTCGTTATG
AGATTGGACGCCAAGCAATGTTGATGATGCTCGACGTACTTAAAGGCAACGATGTGCAAGCGGGGTCGCGCCTGCTTGAA
GCCAAATTAGTCGTTCGAGGTAGTACAGCGCCGCCTCGAATCTAA

Upstream 100 bases:

>100_bases
AAAAGTGTTAGCAACACTTTCACAATATCTATTCGATTACATTTATTATTCATGCCTTAGATACTTAGGCAGCAAAGGAA
TTAAAAAGAGGGTTTAATTT

Downstream 100 bases:

>100_bases
TCTGAAGAAATATCGTTATAATTCTGCGGCACATTTTGATGTGCCGCTTCCATTTCTGCACTGTTATCCTCGCTCAATCT
GGATTACCATGAGAGCAGAA

Product: DNA-binding transcriptional regulator CytR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MATMKDVAQLAGVSTATVSRALMNPEKVSVSTRKRVETAVLEAGYSPNTLARNLRRNESKTIITIVPDICDPYFAEIIRG
IEDAAVENDYLVLLGDSGQQKKRESSFVNLVFTKQADGMLLLGTDHPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDN
LTSAFEAVNYLAQLGHKRIAQISGPISATLCKFRQQGYQQALRRAGVSMNPAYSTVGDFTFEAGAQAVRQLLALPEQPTA
IFCHNDAMAIGAIQEAKKLGLRVPQDLSIVGFDDIQFAQYCDPPLTTISQPRYEIGRQAMLMMLDVLKGNDVQAGSRLLE
AKLVVRGSTAPPRI

Sequences:

>Translated_334_residues
MATMKDVAQLAGVSTATVSRALMNPEKVSVSTRKRVETAVLEAGYSPNTLARNLRRNESKTIITIVPDICDPYFAEIIRG
IEDAAVENDYLVLLGDSGQQKKRESSFVNLVFTKQADGMLLLGTDHPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDN
LTSAFEAVNYLAQLGHKRIAQISGPISATLCKFRQQGYQQALRRAGVSMNPAYSTVGDFTFEAGAQAVRQLLALPEQPTA
IFCHNDAMAIGAIQEAKKLGLRVPQDLSIVGFDDIQFAQYCDPPLTTISQPRYEIGRQAMLMMLDVLKGNDVQAGSRLLE
AKLVVRGSTAPPRI
>Mature_333_residues
ATMKDVAQLAGVSTATVSRALMNPEKVSVSTRKRVETAVLEAGYSPNTLARNLRRNESKTIITIVPDICDPYFAEIIRGI
EDAAVENDYLVLLGDSGQQKKRESSFVNLVFTKQADGMLLLGTDHPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDNL
TSAFEAVNYLAQLGHKRIAQISGPISATLCKFRQQGYQQALRRAGVSMNPAYSTVGDFTFEAGAQAVRQLLALPEQPTAI
FCHNDAMAIGAIQEAKKLGLRVPQDLSIVGFDDIQFAQYCDPPLTTISQPRYEIGRQAMLMMLDVLKGNDVQAGSRLLEA
KLVVRGSTAPPRI

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=328, Percent_Identity=64.3292682926829, Blast_Score=456, Evalue=1e-130,
Organism=Escherichia coli, GI1790194, Length=331, Percent_Identity=37.4622356495468, Blast_Score=221, Evalue=4e-59,
Organism=Escherichia coli, GI1787948, Length=333, Percent_Identity=34.2342342342342, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1789202, Length=291, Percent_Identity=32.6460481099656, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1788474, Length=330, Percent_Identity=32.7272727272727, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789068, Length=340, Percent_Identity=31.7647058823529, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI48994940, Length=312, Percent_Identity=30.1282051282051, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786540, Length=341, Percent_Identity=30.2052785923754, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1790715, Length=313, Percent_Identity=29.3929712460064, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787580, Length=314, Percent_Identity=25.4777070063694, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1787906, Length=332, Percent_Identity=26.2048192771084, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1789456, Length=341, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786268, Length=312, Percent_Identity=23.7179487179487, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790192, Length=299, Percent_Identity=25.4180602006689, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36524; Mature: 36392

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATMKDVAQLAGVSTATVSRALMNPEKVSVSTRKRVETAVLEAGYSPNTLARNLRRNESK
CCCHHHHHHHHCCHHHHHHHHHCCCHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
TIITIVPDICDPYFAEIIRGIEDAAVENDYLVLLGDSGQQKKRESSFVNLVFTKQADGML
EEEEECCHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCEEEEEEEECCCCEE
LLGTDHPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDNLTSAFEAVNYLAQLGHKRIA
EEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
QISGPISATLCKFRQQGYQQALRRAGVSMNPAYSTVGDFTFEAGAQAVRQLLALPEQPTA
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCE
IFCHNDAMAIGAIQEAKKLGLRVPQDLSIVGFDDIQFAQYCDPPLTTISQPRYEIGRQAM
EEEECCCEEHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHH
LMMLDVLKGNDVQAGSRLLEAKLVVRGSTAPPRI
HHHHHHHCCCCCHHHHHHHHHEEEEECCCCCCCC
>Mature Secondary Structure 
ATMKDVAQLAGVSTATVSRALMNPEKVSVSTRKRVETAVLEAGYSPNTLARNLRRNESK
CCHHHHHHHHCCHHHHHHHHHCCCHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
TIITIVPDICDPYFAEIIRGIEDAAVENDYLVLLGDSGQQKKRESSFVNLVFTKQADGML
EEEEECCHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCEEEEEEEECCCCEE
LLGTDHPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDNLTSAFEAVNYLAQLGHKRIA
EEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
QISGPISATLCKFRQQGYQQALRRAGVSMNPAYSTVGDFTFEAGAQAVRQLLALPEQPTA
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCE
IFCHNDAMAIGAIQEAKKLGLRVPQDLSIVGFDDIQFAQYCDPPLTTISQPRYEIGRQAM
EEEECCCEEHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHH
LMMLDVLKGNDVQAGSRLLEAKLVVRGSTAPPRI
HHHHHHHCCCCCHHHHHHHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]