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The map label for this gene is argE

Identifier: 218710806

GI number: 218710806

Start: 3038617

End: 3039753

Strand: Direct

Name: argE

Synonym: VS_2889

Alternate gene names: 218710806

Gene position: 3038617-3039753 (Clockwise)

Preceding gene: 218710801

Following gene: 218710807

Centisome position: 92.1

GC content: 47.05

Gene sequence:

>1137_bases
ATGCAATTACCGAGTTTCCTTGAGGTCTATAAAGGCCTAATTTCCACCGACTCCATTAGCTCAACAGATCCAAGCTGGGA
TCATGGCAACGAGAAAGTGATCGAAAAAATGGCTCAATGGTTTAAAGACGTAGGCTTTAGCGTTGAGGTCGTGGAAGTCG
AACCCGGCAAGCATAATATGGTCGCAAAGATGGGTTCTGGCGAAGGGGGCTTATTGCTTGCAGGACACAGCGATACCGTG
CCATTCGATGAAGGACGTTGGAACTTCGATCCTCACGCATTGACAGAACACAACAACCGCTTCTACGGATTAGGCACCGC
CGATATGAAAGGCTTTTTTGCCTTCGTTTATGAAGCTGCTAAGAAAATGGATTGGAGCAAGCAAACCAAGCCGCTTTATG
TTTTAGCTACGTGTGACGAAGAAACCACTATGCTAGGTGCACGTCATTTCACTGAAAATGCGCCGTTTAAACCGGACTAC
TGCATTATTGGTGAGCCGACCAGCCTAGTGCCTATCCGTGGTCATAAGGGGCATGTCGCTAATGCTGTGCGAGTAACGGG
TAAATCAGGTCACTCTTCTGATCCTGCATTAGGCGTTAACGCCATCGAGATCATGCATGAAGTGCTGTTTGCTTTAATGC
AGCTGCGTGACAAGTTAGTCAAAGAGTACCATCACCCGGGTTTCGCGATTCCAAGCCCTACTCTAAATCTTGGGCATATT
CACGGAGGAGATAGCGCTAACCGAATCTGTGGTTGTTGTGAATTACACTACGACGTTCGTCCTTTACCGGGCATCAGCTT
AGATGGTTTGGATAACATGCTACGCAGCGCGCTCAAGGAAGTAGAAGCAAAATGGCCGGGCAGGATTGAGATTACTCCCC
TGCATGAGCCGATTCCGGGTTACGAATGTCAGCACGATCATCCATTTATCGGTGGCATGGAATCAGTGTGTGAAACCGAA
TCTCAAACTGTGAACTATTGTACTGAAGCACCTTTCCTTCAGGAGTTATGTCCAACCTTAGTGTTAGGCCCAGGCTCAAT
CGACCAAGCTCACCAACCGGATGAGTTCTTAAGCTTCGATTTTATTGACCCTACAATTGATGTTCTGAGTAAATCGATCC
GTAAATATTGTTTCTAG

Upstream 100 bases:

>100_bases
TTAATTTTTAGCTATATTTGATTTCTTATGCATTAAATATGATTTAATATGTGTTTTACCGACTTATGGTTTTCCTGTCA
ATAGTAGAAGTGAAGATATT

Downstream 100 bases:

>100_bases
TTATTACTTTCCTTCCGATATTTTCATATAAAAGCCACCCGAAAAGGTGGCTTTTATTCTGTTATCCCTGATACAGCCCG
ATCTTGTAATTAAATTTCAC

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MQLPSFLEVYKGLISTDSISSTDPSWDHGNEKVIEKMAQWFKDVGFSVEVVEVEPGKHNMVAKMGSGEGGLLLAGHSDTV
PFDEGRWNFDPHALTEHNNRFYGLGTADMKGFFAFVYEAAKKMDWSKQTKPLYVLATCDEETTMLGARHFTENAPFKPDY
CIIGEPTSLVPIRGHKGHVANAVRVTGKSGHSSDPALGVNAIEIMHEVLFALMQLRDKLVKEYHHPGFAIPSPTLNLGHI
HGGDSANRICGCCELHYDVRPLPGISLDGLDNMLRSALKEVEAKWPGRIEITPLHEPIPGYECQHDHPFIGGMESVCETE
SQTVNYCTEAPFLQELCPTLVLGPGSIDQAHQPDEFLSFDFIDPTIDVLSKSIRKYCF

Sequences:

>Translated_378_residues
MQLPSFLEVYKGLISTDSISSTDPSWDHGNEKVIEKMAQWFKDVGFSVEVVEVEPGKHNMVAKMGSGEGGLLLAGHSDTV
PFDEGRWNFDPHALTEHNNRFYGLGTADMKGFFAFVYEAAKKMDWSKQTKPLYVLATCDEETTMLGARHFTENAPFKPDY
CIIGEPTSLVPIRGHKGHVANAVRVTGKSGHSSDPALGVNAIEIMHEVLFALMQLRDKLVKEYHHPGFAIPSPTLNLGHI
HGGDSANRICGCCELHYDVRPLPGISLDGLDNMLRSALKEVEAKWPGRIEITPLHEPIPGYECQHDHPFIGGMESVCETE
SQTVNYCTEAPFLQELCPTLVLGPGSIDQAHQPDEFLSFDFIDPTIDVLSKSIRKYCF
>Mature_378_residues
MQLPSFLEVYKGLISTDSISSTDPSWDHGNEKVIEKMAQWFKDVGFSVEVVEVEPGKHNMVAKMGSGEGGLLLAGHSDTV
PFDEGRWNFDPHALTEHNNRFYGLGTADMKGFFAFVYEAAKKMDWSKQTKPLYVLATCDEETTMLGARHFTENAPFKPDY
CIIGEPTSLVPIRGHKGHVANAVRVTGKSGHSSDPALGVNAIEIMHEVLFALMQLRDKLVKEYHHPGFAIPSPTLNLGHI
HGGDSANRICGCCELHYDVRPLPGISLDGLDNMLRSALKEVEAKWPGRIEITPLHEPIPGYECQHDHPFIGGMESVCETE
SQTVNYCTEAPFLQELCPTLVLGPGSIDQAHQPDEFLSFDFIDPTIDVLSKSIRKYCF

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily

Homologues:

Organism=Escherichia coli, GI1790395, Length=380, Percent_Identity=57.8947368421053, Blast_Score=484, Evalue=1e-138,
Organism=Escherichia coli, GI1789236, Length=358, Percent_Identity=24.8603351955307, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788816, Length=255, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17551016, Length=377, Percent_Identity=26.525198938992, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGE_VIBSL (B7VLL4)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002418427.1
- ProteinModelPortal:   B7VLL4
- SMR:   B7VLL4
- MEROPS:   M20.974
- GeneID:   7162373
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_2889
- HOGENOM:   HBG728841
- OMA:   RICGQCA
- ProtClustDB:   PRK05111
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_01108
- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650
- TIGRFAMs:   TIGR01892

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20; SSF55031 Peptidase_M20_dimer

EC number: =3.5.1.16

Molecular weight: Translated: 41899; Mature: 41899

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00758 ARGE_DAPE_CPG2_1; PS00759 ARGE_DAPE_CPG2_2

Important sites: ACT_SITE 78-78 ACT_SITE 140-140

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLPSFLEVYKGLISTDSISSTDPSWDHGNEKVIEKMAQWFKDVGFSVEVVEVEPGKHNM
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCE
VAKMGSGEGGLLLAGHSDTVPFDEGRWNFDPHALTEHNNRFYGLGTADMKGFFAFVYEAA
EEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
KKMDWSKQTKPLYVLATCDEETTMLGARHFTENAPFKPDYCIIGEPTSLVPIRGHKGHVA
HHCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEECCCCCCCC
NAVRVTGKSGHSSDPALGVNAIEIMHEVLFALMQLRDKLVKEYHHPGFAIPSPTLNLGHI
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECEE
HGGDSANRICGCCELHYDVRPLPGISLDGLDNMLRSALKEVEAKWPGRIEITPLHEPIPG
ECCCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
YECQHDHPFIGGMESVCETESQTVNYCTEAPFLQELCPTLVLGPGSIDQAHQPDEFLSFD
CCCCCCCCCCCCHHHHHHCCHHHHHHHHCCHHHHHHHHHEEECCCCCCCCCCCCHHCEEC
FIDPTIDVLSKSIRKYCF
CCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLPSFLEVYKGLISTDSISSTDPSWDHGNEKVIEKMAQWFKDVGFSVEVVEVEPGKHNM
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCE
VAKMGSGEGGLLLAGHSDTVPFDEGRWNFDPHALTEHNNRFYGLGTADMKGFFAFVYEAA
EEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
KKMDWSKQTKPLYVLATCDEETTMLGARHFTENAPFKPDYCIIGEPTSLVPIRGHKGHVA
HHCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEECCCCCCCC
NAVRVTGKSGHSSDPALGVNAIEIMHEVLFALMQLRDKLVKEYHHPGFAIPSPTLNLGHI
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECEE
HGGDSANRICGCCELHYDVRPLPGISLDGLDNMLRSALKEVEAKWPGRIEITPLHEPIPG
ECCCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
YECQHDHPFIGGMESVCETESQTVNYCTEAPFLQELCPTLVLGPGSIDQAHQPDEFLSFD
CCCCCCCCCCCCHHHHHHCCHHHHHHHHCCHHHHHHHHHEEECCCCCCCCCCCCHHCEEC
FIDPTIDVLSKSIRKYCF
CCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA