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The map label for this gene is mltC [H]

Identifier: 218710640

GI number: 218710640

Start: 2879737

End: 2880870

Strand: Direct

Name: mltC [H]

Synonym: VS_2694

Alternate gene names: 218710640

Gene position: 2879737-2880870 (Clockwise)

Preceding gene: 218710639

Following gene: 218710642

Centisome position: 87.28

GC content: 41.89

Gene sequence:

>1134_bases
ATGAAAAAGCTAAGTTACTTCCTAACAGCCATGTTGTTAACAGGGTGCAGTCGTGAATTTGTCGAGAGCATTTATGATGT
TAACTACGAACCAACCAACCGGTTTGTAAGTAATTTGGCAGAACTACCAGGGCAATTTGAAAAAGATACTGGGGCGTTGG
ATGCTTTGATTAGTAGCTTTTCAGGCAATATCCAAAAGCGTTGGGGCAGCAGTGAAGTAAAGATGGCAGGTAAGAGTAAC
TATGTGAAATACATAGACAATTATCTAAGCCGTTCAGAAGTTAACTTCAGTCAAGGTCTCATAACGGTAGAAACCGTCTC
CTTAACAGATCCTAAAAAGCACCTCAAAAATGCGATCATGACGACGCTCCTGACACCCGATGATCCAGCTCATGTCGATC
TATTTTCGTCCAAAAGCATAAAGCTAGAAGGTCAACCTTTCCTCTACAACCAAGTCGTAGACCAAGAGAAAAAGCCCATC
CAATGGACATGGCGTGCTAACAAATTCGCAGATTACCTGATCGCCAATAACCTAAAAACCAAAGAGGTAGACTTTAAAAA
AGCCTACTACGTCGAAATCCCAATGGTGGCAGATCATGCGAGCAAACGTAGTTATAAGTATGCCGACATAGTACAACGAG
CATCTCAACGCTATGACATCCCTGAAGACTTGATCTATGCAATCATCAAGACAGAAAGCAGCTTCAATCCTTACGCAGTG
AGCTGGGCAAATGCTTATGGTCTTATGCAGGTGGTACCTAAAACCGCTGGCCGAGATGTCTTTAAGCTCGTTAAAAAGAA
ACCTGGAGAACCAAGTCCTGAGTACTTATTCAATCCAGAAAACAACATTGATGCAGGCACCGCATACTTTTACATCCTTA
AAAATCGTTATTTAAAAGACGTAAAACACCCAACCACGCTTGAGTACAGTATGATCTCTGCATACAACGGCGGCACTGGT
GGCGTGCTCAATACTTTTAGTAAGGATAGAAAGCGAGCAATGCGTGACTTAAATTCACTGCAACCGAGTCAAGCTTACTG
GGCACTAACAAAGAAACATCCCAATAAAGAGTCGCGCCGATACTTAGAGAAAGTAACAAAATTCAAGAAAGATTTTAACC
AAGGTAAAACGTAA

Upstream 100 bases:

>100_bases
TATTGATGGCTATACCCCGCCTAGCGAATAAGACATTTATTTAAATAAATTTTAATGACATCATGGTTTACGCCGCGATG
TCATTTTTGTATGAGGAACT

Downstream 100 bases:

>100_bases
GCCTCACTTTTGAATAAAAAAACAACTAACGAACGTTTTTTTTAGTTATTTTCAAAAAAGGTGTTGACGGTTATGCAGAA
AATCCGTTTAATAGCGCTCC

Product: membrane-bound lytic murein transglycosylase C

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKKLSYFLTAMLLTGCSREFVESIYDVNYEPTNRFVSNLAELPGQFEKDTGALDALISSFSGNIQKRWGSSEVKMAGKSN
YVKYIDNYLSRSEVNFSQGLITVETVSLTDPKKHLKNAIMTTLLTPDDPAHVDLFSSKSIKLEGQPFLYNQVVDQEKKPI
QWTWRANKFADYLIANNLKTKEVDFKKAYYVEIPMVADHASKRSYKYADIVQRASQRYDIPEDLIYAIIKTESSFNPYAV
SWANAYGLMQVVPKTAGRDVFKLVKKKPGEPSPEYLFNPENNIDAGTAYFYILKNRYLKDVKHPTTLEYSMISAYNGGTG
GVLNTFSKDRKRAMRDLNSLQPSQAYWALTKKHPNKESRRYLEKVTKFKKDFNQGKT

Sequences:

>Translated_377_residues
MKKLSYFLTAMLLTGCSREFVESIYDVNYEPTNRFVSNLAELPGQFEKDTGALDALISSFSGNIQKRWGSSEVKMAGKSN
YVKYIDNYLSRSEVNFSQGLITVETVSLTDPKKHLKNAIMTTLLTPDDPAHVDLFSSKSIKLEGQPFLYNQVVDQEKKPI
QWTWRANKFADYLIANNLKTKEVDFKKAYYVEIPMVADHASKRSYKYADIVQRASQRYDIPEDLIYAIIKTESSFNPYAV
SWANAYGLMQVVPKTAGRDVFKLVKKKPGEPSPEYLFNPENNIDAGTAYFYILKNRYLKDVKHPTTLEYSMISAYNGGTG
GVLNTFSKDRKRAMRDLNSLQPSQAYWALTKKHPNKESRRYLEKVTKFKKDFNQGKT
>Mature_377_residues
MKKLSYFLTAMLLTGCSREFVESIYDVNYEPTNRFVSNLAELPGQFEKDTGALDALISSFSGNIQKRWGSSEVKMAGKSN
YVKYIDNYLSRSEVNFSQGLITVETVSLTDPKKHLKNAIMTTLLTPDDPAHVDLFSSKSIKLEGQPFLYNQVVDQEKKPI
QWTWRANKFADYLIANNLKTKEVDFKKAYYVEIPMVADHASKRSYKYADIVQRASQRYDIPEDLIYAIIKTESSFNPYAV
SWANAYGLMQVVPKTAGRDVFKLVKKKPGEPSPEYLFNPENNIDAGTAYFYILKNRYLKDVKHPTTLEYSMISAYNGGTG
GVLNTFSKDRKRAMRDLNSLQPSQAYWALTKKHPNKESRRYLEKVTKFKKDFNQGKT

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=328, Percent_Identity=48.780487804878, Blast_Score=328, Evalue=3e-91,
Organism=Escherichia coli, GI87081855, Length=178, Percent_Identity=37.0786516853933, Blast_Score=122, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 43193; Mature: 43193

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLSYFLTAMLLTGCSREFVESIYDVNYEPTNRFVSNLAELPGQFEKDTGALDALISSF
CCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SGNIQKRWGSSEVKMAGKSNYVKYIDNYLSRSEVNFSQGLITVETVSLTDPKKHLKNAIM
CCCHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCHHCCEEEEEEEECCCHHHHHHHHHH
TTLLTPDDPAHVDLFSSKSIKLEGQPFLYNQVVDQEKKPIQWTWRANKFADYLIANNLKT
HHHCCCCCCCEEEEECCCCEEECCCCCHHHHHHCCCCCCEEEEEECHHHHHHHHHCCCCC
KEVDFKKAYYVEIPMVADHASKRSYKYADIVQRASQRYDIPEDLIYAIIKTESSFNPYAV
CCCCCCEEEEEEECHHHCCHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEE
SWANAYGLMQVVPKTAGRDVFKLVKKKPGEPSPEYLFNPENNIDAGTAYFYILKNRYLKD
EHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHEEHHHHHHHHHH
VKHPTTLEYSMISAYNGGTGGVLNTFSKDRKRAMRDLNSLQPSQAYWALTKKHPNKESRR
CCCCCCEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHH
YLEKVTKFKKDFNQGKT
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKLSYFLTAMLLTGCSREFVESIYDVNYEPTNRFVSNLAELPGQFEKDTGALDALISSF
CCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SGNIQKRWGSSEVKMAGKSNYVKYIDNYLSRSEVNFSQGLITVETVSLTDPKKHLKNAIM
CCCHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCHHCCEEEEEEEECCCHHHHHHHHHH
TTLLTPDDPAHVDLFSSKSIKLEGQPFLYNQVVDQEKKPIQWTWRANKFADYLIANNLKT
HHHCCCCCCCEEEEECCCCEEECCCCCHHHHHHCCCCCCEEEEEECHHHHHHHHHCCCCC
KEVDFKKAYYVEIPMVADHASKRSYKYADIVQRASQRYDIPEDLIYAIIKTESSFNPYAV
CCCCCCEEEEEEECHHHCCHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEE
SWANAYGLMQVVPKTAGRDVFKLVKKKPGEPSPEYLFNPENNIDAGTAYFYILKNRYLKD
EHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHEEHHHHHHHHHH
VKHPTTLEYSMISAYNGGTGGVLNTFSKDRKRAMRDLNSLQPSQAYWALTKKHPNKESRR
CCCCCCEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHH
YLEKVTKFKKDFNQGKT
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]