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The map label for this gene is cobC [H]

Identifier: 218710616

GI number: 218710616

Start: 2857150

End: 2858220

Strand: Direct

Name: cobC [H]

Synonym: VS_2670

Alternate gene names: 218710616

Gene position: 2857150-2858220 (Clockwise)

Preceding gene: 218710615

Following gene: 218710617

Centisome position: 86.6

GC content: 46.69

Gene sequence:

>1071_bases
ATGACGATTAAACAACACTCAACCTCAAACGAACTTCCGCATCACGGTGGTAAGTTAATCGAGTTTTCATTGCGCTATCA
AAGGCCAATCGAACAATGGGTCGACCTTTCAACTGGAGTAAGCCCGCACCACTACCCTATACCTGAAATCCCGACATCGG
TATGGAATCGGCTACCAGAAGACGATGATGGCTTAATCACAGCCGCGCAAACCTACTATCAAAGTGATGCCTTGTTACCC
GTAGCTGGCAGTCAGGCAGCCATTCAATCGCTACCTCATATGATTGCAAAGACACAGCCAACATTGACGTACATCCTATT
GCCTCATACGGGTTACAAAGAACATCAACATGCGTGGCAGCAGTACGCAGAACAAAGCATACAAGCCGTCATATTCGACT
TTTACCTACACAAACCGACAATCGAACAGCTGAAAACGGCAGACGTGGTCGTAGTGATTAATCCCAATAATCCAACCGCA
CTGAATGTGCCACCAAGTGAAGTACTGACTTGGCTAGATCATATCCAAGATCATTCAACGCTCGTGATTGATGAGGCGTT
TGTAGACTGTACTCCTGAGCTTTCAGTGTTACCGAGTTTCCCAACAGGAGTTCCAGATAACCTGATTGTATTGCGCTCAG
TGGGTAAATTTTTTGGACTGGCAGGGATTCGCGCAGGCTTTTGTTTTGCCTCGCCATTGCGTTTAAATATTCTTAAACAA
CACCTTGGACCTTGGACACTCAGTGGCCCAACGCGCTATGTCACCACACATGCCTTACTCAACTCCAATTGGCAGAAGAA
AAACCGCCAACGCCTGCATGAAGAGGCTCAGCGTATGAACCAACTCTTACAACTACATTTTGGCCAAATGGCGGGCTCGG
TAAAAATAACATCACAGATACTCTTTCACCGAGTTGAAATTTCAGATTCGGCATCATGGCACCATCAGCTCGCCAAGTTA
GGGGTTTTTACTCGTCATTGTGATGAAAACGATGCACTTCGTTTCGGGTTACCCGCCAACGAATCACAATGGCAAGCGCT
CACTCGCGCACTCGAACAACTCAAGGAATAA

Upstream 100 bases:

>100_bases
CCAGTGTGCTTTGGGCCATCGTAATGCTATTGCTTTCTCTTTTAACTCTTTGTTTATTTTGATTTCATGTCTATTTTAAC
TCTTTACTTTAAGTACGCTA

Downstream 100 bases:

>100_bases
TTATGTCTACAGCTTACTGTTCTGCCCTAGTGGTAGGCGCACCTTCTTCTGGAAGCGGAAAAACAACCGTGGTCGCCGCT
CTAGCAAGAGCTTTGGTTCA

Product: cobalamin biosynthetic protein CobC

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTIKQHSTSNELPHHGGKLIEFSLRYQRPIEQWVDLSTGVSPHHYPIPEIPTSVWNRLPEDDDGLITAAQTYYQSDALLP
VAGSQAAIQSLPHMIAKTQPTLTYILLPHTGYKEHQHAWQQYAEQSIQAVIFDFYLHKPTIEQLKTADVVVVINPNNPTA
LNVPPSEVLTWLDHIQDHSTLVIDEAFVDCTPELSVLPSFPTGVPDNLIVLRSVGKFFGLAGIRAGFCFASPLRLNILKQ
HLGPWTLSGPTRYVTTHALLNSNWQKKNRQRLHEEAQRMNQLLQLHFGQMAGSVKITSQILFHRVEISDSASWHHQLAKL
GVFTRHCDENDALRFGLPANESQWQALTRALEQLKE

Sequences:

>Translated_356_residues
MTIKQHSTSNELPHHGGKLIEFSLRYQRPIEQWVDLSTGVSPHHYPIPEIPTSVWNRLPEDDDGLITAAQTYYQSDALLP
VAGSQAAIQSLPHMIAKTQPTLTYILLPHTGYKEHQHAWQQYAEQSIQAVIFDFYLHKPTIEQLKTADVVVVINPNNPTA
LNVPPSEVLTWLDHIQDHSTLVIDEAFVDCTPELSVLPSFPTGVPDNLIVLRSVGKFFGLAGIRAGFCFASPLRLNILKQ
HLGPWTLSGPTRYVTTHALLNSNWQKKNRQRLHEEAQRMNQLLQLHFGQMAGSVKITSQILFHRVEISDSASWHHQLAKL
GVFTRHCDENDALRFGLPANESQWQALTRALEQLKE
>Mature_355_residues
TIKQHSTSNELPHHGGKLIEFSLRYQRPIEQWVDLSTGVSPHHYPIPEIPTSVWNRLPEDDDGLITAAQTYYQSDALLPV
AGSQAAIQSLPHMIAKTQPTLTYILLPHTGYKEHQHAWQQYAEQSIQAVIFDFYLHKPTIEQLKTADVVVVINPNNPTAL
NVPPSEVLTWLDHIQDHSTLVIDEAFVDCTPELSVLPSFPTGVPDNLIVLRSVGKFFGLAGIRAGFCFASPLRLNILKQH
LGPWTLSGPTRYVTTHALLNSNWQKKNRQRLHEEAQRMNQLLQLHFGQMAGSVKITSQILFHRVEISDSASWHHQLAKLG
VFTRHCDENDALRFGLPANESQWQALTRALEQLKE

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=121, Percent_Identity=33.0578512396694, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 40232; Mature: 40101

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKQHSTSNELPHHGGKLIEFSLRYQRPIEQWVDLSTGVSPHHYPIPEIPTSVWNRLPE
CCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCC
DDDGLITAAQTYYQSDALLPVAGSQAAIQSLPHMIAKTQPTLTYILLPHTGYKEHQHAWQ
CCCCEEEHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHH
QYAEQSIQAVIFDFYLHKPTIEQLKTADVVVVINPNNPTALNVPPSEVLTWLDHIQDHST
HHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCCCEECCCHHHHHHHHHHHCCCCE
LVIDEAFVDCTPELSVLPSFPTGVPDNLIVLRSVGKFFGLAGIRAGFCFASPLRLNILKQ
EEEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
HLGPWTLSGPTRYVTTHALLNSNWQKKNRQRLHEEAQRMNQLLQLHFGQMAGSVKITSQI
HCCCEEECCCCHHEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LFHRVEISDSASWHHQLAKLGVFTRHCDENDALRFGLPANESQWQALTRALEQLKE
HHHHEECCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TIKQHSTSNELPHHGGKLIEFSLRYQRPIEQWVDLSTGVSPHHYPIPEIPTSVWNRLPE
CCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCC
DDDGLITAAQTYYQSDALLPVAGSQAAIQSLPHMIAKTQPTLTYILLPHTGYKEHQHAWQ
CCCCEEEHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHH
QYAEQSIQAVIFDFYLHKPTIEQLKTADVVVVINPNNPTALNVPPSEVLTWLDHIQDHST
HHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCCCEECCCHHHHHHHHHHHCCCCE
LVIDEAFVDCTPELSVLPSFPTGVPDNLIVLRSVGKFFGLAGIRAGFCFASPLRLNILKQ
EEEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
HLGPWTLSGPTRYVTTHALLNSNWQKKNRQRLHEEAQRMNQLLQLHFGQMAGSVKITSQI
HCCCEEECCCCHHEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LFHRVEISDSASWHHQLAKLGVFTRHCDENDALRFGLPANESQWQALTRALEQLKE
HHHHEECCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]