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The map label for this gene is cobL [H]

Identifier: 218710609

GI number: 218710609

Start: 2849660

End: 2850958

Strand: Direct

Name: cobL [H]

Synonym: VS_2663

Alternate gene names: 218710609

Gene position: 2849660-2850958 (Clockwise)

Preceding gene: 218710608

Following gene: 218710610

Centisome position: 86.37

GC content: 46.5

Gene sequence:

>1299_bases
ATGAATAATGTAAGTACTCACTCTCAGCTTATCGATTGCTATCAAACGGCCATCACGGTAGTCGGAGTACCCGAAGATGG
GTGTTTAAGCCTAACCAGTCGAGCTGTTAATGCAGTTGAGTCTGCACGCATTGTTGCAGGTAACGACCGACTATTGGATT
GGTTCCCCCAATTCAAAGGTCAACGCTTATCGATGAAAGAAGGCTATCAATCTTGGTTCGCTAAGTTGCTTGATGAATGC
GAGGAAGGCGGCGTCGTCATATTAGCTTCTGGCGACCCATTGTTCTTTGGCATCGGCGAATCGTTATTAAAAAAACTGCC
TAATGATGAAGTGCGCTTTATTCCCTCCCCTTGTTCAATGCAACTCGCTTGCAGCCGAGTCGGCATTGCATGGCAAGAAA
CCAAAGCGATTTCACTACATGGAAGAAAGCAGCATTACGATGGCATTAAAGGTATCGCAAGCCAAATGCAATGGGGAACT
AGCTACTGCTTGCTAACCGATGTTCAAAACAACCCAGCTCGTATTGCGAAACACTTAGTCGAATTTAATCAACAAGGTTG
GACGGCTTGGGTATGTGAGAACTTAGGTGGCACCGACGAAAAGATAAGCCAGTGGACTCTCGAAGACCTCGCACTAAAAC
GTTCCGACGACTTCTCTACGCTCAATGTAATGGTACTGCACCGACCGCTACCTCATGCGTGGGGTGAATTGGGCCAATAC
GCCAACGATGATGACTTCATGAAGCGCATGCCTAAGCGCGGCTTAATTACCAAACAGCCCGTTCGTCACTTAGCGTTAGC
AAGTATGCGTATTCAGCCAAGATCTGTGGTGTGGGATATAGGCACAGGCTCAGGTTCTATTGCGATAGAAGCCGCTAAAC
AGTGCTATCAAGGACAAGTCTTCACCATTGAATCAAACCAAGAATGTTATGAGTCGGTCGAGGCTAACTTTAGAGCGCAC
GGTACCGACAACGTACAACTGATTCGAGATAAAGCCCCAATGCAGCTCGACACCTTGCCTCAGCCGGACAGTATTTTTAT
TGGTGGAAGCCGCGGCAACATGCACACCATTTTAGATTTCTGTTGGTCAGCAATAAAACCCGGTGGCGTTGTGATTGGTT
CAGCGGTAACGGTAGATTCAGTTTGCGAACTTCATCAATGGAGTAAAGACAGCAATGCTCCGACACAGGTTCAACTGGTC
TCTATATCAACAGGCGTACCACTCGCTCACTACACCCGTTATCAATCAGAAAATCCGATTCACTTATTTATTTTTACCAA
GCCGTTTATTCAGAAATAA

Upstream 100 bases:

>100_bases
CCGAACAAAACACAGTGCCTTACATTGCCAGCCTAGGCCGTAAAGGTGGCAGCCCGTTAGTGGTATCGACTATTCACGCC
CTACTTGCTGAGTCAGTAAA

Downstream 100 bases:

>100_bases
GCGCTTAATTTTTTAATTAAGCGCCACTCAACATATTAAATAAAAACATAATTAGAGAAAGCACAGATGAAATTAGGAAC
TATGTACGCAATTGGTGTCG

Product: precorrin-6y methylase

Products: NA

Alternate protein names: Precorrin-6 methyltransferase; Precorrin-6Y methylase [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MNNVSTHSQLIDCYQTAITVVGVPEDGCLSLTSRAVNAVESARIVAGNDRLLDWFPQFKGQRLSMKEGYQSWFAKLLDEC
EEGGVVILASGDPLFFGIGESLLKKLPNDEVRFIPSPCSMQLACSRVGIAWQETKAISLHGRKQHYDGIKGIASQMQWGT
SYCLLTDVQNNPARIAKHLVEFNQQGWTAWVCENLGGTDEKISQWTLEDLALKRSDDFSTLNVMVLHRPLPHAWGELGQY
ANDDDFMKRMPKRGLITKQPVRHLALASMRIQPRSVVWDIGTGSGSIAIEAAKQCYQGQVFTIESNQECYESVEANFRAH
GTDNVQLIRDKAPMQLDTLPQPDSIFIGGSRGNMHTILDFCWSAIKPGGVVIGSAVTVDSVCELHQWSKDSNAPTQVQLV
SISTGVPLAHYTRYQSENPIHLFIFTKPFIQK

Sequences:

>Translated_432_residues
MNNVSTHSQLIDCYQTAITVVGVPEDGCLSLTSRAVNAVESARIVAGNDRLLDWFPQFKGQRLSMKEGYQSWFAKLLDEC
EEGGVVILASGDPLFFGIGESLLKKLPNDEVRFIPSPCSMQLACSRVGIAWQETKAISLHGRKQHYDGIKGIASQMQWGT
SYCLLTDVQNNPARIAKHLVEFNQQGWTAWVCENLGGTDEKISQWTLEDLALKRSDDFSTLNVMVLHRPLPHAWGELGQY
ANDDDFMKRMPKRGLITKQPVRHLALASMRIQPRSVVWDIGTGSGSIAIEAAKQCYQGQVFTIESNQECYESVEANFRAH
GTDNVQLIRDKAPMQLDTLPQPDSIFIGGSRGNMHTILDFCWSAIKPGGVVIGSAVTVDSVCELHQWSKDSNAPTQVQLV
SISTGVPLAHYTRYQSENPIHLFIFTKPFIQK
>Mature_432_residues
MNNVSTHSQLIDCYQTAITVVGVPEDGCLSLTSRAVNAVESARIVAGNDRLLDWFPQFKGQRLSMKEGYQSWFAKLLDEC
EEGGVVILASGDPLFFGIGESLLKKLPNDEVRFIPSPCSMQLACSRVGIAWQETKAISLHGRKQHYDGIKGIASQMQWGT
SYCLLTDVQNNPARIAKHLVEFNQQGWTAWVCENLGGTDEKISQWTLEDLALKRSDDFSTLNVMVLHRPLPHAWGELGQY
ANDDDFMKRMPKRGLITKQPVRHLALASMRIQPRSVVWDIGTGSGSIAIEAAKQCYQGQVFTIESNQECYESVEANFRAH
GTDNVQLIRDKAPMQLDTLPQPDSIFIGGSRGNMHTILDFCWSAIKPGGVVIGSAVTVDSVCELHQWSKDSNAPTQVQLV
SISTGVPLAHYTRYQSENPIHLFIFTKPFIQK

Specific function: Catalyzes the methylation of both C-5 and C-15 in precorrin-6Y to form precorrin-8X [H]

COG id: COG2241

COG function: function code H; Precorrin-6B methylase 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR012818
- InterPro:   IPR014008
- InterPro:   IPR006365 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.132 [H]

Molecular weight: Translated: 48043; Mature: 48043

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVSTHSQLIDCYQTAITVVGVPEDGCLSLTSRAVNAVESARIVAGNDRLLDWFPQFKG
CCCCHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHCC
QRLSMKEGYQSWFAKLLDECEEGGVVILASGDPLFFGIGESLLKKLPNDEVRFIPSPCSM
CCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHCCCCCEEEECCCCCH
QLACSRVGIAWQETKAISLHGRKQHYDGIKGIASQMQWGTSYCLLTDVQNNPARIAKHLV
HHHHHHCCCEEECCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
EFNQQGWTAWVCENLGGTDEKISQWTLEDLALKRSDDFSTLNVMVLHRPLPHAWGELGQY
HHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHCC
ANDDDFMKRMPKRGLITKQPVRHLALASMRIQPRSVVWDIGTGSGSIAIEAAKQCYQGQV
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHCCCE
FTIESNQECYESVEANFRAHGTDNVQLIRDKAPMQLDTLPQPDSIFIGGSRGNMHTILDF
EEEECCHHHHHHHHCCEEECCCCCEEEEECCCCCEECCCCCCCEEEEECCCCCHHHHHHH
CWSAIKPGGVVIGSAVTVDSVCELHQWSKDSNAPTQVQLVSISTGVPLAHYTRYQSENPI
HHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHCCCCCCE
HLFIFTKPFIQK
EEEEECCHHHCC
>Mature Secondary Structure
MNNVSTHSQLIDCYQTAITVVGVPEDGCLSLTSRAVNAVESARIVAGNDRLLDWFPQFKG
CCCCHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHCC
QRLSMKEGYQSWFAKLLDECEEGGVVILASGDPLFFGIGESLLKKLPNDEVRFIPSPCSM
CCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHCCCCCEEEECCCCCH
QLACSRVGIAWQETKAISLHGRKQHYDGIKGIASQMQWGTSYCLLTDVQNNPARIAKHLV
HHHHHHCCCEEECCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
EFNQQGWTAWVCENLGGTDEKISQWTLEDLALKRSDDFSTLNVMVLHRPLPHAWGELGQY
HHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHCC
ANDDDFMKRMPKRGLITKQPVRHLALASMRIQPRSVVWDIGTGSGSIAIEAAKQCYQGQV
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHCCCE
FTIESNQECYESVEANFRAHGTDNVQLIRDKAPMQLDTLPQPDSIFIGGSRGNMHTILDF
EEEECCHHHHHHHHCCEEECCCCCEEEEECCCCCEECCCCCCCEEEEECCCCCHHHHHHH
CWSAIKPGGVVIGSAVTVDSVCELHQWSKDSNAPTQVQLVSISTGVPLAHYTRYQSENPI
HHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHCCCCCCE
HLFIFTKPFIQK
EEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]