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The map label for this gene is envZ [H]

Identifier: 218710598

GI number: 218710598

Start: 2837778

End: 2839211

Strand: Reverse

Name: envZ [H]

Synonym: VS_2651

Alternate gene names: 218710598

Gene position: 2839211-2837778 (Counterclockwise)

Preceding gene: 218710599

Following gene: 218710597

Centisome position: 86.05

GC content: 39.96

Gene sequence:

>1434_bases
TTGAAAAAAAACATACACCAGTCAATGGTTGCGCGTATCACCCTGTCTACGTTCATGGTTATTCTCATGGCTGAAATACT
GGCAGGTGCGGTATGGTTTACGGCAACATCAGCATCAAAAAAAGAGTCAGCTAGCCACGCCATGACAGCTATATCATCAG
CTGCAGCAGATACTATTAATTACTTCTCTGGCTTACCCATTAATTACCGTCACTTGGTGTTGGAACAGCTACGAAATATA
GGAGGAACAAGGTTTTTCATATCCATAAATAACCATAAACTTCCTATCACTTCTTTATCTGATTACTCATTGGTTCCTCA
GATGGAAGTACAAGCGTCTGAACTTCTGAATCAGCAACTTAGAGACTCCCGCAAAGTGCATGTCACTTTGACTAAGCGAG
AAGATTTACGGGTGTTTAACTCTGGTATAAAGCTTCATGAACTTCCTGCATTGTGGAAAGACTACAGTTTAGTATTAGGA
AAACTGGATCTCCCAATTGCTGTTATTCAGGTGGAGTTTTCAGATAATGAATGGCTTTATTTAGCCACCGTTCTACCGCT
GTCTTTTGATAGTCTGACCGATAATTTCATTGATAGCAGACAAGTCATATTTCTCCTTATTGTTACCTTCATGCTTATGG
GTGTTTCTTATGTTGTCTTACAGATGGAAATTCGTCCTTTTCGTTCTTTAGCACGCTCTGCCACTCTTATGGGGTCGCAA
ATGCAGATTGAAGAAATCAAAGAAGAAGGCAGCTCAGAAACCAGAGCGGCTATTCATGCTTTCAACAAAATGAACCGTCG
AATCAAATCGTATTTGCGGGATAGAGATATGTTTTTTAATGCGATATCCCATGATATTAAAACACCATTAGCCTGTTTAA
AGTTACGAACTGAAATGATGGATGATGAGCAAACAAAGTTAAGGTTTGAAAAGCTATTGAACGAAGTCGATATGATGTTG
AACGGGGCTTTGCAATATATGCGAGAGAATGACATCCACGAAGAGTTAGAGTGGATTGATATTAACGATATCCTTGAACA
ATGCGCGGCTGTTCATAACAAAAATGGAGTATGCGTAAGCCTGATAGATCTGCCAAGGATTGAGCTTTATGGCAAGCCAC
TAGCAATCAAACGTTGTTTATTCAACTTAGTTGATAATGGCGTTAAATATGGAAATACGGTCGACATCAGTATGTTTTCT
CACTCTGATTCTATTCAAATCGTGCTGCGTGATGCAGGAAAAGGAATCAAAGAAGATATGTTAGAAAAAGTCTTTGAACC
TTACTTTAGAGACAATGATACAGGCATTGAAGGTTCAGGTTTGGGACTAGCAATTGCTCGTAGTATCGCAAGGGCACACG
GTGGGGACGTTCAGTTATCTAATTCACCAGAAGGTGGGCTTGAGGTGGACATTATTTTGGTGAATGCCCTATGA

Upstream 100 bases:

>100_bases
TAAGGAAGCAATTAAGAGACGATGACCGTAACACGATTATGACGGTAAGGCATCGCGGCTATATGTTAGTGATCGATTCA
CATATCAATCGTATTAAATT

Downstream 100 bases:

>100_bases
AAAAATGGTTACTGTTAAGTCTTTTGTTATCGACGAACCCCGCGTTTTCTTCCCCCTCTGTTGAAATGCTGCATTGGTGG
ACGGCTGCTGGAGAAGAAAA

Product: putative sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MKKNIHQSMVARITLSTFMVILMAEILAGAVWFTATSASKKESASHAMTAISSAAADTINYFSGLPINYRHLVLEQLRNI
GGTRFFISINNHKLPITSLSDYSLVPQMEVQASELLNQQLRDSRKVHVTLTKREDLRVFNSGIKLHELPALWKDYSLVLG
KLDLPIAVIQVEFSDNEWLYLATVLPLSFDSLTDNFIDSRQVIFLLIVTFMLMGVSYVVLQMEIRPFRSLARSATLMGSQ
MQIEEIKEEGSSETRAAIHAFNKMNRRIKSYLRDRDMFFNAISHDIKTPLACLKLRTEMMDDEQTKLRFEKLLNEVDMML
NGALQYMRENDIHEELEWIDINDILEQCAAVHNKNGVCVSLIDLPRIELYGKPLAIKRCLFNLVDNGVKYGNTVDISMFS
HSDSIQIVLRDAGKGIKEDMLEKVFEPYFRDNDTGIEGSGLGLAIARSIARAHGGDVQLSNSPEGGLEVDIILVNAL

Sequences:

>Translated_477_residues
MKKNIHQSMVARITLSTFMVILMAEILAGAVWFTATSASKKESASHAMTAISSAAADTINYFSGLPINYRHLVLEQLRNI
GGTRFFISINNHKLPITSLSDYSLVPQMEVQASELLNQQLRDSRKVHVTLTKREDLRVFNSGIKLHELPALWKDYSLVLG
KLDLPIAVIQVEFSDNEWLYLATVLPLSFDSLTDNFIDSRQVIFLLIVTFMLMGVSYVVLQMEIRPFRSLARSATLMGSQ
MQIEEIKEEGSSETRAAIHAFNKMNRRIKSYLRDRDMFFNAISHDIKTPLACLKLRTEMMDDEQTKLRFEKLLNEVDMML
NGALQYMRENDIHEELEWIDINDILEQCAAVHNKNGVCVSLIDLPRIELYGKPLAIKRCLFNLVDNGVKYGNTVDISMFS
HSDSIQIVLRDAGKGIKEDMLEKVFEPYFRDNDTGIEGSGLGLAIARSIARAHGGDVQLSNSPEGGLEVDIILVNAL
>Mature_477_residues
MKKNIHQSMVARITLSTFMVILMAEILAGAVWFTATSASKKESASHAMTAISSAAADTINYFSGLPINYRHLVLEQLRNI
GGTRFFISINNHKLPITSLSDYSLVPQMEVQASELLNQQLRDSRKVHVTLTKREDLRVFNSGIKLHELPALWKDYSLVLG
KLDLPIAVIQVEFSDNEWLYLATVLPLSFDSLTDNFIDSRQVIFLLIVTFMLMGVSYVVLQMEIRPFRSLARSATLMGSQ
MQIEEIKEEGSSETRAAIHAFNKMNRRIKSYLRDRDMFFNAISHDIKTPLACLKLRTEMMDDEQTKLRFEKLLNEVDMML
NGALQYMRENDIHEELEWIDINDILEQCAAVHNKNGVCVSLIDLPRIELYGKPLAIKRCLFNLVDNGVKYGNTVDISMFS
HSDSIQIVLRDAGKGIKEDMLEKVFEPYFRDNDTGIEGSGLGLAIARSIARAHGGDVQLSNSPEGGLEVDIILVNAL

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=271, Percent_Identity=29.1512915129151, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=30.4832713754647, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1789403, Length=292, Percent_Identity=25, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1787894, Length=234, Percent_Identity=29.9145299145299, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=25.9414225941423, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786783, Length=343, Percent_Identity=23.9067055393586, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=289, Percent_Identity=24.9134948096886, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=213, Percent_Identity=27.6995305164319, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787374, Length=292, Percent_Identity=26.7123287671233, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=208, Percent_Identity=24.0384615384615, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790861, Length=235, Percent_Identity=25.1063829787234, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=217, Percent_Identity=23.5023041474654, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789149, Length=228, Percent_Identity=25, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53839; Mature: 53839

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNIHQSMVARITLSTFMVILMAEILAGAVWFTATSASKKESASHAMTAISSAAADTIN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHH
YFSGLPINYRHLVLEQLRNIGGTRFFISINNHKLPITSLSDYSLVPQMEVQASELLNQQL
HHCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
RDSRKVHVTLTKREDLRVFNSGIKLHELPALWKDYSLVLGKLDLPIAVIQVEFSDNEWLY
HCCCEEEEEEECCHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEE
LATVLPLSFDSLTDNFIDSRQVIFLLIVTFMLMGVSYVVLQMEIRPFRSLARSATLMGSQ
EEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MQIEEIKEEGSSETRAAIHAFNKMNRRIKSYLRDRDMFFNAISHDIKTPLACLKLRTEMM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DDEQTKLRFEKLLNEVDMMLNGALQYMRENDIHEELEWIDINDILEQCAAVHNKNGVCVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEECHHHHHHHHHHHHCCCCCEEE
LIDLPRIELYGKPLAIKRCLFNLVDNGVKYGNTVDISMFSHSDSIQIVLRDAGKGIKEDM
EECCCCHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHH
LEKVFEPYFRDNDTGIEGSGLGLAIARSIARAHGGDVQLSNSPEGGLEVDIILVNAL
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MKKNIHQSMVARITLSTFMVILMAEILAGAVWFTATSASKKESASHAMTAISSAAADTIN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHH
YFSGLPINYRHLVLEQLRNIGGTRFFISINNHKLPITSLSDYSLVPQMEVQASELLNQQL
HHCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
RDSRKVHVTLTKREDLRVFNSGIKLHELPALWKDYSLVLGKLDLPIAVIQVEFSDNEWLY
HCCCEEEEEEECCHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEE
LATVLPLSFDSLTDNFIDSRQVIFLLIVTFMLMGVSYVVLQMEIRPFRSLARSATLMGSQ
EEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MQIEEIKEEGSSETRAAIHAFNKMNRRIKSYLRDRDMFFNAISHDIKTPLACLKLRTEMM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DDEQTKLRFEKLLNEVDMMLNGALQYMRENDIHEELEWIDINDILEQCAAVHNKNGVCVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEECHHHHHHHHHHHHCCCCCEEE
LIDLPRIELYGKPLAIKRCLFNLVDNGVKYGNTVDISMFSHSDSIQIVLRDAGKGIKEDM
EECCCCHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHH
LEKVFEPYFRDNDTGIEGSGLGLAIARSIARAHGGDVQLSNSPEGGLEVDIILVNAL
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]