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The map label for this gene is serA [H]

Identifier: 218710589

GI number: 218710589

Start: 2825826

End: 2827055

Strand: Direct

Name: serA [H]

Synonym: VS_2640

Alternate gene names: 218710589

Gene position: 2825826-2827055 (Clockwise)

Preceding gene: 218710588

Following gene: 218710592

Centisome position: 85.65

GC content: 45.12

Gene sequence:

>1230_bases
ATGGCCAAAGTTTCACTGGAAAAAGAAAAAATAAAAATTCTACTTCTAGAAGGTCTTCACCCTTCTTCTGTAGAAGTACT
GCAAGCCGCTGGTTACACAAACATTGAGTACCACAAAGGCTCACTACCTGAAGATGAACTTCTTGAAGCAGTTAAAGATG
CTCACTTCATTGGTATCCGTTCTCGCACCAACATATCCCAAGAAGTTATTGATGCGGCTGAAAAGCTGGTTGCAGTCGGT
TGTTTCTGTATTGGTACTAACCAAGTCAACCTTCAAGCAGCAGCAAAGCGCGGTATCCCTGTTTTCAATGCACCGTTCTC
AAACACTCGAAGTGTTGCTGAACTCGTTCTAGGTCAGGTTCTATTACTGCTTCGCGGTATTCCAGAGAAGAATGCTCTTG
CTCACCGTGGTATCTGGAAAAAGAGTGCAGACAACTCTTACGAAGCTCGTGGTAAGCGTTTAGGTATTATTGGCTACGGT
CACATCGGTACTCAGCTGGGTATTATTGCTGAAAACCTTGGTATGCGTGTTTACTTTTACGATATCGAAAACAAGCTGTC
TCTAGGTAATGCCACTCAAGTTCATACTATGACCGAGTTGCTGAACAAGTGTGACGTGATCTCTTTACACGTACCTGAAA
CCAATGAAACTAAAGACATGATGGGTAAAGAAGAGTTCGAGCGCATGAAGCCTGGCTCTATCTTTATCAATGCAGCTCGT
GGCACGGTAGTTGACATCCCTGCTCTGTGTGGCGCTCTGGATTCTGGTCACCTTTCTGGTGCGGCTATTGATGTTTTCCC
AACAGAACCAAAAACCAATGCAGACCCGTTTGAGTCTCCATTAATGCAGTTCGATAACGTGATTCTAACGCCTCATGTTG
GTGGTTCAACTCAAGAAGCACAAGAGAACATCGGAGTTGAAGTTGCAGGAAAACTAGCGAAATACTCTGATAACGGCTCT
ACGCTATCAAGTGTTAACTTCCCAGAGGTATCACTGCCATTGCATACGGGCACATCTCGCTTGCTACACATTCACGAAAA
CCGCCCAGGTATCCTAACTCAGATCAACACCATCTTCGCAGAAGAAGGGATCAACATCGCGGGTCAGTACCTACAGACTG
CAGCAGATATGGGTTATGTTGTGATCGACGTGGAAGCGAATCGCTCTGAAGAAGCACTGCTTAAACTGAAAGAGATCGAA
GGCACAATCCGTGCTCGTCTTCTTCACTAA

Upstream 100 bases:

>100_bases
CGTTTGTCTCCTAACAAAGTGGTGAATTTGTTCCCCTTTCAGCCATTTTGTAGCACGTGCGCCGCATTTGCCCAACCTTT
CCATTTTAAGGACGAGAACA

Downstream 100 bases:

>100_bases
TCATCACATTCAAAATGCATAAAAAAGGCTCTCATCATGAGAGCCTTTCTAGTATTTGGCCTATCGTAGGTAATTAGATC
ACCATGATCCAAAAGCCTCT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAKVSLEKEKIKILLLEGLHPSSVEVLQAAGYTNIEYHKGSLPEDELLEAVKDAHFIGIRSRTNISQEVIDAAEKLVAVG
CFCIGTNQVNLQAAAKRGIPVFNAPFSNTRSVAELVLGQVLLLLRGIPEKNALAHRGIWKKSADNSYEARGKRLGIIGYG
HIGTQLGIIAENLGMRVYFYDIENKLSLGNATQVHTMTELLNKCDVISLHVPETNETKDMMGKEEFERMKPGSIFINAAR
GTVVDIPALCGALDSGHLSGAAIDVFPTEPKTNADPFESPLMQFDNVILTPHVGGSTQEAQENIGVEVAGKLAKYSDNGS
TLSSVNFPEVSLPLHTGTSRLLHIHENRPGILTQINTIFAEEGINIAGQYLQTAADMGYVVIDVEANRSEEALLKLKEIE
GTIRARLLH

Sequences:

>Translated_409_residues
MAKVSLEKEKIKILLLEGLHPSSVEVLQAAGYTNIEYHKGSLPEDELLEAVKDAHFIGIRSRTNISQEVIDAAEKLVAVG
CFCIGTNQVNLQAAAKRGIPVFNAPFSNTRSVAELVLGQVLLLLRGIPEKNALAHRGIWKKSADNSYEARGKRLGIIGYG
HIGTQLGIIAENLGMRVYFYDIENKLSLGNATQVHTMTELLNKCDVISLHVPETNETKDMMGKEEFERMKPGSIFINAAR
GTVVDIPALCGALDSGHLSGAAIDVFPTEPKTNADPFESPLMQFDNVILTPHVGGSTQEAQENIGVEVAGKLAKYSDNGS
TLSSVNFPEVSLPLHTGTSRLLHIHENRPGILTQINTIFAEEGINIAGQYLQTAADMGYVVIDVEANRSEEALLKLKEIE
GTIRARLLH
>Mature_408_residues
AKVSLEKEKIKILLLEGLHPSSVEVLQAAGYTNIEYHKGSLPEDELLEAVKDAHFIGIRSRTNISQEVIDAAEKLVAVGC
FCIGTNQVNLQAAAKRGIPVFNAPFSNTRSVAELVLGQVLLLLRGIPEKNALAHRGIWKKSADNSYEARGKRLGIIGYGH
IGTQLGIIAENLGMRVYFYDIENKLSLGNATQVHTMTELLNKCDVISLHVPETNETKDMMGKEEFERMKPGSIFINAARG
TVVDIPALCGALDSGHLSGAAIDVFPTEPKTNADPFESPLMQFDNVILTPHVGGSTQEAQENIGVEVAGKLAKYSDNGST
LSSVNFPEVSLPLHTGTSRLLHIHENRPGILTQINTIFAEEGINIAGQYLQTAADMGYVVIDVEANRSEEALLKLKEIEG
TIRARLLH

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=35.9621451104101, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI145580578, Length=233, Percent_Identity=30.4721030042918, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI4557499, Length=233, Percent_Identity=30.4721030042918, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI145580575, Length=250, Percent_Identity=30, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI61743967, Length=243, Percent_Identity=28.8065843621399, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI4557497, Length=243, Percent_Identity=28.8065843621399, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI6912396, Length=278, Percent_Identity=27.6978417266187, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=73.9659367396594, Blast_Score=632, Evalue=0.0,
Organism=Escherichia coli, GI87082289, Length=256, Percent_Identity=31.640625, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787645, Length=232, Percent_Identity=28.448275862069, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87081824, Length=190, Percent_Identity=27.8947368421053, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788660, Length=305, Percent_Identity=24.5901639344262, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=323, Percent_Identity=31.8885448916409, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=251, Percent_Identity=27.8884462151394, Blast_Score=98, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=46.6183574879227, Blast_Score=391, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=45.6521739130435, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324055, Length=236, Percent_Identity=27.9661016949153, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=276, Percent_Identity=26.8115942028986, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=161, Percent_Identity=27.3291925465839, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=32.5581395348837, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28571528, Length=293, Percent_Identity=30.0341296928328, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI28574286, Length=265, Percent_Identity=29.811320754717, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646446, Length=241, Percent_Identity=29.8755186721992, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646448, Length=241, Percent_Identity=29.8755186721992, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646452, Length=241, Percent_Identity=29.8755186721992, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646450, Length=241, Percent_Identity=29.8755186721992, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI62472511, Length=241, Percent_Identity=29.8755186721992, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24585516, Length=303, Percent_Identity=27.0627062706271, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24585514, Length=275, Percent_Identity=24.3636363636364, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574282, Length=275, Percent_Identity=24.3636363636364, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574284, Length=275, Percent_Identity=24.3636363636364, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45551003, Length=275, Percent_Identity=24.3636363636364, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45552429, Length=275, Percent_Identity=24.3636363636364, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44451; Mature: 44320

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVSLEKEKIKILLLEGLHPSSVEVLQAAGYTNIEYHKGSLPEDELLEAVKDAHFIGIR
CCCCCCCCCEEEEEEEECCCCCHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCEEEEEC
SRTNISQEVIDAAEKLVAVGCFCIGTNQVNLQAAAKRGIPVFNAPFSNTRSVAELVLGQV
CCCCHHHHHHHHHHHHHHHEEEEEECCEEEEHHHHHCCCEEEECCCCCHHHHHHHHHHHH
LLLLRGIPEKNALAHRGIWKKSADNSYEARGKRLGIIGYGHIGTQLGIIAENLGMRVYFY
HHHHHCCCCCCCHHHCCCCCCCCCCCHHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEEE
DIENKLSLGNATQVHTMTELLNKCDVISLHVPETNETKDMMGKEEFERMKPGSIFINAAR
ECCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCHHHHHHCCCCCEEEEECC
GTVVDIPALCGALDSGHLSGAAIDVFPTEPKTNADPFESPLMQFDNVILTPHVGGSTQEA
CCEEEHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCEEEECCCCCCHHHH
QENIGVEVAGKLAKYSDNGSTLSSVNFPEVSLPLHTGTSRLLHIHENRPGILTQINTIFA
HHHCCEEEECHHHEECCCCCEEEECCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHH
EEGINIAGQYLQTAADMGYVVIDVEANRSEEALLKLKEIEGTIRARLLH
HCCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCHHEECC
>Mature Secondary Structure 
AKVSLEKEKIKILLLEGLHPSSVEVLQAAGYTNIEYHKGSLPEDELLEAVKDAHFIGIR
CCCCCCCCEEEEEEEECCCCCHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCEEEEEC
SRTNISQEVIDAAEKLVAVGCFCIGTNQVNLQAAAKRGIPVFNAPFSNTRSVAELVLGQV
CCCCHHHHHHHHHHHHHHHEEEEEECCEEEEHHHHHCCCEEEECCCCCHHHHHHHHHHHH
LLLLRGIPEKNALAHRGIWKKSADNSYEARGKRLGIIGYGHIGTQLGIIAENLGMRVYFY
HHHHHCCCCCCCHHHCCCCCCCCCCCHHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEEE
DIENKLSLGNATQVHTMTELLNKCDVISLHVPETNETKDMMGKEEFERMKPGSIFINAAR
ECCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCHHHHHHCCCCCEEEEECC
GTVVDIPALCGALDSGHLSGAAIDVFPTEPKTNADPFESPLMQFDNVILTPHVGGSTQEA
CCEEEHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCEEEECCCCCCHHHH
QENIGVEVAGKLAKYSDNGSTLSSVNFPEVSLPLHTGTSRLLHIHENRPGILTQINTIFA
HHHCCEEEECHHHEECCCCCEEEECCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHH
EEGINIAGQYLQTAADMGYVVIDVEANRSEEALLKLKEIEGTIRARLLH
HCCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]